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Hamamatsu, Japan

Seirei Christopher University is a co-educational private university in Hamamatsu city, Shizuoka Prefecture Japan. Wikipedia.

Yamagishi A.,Seirei Christopher University | Morita T.,Palliative Care Team | Miyashita M.,Tohoku University | Igarashi A.,Dia Foundation for Research on Ageing Societies | And 4 more authors.
Journal of Pain and Symptom Management | Year: 2012

Context: Increasing numbers of patients with advanced cancer are receiving anticancer and/or palliative treatment in outpatient settings, and palliative care for outpatients with advanced cancer is being recognized as one of the most important areas for comprehensive cancer treatment. Objectives: The aim of this study was to evaluate pain intensity, quality of life, quality of palliative care, and satisfaction reported by outpatients with advanced cancer. Methods: Questionnaires were sent to 1493 consecutive outpatients with metastatic or recurrent cancer from four regions in Japan; 859 responses were analyzed (58%). Questionnaires included the Brief Pain Inventory, Good Death Inventory, Care Evaluation Scale, and a six-point satisfaction scale. Results: Approximately 20% of the patients reported moderate to severe pain. Whereas more than 70% agreed or strongly agreed with "good relationship with medical staff" and "being respected as an individual," less than 60% agreed or strongly agreed with "free from physical distress," "free from emotional distress," "maintaining hope," and "fulfillment at life's completion"; 54% reported some agreement with "feel a burden to others." About 20% reported that improvement is necessary in physical care by physicians, physical care by nurses, psycho-existential care, help with decision making, and coordination/consistency of care; 13% reported some levels of dissatisfaction. Conclusion: A considerable number of outpatients with metastatic or recurrent cancer experienced pain, physical symptoms, emotional distress, and existential suffering, and advocated improvements in palliative care across multiple areas. © 2012 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved. Source

Qiu S.,Chongqing Medical University | Cai Y.,Chongqing Medical University | Gao X.,Chongqing Medical University | Gu S.-Z.,Chongqing Medical University | And 2 more authors.
Cancer Letters | Year: 2015

One of the most important tumor suppression functions of p53 is its ability to induce apoptosis. iASPP is an inhibitory member of the ASPP protein family. It can specifically inhibit the normal function of p53 as a suppressor. The mechanism of iASPP suppressing the cell apoptotosis is through inhibiting the transactivation function of p53 on the promoters of proapoptotic genes by binding with p53. Therefore, relieving the combination of iASPP with p53 and leaving p53 free may be a useful strategy to activate p53 function. We therefore use A34, a small peptide derived from p53 linker region, to investigate the possibility of resuming the apoptosis activity of p53 by sequestering iASPP with p53 and derepressing p53. The results show that A34 can competitively combine with iASPP and therefore release p53 from iASPP; A34 can enhance the transcriptional activity of p53 on the promoters of Bax and PUMA; A34 can increase cell apoptosis and slow tumor growth in vitro and vivo. This study will open the way for using small molecule peptides that directly disturb the interaction of p53 with iASPP, thereby resume function of p53 as a suppressor. © 2014 Elsevier Ireland Ltd. Source

Takeuchi S.,Hamamatsu University School of Medicine | Nishida Y.,Seirei Christopher University | Mizushima T.,Hamamatsu University School of Medicine
Journal of Sports Science and Medicine | Year: 2014

The objective of the study was to investigate whether the occurrence of cardiac–locomotor synchronization (CLS) affects oxygen pulse (O2 pulse, mL/beat) during walking. Twelve healthy men were studied under two treadmill protocols. The CLS protocol involved subjects walking at a frequency of their heart rate (HR) to induce CLS. The free protocol (reference) involved subjects walking at a self-selected cadence. The treadmill load was equal between the two protocols and was adjusted so that the subject’s HR was maintained at approximately 120 bpm. Electrocardiographic signals, foot switch signals, and oxygen consumption (VO2) were measured continuously for 10 min after the heart rate reached a steady state. VO2, O2 pulse, and mean HR were calculated. VO2 and O2 pulse were significantly higher in subjects in the CLS protocol compared to those in the free protocol. However, mean HR was not different between the two groups. The synchronization strength was significantly related to the increase in O2 pulse in subjects in the CLS protocol compared with those in the free protocol. These results suggest that the occurrence of CLS enhances O2 pulse by increasing the strength of CLS during walking. © Journal of Sports Science and Medicine. Source

Yamagishi A.,Seirei Christopher University | Morita T.,Palliative Care Team and Seirei Hospice | Miyashita M.,Tohoku University | Yoshida S.,University of Tokyo | And 4 more authors.
Supportive Care in Cancer | Year: 2012

Dying at a favorite place is one of the important determinants for terminally ill cancer patients. The primary aim was to clarify (1) differences in preferred place of care and place of death among the general public across four areas across Japan and (2) preferred place of care and place of death among community-representative cancer patients. A cross-sectional mail survey was conducted on 8,000 randomly selected general population. We examined preferred place of care and place of death using two vignettes and obtained a total of 3,984 (50%) responses. For the pain scenario, approximately 50% of the general public throughout four areas chose home as their preferred place of care; and for the dependent-without-pain scenario, about 40% chose home as preferred place of care. In cancer patients, for both scenarios, approximately 40% chose home as the preferred place of care, and they were significantly less likely to choose home. The most preferred combination of place of care and place of death was home hospice for both groups. Although there were statistically significant differences in preferred place of care and place of death among the four regions, the absolute difference was less than 8%. Independent determinants of choosing home as place of care included concern about family burden and being unable to adequately respond to sudden changes out of working hours. In conclusion, establishing more accessible home and hospice service is strongly required through arranging regional resources to reduce family burden, alleviating patient-perceived burdens, and improving 24-h support at home. © 2012 Springer-Verlag. Source

Shibazaki K.,Seirei Christopher University | Marshall N.A.,University of Sussex
Aging and Mental Health | Year: 2015

Objectives: This study explores the specific effects of live music concerts on the clients with dementia, their families and nursing staff/caregivers. Methods: Researchers attended 22 concerts in care facilities in England and Japan. Interviews were carried out with clients with dementia, nursing staff and family members. Observations were also carried out before, during and after the concerts. All observations were recorded in field notes. Results: The effect of the concerts in both countries was seen to be beneficial to all clients and nursing staff, whether or not they attended the concert. Interviews with clients with mild to mid-stage dementia noted increased levels of cooperation, interaction and conversation. Those with more advanced forms of dementia exhibited decreased levels of agitation and anti-social behaviour. Staff members reported increased levels of care, cooperation and opportunities for assessment. Family members noted an increase in the levels of well-being in their partner/parent as well as in themselves. The study also suggested that the knowledge of musical components, an awareness of the rules of music and specific musical preferences appear to remain well beyond the time when other cognitive skills and abilities have disappeared. Conclusions: This initial study provided some further indication in terms of the uses of music as a non-pharmacological intervention for those living with all stages of dementia. These included opportunities for assessment of physical abilities as well as facilitating an increasing level of care. © 2015 Taylor & Francis Source

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