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Ma J.-X.,Second Peoples Hospital of Lianyungang
International Journal of Biological Macromolecules | Year: 2014

This study was performed to investigate the hypolipidemic effect of the polysaccharides extracted from Porphyra yezoensis. Male Sprague-Dawley rats were divided into three groups and orally treated with diets containing either high fat, P. yezoensis polysaccharides (PPs), or normal fat. Treatment of male Sprague-Dawley rats with PPs led not only to significant decreases in plasma triacylglycerol, total cholesterol, and plasma low-density lipoprotein cholesterol and an increase in plasma high-density lipoprotein cholesterol, but also to significant decreases in liver weight, triacylglycerol and cholesterol. Therefore, the results suggest that PPs had a high hypolipidemic activity and could be used as a potential therapeutic agent for hyperlipidemia. © 2014 Elsevier B.V.

Zhu H.-C.,Nanjing Medical University | Yang X.,Nanjing Medical University | Xu L.-P.,Nanjing Medical University | Zhao L.-J.,Nanjing Medical University | And 9 more authors.
Digestive Diseases and Sciences | Year: 2014

Background We conducted a systematic review and meta-analysis of meat intake and esophageal cancer risk, with subgroup analyses based on meat type and histological type of cancer. Aims The purpose of this study was to investigate the association between meat intake and risk of esophageal cancer. Methods We searched MEDLINE, EMBASE and Cochrane Library (April 2013) for cohort and case-control studies that assessed meat intake and esophageal cancer risk. Random-effect or fixed-effect models were used to pool relative risks (RRs) from individual studies with heterogeneity and publication bias analyses carried out. Seven cohort and 28 case-control studies were included. Results The summary RRs for esophageal cancer for the highest versus lowest consumption categories were 1.19 (95 % confidence interval [CI] 0.98-1.46) for total meat, 1.55 (95 % CI 1.22-1.96) for red meat, 1.33 (95 % CI 1.04-1.69) for processed meat, 0.72 (95 % CI 0.60-0.86) for white meat, 0.83 (95 % CI 0.72-0.96) for poultry, and 0.95 (95 % CI 0.76-1.19) for fish. When striated by histological subtype, positive associations were seen among esophageal squamous cell carcinoma and red meat, white meat and poultry, and esophageal adenocarcinoma with total meat and processed meat. Conclusions Meat consumption is associated with esophageal cancer risk, which depends on meat type and histological type of esophageal cancer. High intake of red meat and low intake of poultry are associated with an increased risk of esophageal squamous cell carcinoma. High meat intake, especially processed meat, is likely to increase esophageal adenocarcinoma risk. And fish consumption may not be associated with incidence of esophageal cancer. © Springer Science+Business Media New York 2013.

Xu J.,Xuzhou Medical College | Zhang Y.,Xuzhou Medical College | Wei H.,Second Peoples Hospital of Lianyungang | Xu Y.,Xuzhou Medical College | And 3 more authors.
Neurological Research | Year: 2015

Background and purpose: Thrombolytic treatment criteria vary significantly between China and the USA. We reviewed current intravenous (IV) thrombolytic therapy practices in China and the USA to determine the most appropriate.Methods: We conducted a systematic review of studies that used IV recombinant tissue plasminogen activator (rt-PA) therapy in China and the USA published between January 1950 and April 2012.Results: Literature search identified 17 American and 9 Chinese studies with a total of 2545 subjects. We found a significantly lower mortality rate in the US data compared with China (8% versus 13%; Chi-square = 24.412, P < 0.001). Our meta-regression analysis uncovered significant factors influencing mortality including male sex, hypertension, high cholesterol, smoking, and onset to treatment time (all P < 0.05). There were significantly more favorable outcomes in China than in the USA (61% versus 49%, Chi-square = 19.159, P < 0.001). No prior history of stroke and shorter onset to IV time were also significantly associated with a favorable outcome (P < 0.05).Conclusions: Onset to IV time is critical for reducing mortality and improving favorable outcomes. We suggest Chinese acute ischemic stroke treatment guidelines be revised to include an increase in the age limit of 80 years, removing contraindications such as a history of previous sever heart, liver, and kidney dysfunction, and placing more emphasis on physician expertise. © W. S. Maney & Son Ltd 2015.

Tian C.-R.,Second Peoples Hospital of Lianyungang | Shen X.-Z.,Second Peoples Hospital of Lianyungang | Li J.-J.,Second Peoples Hospital of Lianyungang | Wen J.-T.,Second Peoples Hospital of Lianyungang
PLoS ONE | Year: 2014

The serum total protein levels of the elderly possibly decrease gradually with aging. However, serum total protein levels are not suitable as a uniform reference standard for the elderly at different ages and genders. Thus, we investigated the total serum protein distribution in different gender and age groups of 11,453 elderly individuals aged ≥60 years and without liver or renal disease from Lianyungang, Jiangsu, China. The total protein levels (TPL) of these individuals exhibited normal distribution (Z = 1.206, P = 0.109), whereas the reference range (95% CI) was 54.1 g/L to 82.3 g/L. TPL was higher in females than in males for those aged between 60 and 75 years, whereas no significant difference was observed for those aged between 80 and 95 years. TPL was negatively correlated with age in males (r = -0.1342, P<0.05), females (r = -0.304, P<0.05), and the total group (r = -0.2136, P<0.05). TPL also decreased with aging and showed a faster rate in women than in men. These results indicated that an appropriate range of serum total protein based on age and gender differences should be used for clinical applications. © 2014 Tian et al.

Chen J.-C.,Second Peoples Hospital of Lianyungang | Sun D.-J.,Second Peoples Hospital of Lianyungang | Ge Z.-L.,Second Peoples Hospital of Lianyungang
Journal of Clinical Neurology | Year: 2010

Objective: To investigate the effects of intensively antihypertensive therapy by Urapidil on hematoma enlargement in patients with hypertensive intracerebral hemorrhage(HICH). Methods: Hundred and four-six HICH patients were randomly divided into intensively antihypertensive group (intensive group, 75 cases, Urapidil was intravenous injected by micro-pump, the target value of mean arterial pressure was 110 mmHg) and the conventional antihypertensive group (control group, 71 cases, Captopril was taken, the target value of mean arterial pressure was 130 mmHg). The changes of hematoma volume and score of NIHSS were observed after treatment, as well as mortality and adverse drug reaction. Results: Twenty-four h after treatment in intensive group, the average volume of hematoma [(11.9 ± 9.5) ml], the rate of hematoma enlargement (14.7%, 11 cases), and the score of NIHSS (7.2 ± 5.0) were significantly differences compared with the control group [(13.2 ± 9.9) ml, (31.0%, 22 cases), (8.9 ± 6.8) scores] (all P < 0.05). Thirty d after onset, the score of NIHSS (4.6 ± 3.4) in intensive group was significant lower than control group (5.7 ± 4.1) (P < 0.01); the mortality rate (5.3%) was lower than control group (9.9%), but the difference was no statistically significant. The adverse reactions between the two groups was no significant different. Conclusion: Therapy of Urapidil intensive antihypertension can prevent hematoma enlargement of HICH patients, and the method is safe and reliable.

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