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Hu W.,The Second Affiliated Hospital Binjiang Branch | Xu J.-H.,The Second Affiliated Hospital | Pan W.-S.,The Second Affiliated Hospital Binjiang Branch
Journal of Practical Oncology | Year: 2014

Multiple primary carcinomas refer to two or more primary malignancies synchronously or metachronously occur in the same organ, different locations of one system or different organs in one person. One case of metachronous hypopharyngeal and esophageal multiple primary carcinomas was reported. Hypopharyngeal carcinoma was diagnosed during routine gastroscopy examine after esophageal carcinoma surgery and clinical stage was T1N0M0. Some scholars suggest endoscopic submucosal dissection for early stage hypopharyngeal carcinoma. Endoscopists should pay attention to suspicious lesions in pharynx besides esophagus, stomach and duodenum, and new techniques can be applied for the detection of early stage hypopharyngeal carcinomas.

Zeng L.,The Second Affiliated Hospital
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation | Year: 2011

According to hospital medical equipment, information equipment and water, electricity and other equipment maintenance procedures, this paper planned and developed a comprehensive maintenance management system for hospitals. The system implements equipment maintenance, maintenance applications, maintenance registration, preventive maintenance, data quantitative analysis and other functions.

Xie J.,the Affiliated Sir Run Run Shaw Hospital | Lv R.,the Affiliated Sir Run Run Shaw Hospital | Yu L.,The Second Affiliated Hospital | Huang W.,The First Affiliated Hospital
Journal of Surgical Research | Year: 2010

Background: Hydroxyethyl starch (HES) is one of the most frequently used plasma substitutes, and could modulate inflammatory response in sepsis. Our aim of this study was to investigate the mechanism of the effect of HES 130/0.4 by studying plasma levels of inflammatory cytokines, nuclear factor-κB (NF-κB) activation, and Toll-like receptors (TLRs) expression in peripheral monocytes during polymicrobial sepsis. Materials and Methods: Rats with sepsis induced by cecal ligation and puncture (CLP) were treated with HES130/0.4 (7.5, 15, or 30 mL/kg, intravenously); then, rat plasma and monocytes were isolated from blood 5 h later. The plasma level of cytokines (tumor necrosis factor [TNF]-α and interleukin [IL]-6), NF-κB activity, and mRNA and protein levels of TLRs (TLR2 and TLR4) in peripheral blood monocytes were determined by enzyme-linked immunosorbent assay, electrophoretic mobility shift assay, reverse transcription-polymerase chain reaction, and Western blotting, respectively. Results: HES130/0.4 dose-dependently reduced the plasma level of TNF-α and IL-6 in rats with sepsis. HES130/0.4 also significantly inhibited NF-κB activation, and TLRs mRNA and protein levels in peripheral monocytes. Conclusion: During sepsis, HES130/0.4 can down-regulate the inflammatory response, possibly through inhibition of the TLRs/NF-κB signaling pathway, and could be one more appropriate plasma substitute in sepsis. © 2010 Elsevier Inc. All rights reserved.

Qin W.B.,The Second Affiliated Hospital
Zhonghua nan ke xue = National journal of andrology | Year: 2013

To study the changes in the activities of carbon monoxide (CO) and heme oxygenase 2 (HO-2) in ED rats with hyperhomocysteinemia (HHcy). This study included 40 male Wistar rats weighing 280 - 310 g, 10 as normal controls (group A). HHcy models were made in the other 30 by giving 3% methionine for 4 weeks, and then divided into groups B, C and D. The rats in group B continued to be fed with 3% methionine, those in group C were treated with betaine hydrochloride, and those in group D were given zinc porphyrin IX at 45 micromol per kg per d. Penile erections of the rats were recorded, and 4 weeks later, all were killed for determination of the levels of homocysteine (Hcy) in the blood plasma and the activities of CO and HO-2 in the corpus cavernosum of the penis. The level of plasma Hcy, penile erection frequency and the content of CO in the corpus cavernosum were (12.55 +/- 0.82) micromol/L, (1.88 +/- 0.05) times and (10.55 +/- 1.73) micromol/L in group A, the Hcy level significantly higher while the penile erection frequency and CO content remarkably lower than in group B ([25.01 +/- 0.94] micromol/L, [0.70 +/- 0.05] times and [9.51 +/- 1.52] micromol/L, P < 0.05 or P < 0.01), with a negative correlation between the level of Hcy and that of CO and HO-2 (P < 0.01). Compared with group B, the three parameters were all significantly increased in C ([14.37 +/- 0.47] micromol/L, [1.18 +/- 0.08] times and [10.36 +/- 1.56] micromol/L, all P < 0.05 or P < 0.01). Decreased expressions of CO and HO-2 in the corpus cavernosum of the penis may result in ED in HHcy rats. Betaine can reduce the Hcy level in the blood plasma and CO content in the corpus cavernosum, which might be one of the mechanisms of its action on ED with HHcy.

Liang B.,The Second Affiliated Hospital | Dai M.,Nanchang University | Zou Z.,The Second Affiliated Hospital
Journal of Gastroenterology and Hepatology (Australia) | Year: 2016

Background and Aim:: Owing to persistent controversy regarding the use of routine antibiotic prophylaxis in patients undergoing elective laparoscopic cholecystectomy and the availability of several new randomized controlled trials (RCTs), we conducted an up-to-date meta-analysis to provide the best current evidence. The aim of the article is to evaluate the safety and efficacy of routine antibiotic prophylaxis in low-risk patients undergoing elective laparoscopic cholecystectomy. Methods:: We conducted a comprehensive literature review of the PubMed, Embase, and Cochrane Library databases for RCTs that compared antibiotic prophylaxis versus placebo or no antibiotics in low-risk patients undergoing elective laparoscopic cholecystectomy. Results:: The meta-analysis included 21 RCTs (5207 patients). Antibiotic prophylaxis reduced the incidence of surgical site infections (risk ratio [RR] 0.61, 95% confidence interval [CI] 0.45 to 0.82, P=0.001) and global infections (RR 0.55, 95% CI 0.38 to 0.79, P=0.001) during hospitalization or after discharge, and postoperative length of hospital stay (weighted mean difference -0.16, 95% CI -0.28 to -0.04, P=0.008). No adverse events were reported. Subgroup analyses demonstrated that two doses of antibiotic and 3-10 doses of antibiotic significantly reduced the incidence of surgical site infections compared with placebo or no antibiotics (two doses: RR 0.16, 95% CI 0.06-0.47; 3-10 doses: RR 0.46, 95% CI 0.27-0.80), while a single dose of antibiotic administration did not. Conclusion:: Antibiotic prophylaxis is safe and effective in reducing surgical site infections and global infections during hospitalization or after discharge, and postoperative length of hospital stay in low-risk patients undergoing elective laparoscopic cholecystectomy. © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

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