Seirei Christopher University
Hamamatsu, Japan

Seirei Christopher University is a co-educational private university in Hamamatsu city, Shizuoka Prefecture Japan. Wikipedia.

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Ohsugi H.,Seirei Christopher University | Ohgi S.,Seirei Christopher University | Shigemori K.,Kansai University | Schneider E.B.,The Surgical Center
BMC Neuroscience | Year: 2013

Background: The purpose of this study was to examine task-related changes in prefrontal cortex (PFC) activity during a dual-task in both healthy young and older adults and compare patterns of activation between the age groups. We also sought to determine whether brain activation during a dual-task relates to executive/attentional function and how measured factors associated with both of these functions vary between older and younger adults.Results: Thirty-five healthy volunteers (20 young and 15 elderly) participated in this study. Near-infrared spectroscopy (NIRS) was employed to measure PFC activation during a single-task (performing calculations or stepping) and dual-task (performing both single-tasks at once). Cognitive function was assessed in the older patients with the Trail-making test part B (TMT-B). Major outcomes were task performance, brain activation during task (oxygenated haemoglobin: Oxy-Hb) measured by NIRS, and TMT-B score. Mixed ANOVAs were used to compare task factors and age groups in task performance. Mixed ANOVAs also compared task factors, age group and time factors in task-induced changes in measured Oxy-Hb. Among the older participants, correlations between the TMT-B score and Oxy-Hb values measured in each single-task and in the dual-task were examined using a Pearson correlation coefficient.Oxy-Hb values were significantly increased in both the calculation task and the dual-task within patients in both age groups. However, the Oxy-Hb values associated with there were higher in the older group during the post-task period for the dual-task. Also, there were significant negative correlations between both task-performance accuracy and Oxy-Hb values during the dual-task and participant TMT-B scores.Conclusions: Older adults demonstrated age-specific PFC activation in response to dual-task challenge. There was also a significant negative correlation between PFC activation during dual-task and executive/attentional function. These findings suggest that the high cognitive load induced by dual-task activity generates increased PFC activity in older adults. However, this relationship appeared to be strongest in participants with better baseline attention and executive functions. © 2013 Ohsugi et al.; licensee BioMed Central Ltd.

Yamagishi A.,Seirei Christopher University | Morita T.,Seirei Mikatahara General Hospital | Miyashita M.,Tohoku University | Igarashi A.,Dia Foundation for Research on Ageing Societies | And 4 more authors.
Journal of Pain and Symptom Management | Year: 2012

Context: Increasing numbers of patients with advanced cancer are receiving anticancer and/or palliative treatment in outpatient settings, and palliative care for outpatients with advanced cancer is being recognized as one of the most important areas for comprehensive cancer treatment. Objectives: The aim of this study was to evaluate pain intensity, quality of life, quality of palliative care, and satisfaction reported by outpatients with advanced cancer. Methods: Questionnaires were sent to 1493 consecutive outpatients with metastatic or recurrent cancer from four regions in Japan; 859 responses were analyzed (58%). Questionnaires included the Brief Pain Inventory, Good Death Inventory, Care Evaluation Scale, and a six-point satisfaction scale. Results: Approximately 20% of the patients reported moderate to severe pain. Whereas more than 70% agreed or strongly agreed with "good relationship with medical staff" and "being respected as an individual," less than 60% agreed or strongly agreed with "free from physical distress," "free from emotional distress," "maintaining hope," and "fulfillment at life's completion"; 54% reported some agreement with "feel a burden to others." About 20% reported that improvement is necessary in physical care by physicians, physical care by nurses, psycho-existential care, help with decision making, and coordination/consistency of care; 13% reported some levels of dissatisfaction. Conclusion: A considerable number of outpatients with metastatic or recurrent cancer experienced pain, physical symptoms, emotional distress, and existential suffering, and advocated improvements in palliative care across multiple areas. © 2012 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

Shibazaki K.,Seirei Christopher University | Marshall N.A.,University of Sussex
Aging and Mental Health | Year: 2015

Objectives: This study explores the specific effects of live music concerts on the clients with dementia, their families and nursing staff/caregivers. Methods: Researchers attended 22 concerts in care facilities in England and Japan. Interviews were carried out with clients with dementia, nursing staff and family members. Observations were also carried out before, during and after the concerts. All observations were recorded in field notes. Results: The effect of the concerts in both countries was seen to be beneficial to all clients and nursing staff, whether or not they attended the concert. Interviews with clients with mild to mid-stage dementia noted increased levels of cooperation, interaction and conversation. Those with more advanced forms of dementia exhibited decreased levels of agitation and anti-social behaviour. Staff members reported increased levels of care, cooperation and opportunities for assessment. Family members noted an increase in the levels of well-being in their partner/parent as well as in themselves. The study also suggested that the knowledge of musical components, an awareness of the rules of music and specific musical preferences appear to remain well beyond the time when other cognitive skills and abilities have disappeared. Conclusions: This initial study provided some further indication in terms of the uses of music as a non-pharmacological intervention for those living with all stages of dementia. These included opportunities for assessment of physical abilities as well as facilitating an increasing level of care. © 2015 Taylor & Francis

Qiu S.,Chongqing Medical University | Cai Y.,Chongqing Medical University | Gao X.,Chongqing Medical University | Gu S.-Z.,Chongqing Medical University | And 2 more authors.
Cancer Letters | Year: 2015

One of the most important tumor suppression functions of p53 is its ability to induce apoptosis. iASPP is an inhibitory member of the ASPP protein family. It can specifically inhibit the normal function of p53 as a suppressor. The mechanism of iASPP suppressing the cell apoptotosis is through inhibiting the transactivation function of p53 on the promoters of proapoptotic genes by binding with p53. Therefore, relieving the combination of iASPP with p53 and leaving p53 free may be a useful strategy to activate p53 function. We therefore use A34, a small peptide derived from p53 linker region, to investigate the possibility of resuming the apoptosis activity of p53 by sequestering iASPP with p53 and derepressing p53. The results show that A34 can competitively combine with iASPP and therefore release p53 from iASPP; A34 can enhance the transcriptional activity of p53 on the promoters of Bax and PUMA; A34 can increase cell apoptosis and slow tumor growth in vitro and vivo. This study will open the way for using small molecule peptides that directly disturb the interaction of p53 with iASPP, thereby resume function of p53 as a suppressor. © 2014 Elsevier Ireland Ltd.

Cai Y.,Chongqing Medical University | Qiu S.,Chongqing Medical University | Gao X.,Chongqing Medical University | Gu S.-Z.,Chongqing Medical University | And 2 more authors.
Apoptosis | Year: 2012

The ability to induce apoptosis is the most important tumor-suppression function of p53. Inhibitory member of apoptosis-stimulating protein of p53 family (iASPP) is an apoptotic-specific regulator of p53. iASPP suppresses apoptosis by inhibiting the transactivation function of p53 on the promoters of proapoptotic genes; however, the mechanism whereby iASPP influences apoptosis in tumor cells with mutant or deficient p53 has not been completely defined. In this study, we investigated the role of iASPP in the p63/p73 apoptosis pathway. iASPP inhibited apoptosis independently of p53 in tumor cells, mainly by inhibiting the transcriptional activity of p63/p73 on the promoters of proapoptotic genes. Because p63 and p73 are rarely mutated in human cancers, inhibiting the expression of endogenous iASPP may provide a useful strategy for restoring the apoptotic activity of p63 and p73 in human tumors with p53 loss or mutation. These results represent a promising new strategy for the treatment of cancers with non-wild-type p53. © Springer Science+Business Media, LLC 2012.

Takeuchi S.,Hamamatsu University School of Medicine | Nishida Y.,Seirei Christopher University | Mizushima T.,Hamamatsu University School of Medicine
Journal of Sports Science and Medicine | Year: 2014

The objective of the study was to investigate whether the occurrence of cardiac–locomotor synchronization (CLS) affects oxygen pulse (O2 pulse, mL/beat) during walking. Twelve healthy men were studied under two treadmill protocols. The CLS protocol involved subjects walking at a frequency of their heart rate (HR) to induce CLS. The free protocol (reference) involved subjects walking at a self-selected cadence. The treadmill load was equal between the two protocols and was adjusted so that the subject’s HR was maintained at approximately 120 bpm. Electrocardiographic signals, foot switch signals, and oxygen consumption (VO2) were measured continuously for 10 min after the heart rate reached a steady state. VO2, O2 pulse, and mean HR were calculated. VO2 and O2 pulse were significantly higher in subjects in the CLS protocol compared to those in the free protocol. However, mean HR was not different between the two groups. The synchronization strength was significantly related to the increase in O2 pulse in subjects in the CLS protocol compared with those in the free protocol. These results suggest that the occurrence of CLS enhances O2 pulse by increasing the strength of CLS during walking. © Journal of Sports Science and Medicine.

Niimi Y.,Seirei Christopher University | Ota K.,Nagoya University
Studies in Health Technology and Informatics | Year: 2016

The purpose of this study is to ascertain if patients will accept an electronic patient record system that temporarily conceals their private information. We interviewed 11 outpatients at a core hospital in Shizuoka prefecture of Japan. Most patients agree with our idea using temporary mosaic on the screen to protect their privacy. © 2016 IMIA and IOS Press.

Kamo T.,Seirei Christopher University | Nishida Y.,Seirei Christopher University
Geriatrics and Gerontology International | Year: 2014

Aim: To identify the direct and indirect effects of nutritional status, physical function, and cognitive function on activities of daily living in Japanese older adults requiring long-term care. Methods: In total, 179 participants aged ≥65 years who were eligible for long-term care insurance (mean age 85.5±7.8 years) were recruited for this study. Nutritional status (Mini Nutritional Assessment, Short Form) and physical function (Short Physical Performance Battery) were examined. Activities of daily living, cognitive function and frailty were assessed using the Barthel Index, Mini-Mental State Examination and Clinical Frailty Scale, respectively. Path analysis was used to determine relationships between these factors and the activities of daily living. Results: For Japanese older adults requiring long-term care, pathways were modeled for nutritional status, physical function and the activities of daily living. The total effect of nutritional status was 0.516 (P<0.001). The indirect effect of nutritional status through physical function on the activities of daily living was 0.458 (P<0.001). Finally, no significant direct effect of nutritional status on activities of daily living was observed (b=0.058, P=0.258). Conclusions: The present study identified the complex pathway from nutritional status to the activities of daily living through physical function in aged Japanese people requiring long-term care. These findings suggest that maintaining good nutritional status and nutritional support might delay physical function decline, and prolong the activities of daily living. © 2014 Japan Geriatrics Society.

Usui H.,Seirei Christopher University | Nishida Y.,Seirei Christopher University
Journal of Stroke and Cerebrovascular Diseases | Year: 2015

Background: The present study aimed to clarify the relationship between high physical activity (PA) and function of the autonomic nervous system, which is important in the prognosis after stroke. We hypothesized a positive association between PA and the very low-frequency (VLF) component of heart rate variability (HRV). Methods: Eight patients participated in this study. PA was measured using an accelerometer, and HRV was measured using a heart rate monitor. Results: A significant and positive relationship was observed between the VLF component of HRV and PA. A significant negative relationship was observed between the VLF component of HRV and the duration of inactivity. No significant relationship was identified between the low-to-high frequency ratio of HRV and between the highfrequency component of HRV and PA. Conclusions: A positive correlation was observed between the VLF component of HRV and PA in stroke patients. Therefore, the VLF component of HRV links PA to cardiovascular prognosis. © 2015 by National Stroke Association.

Niimi Y.,Seirei Christopher University
CIN - Computers Informatics Nursing | Year: 2016

Electronic patient records facilitate the provision of safe, high-quality medical care. However, because personnel can view almost all stored information, this study designed a display method using a mosaic blur (pixelation) to temporarily conceal information patients do not want shared. This study developed an electronic patient records display method for patient information that balanced the patient’s desire for personal information protection against the need for information sharing among medical personnel. First, medical personnel were interviewed about the degree of information required for both individual duties and team-based care. Subsequently, they tested a mock display method that partially concealed information using a mosaic blur, and they were interviewed about the effectiveness of the display method that ensures patient privacy. Participants better understood patients’ demand for confidentiality, suggesting increased awareness of patients’ privacy protection. However, participants also indicated that temporary concealment of certain information was problematic. Other issues included the inconvenience of removing the mosaic blur to obtain required information and risk of insufficient information for medical care. Despite several issues with using a display method that temporarily conceals information according to patient privacy needs, medical personnel could accept this display method if information essential to medical safety remains accessible. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

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