Second Peoples Hospital of Lianyungang

Xinpu, China

Second Peoples Hospital of Lianyungang

Xinpu, China
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Chen X.,Nantong University | Cao X.,Nantong University | Tao G.,Nantong University | Cao Z.,Nantong University | And 6 more authors.
Journal of Molecular Neuroscience | Year: 2012

Foxj2 (forkhead box J2), a novel member of the forkhead/HNF3 family, binds DNA with a dual sequence specificity. It may play a role in maintenance and survival of developing and adult neurons. However, its expression and function in the central nervous system lesion are still unclear. In this study, we performed a spinal cord injury (SCI) model in adult Sprague-Dawley rats and investigated the dynamic changes of Foxj2 expression in the spinal cord. Western blot analysis revealed that Foxj2 was present in normal spinal cord. It gradually increased, reached a peak at day 5 after SCI, and then declined during the following days. Double immunofluorescence staining revealed wide expression of Foxj2, which is detected in neurons and astrocytes. After injury, Foxj2 expression was increased predominantly in astrocytes, which highly expressed proliferating cell nuclear antigen, a marker for proliferating cells. And knockdown of Foxj2 in cultured primary astrocytes by siRNA showed that Foxj2 played an important role in lipopolysaccharide-induced inflammatory responses. These results suggested that Foxj2 may be involved in the pathophysiology of SCI, and further research is needed to have a good understanding of its function and mechanism. © 2012 Springer Science+Business Media, LLC.


Chen C.,Second Peoples Hospital of Lianyungang | Ma J.,Second Peoples Hospital of Lianyungang | Ding Q.,Second Peoples Hospital of Lianyungang | Shang Y.,Second Peoples Hospital of Lianyungang | Wang Z.,Second Peoples Hospital of Lianyungang
Chinese Journal of Clinical Oncology | Year: 2016

Objective: To compare the therapeutic and adverse effects of concurrent raltitrexed plus oxaliplatin and radiotherapy with those of PF synchronous radiotherapy in the treatment of advanced esophageal cancer. Methods: A total of 84 pathologically confirmed patients with advanced esophageal carcinoma were randomly distributed to the concurrent raltitrexed plus oxaliplatin and radiotherapy group (experimental group, n=40) and to the PF synchronous radiotherapy group (control group, n=44). All patients were treated with 3DCRT at a total dose of 60 Gy/30f. The chemotherapy in the experimental group consists of raltitrexed at 2.5 mg/m2, d1, plus oxaliplatin at 130 mg/m2, d2. The chemotherapy of the control group consists of DDP at 25 mg/m2, Dd1-3, plus 5-FU 500 mg/m2, d1-5. Two cycles of concurrent chemotherapy were administered during radiotherapy on d1 and d29. The comparison results were used to estimate the therapeutic and adverse effects of the two groups. Results: The rerponse rate, complete response, and one-year overall survival rate of the experimental group were higher than those of the control group [(87.50% vs. 79.54%, P=0.3293), (32.50% vs. 18.18%, P=0.13), and (82.50% vs. 79.50%, P=0.701)], but the difference was not statistically significant. The incidence rates of nausea and vomiting, appetite degression, leucopenia, radiation-induced esophagitis, and cardiotoxicity were significantly lower (P<0.05) in the experimental group than in the control group. Other adverse effects of the two groups were similar (P>0.05). Conclusion: Similar to PF chemotherapy and radiotherapy, the concurrent raltitrexed plus oxaliplatin and radiotherapy achieved a similar short-term therapeutic effect but lower adverse effects on patients with esophageal cancer.


Qian L.,Second Peoples Hospital of Lianyungang | Wang W.,Second Peoples Hospital of Lianyungang | Zhou Y.,Second Peoples Hospital of Lianyungang | Ma J.,Second Peoples Hospital of Lianyungang
Central European Journal of Immunology | Year: 2017

Developed chronic hepatitis B (CUB) causes death in approximately one million patients every year. Therefore, natural drugs with high therapeutic efficacy and minimal side effects must be developed for CHB treatment. This study aimed to relate the therapeutic effects of glutathione on CUB. A total of 104 CHB patients were randomly divided into two groups: the control group, which received an intravenous drip of 0.4 g of inosine injection with 250 ml of 5% glucose once a day for eight weeks, and the treatment group, which received an intravenous drip of 1200 mg of glutathione on the basis of the treatment of the control group. Glutathione treatment decreased the serum levels of asparaginic acid transaminase, alanine aminotransferase, total bilirubin, total bile acids, haluronic acid, collagen IV, laminin, transforming growth factor-βl, tumour necrosis factor-α, interleukin-6, and interleukin-8, compared with the control group. The results indicate that glutathione treatment can improve liver function and inhibit inflammation and hepatic fibrosis in CHB patients.


Zhu H.-C.,Nanjing Medical University | Yang X.,Nanjing Medical University | Xu L.-P.,Nanjing Medical University | Zhao L.-J.,Nanjing Medical University | And 9 more authors.
Digestive Diseases and Sciences | Year: 2014

Background We conducted a systematic review and meta-analysis of meat intake and esophageal cancer risk, with subgroup analyses based on meat type and histological type of cancer. Aims The purpose of this study was to investigate the association between meat intake and risk of esophageal cancer. Methods We searched MEDLINE, EMBASE and Cochrane Library (April 2013) for cohort and case-control studies that assessed meat intake and esophageal cancer risk. Random-effect or fixed-effect models were used to pool relative risks (RRs) from individual studies with heterogeneity and publication bias analyses carried out. Seven cohort and 28 case-control studies were included. Results The summary RRs for esophageal cancer for the highest versus lowest consumption categories were 1.19 (95 % confidence interval [CI] 0.98-1.46) for total meat, 1.55 (95 % CI 1.22-1.96) for red meat, 1.33 (95 % CI 1.04-1.69) for processed meat, 0.72 (95 % CI 0.60-0.86) for white meat, 0.83 (95 % CI 0.72-0.96) for poultry, and 0.95 (95 % CI 0.76-1.19) for fish. When striated by histological subtype, positive associations were seen among esophageal squamous cell carcinoma and red meat, white meat and poultry, and esophageal adenocarcinoma with total meat and processed meat. Conclusions Meat consumption is associated with esophageal cancer risk, which depends on meat type and histological type of esophageal cancer. High intake of red meat and low intake of poultry are associated with an increased risk of esophageal squamous cell carcinoma. High meat intake, especially processed meat, is likely to increase esophageal adenocarcinoma risk. And fish consumption may not be associated with incidence of esophageal cancer. © Springer Science+Business Media New York 2013.


Zhang S.,Nanjing Medical University | Zhang S.,Second Peoples Hospital of Lianyungang | Xu K.,Nanjing Medical University | Yang N.,Xuzhou Medical College | Li C.,Nanjing Medical University
Nigerian Journal of Clinical Practice | Year: 2016

A number of treatment strategies for complex coronary lesions have been utilized in varying clinical settings over the last decade. However, cardiologists still encounter some difficult scenarios such as variant coronary artery origins, severely calcified and highly tortuous lesions. We report four cases in which the stents failed to cross lesions using the conventional percutaneous coronary intervention techniques, but all the target lesions were successfully stented finally using a new combined technique of anchor balloon assisted deep intubation of 5F 'child-in-mother' catheter. © 2016 Nigerian Journal of Clinical Practice | Published by Wolters Kluwer - Medknow.


Qian L.,Second Peoples Hospital of Lianyungang | Zhou Y.,Second Peoples Hospital of Lianyungang | Ma J.-X.,Second Peoples Hospital of Lianyungang
International Journal of Biological Macromolecules | Year: 2014

This study was performed to investigate the hypolipidemic effect of the polysaccharides extracted from Porphyra yezoensis. Male Sprague-Dawley rats were divided into three groups and orally treated with diets containing either high fat, P. yezoensis polysaccharides (PPs), or normal fat. Treatment of male Sprague-Dawley rats with PPs led not only to significant decreases in plasma triacylglycerol, total cholesterol, and plasma low-density lipoprotein cholesterol and an increase in plasma high-density lipoprotein cholesterol, but also to significant decreases in liver weight, triacylglycerol and cholesterol. Therefore, the results suggest that PPs had a high hypolipidemic activity and could be used as a potential therapeutic agent for hyperlipidemia. © 2014 Elsevier B.V.


Chen J.-C.,Second Peoples Hospital of Lianyungang | Sun D.-J.,Second Peoples Hospital of Lianyungang | Ge Z.-L.,Second Peoples Hospital of Lianyungang
Journal of Clinical Neurology | Year: 2010

Objective: To investigate the effects of intensively antihypertensive therapy by Urapidil on hematoma enlargement in patients with hypertensive intracerebral hemorrhage(HICH). Methods: Hundred and four-six HICH patients were randomly divided into intensively antihypertensive group (intensive group, 75 cases, Urapidil was intravenous injected by micro-pump, the target value of mean arterial pressure was 110 mmHg) and the conventional antihypertensive group (control group, 71 cases, Captopril was taken, the target value of mean arterial pressure was 130 mmHg). The changes of hematoma volume and score of NIHSS were observed after treatment, as well as mortality and adverse drug reaction. Results: Twenty-four h after treatment in intensive group, the average volume of hematoma [(11.9 ± 9.5) ml], the rate of hematoma enlargement (14.7%, 11 cases), and the score of NIHSS (7.2 ± 5.0) were significantly differences compared with the control group [(13.2 ± 9.9) ml, (31.0%, 22 cases), (8.9 ± 6.8) scores] (all P < 0.05). Thirty d after onset, the score of NIHSS (4.6 ± 3.4) in intensive group was significant lower than control group (5.7 ± 4.1) (P < 0.01); the mortality rate (5.3%) was lower than control group (9.9%), but the difference was no statistically significant. The adverse reactions between the two groups was no significant different. Conclusion: Therapy of Urapidil intensive antihypertension can prevent hematoma enlargement of HICH patients, and the method is safe and reliable.


Liu Y.,Second Peoples Hospital of Lianyungang | Yu J.,Second Peoples Hospital of Lianyungang | Bai J.,Second Peoples Hospital of Lianyungang | Gu J.-S.,Second Peoples Hospital of Lianyungang | And 2 more authors.
Chinese Journal of Burns | Year: 2013

Objective: To study the effects of cuttlefish bone-bone morphogenetic protein (BMP) composite material on osteogenesis and revascularization of bone defect in rats. Methods: The cuttlefish bone was formed into cylinder with the diameter of about 5 mm and height of about 2 mm after the shell was removed, and then it was soaked in the recombinant human BMP 2 to make a cuttlefish bone-BMP (CBB) composite material. Thirty SD rats, with a defect of skull in every rat, were divided into the CBB and pure cuttlefish bone (PCB) groups according to the random number table, with 15 rats in each group. The rats in the group CBB and group PCB were transplanted with the corresponding material to repair the skull defect. At post transplantation week (PTW) 4, 6, and 8, 5 rats from every group were sacrificed by exsanguination, and ink perfusion was performed. One day later, all the transplants and part of the skull surrounding the defect were harvested, and general observation was conducted at the same time. The specimens were paraffin sectioned for HE staining and Masson staining. The area of microvessel and the area of newborn bone were observed and analyzed through histopathological techniques and image collection system. Data were processed with the analysis of variance of factorial design and LSD test. The correlation between the area of microvessel and the area of newborn bone of the group CBB was analyzed with Pearson correlation analysis. Results: (1) The general observation of the transplant region showed that the transplants were encapsulated by a capsule of fibrous connective tissue. The texture of capsule was soft and relatively thick at PTW 4. The texture was tenacious and thin, but rather compact at PTW 6 and 8. The transplants became gelatinous at PTW 4, and similar to the cartilage tissue at PTW 6 and 8. (2) Histological observation showed that the structure of the transplants in two groups was damaged at PTW 4. A moderate quantity of inflammatory cell infiltration could be observed. The amounts of the primary bone trabeculae and microvessels in group CBB were more abundant than those of group PCB, while the number of osteoclasts was less than those of group PCB. At PTW 6, the inflammatory cell infiltration in the transplants in both groups decreased obviously, the cuttlefish bone was found to be further degraded, and the number of newborn microvessels was increased. There were mature bone trabeculae around the transplants in both groups. And there were also mature bone trabeculae in the degraded CBB in group CBB. At PTW 8, the inflammatory reaction in the transplants in both groups disappeared; there were more mature bone trabeculae; the structure of the cuttlefish bone was found to be damaged basically. Bone trabeculae in group PCB were found around the transplant, while the bone trabeculae could be observed not only around the transplant but also in the degraded CBB in group CBB. The amount of the microvessels in group CBB was still larger than that of group PCB. (3) From PTW 4 to 8, the area of microvessel in group CBB [(63 ± 4), (136 ± 36), (347 ± 31) μm2] was larger than that in group PCB [(44 ± 7), (73 ± 4), (268 ± 42) μm2, P < 0.05 or P < 0.01]. From PTW 4 to 8, the area of newborn bone in group CBB [(236 ± 26), (339 ± 42), (553 ± 40) μm2] was larger than that in group PCB [(137 ± 15), (243 ± 21), (445 ± 29) μm2, with P values all below 0.01]. (4) The relation between the area of microvessel and the area of newborn bone was significantly positive (r = 0.948, P = 0.001). Conclusions: The CBB may exert good effect on osteogenesis and vascularization of rats with bone defect. It is a good three dimensional scaffold in bone tissue engineering.


Tian C.-R.,Second Peoples Hospital of Lianyungang | Qian L.,Second Peoples Hospital of Lianyungang | Shen X.-Z.,Second Peoples Hospital of Lianyungang | Li J.-J.,Second Peoples Hospital of Lianyungang | Wen J.-T.,Second Peoples Hospital of Lianyungang
PLoS ONE | Year: 2014

The serum total protein levels of the elderly possibly decrease gradually with aging. However, serum total protein levels are not suitable as a uniform reference standard for the elderly at different ages and genders. Thus, we investigated the total serum protein distribution in different gender and age groups of 11,453 elderly individuals aged ≥60 years and without liver or renal disease from Lianyungang, Jiangsu, China. The total protein levels (TPL) of these individuals exhibited normal distribution (Z = 1.206, P = 0.109), whereas the reference range (95% CI) was 54.1 g/L to 82.3 g/L. TPL was higher in females than in males for those aged between 60 and 75 years, whereas no significant difference was observed for those aged between 80 and 95 years. TPL was negatively correlated with age in males (r = -0.1342, P<0.05), females (r = -0.304, P<0.05), and the total group (r = -0.2136, P<0.05). TPL also decreased with aging and showed a faster rate in women than in men. These results indicated that an appropriate range of serum total protein based on age and gender differences should be used for clinical applications. © 2014 Tian et al.


Xu J.,Xuzhou Medical College | Zhang Y.,Xuzhou Medical College | Wei H.,Second Peoples Hospital Of Lianyungang | Xu Y.,Xuzhou Medical College | And 3 more authors.
Neurological Research | Year: 2015

Background and purpose: Thrombolytic treatment criteria vary significantly between China and the USA. We reviewed current intravenous (IV) thrombolytic therapy practices in China and the USA to determine the most appropriate.Methods: We conducted a systematic review of studies that used IV recombinant tissue plasminogen activator (rt-PA) therapy in China and the USA published between January 1950 and April 2012.Results: Literature search identified 17 American and 9 Chinese studies with a total of 2545 subjects. We found a significantly lower mortality rate in the US data compared with China (8% versus 13%; Chi-square = 24.412, P < 0.001). Our meta-regression analysis uncovered significant factors influencing mortality including male sex, hypertension, high cholesterol, smoking, and onset to treatment time (all P < 0.05). There were significantly more favorable outcomes in China than in the USA (61% versus 49%, Chi-square = 19.159, P < 0.001). No prior history of stroke and shorter onset to IV time were also significantly associated with a favorable outcome (P < 0.05).Conclusions: Onset to IV time is critical for reducing mortality and improving favorable outcomes. We suggest Chinese acute ischemic stroke treatment guidelines be revised to include an increase in the age limit of 80 years, removing contraindications such as a history of previous sever heart, liver, and kidney dysfunction, and placing more emphasis on physician expertise. © W. S. Maney & Son Ltd 2015.

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