Seemanta Institute of Pharmaceutical science

Mayurbhanj, India

Seemanta Institute of Pharmaceutical science

Mayurbhanj, India
SEARCH FILTERS
Time filter
Source Type

Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,A And G Pharmaceutical, Inc.
Journal of Scientific and Industrial Research | Year: 2013

The work investigates the development and optimization of ionotropically-gelled mucoadhesive beads composed of tamarind seed polysaccharide (TSP)-alginate polymer-blend for oral delivery of metformin HCl using 32 factorial design. The optimized mucoadhesive beads exhibited 94.86 ± 3.92 % drug encapsulation efficiency and good mucoadhesivity with the biological membrane in wash-off test, and sustained drug release profile over 10 h. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern (R2 = 0.9873 to 0.9980) with super case-II transport mechanism. The optimized TSPalginate mucoadhesive beads containing metformin HCl showed significant antidiabetic effect in alloxan-induced diabetic rats over prolonged period after oral administration. These results clearly demonstrated that the developed mucoadhesive beads was found suitable for prolonged systemic absorption of metformin HCl through sustained drug release and mucoadhesive properties after oral administration in the management of non-insulin dependent diabetes mellitus with maintenance of blood glucose level.


Nayak A.K.,Seemanta Institute of Pharmaceutical science
Chemical Engineering Research and Design | Year: 2012

This present investigation deals with the development and optimization of buoyant beads containing ibuprofen by emulsion-gelation method for gastroretentive delivery. The effect of three independent process variables like amount of sodium alginate, magnesium stearate, and liquid paraffin on drug entrapment, density, and drug release of buoyant beads containing ibuprofen was optimized using 2 3 factorial design. The observed responses were coincided well with the predicted values, given by the optimization technique. The optimized beads showed drug entrapment efficiency of 83.07±3.25%, density of 0.89±0.11g/cm 3, cumulative drug release of 35.02±1.24% after 8h, and floated well over 8h in simulated gastric fluid (pH 1.2) with 4.50min buoyant lag-time. The average size of all buoyant beads ranged from 1.43±0.05 to 1.82±0.14mm. The buoyant beads were characterized by SEM and FTIR spectroscopy for surface morphology and excipients-drug interaction analysis, respectively. All these beads showed prolonged sustained release of ibuprofen over 8h in simulated gastric fluid (pH 1.2). The ibuprofen release profile from these buoyant beads followed Korsmeyer-Peppas model over a period of 8h with anomalous (non-Fickian) diffusion mechanism for drug release. © 2012 The Institution of Chemical Engineers.


Nayak A.K.,Seemanta Institute of Pharmaceutical science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2010

A budding interest in production and delivery of therapeutic proteins has generated a number of advancements throughout recent years. Therapeutic proteins offer great importance in the treatment of various diseases like cancers, heart attacks, strokes, cystic fibrosis, diabetes, anemia and hemophilia. They are produced by using microbial fermentation on cell cultures in transgenic plants and animals. Various therapeutic proteins are mainly administered by parenteral routes. Other routes of administration of therapeutic proteins are pulmonary, nasal, oral, buccal, transdermal, mucosal, rectal and vaginal. Many new approaches of delivery of therapeutic proteins have been investigated and designed to achieve maximal efficacy with minimal side effects. This review highlights current state and future of production and delivery of therapeutic proteins for the use in human health care.


Nayak A.K.,Seemanta Institute of Pharmaceutical science
International Journal of Pharmaceutical Sciences Review and Research | Year: 2010

Various commercially available paracetamol tablets (500 mg) were evaluated comparatively for in vitro dissolution qualities along with drug content (assay). The assay results ascertain the presence and compendial quality of paracetamol in all these products. The in vitro dissolution profiles were found to be varying for each tablet, but within the prescribed limit. The dissolution at 15 minutes (t15 min, %) and 50 % of dissolution (D50 %, min) were also determined. The paracetamol tablet, C exhibited highest dissolution (%) in 15 minutes (80.85 ± 1.84 %) and lowest value of 50 % dissolution (3.75 ± 0.18 min) along with comparatively highest drug content (99.78 ± 0.49). Statistical assessment of various in vitro dissolution parameters and assay results was also conducted to establish if there were any significant difference among them.


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,IFTM University
International Journal of Biological Macromolecules | Year: 2011

The present study deals with the development of novel pH-sensitive tamarind seed polysaccharide (TSP)-alginate composite beads for controlled diclofenac sodium delivery using response surface methodology by full 3 2 factorial design. The effect of polymer-blend ratio (sodium alginate:TSP) and cross-linker (CaCl 2) concentration on the drug encapsulation efficiency (DEE, %) and drug release from diclofenac sodium loaded TSP-alginate composite beads prepared by ionotropic gelation was optimized. The observed responses were coincided well with the predicted values by the experimental design. The DEE (%) of these beads containing diclofenac sodium was within the range between 72.23±2.14 and 97.32±4.03% with sustained in vitro drug release (69.08±2.36-96.07±3.54% in 10h). The in vitro drug release from TSP-alginate composite beads containing diclofenac sodium was followed by controlled-release pattern (zero-order kinetics) with case-II transport mechanism. Particle size range of these beads was 0.71±0.03-1.33±0.04mm. The swelling and degradation of the developed beads were influenced by different pH of the test medium. The FTIR and NMR analyses confirmed the compatibility of the diclofenac sodium with TSP and sodium alginate used to prepare the diclofenac sodium loaded TSP-alginate composite beads. The newly developed TSP-alginate composite beads are suitable for controlled delivery of diclofenac sodium for prolonged period. © 2011 Elsevier B.V.


Nayak A.K.,Seemanta Institute of Pharmaceutical science
Current drug delivery | Year: 2013

The present investigation describes development and optimization of pioglitazone-loaded jackfruit seed starch (JFSS)-alginate beads by ionotropic-gelation using 3(2) factorial design. The effect of polymer-blend ratio and CaCl2 concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10 hours (R10h, %) was optimized. The DEE (%) of these beads were 64.80 ± 1.92 to 94.07 ± 3.82 % with sustained in vitro drug release of 64.± 1.83 to 92.66 ± 4.54 % over 10 hours. The in vitro drug release from these beads followed controlled-release pattern with super case-II transport. Particle size range of these beads was 0.77 ± 0.04 to 1.24 ± 0.09 mm. The beads were also characterized by SEM and FTIR. The swelling of these beads was influenced by pH of the test medium. The optimized pioglitazone-loaded JFSS-alginate beads showed significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.


Nayak A.K.,Seemanta Institute of Pharmaceutical science
International Journal of ChemTech Research | Year: 2010

Hydroxyapatite (HAp) is the emerging most bioceramic, which is widely used in various biomedical applications, mainly in orthopedics and dentistry due to its close similarities with inorganic mineral component of bone and teeth. Synthetic HAp is known to be similar to naturally occurring HAp on the basis of crystallographic and chemical studies. Several methodologies have been investigated and developed for the synthesis of HAp. But, new economic and versatile methods for HAp synthesis are of interest due to its immense importance and wide utilization in biomedical applications. This review presents various well known methodologies for HAp synthesis like precipitation technique, sol-gel approach, hydrothermal technique, multiple emulsion technique, biomimetic deposition technique, electrodeposition technique etc.


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,Guru Ghasidas University
Carbohydrate Polymers | Year: 2014

Fenugreek (Trigonella foenum-graecum L.) seed mucilage (FSM)-gellan gum (GG) mucoadhesive beads containing metformin HCl for oral use were developed through ionotropic-gelation technique. Effects of GG to FSM ratio and cross-linker (CaCl2) concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10 h (R10h, %) of ionotropically-gelled FSM-GG mucoadhesive beads containing metformin HCl were optimized by 32 factorial design. The optimized mucoadhesive beads showed DEE of 92.53 ± 3.85% and R10h of 55.28 ± 1.58% and mean diameter of 1.62 ± 0.22 mm. The in vitro metformin HCl release from these ionotropically-gelled FSM-GG beads was prolonged over 10 h and followed zero-order model with super case-II transport mechanism. The optimized mucoadhesive beads also exhibited pH-dependent swelling, good mucoadhesivity with biological mucosal membrane and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. © 2014 Elsevier Ltd. All rights reserved.


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,Guru Ghasidas University
International Journal of Biological Macromolecules | Year: 2013

The present study deals with the formulation optimization of jackfruit (Artocarpus heterophyllus Lam., family: Moraceae) seed starch (JFSS)-alginate mucoadhesive beads containing metformin HCl through ionotropic gelation using 32 factorial design. The effect of sodium alginate to JFSS ratio and CaCl2 concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release at 10h (R10h, %) was optimized. The optimized beads containing metformin HCl showed DEE of 97.48±3.92%, R10h of 65.70±2.22%, and mean diameter of 1.16±0.11mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. The beads were also characterized by SEM and FTIR. The swelling and degradation of these beads were influenced by pH of the test medium. The optimized beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. © 2013 Elsevier B.V.


Nayak A.K.,Seemanta Institute of Pharmaceutical science | Pal D.,Guru Ghasidas University
International Journal of Biological Macromolecules | Year: 2013

In this work, calcium pectinate-jackfruit (Artocarpus heterophyllus Lam.) seed starch (JFSS) mucoadhesive beads containing metformin HCl were developed through ionotropic-gelation. Effects of pectin and JFSS amounts on drug encapsulation efficiency (DEE), and cumulative drug release after 10h (R10h) were optimized using 32 factorial design. The optimized calcium pectinate-JFSS beads containing metformin HCl showed DEE of 94.11±3.92%, R10h of 48.88±2.02%, and mean diameter of 2.06±0.20mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. The beads were also characterized by SEM and FTIR. The pH of test mediums was found critical for swelling and mucoadhesion of these beads. The optimized calcium pectinate-JFSS beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. © 2013 Elsevier B.V.

Loading Seemanta Institute of Pharmaceutical science collaborators
Loading Seemanta Institute of Pharmaceutical science collaborators