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Nishi-Tokyo-shi, Japan

Hiramoto K.,Osaka City University | Kobayashi H.,Osaka City University | Yamate Y.,Osaka City University | Ishii M.,Osaka City University | And 2 more authors.
Contact Lens and Anterior Eye | Year: 2013

Purpose: Irradiation by ultraviolet (UV) B is known to increase the number of Dopa-positive melanocytes in the skin. This study examines the effectiveness of a contact lens for the defense of UVB eye irradiation-induced pigmentation. Methods: A 2.5kJ/m2 dose of UVB radiation was delivered by a sunlamp to the eye of C57BL/6j male mice, and changes in the expression of Dopa-positive melanocytes in the epidermis and the plasma level of alpha-melanocyte-stimulating hormone (α-MSH) was analyzed. Results: The degree of change in the Dopa-positive melanocytes expression was reduced by UVB blocking contact lens using mice given UVB irradiation to the eye. The plasma level of α-MSH increased in the C57BL/6j mice after irradiation to the eye, but there was no increase in the UVB blocking contact lens mice given UVB irradiation to the eye. Both the increase of the expression of Dopa-positive melanocytes and the plasma level of α-MSH were strongly suppressed by an alignment fitting UVB blocking contact lens and only a slightly suspended UVB blocking contact lens. In addition, these changes were successfully inhibited by a UVB blocking contact lens but not by a non-UVB blocking contact lens with a similar absorbance. Conclusion: These observations suggest that the UVB blocking contact lens inhibits the pigmentation of the epidermis in mice by suppressing of the α-MSH. © 2012 British Contact Lens Association.


Abakemal D.,Ethiopian Institute of Agricultural Research | Shimelis H.,University of KwaZulu - Natal | Derera J.,SEED Co.
Euphytica | Year: 2016

Maize (Zea mays L.) yields are significantly lower in the tropical-highlands than other environments predominantly due to the lack of well-adapted and improved cultivars and due to genotype by environment (G × E) interaction. The objectives of this study were to determine G × E interaction and yield stability of quality protein maize (QPM) single-cross hybrids recently developed from tropical-highland adapted inbred lines, and to identify promising genotypes and representative test and seed production environments. The study was conducted at seven environments representing the tropical-highland sub-humid maize growing agro-ecology in Ethiopia. Sixty-six QPM hybrids and two commercial check hybrids were evaluated using a 4 × 17 alpha lattice design. Data were analysed using the additive main effects and multiplicative interaction (AMMI) and genotype and genotype by environment (GGE) biplot methods. Using AMMI analysis, four promising QPM hybrids were identified compared to the commercial checks and designated as hybrid 10 (KIT32 × 142-1-eQ), hybrid 66 (142-1-eQ × CML144), hybrid 59 (FS60 × 142-1-eQ), and hybrid 38 (FS67 × CML144) with grain yields of 10.3, 9.6, 9.4 and 8.9 t ha−1, respectively. The same hybrids were identified as the best performers for being close to the ideal cultivar using the GGE biplot analysis. The GGE analysis delineated the test environments into two mega-environments useful for targeted evaluation of genotypes and effective maize breeding and seed production. Kulumsa site during 2013 (KUL13) was the most suitable environment in discriminating the QPM hybrids and being a representative test environment. © 2016 Springer Science+Business Media Dordrecht


Yoshimura Y.,Tohoku Pharmaceutical University | Yamazaki Y.,Tohoku Pharmaceutical University | Yamazaki Y.,SEED Co. | Saito Y.,Tohoku Pharmaceutical University | And 3 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

As a part of our ongoing efforts to identify new anti-HIV agents, a 5′-thiopyrano-nucleoside derivative 4, designed based on 4′-thioD4C 1 and cyclohexenylnucleoside 3, was synthesized. The dihydrothiopyran skeleton of 4 was constructed by the ring closing metathesis of 21 which was synthesized from but-2-yne-1,4-diol. After converting the protecting group from MOM to TBS followed by oxidation, a Pummerer-type thioglycosylation reaction of 24 with persilylated uracil gave the desired 5-thiodihydrothiopyranyluracils 25 and 26 as a mixture of anomers. The conversion of 25 to a cytosine derivative and subsequent deprotection gave a 5-thiodidehydropyranosylcytosine derivative 4 in good yield. The anti-HIV activity of 4 was also evaluated. © 2011 Elsevier Ltd. All rights reserved.


Rpm

Trademark
Seed Co. | Date: 2012-09-11

Machinery for the mechanical recycling of used paper, namely, machines for pulp making, paper shredding machines, crushing units and beating units for pulp making machines, and beating machines and mashing machines for use in beating units; machines for paper making; paper-making machinery, namely, paper pulp feeding units, paper making net conveyor units, dewatering roll units, drying belt conveyor units, smooth surface finishing roll units and heater plate units for paper making apparatus, mesh belts for paper making net conveyor units, dewatering rolls and press rolls for dewatering roll units, smooth surface belts for drying belt conveyor units.


Trademark
Seed Co. | Date: 2012-03-06

Machinery for the mechanical recycling of used paper, namely, machines for pulp making, paper shredding machines, crushing units and beating units for pulp making machines, and beating machines and mashing machines for use in beating units; machines for paper making; paper-making machinery, namely, paper pulp feeding units, paper making net conveyor units, dewatering roll units, drying belt conveyor units, smooth surface finishing roll units and heater plate units for paper making apparatus, mesh belts for paper making net conveyor units, dewatering rolls and press rolls for dewatering roll units, smooth surface belts for drying belt conveyor units.

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