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Guan Z.,Second Hospital of Fuzhou
Journal of cataract and refractive surgery | Year: 2012

To describe and quantify the pattern of corneal astigmatism in cataract surgery candidates and to provide information for cataract surgeons and intraocular lens (IOL) manufacturers. Zhongshan Hospital, Fudan University, Shanghai, China. Cross-sectional study. The datasets of cataract surgery candidates acquired between November 1, 2009, and November 30, 2011, were collected and analyzed. Keratometry values were optically measured by partial coherence interferometry (IOLMaster) before cataract extraction. Spearman rank correlation coefficients were used to estimate bivariate correlations. The power vector method, J(0) and J(45) values, and linear regression models were used to assess the association between age and astigmatism. The study evaluated the keratometry values in 1430 eyes (827 patients) with a median age of 75 years (range 16 to 98 years). The corneal astigmatism was 1.00 diopter (D) or higher in 45.45% of eyes. The magnitude of corneal astigmatism was positively correlated with age (ρ = 0.126, P = .000). A trend toward increasing against-the-rule astigmatism with age was found by linear regression models; the per-year increase in age was associated with a J(0) decrease of 0.016 D in right eyes and 0.018 D in left eyes (both P = .000). No association was found between age and J(45). Most eyes having corneal astigmatism of 1.00 D or greater could be covered by the range of the cylindrical power of the toric IOLs available on the market. Against-the-rule corneal astigmatism of relatively younger cataract surgery candidates should be managed more aggressively. No author has a financial or proprietary interest in any material or method mentioned. Copyright © 2012 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved. Source


Dong O.,Second Hospital of Fuzhou
Hepato-Gastroenterology | Year: 2012

Background/Aims: 1H-NMR is a powerful approach of metabolomics. This study aimed to apply it to the profiling of serum metabolites in patients with pancreatitis, and to analyze the characteristic metabolites of pancreatitis. Methodology: Serum samples were taken from 17 pancreatitis patients and 23 healthy subjects and subjected to 1H-NMR and principle component analysis to compare endogenous small-molecule metabolites. Results: 3-hydroxybutyrate, trimethylamine-N-oxide, acetate and acetone levels were significantly lower in the pancreatitis group than in the control group. Isoleucine, acetylglycine, triglyceride and inosine levels were significantly higher in the pancreatitis group than in the control group. Conclusions: 1H-NMR-based metabolomics is an effective method to investigate the small-molecule metabolites in the sera of patients with pancreatitis. Metabolites identified in this study may be exploited as metabolic markers for the early detection of pancreatitis. © H.G.E. Update Medical Publishing S.A. Source


Wu G.,Fujian Medical University | Song Y.,Second Hospital of Fuzhou | Zheng X.,Fujian Medical University | Jiang Z.,Fujian Medical University
Tissue and Cell | Year: 2011

We aimed to investigate the application of adipose-derived stromal cells in the treatment of stress urinary incontinence (SUI). Animal models of stress urinary incontinence were established with Sprague-Dawley female rats by complete cutting of the pudendal nerve. Rat adipose-derived stromal cells were isolated, cultured and successfully transplanted into animal models. Effects of stem cell transplantation were evaluated through urodynamic testing and morphologic changes of the urethra and surrounding tissues before and after transplantation. Main urodynamic outcome measures were measured. Intra-bladder pressure and leak point pressure were measured during filling phase. Morphologic examinations were performed. Transplantation of adipose-derived stem cells significantly strengthened local urethral muscle layers and significantly improved the morphology and function of sphincters. Urodynamic testing showed significant improvements in maximum bladder capacity, abdominal leak point pressure, maximum urethral closure pressure, and functional urethral length. Morphologic changes and significant improvement in urination control were consistent over time. It was concluded that periurethral injection of adipose-derived stromal cells improves function of the striated urethral sphincter, resulting in therapeutic effects on SUI. Reconstruction of the pelvic floor through transplantation of adipose-derived cells is a minimally invasive and effective treatment for SUI. © 2011 Elsevier Ltd. Source


Yang C.-Z.,Fujian Medical University | Zhang Y.-Y.,Second Hospital of Fuzhou | Zheng M.,Fujian Medical University
Clinical Biochemistry | Year: 2011

Objectives: This study was aimed to measure soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate the correlation between sLOX-1 levels and the disease severity. Design and methods: Two hundred and sixteen OA patients and 83 healthy controls were enrolled in this study. All OA patients were scored for Kellgren-Lawrence (KL) grade (0-4). The sLOX-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: In OA patients, the mean sLOX-1 levels in SF were markedly lower than those in paired serum samples (P. <. 0.01). The SF sLOX-1 levels increased with higher KL grade (P. <. 0.01) and were significantly correlated with disease severity (r= 0.324, P. <. 0.01). SF sLOX-1 level was the independent factor for predicting the disease severity of OA (β: 0.281, 95%CI: 0.145-0.396). Conclusions: SF sLOX-1 levels were independently and positively associated with disease severity in knee OA. © 2011 The Canadian Society of Clinical Chemists. Source


Wu Z.,Second Hospital of Fuzhou | Wang S.,Fuzhou General Hospital
International Journal of Clinical and Experimental Medicine | Year: 2016

Pituitary adenoma (PA) concomitant with Rathke cleft cyst (RCC) is extremely rare. The risk of recurrence of both PA and RCC necessitates post-operative follow-up. Here we describe a 22-year-old woman was admitted for headache and hypopsia. Magnetic resonance imaging (MRI) revealed a sellar mass. During surgery, a small RCC was incidentally found inside the PA. Both tumors were completely resected. Follow-up MRI 6 years later demonstrated a sellar lesion and a following surgery were performed, during which an RCC was validated without evidence of PA recurrence. This is the first report of the recurrence of PA concomitant with RCC 6 years after surgery, suggesting that PA and concomitant RCC requires periodical post-operative follow-up. For recurrent tumors, especially for symptomatic ones, a second surgery is needed. During the surgery, lesion should be removed as completely as possible, without damage of the normal pituitary. © 2016, E-Century Publishing Corporation. All rights reserved. Source

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