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Yuan H.,Second Peoples Hospital of Hefei City | Xia Q.,Second Peoples Hospital of Hefei City | Ge P.,Second Peoples Hospital of Hefei City | Wu S.,Second Peoples Hospital of Hefei City
Molecular Biology Reports | Year: 2013

A large number of epidemiological studies have been performed to investigate the association between Alzheimer's disease (AD) risk and interleukin-1β -511C/T genetic polymorphism, however, inconsistent results have been reported. The effect of the IL-1β -511C/T polymorphism on AD susceptibility was evaluated by a meta-analysis. Series of databases were researched. 14 studies involving 2640 AD case and 3493 control subjects were identified. The pooled results showed there were no statistical associations of interleukin-1β -511C/T genetic polymorphism with susceptibility to AD for five analysis models in all subjects. However, obvious heterogeneity among studies was detected. When stratifying for age at onset, ethnicity and geographic distribution of population to explore the original source of heterogeneity, the meta-analysis results based on geographic distribution of population showed the significant difference (CC vs CT, OR 1.26, 95 % CI: 1.03, 1.54, z = 2.25, P = 0.025; CC vs CT+TT, OR 1.24, 95 % CI: 1.03, 1.50, z = 2.24, P = 0.025) only in non-Europe. These findings indicate that the IL-1β -511C/T polymorphism might be associated with AD risk, and individuals with IL-1β -511C/C genotype might be at higher risk of AD in non-Europe. Further larger sample research would be warranted to confirm these conclusions. © 2012 Springer Science+Business Media Dordrecht.


Wang Q.,Second Peoples Hospital of Hefei City | Xu S.-C.,Anhui Medical University | Liu Y.-H.,Anhui Medical University | Hu G.-Q.,Second Peoples Hospital of Hefei City | And 2 more authors.
Acta Anatomica Sinica | Year: 2015

Objective To investigate the changes in the lumen diameter of pharyngeal esophageal segment during the aging process. Methods The pharyngeal esophageal lumen was dissected and examined in 60 cadareric specimens. Results Pharyngeal esophageal lumen appeared in a compact or a smooth shapes. The measurement pharyngeal esophageal lumen was performed at 4 planes: lateral cricopharyngeal triangle, inferior horn of thyroid cartilage, narrowest point and inferior margin of the cricoid cartilage. It was observed that the lumen from the lateral cricopharyngeal triangle to cricoid inferior plane became gradually narrowed (P <0. 05). The diameter of the pharyngeal esophageal lumens was greater in the elderly group than that in the youth group and the young group (P <0. 05). There were significant differences in the lumen diameter at different planes (P <0. 05) and in the 3 age groups (P <0. 05). Conclusion The diameter of the pharyngeal esophageal lumens is greater in the elderly group than that in the youth group, suggesting compensatory changes in the aging process.


Yu Z.-Y.,Anhui Medical University | Lu W.-S.,Anhui Medical University | Zuo X.-B.,Anhui Medical University | Hu J.,Second Peoples Hospital of Hefei City | And 11 more authors.
Rheumatology International | Year: 2013

The aim of the study is to explore additional susceptibility factors for systemic lupus erythematosus (SLE) in Chinese Hans. Based on our previous GWAS of SLE, we performed a multistage replication study involving 3,152 cases and 7,050 controls from China to identify additional susceptibility loci for SLE by using the Sequenom MassArray system. All Chinese Han samples used in this study were obtained from doctors through collaboration with multiple hospitals in two geographic regions (central and southern China). Single-marker association analyses were performed using logistic regression with gender as a covariate in each case-control cohort. The joint analysis of all combined samples was performed using logistic regression with gender and sample cohorts as covariates. The significant association evidence for rs906868 (OR = 1.14, 95 % CI 1.08-1.20, P combined = 7.71 × 10-10) and rs7579944 (OR = 1.13, 95 % CI 1.07-1.19, P combined = 5.55 × 10-9) was observed, which located at 2p23.1. In this region, limb bud and heart development homolog (LBH) was the only gene indicated, suggesting LBH might be a susceptibility gene for SLE, although its function was still unknown. The results indicated that the SNP rs7579944, rs906868 at 2p23.1 showed significant association with SLE. The genes LBH which located in this loci might be the predisposing genes of SLE. © 2013 Springer-Verlag Berlin Heidelberg.

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