Secretaria Estadual de Saude

Sinop, Turkey

Secretaria Estadual de Saude

Sinop, Turkey

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Regis L.N.,Fundacao Oswaldo Cruz Fiocruz Pe | Acioli R.V.,Secretaria Estadual de Saude | Silveira Jr. J.C.,Fundacao Oswaldo Cruz Fiocruz Pe | Melo-Santos M.A.V.,Fundacao Oswaldo Cruz Fiocruz Pe | And 14 more authors.
PLoS ONE | Year: 2013

Aedes aegypti has developed evolution-driven adaptations for surviving in the domestic human habitat. Several trap models have been designed considering these strategies and tested for monitoring this efficient vector of Dengue. Here, we report a real-scale evaluation of a system for monitoring and controlling mosquito populations based on egg sampling coupled with geographic information systems technology. The SMCP-Aedes, a system based on open technology and open data standards, was set up from March/2008 to October/2011 as a pilot trial in two sites of Pernambuco -Brazil: Ipojuca (10,000 residents) and Santa Cruz (83,000), in a joint effort of health authorities and staff, and a network of scientists providing scientific support. A widespread infestation by Aedes was found in both sites in 2008-2009, with 96.8%-100% trap positivity. Egg densities were markedly higher in SCC than in Ipojuca. A 90% decrease in egg density was recorded in SCC after two years of sustained control pressure imposed by suppression of >7,500,000 eggs and >3,200 adults, plus larval control by adding fishes to cisterns. In Ipojuca, 1.1 million mosquito eggs were suppressed and a 77% reduction in egg density was achieved. This study aimed at assessing the applicability of a system using GIS and spatial statistic analysis tools for quantitative assessment of mosquito populations. It also provided useful information on the requirements for reducing well-established mosquito populations. Results from two cities led us to conclude that the success in markedly reducing an Aedes population required the appropriate choice of control measures for sustained mass elimination guided by a user-friendly mosquito surveillance system. The system was able to support interventional decisions and to assess the program's success. Additionally, it created a stimulating environment for health staff and residents, which had a positive impact on their commitment to the dengue control program. © 2013 Regis et al.


De Barros Lopes L.,Instituto Oswaldo Cruz | Guterres A.,Instituto Oswaldo Cruz | Rozental T.,Instituto Oswaldo Cruz | Carvalho De Oliveira R.,Instituto Oswaldo Cruz | And 14 more authors.
Parasites and Vectors | Year: 2014

Background: The purpose of this study was to identify the presence of rickettsia and hantavirus in wild rodents and arthropods in response to an outbreak of acute unidentified febrile illness among Indians in the Halataikwa Indian Reserve, northwest of the Mato Grosso state, in the Brazilian Amazon. Where previously surveillance data showed serologic evidence of rickettsia and hantavirus human infection. Methods. The arthropods were collected from the healthy Indian population and by flagging vegetation in grassland or woodland along the peridomestic environment of the Indian reserve. Wild rodents were live-trapped in an area bordering the reserve limits, due the impossibility of capturing wild animals in the Indian reserve. The wild rodents were identified based on external and cranial morphology and karyotype. DNA was extracted from spleen or liver samples of rodents and from invertebrate (tick and louse) pools, and the molecular characterization of the rickettsia was through PCR and DNA sequencing of fragments of two rickettsial genes (gltA and ompA). In relation to hantavirus, rodent serum samples were serologically screened by IgG ELISA using the Araraquara-N antigen and total RNA was extracted from lung samples of IgG-positive rodents. The amplification of the complete S segment was performed. Results: A total of 153 wild rodents, 121 louse, and 36 tick specimens were collected in 2010. Laguna Negra hantavirus was identified in Calomys callidus rodents and Rickettsia bellii, Rickettsia amblyommii were identified in Amblyomma cajennense ticks. Conclusions: Zoonotic diseases such as HCPS and spotted fever rickettsiosis are a public health threat and should be considered in outbreaks and acute febrile illnesses among Indian populations. The presence of the genome of rickettsias and hantavirus in animals in this Indian reserve reinforces the need to include these infectious agents in outbreak investigations of febrile cases in Indian populations. © 2014 de Barros Lopes et al.; licensee BioMed Central Ltd.


Santelli A.C.,Programa Nacional de Controle da Malaria | Ribeiro I.,Institute Tecnologia em Farmacos Farmanguinhos | Daher A.,Drugs for Neglected Diseases Initiative | Daher A.,Institute Tecnologia em Farmacos Farmanguinhos | And 8 more authors.
Malaria Journal | Year: 2012

Background: Studies in South-East Asia have suggested that early diagnosis and treatment with artesunate (AS) and mefloquine (MQ) combination therapy may reduce the transmission of Plasmodium falciparum malaria and the progression of MQ resistance. Methods. The effectiveness of a fixed-dose combination of AS and MQ (ASMQ) in reducing malaria transmission was tested in isolated communities of the Juruá valley in the Amazon region.Priority municipalities within the Brazilian Legal Amazon area were selected according to pre-specified criteria. Routine national malaria control programmatic procedures were followed. Existing health structures were reinforced and health care workers were trained to treat with ASMQ all confirmed falciparum malaria cases that match inclusion criteria. A local pharmacovigilance structure was implemented. Incidence of malaria and hospitalizations were recorded two years before, during, and after the fixed-dose ASMQ intervention. In total, between July 2006 and December 2008, 23,845 patients received ASMQ. Two statistical modelling approaches were applied to monthly time series of P. falciparum malaria incidence rates, P. falciparum/Plasmodium vivax infection ratio, and malaria hospital admissions rates. All the time series ranged from January 2004 to December 2008, whilst the intervention period span from July 2006 to December 2008. Results: The ASMQ intervention had a highly significant impact on the mean level of each time series, adjusted for trend and season, of 0.34 (95%CI 0.20 - 0.58) for the P. falciparum malaria incidence rates, 0.67 (95%CI 0.50 - 0.89) for the P. falciparum/P. vivax infection ratio, and 0.53 (95%CI 0.41 - 0.69) for the hospital admission rates. There was also a significant change in the seasonal (or monthly) pattern of the time series before and after intervention, with the elimination of the malaria seasonal peak in the rainy months of the years following the introduction of ASMQ. No serious adverse events relating to the use of fixed-dose ASMQ were reported. Conclusions: In the remote region of the Juruá valley, the early detection of malaria by health care workers and treatment with fixed-dose ASMQ was feasible and efficacious, and significantly reduced the incidence and morbidity of P. falciparum malaria. © 2012Santelli et al.; licensee BioMed Central Ltd.


Nobres E.S.,Secretaria Estadual de Saude | Souza L.A.,Secretaria Estadual de Saude | Rodrigues D.J.,Federal University of Mato Grosso
Acta Amazonica | Year: 2013

Incidence of cutaneous leishmaniasis recorded in the Health Regional Office of Sinop (ERS-SINOP), which covers 17 cities located at the north of Mato Grosso was examined considering the numbers of reported cases by municipalities, gender, age and rainfall seasonality. Data were obtained from the National System of Notification Diseases (Sistema Nacional de Agravos de Notificações) between 2001 and 2008. We calculated the incidence of cutaneous leishmaniasis in each municipality. Leishmaniasis prevalence rate from 2001 to 2008 was higher in the cities of Nova Ubiratã (857.2 cases per 100,000 population), Feliz Natal (834.5 per 100,000) and Vera (557.0 per 100,000). The average incidence (334.9 per 100,000 population) recorded at the ERS-Sinop was 4.5 times higher than that recorded for the whole North Region of Mato Grosso. The disease was more severe for people between 20 and 49 years old, irrespective of gender. Incidence was higher in males (64.8%). The number of cases recorded in the drought period was 60%. In the region, part of the population of the study area is exposed to direct contact with the vector of Leishmania, while they are working in activities such as selective logging, farming and mining.


De Oliveira J.,São Paulo State University | Mendonca V.J.,University of Brasilia | De Araujo R.F.,Secretaria Estadual de Saude | Nascimento E.G.,Secretaria Estadual de Saude | Da Rosa J.A.,São Paulo State University
Zootaxa | Year: 2015

Triatoma melanocephala Neiva & Pinto is found in the Brazilian states of Bahia, Paraíba, Pernambuco, Rio Grande do Norte, and Sergipe. In addition to the species' specific description, eight other articles on this insect were found in the literature. In this study, data was obtained on the morphology, morphometry, and life cycle of T. Melanocephala, since this vector is of epidemiological and taxonomic importance. The specimens studied were obtained from a colony that has been kept at the Triatomine Insectarium of the College of Pharmaceutical Sciences of São Paulo State University's in Brazil. The morphological studies were performed using scanning electron microscopy. These studies characterized the eggs, the external adult female genitalia, and the ninth ventral abdominal segments of male and female nymphs. The morphometric studies characterized the five nymphal instars and the adult stage by measuring the head, thorax, abdomen, antennae, and mouthparts parameters. The life cycle of T. Melanocephala was developed starting by 15 couples in the fifth instar. They were fed on Swiss mice every two weeks and observed daily. During daily observation, minimum temperature, maximum temperature, and relative humidity of the laboratory were measured. The results of the biological, morphometric, and morphological studies have increased the knowledge available on T. Melanocephala. Copyright © 2015 Magnolia Press.


Maeda M.H.,University of Brasilia | Knox M.B.,Secretaria Estadual de Saude | Gurgel-Goncalves R.,University of Brasilia
Revista da Sociedade Brasileira de Medicina Tropical | Year: 2012

Introduction: Entomological surveillance of Chagas disease in the Federal District of Brazil (DF), has recorded the following triatomine species: Panstrongylus megistus, P. geniculatus, P. diasi, Rhodnius neglectus, Triatoma pseudomaculata, and T. sordida. We aimed to analyze the spatial and temporal occurrence of triatomine species collected in DF, and their indices of natural infection with trypanosomes. Methods: The Health State Secretariat of DF recorded triatomines between 2002 and 2010 in 20 administrative regions. This retrospective analysis considered the number of adults and nymphs of each species collected and infected in both intradomicile and peridomicile. Results: A total of 754 triatomines were collected in 252 reported domiciles. Panstrongylus megistus was the most frequent species (65%), followed by T. pseudomaculata (14%). Of the 309 examined insects, only 3 (1%) specimens of P. megistus were infected with flagellates morphologically similar to Trypanosoma cruzi. The spatial occurrence indicated a higher diversity of triatomines and frequency of T. sordida in rural areas. Moreover, there was a predominance of P. megistus in urban areas. The number of records of P. megistus in the rainy season was two times higher than that during the dry season. The largest number of triatomines was collected in November. Conclusions: The presence of P. megistus specimens infected with trypanosomes in domiciles, shows the potential risk of human infection in DF. Thus, it is essential to continue entomological surveillance, intensifying it in the rainy season and in regions of greater occurrence.


PubMed | São Paulo State University, Secretaria Estadual de Saude and University of Brasilia
Type: Journal Article | Journal: Zootaxa | Year: 2015

Triatoma melanocephala Neiva & Pinto is found in the Brazilian states of Bahia, Paraba, Pernambuco, Rio Grande do Norte, and Sergipe. In addition to the species specific description, eight other articles on this insect were found in the literature. In this study, data was obtained on the morphology, morphometry, and life cycle of T. melanocephala, since this vector is of epidemiological and taxonomic importance. The specimens studied were obtained from a colony that has been kept at the Triatomine Insectarium of the College of Pharmaceutical Sciences of So Paulo State Universitys in Brazil. The morphological studies were performed using scanning electron microscopy. These studies characterized the eggs, the external adult female genitalia, and the ninth ventral abdominal segments of male and female nymphs. The morphometric studies characterized the five nymphal instars and the adult stage by measuring the head, thorax, abdomen, antennae, and mouthparts parameters. The life cycle of T. melanocephala was developed starting by 15 couples in the fifth instar. They were fed on Swiss mice every two weeks and observed daily. During daily observation, minimum temperature, maximum temperature, and relative humidity of the laboratory were measured. The results of the biological, morphometric, and morphological studies have increased the knowledge available on T. melanocephala.


The study aimed to identify the knowledge of adolescents, residents in an area where the Family Health Strategy is present, about the vaccination calendar and acquired protection. The nature of this inquiry was quantitative, sectional and it was developed through home inquiry, from 2008 March to April. The data had been typed and processed by using the Epi-Info software. It was noted that the adolescents in this study were unaware of the recommended vaccines present in the Ministry of Health calendar. Considering that the study was carried out in Family Health Strategy environment and being the vaccine a priority action, it was expected to find a population more aware on the vaccination calendar.


PubMed | Secretaria Estadual de Saude
Type: Journal Article | Journal: Revista brasileira de enfermagem | Year: 2012

The study aimed to identify the knowledge of adolescents, residents in an area where the Family Health Strategy is present, about the vaccination calendar and acquired protection. The nature of this inquiry was quantitative, sectional and it was developed through home inquiry, from 2008 March to April. The data had been typed and processed by using the Epi-Info software. It was noted that the adolescents in this study were unaware of the recommended vaccines present in the Ministry of Health calendar. Considering that the study was carried out in Family Health Strategy environment and being the vaccine a priority action, it was expected to find a population more aware on the vaccination calendar.


PubMed | Secretaria Estadual de Saude
Type: Journal Article | Journal: Revista da Sociedade Brasileira de Medicina Tropical | Year: 2012

Entomological surveillance of Chagas disease in the Federal District of Brazil (DF), has recorded the following triatomine species: Panstrongylus megistus, P. geniculatus, P. diasi, Rhodnius neglectus, Triatoma pseudomaculata, and T. sordida. We aimed to analyze the spatial and temporal occurrence of triatomine species collected in DF, and their indices of natural infection with trypanosomes.The Health State Secretariat of DF recorded triatomines between 2002 and 2010 in 20 administrative regions. This retrospective analysis considered the number of adults and nymphs of each species collected and infected in both intradomicile and peridomicile.A total of 754 triatomines were collected in 252 reported domiciles. Panstrongylus megistus was the most frequent species (65%), followed by T. pseudomaculata (14%). Of the 309 examined insects, only 3 (1%) specimens of P. megistus were infected with flagellates morphologically similar to Trypanosoma cruzi. The spatial occurrence indicated a higher diversity of triatomines and frequency of T. sordida in rural areas. Moreover, there was a predominance of P. megistus in urban areas. The number of records of P. megistus in the rainy season was two times higher than that during the dry season. The largest number of triatomines was collected in November.The presence of P. megistus specimens infected with trypanosomes in domiciles, shows the potential risk of human infection in DF. Thus, it is essential to continue entomological surveillance, intensifying it in the rainy season and in regions of greater occurrence.

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