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De Pedro S.,Sector de Endocrinologia | Benozzi S.,National University of Costa Rica | Becerra H.,Sector de Endocrinologia | Bonacorsi S.M.,Sector de Endocrinologia | And 5 more authors.
Revista Argentina de Endocrinologia y Metabolismo | Year: 2012

Introduction: there are significant discrepancies in epidemiological data about cardiovascular risk in subclinical hypothyroidism (SH). Objective: to study the association between clinical and biochemical indicators of cardiovascular risk factors with the presence of HS. Material and Methods: case-control study with observational endpoint, epidemiological, non-interventional. SH was defined as patients presenting with a serum thyrotropin-stimulating hormone (TSH) value greater than 4 uIU / mL with free thyroxine (FT4) levels in the reference range. Age, gender, weight, body mass index (BMI), waist circumference (WC) and blood pressure were recorded. Blood count, total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TG), glucose, insulin, TSH, FT4 were measured. Results: we studied 78 patients [48 controls (C) and 30 with SH]. The age of C was 38 ± 12 years and 38 ± 13 years for SH, BMI was 30 ± 6 kg/m2 for C and 30 ± 7 kg/m2 for SH, WC was 103 ± 16 cm for C and 102 ± 17 cm for SH. There were no statistically significant differences in BP (p = 0.426), HOMA: C 1.76, SH 1.27 (p = 0.211) and lipid levels. Statistically significant differences were observed in leukocytes (p = 0.009) and platelets (p = 0.044). Conclusions: Patients with SH have leukocyte and platelet counts higher than controls. Patients with SH were found to have higher levels of TC, LDL-C, non-HDL C and TG, although there were not statistically significant differences. Copyright © 2012 por la Sociedad Argentina de Endocrinología y Metabolismo.

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