Seemanta Institute of Pharmaceutical science

Mayurbhanj, India

Seemanta Institute of Pharmaceutical science

Mayurbhanj, India

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Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,IFTM University
International Journal of Biological Macromolecules | Year: 2012

This work investigates the development, optimization and in vitro evaluation of liquid paraffin-entrapped multiple-unit alginate-based floating system containing cloxacillin by emulsion-gelation method for gastro retentive delivery. The effect of process variables like drug to polymer ratio by weight, and liquid paraffin to water ratio by volume on various physicochemical properties in case of liquid paraffin-entrapped calcium alginate beads containing cloxacillin applicable to drug entrapment efficiency, density and drug release was optimized using 3 2 factorial design and analyzed using response surface methodology. The observed (actual values) responses were coincided well with the predicted values, given by the optimization technique. The optimized beads showed drug entrapment efficiency of 64.63±0.78%, density of 0.90±0.05g/cm 3, and drug release of 56.72±0.85% in simulated gastric fluid (pH 1.2) after 8h with floating lag time of 8.45min and floated well over 12h in simulated gastric fluid (pH 1.2). The average size of all dried beads ranged from 1.73±0.04 to 1.97±0.08mm. The beads were characterized by SEM and FTIR for surface morphology and excipients-drug interaction analysis, respectively. All these beads showed prolonged sustained release of cloxacillin over 8h in simulated gastric fluid (pH 1.2). The cloxacillin release profile from liquid paraffin beads followed Korsmeyer-Peppas model over a period of 8h with anomalous (non-Fickian) diffusion mechanism for drug release. © 2011 Elsevier B.V.


Nayak A.K.,Seemanta Institute of Pharmaceutical science
Chemical Engineering Research and Design | Year: 2012

This present investigation deals with the development and optimization of buoyant beads containing ibuprofen by emulsion-gelation method for gastroretentive delivery. The effect of three independent process variables like amount of sodium alginate, magnesium stearate, and liquid paraffin on drug entrapment, density, and drug release of buoyant beads containing ibuprofen was optimized using 2 3 factorial design. The observed responses were coincided well with the predicted values, given by the optimization technique. The optimized beads showed drug entrapment efficiency of 83.07±3.25%, density of 0.89±0.11g/cm 3, cumulative drug release of 35.02±1.24% after 8h, and floated well over 8h in simulated gastric fluid (pH 1.2) with 4.50min buoyant lag-time. The average size of all buoyant beads ranged from 1.43±0.05 to 1.82±0.14mm. The buoyant beads were characterized by SEM and FTIR spectroscopy for surface morphology and excipients-drug interaction analysis, respectively. All these beads showed prolonged sustained release of ibuprofen over 8h in simulated gastric fluid (pH 1.2). The ibuprofen release profile from these buoyant beads followed Korsmeyer-Peppas model over a period of 8h with anomalous (non-Fickian) diffusion mechanism for drug release. © 2012 The Institution of Chemical Engineers.


Nayak A.K.,Seemanta Institute of Pharmaceutical science
Colloids and Surfaces B: Biointerfaces | Year: 2013

The current investigation deals with the development and optimization of oil-entrapped sterculia gum-alginate buoyant beads containing aceclofenac by ionotropic emulsion-gelation technique using 32 factorial design. The effect of polymer to drug ratio and sodium alginate to sterculia gum ratio on the drug entrapment efficiency (%), and cumulative drug release after 7h (%) was optimized. The optimized oil-entrapped sterculia gum-alginate buoyant beads containing aceclofenac (F-O) showed drug entrapment efficiency of 90.92±2.34%, cumulative drug release of 41.65±3.97% after 7h in simulated gastric fluid (pH 1.2), and well buoyancy over 8h in simulated gastric fluid (pH 1.2) with 5.20min buoyant lag-time. The in vitro drug release from these buoyant beads followed Korsmeyer-Peppas model (R2=0.9866-0.9995) with anomalous (non-Fickian) diffusion drug release mechanism. These new sterculia gum-alginate buoyant beads containing aceclofenac were also characterized using SEM, FTIR, and P-XRD analysis. © 2012 Elsevier B.V.


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,IFTM University
International Journal of Biological Macromolecules | Year: 2011

The present study deals with the development of novel pH-sensitive tamarind seed polysaccharide (TSP)-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology by full 3 2 factorial design. The effect of polymer-blend ratio (sodium alginate:TSP) and cross-linker (CaCl 2) concentration on the drug encapsulation efficiency (DEE, %) and drug release from diclofenac sodium loaded TSP-alginate composite beads prepared by ionotropic gelation was optimized. The observed responses were coincided well with the predicted values by the experimental design. The DEE (%) of these beads containing diclofenac sodium was within the range between 72.23±2.14 and 97.32±4.03% with sustained in vitro drug release (69.08±2.36-96.07±3.54% in 10h). The in vitro drug release from TSP-alginate composite beads containing diclofenac sodium was followed by controlled-release pattern (zero-order kinetics) with case-II transport mechanism. Particle size range of these beads was 0.71±0.03-1.33±0.04mm. The swelling and degradation of the developed beads were influenced by different pH of the test medium. The FTIR and NMR analyses confirmed the compatibility of the diclofenac sodium with TSP and sodium alginate used to prepare the diclofenac sodium loaded TSP-alginate composite beads. The newly developed TSP-alginate composite beads are suitable for controlled delivery of diclofenac sodium for prolonged period. © 2011 Elsevier B.V.


Nayak A.K.,Seemanta Institute of Pharmaceutical science
Current drug delivery | Year: 2013

The present investigation describes development and optimization of pioglitazone-loaded jackfruit seed starch (JFSS)-alginate beads by ionotropic-gelation using 3(2) factorial design. The effect of polymer-blend ratio and CaCl2 concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10 hours (R10h, %) was optimized. The DEE (%) of these beads were 64.80 ± 1.92 to 94.07 ± 3.82 % with sustained in vitro drug release of 64.± 1.83 to 92.66 ± 4.54 % over 10 hours. The in vitro drug release from these beads followed controlled-release pattern with super case-II transport. Particle size range of these beads was 0.77 ± 0.04 to 1.24 ± 0.09 mm. The beads were also characterized by SEM and FTIR. The swelling of these beads was influenced by pH of the test medium. The optimized pioglitazone-loaded JFSS-alginate beads showed significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.


Nayak A.K.,Seemanta Institute of Pharmaceutical science
International Journal of ChemTech Research | Year: 2010

Hydroxyapatite (HAp) is the emerging most bioceramic, which is widely used in various biomedical applications, mainly in orthopedics and dentistry due to its close similarities with inorganic mineral component of bone and teeth. Synthetic HAp is known to be similar to naturally occurring HAp on the basis of crystallographic and chemical studies. Several methodologies have been investigated and developed for the synthesis of HAp. But, new economic and versatile methods for HAp synthesis are of interest due to its immense importance and wide utilization in biomedical applications. This review presents various well known methodologies for HAp synthesis like precipitation technique, sol-gel approach, hydrothermal technique, multiple emulsion technique, biomimetic deposition technique, electrodeposition technique etc.


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,Guru Ghasidas University
Carbohydrate Polymers | Year: 2014

Fenugreek (Trigonella foenum-graecum L.) seed mucilage (FSM)-gellan gum (GG) mucoadhesive beads containing metformin HCl for oral use were developed through ionotropic-gelation technique. Effects of GG to FSM ratio and cross-linker (CaCl2) concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10 h (R10h, %) of ionotropically-gelled FSM-GG mucoadhesive beads containing metformin HCl were optimized by 32 factorial design. The optimized mucoadhesive beads showed DEE of 92.53 ± 3.85% and R10h of 55.28 ± 1.58% and mean diameter of 1.62 ± 0.22 mm. The in vitro metformin HCl release from these ionotropically-gelled FSM-GG beads was prolonged over 10 h and followed zero-order model with super case-II transport mechanism. The optimized mucoadhesive beads also exhibited pH-dependent swelling, good mucoadhesivity with biological mucosal membrane and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. © 2014 Elsevier Ltd. All rights reserved.


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,Guru Ghasidas University
International Journal of Biological Macromolecules | Year: 2013

The present study deals with the formulation optimization of jackfruit (Artocarpus heterophyllus Lam., family: Moraceae) seed starch (JFSS)-alginate mucoadhesive beads containing metformin HCl through ionotropic gelation using 32 factorial design. The effect of sodium alginate to JFSS ratio and CaCl2 concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release at 10h (R10h, %) was optimized. The optimized beads containing metformin HCl showed DEE of 97.48±3.92%, R10h of 65.70±2.22%, and mean diameter of 1.16±0.11mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. The beads were also characterized by SEM and FTIR. The swelling and degradation of these beads were influenced by pH of the test medium. The optimized beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. © 2013 Elsevier B.V.


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,Guru Ghasidas University | Santra K.,Seemanta Institute of Pharmaceutical science
Carbohydrate Polymers | Year: 2014

Novel mucoadhesive beads containing metformin HCl made of low methoxy (LM) pectin-tamarind seedpolysaccharide (TSP) polymer-blend was developed through ionotropic-gelation technique and opti-mized using 32 factorial design. Effects of LM pectin and TSP amounts on drug encapsulation efficiency(DEE), and cumulative drug release at 10 h (R10h) were analyzed using response surface methodology.The optimized calcium pectinate-TSP beads containing metformin HCl showed DEE of 95.12 ± 4.26%, R10hof 46.53 ± 3.28%, and mean diameter of 1.93 ± 0.26 mm. The in vitro drug release from these beads wasfollowed controlled-release (zero-order) pattern with super case-II transport mechanism. These beadswere also characterized by SEM and FTIR. The optimized beads also exhibited pH-dependent swelling,good mucoadhesivity with goat intestinal mucosa and significant hypoglycemic effect in alloxan-induceddiabetic rats over prolonged period after oral administration. © 2013 Elsevier Ltd.


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,Guru Ghasidas University
International Journal of Biological Macromolecules | Year: 2013

In this work, calcium pectinate-jackfruit (Artocarpus heterophyllus Lam.) seed starch (JFSS) mucoadhesive beads containing metformin HCl were developed through ionotropic-gelation. Effects of pectin and JFSS amounts on drug encapsulation efficiency (DEE), and cumulative drug release after 10h (R10h) were optimized using 32 factorial design. The optimized calcium pectinate-JFSS beads containing metformin HCl showed DEE of 94.11±3.92%, R10h of 48.88±2.02%, and mean diameter of 2.06±0.20mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. The beads were also characterized by SEM and FTIR. The pH of test mediums was found critical for swelling and mucoadhesion of these beads. The optimized calcium pectinate-JFSS beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. © 2013 Elsevier B.V.

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