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New Haven, CT, United States

Ogden G.R.,Section of Oral and Maxillofacial Surgery | Mahboobi N.,Tehran University of Medical Sciences
Journal of Cancer Education | Year: 2011

The aim of this study was to assess undergraduate dental students' knowledge about prevention and detection of oral cancer in Tehran University of Medical Sciences (TUMS). A validated questionnaire which tested oral cancer awareness and procedure was given to 3rd to 6th year students of the dental faculty of TUMS. A total of 165 students participated in this survey. As expected, students of the final years showed greater knowledge of risk factors and clinical features of the disease. This study highlights for consideration regarding improvement to undergraduate dental education. © 2010 Springer. Source


Miller K.A.,Murdoch Childrens Research Institute | Tan T.Y.,Murdoch Childrens Research Institute | Tan T.Y.,University of Melbourne | Welfare M.F.,Murdoch Childrens Research Institute | And 15 more authors.
Molecular Syndromology | Year: 2014

The 22q11.2 deletion syndrome (22q11DS) is thought to be a contiguous gene syndrome caused by haploinsufficiency for a variable number of genes with overlapping function during the development of the craniofacial, pharyngeal and cardiac structures. The complexity of genetic and developmental anomalies resulting in 22q11DS has made attributing causation to specific genes difficult. The CRKL gene resides within the common 3-Mb region, most frequently affected in 22q11DS, and has been shown to play an essential role in the development of tissues affected in 22q11DS. Here, we report the characterisation of a mouse strain we named 'snoopy', harbouring a novel Crkl splice-site mutation that results in a loss of Crkl expression. The snoopy strain exhibits a variable phenotype that includes micrognathia, pharyngeal occlusion, aglossia and holoprosencephaly, and altered retinoic acid and endothelin signalling. Together, these features are reminiscent of malformations occurring in auriculocondylar syndrome and agnathia-otocephaly complex, 2 conditions not previously associated with the CRKL function. Comparison of the features of a cohort of patients harbouring small 22q11.2 deletions centred over the CRKL gene, but sparing TBX1, highlights the role of CRKL in contributing to the craniofacial features of 22q11DS. These analyses demonstrate the central role of Crkl in regulating signalling events in the developing oropharyngeal complex and its potential to contribute to dysmorphology. © 2014 S. Karger AG, Basel. Source


e Souza D.P.,Section of Oral and Maxillofacial Surgery | Loureiro C.C.S.,Section of Oral and Maxillofacial Surgery | Falchet P.F.,Section of Oral and Maxillofacial Surgery | Leandro L.F.L.,Section of Oral and Maxillofacial Surgery | Raitz R.,University of Sao Paulo
Cranio - Journal of Craniomandibular Practice | Year: 2010

Synovial chondromatosis of the temporomandibular joint (TMJ) is a rare lesion characterized by the presence of loose bodies in the glenoid fossa. Swelling, unilateral pain, occlusal changes, clicking, crepitation, deviation, and limited mandibular function are the most common characteristics, although this combination is not always apparent. Radiopacities of the TMJ should be thoroughly investigated as some signals and symptoms may be not present or combined, taking months or even years to confirm a diagnosis. A case report is presented here with a brief literature review, where surgical removal was the therapy of choice, calling attention to the absence of symptoms and some signals, which may mislead final diagnosis. © 2010 by CHROMA, Inc. Source


Hinic P.,Section of Oral and Maxillofacial Surgery | Hinic P.,Private Practice | Johnson M.P.,Hospital of Saint Raphael | Kelly J.P.W.,Section of Oral and Maxillofacial Surgery
Journal of Oral and Maxillofacial Surgery | Year: 2012

Purpose: The goal of the survey was to identify the desired characteristics of recently graduated oral surgeons entering private practice in Connecticut and compare these results to a similar study conducted earlier in New Jersey. Materials and Methods: An anonymous survey was mailed to all active members of the Connecticut Society of Oral and Maxillofacial Surgeons in February 2010. The response rate for the survey was 63%, with 69 of 110 surveys returned. Conclusions: The most valued characteristics of a new associate included board certification; clinical competence in dentoalveolar surgery, anesthesia, and implant surgery; and personal character. These results paralleled the results of the New Jersey survey. © 2012 American Association of Oral and Maxillofacial Surgeons. Source


Bedogni A.,Section of Oral and Maxillofacial Surgery | Saia G.,University of Padua | Bettini G.,Section of Oral and Maxillofacial Surgery | Tronchet A.,University of Padua | And 6 more authors.
Oral Oncology | Year: 2011

Surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is controversial. Current recommendations contraindicate aggressive surgery because its results are unpredictable and may trigger disease progression. In this prospective study, we assessed the effectiveness of surgical resection of the jaws in cancer patients with BRONJ. Between June 2004 and July 2009, 30 cancer patients with refractory BRONJ underwent surgical resection of the jaws at our Units. They were followed-up weekly for the first month, at 3-month intervals up to 1 year, and at 6-month intervals up to 2 years. Panoramic radiographs and CT-scan were obtained at 3, 6, 12, 18 and 24 months. Primary outcomes were the 24-month recurrence rate of BRONJ and the 24-month mortality rate. Secondary outcomes were post-operative complications, duration of hospital stay after surgery, time to return to oral diet, and degree of oral pain. The 30 patients had a median age of 66 years and were mostly females (80%). Twenty-eight underwent a single resection and two had both jaws resected, for a total of 32 resected jaws. The cumulative recurrence rate of BRONJ in resected jaws 3.1% and 9.4% at 3 and 6 months, respectively. All the jaws with recurrent BRONJ had osteomyelitis at the margins of bone resection. The cumulative incidence of death was 3%, 12% and 16% at 12, 18 and 24 months. Surgical resection of BRONJ was highly effective, with few post-operative complications and were not associated with long-term mortality. © 2011 Elsevier Ltd. All rights reserved. Source

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