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Sakai, Japan

Yamamoto K.,Osaka Cancer Prevention and Detection Center | Yamamoto K.,Osaka University | Yamazaki H.,Osaka Cancer Prevention and Detection Center | Kuroda C.,Osaka Cancer Prevention and Detection Center | And 5 more authors.
IFMBE Proceedings | Year: 2011

The aim of this study is to evaluate the diagnostic validity of radiographer, first radiologist and second radiologist on gastric cancer screening, in terms of sensitivity, specificity and area under receiver-operating characteristic (ROC) curve (AUC) analysis. The study subjects were 431,949 Osaka residents who underwent gastric cancer screening test at the Osaka Cancer Prevention and Detection Center (the Center) between January 1, 1996 and December 31, 2002. Film readings were carried out at first by 21 radiographers and then double-checked by 31 first radiologists and 9 second radiologists. The sensitivity, specificity and AUC were calculated separately on radiographers, first and second radiologists. Sensitivity, specificity and AUC values on radiographer were 62.5%, 94.1% and 0.79, while those on first radiologist were 78.3%, 94.2% and 0.87, and those on second radiologist were 85.9%, 92.2% and 0.91. Sensitivity and AUC of radiographers were significantly lower than those of radiologists (P < 0.05). Although this result seems to be affected by the first film reading of radiographers, it is considered that more training on film reading is necessary for radiographers. © 2011 Springer-Verlag Berlin Heidelberg. Source


Yabunaka K.,Katsuragi Hospital | Yabunaka K.,University of Tokyo | Nakagami G.,University of Tokyo | Sanada H.,University of Tokyo | And 7 more authors.
IFMBE Proceedings | Year: 2011

Purpose: Videofluoroscopy is generally considered a "gold standard" technique for diagnosing dysphagia; however this technique exposes subjects to radiation. Ultrasonography is applied widely in clinical practice because of low cost, safety of the technique, and absence of radiation exposure. The purpose of this study was to investigate the application of B+M-mode ultrasound imaging as a new approach to quantify activity patterns of the geniohyoid muscles during swallowing and to assess the effect of bolus volume in healthy subjects. Subject and Methods: 25 healthy volunteers (13 male, 12 female) completed three repetitions each of four swallowing conditions: 1-, 5-, 10-, and 20-ml water bolus swallows. Simultaneous B/M-mode images were captured at two regions along the lateral geniohyoid muscle wall. Frozen frames of the moving image were analyzed, and the moving distance of the geniohyoid muscle wall from the resting point was measured (X axis, time; Y axis, perpendicular to the range of motion). We measured moving distance of the geniohyoid muscle wall during contraction and duration of movement of the geniohyoid muscle. Results: In all cases, ultrasonographic images of the geniohyoid muscle movement during swallowing were easily visualized using the real-time B/M-mode. The average moving distance and the average duration of movement of the geniohyoid muscle during swallowing increased gradually by bolus volume increased. Mean moving distance was significantly increased at bolus volume of 20ml compared to 1ml, 5ml, and 10ml, and with 10ml compared to 1ml. Mean duration was significantly increased at bolus volume of 20ml compared to 1ml, 5ml, 10ml. Conclusion: B/M-mode ultrasound imaging provides a simple and noninvasive technique to visually assess the lateral geniohyoid muscle wall and may provide a clinical method for direct evaluation for swallowing. © 2011 Springer-Verlag Berlin Heidelberg. Source


Yoneda M.,Mie University | Yamamoto K.,Osaka Cancer Prevention and Detection Center | Katsuda T.,Seikeikai 2 Gakuin | Kuwano T.,Okayama University
IFMBE Proceedings | Year: 2011

The endoscopic ultrasound-guided fineneedle aspiration (EUS-FNA) is an effective test method for preoperative diagnosis of pancreas tumors, etc. In the specimen extracted from a puncture needle, a mass of cells can be found as the formed element specimen (Fig. 1) and unformed element specimen (Fig. 2). The cell block method allows the users to make paraffin blocks of the specimen, slice and stain them, and preserve them just like a tissue examination. Therefore, this method is used for many cases that require formation of tissue that were not possible to obtain by cell diagnosis or immunostaining of endocrine tumor or malignant lymphoma. However, it is often the case that all masses of cells extracted from the needle puncture cannot be blocked only through fixation by formalin and embedding. Many cell block methods had been designed in the past [1-4]. This time, we improved the cassette sold by ASIAKIZAI Co., Ltd. and came up with a new cell block development method that adapted glucomannan-formalin solution (hereafter referred to as Hold Gel 110). © 2011 Springer-Verlag Berlin Heidelberg. Source


Hayashida K.,Meiwa Hospital | Hayashida K.,Okayama University | Katsuda T.,Seikeikai 2 Gakuin | Yamamoto K.,Osaka Cancer Prevention and Detection Center | Takeda Y.,Okayama University
IFMBE Proceedings | Year: 2011

Proximal femoral bone mineral density (BMD) can be measured by dual energy X-ray absorptiometry (DXA) method in the parts of neck, trochanter, intertrochanter, total and Ward's. Ward's is a measuring part smaller than others, and the position varies on the status of inner rotation of target leg. Therefore, Ward's BMD is higher than neck and trochanter BMD in coefficient of variation (CV). On the other hand, it is reported that Ward's BMD decreases with aging more remarkably than those of lumber vertebra and total neck do. In this study, the measurements of proximal femoral BMD were carried out on 5 parts of neck, trochanter, intertrochanter, total and Ward's, in the condition of subject leg turned inside 15 degrees. Ward's BMD were measured with Ward's cognitive method. The measured BMD were compared among age groups of 50-59, 60-69, 70-79 and 80-89. The correlation between BMD and age was tested using Pearson. On 5 parts, the BMD of age 50 - 59 were significantly higher than those of age 80 - 89. The correlations between BMD and age were negative on 5 parts and the most negative one was on Ward's. The study using Ward's cognitive method showed remarkable nagative relation between Ward's BMD and age. © 2011 Springer-Verlag Berlin Heidelberg. Source


Yamamoto K.,Osaka Cancer Prevention and Detection Center | Yamamoto K.,Osaka University | Takeda Y.,Okayama University | Katsuda T.,Seikeikai 2 Gakuin | And 9 more authors.
IFMBE Proceedings | Year: 2011

High-density barium sulfate (HDB) has been recommended by the Japanese Society of Gastroenterological Cancer Screening (JSGCS) and used in many medical facilities. However, it is not confirmed that the new method using HDB is superior in diagnostic validity compared to the conventional method using moderate-density barium sulfate (MDB). Pre viously, the authors reported that both methods showed simi lar validity in terms of sensitivity and specificity in gastric cancer screening. In this study, sensitivity and specificity were re-examined in more detail by area under receiver-operating characteristic (ROC) curves (AUC) analysis, especially on the sex (male, female) and the ages (≥50, <50, ≥55, <55, ≥60, <60) of subjects. The results showed that the diagnostic validity of the method using HDB is almost same to that of the conven tional method using MDB. Clinical improvement in gastric cancer screening is in need of further studies on the new me thod using HDB. © 2011 Springer-Verlag Berlin Heidelberg. Source

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