Evaluation of growth and tolerance to modified formula for infants with minor digestive disorders in Primary Care [Valoración del crecimiento y tolerancia de fórmula modificada para lactantes con trastornos digestivos menores en Atención Primaria]
Sanchez Sanchez C.,Seccion de Gastroenterologia Pediatrica |
Losada A.,Servicio de Neonatologia
Revista Espanola de Pediatria | Year: 2012
Objectives. To analyze growth patterns, tolerance, adherence and incidence of minor digestive disorders and their resolution in infants with modified commercial adapted formula. Patients and methods. A longitudinal, prospective, open-label and controlled study in Primary Health Care. Healthy infants with indication of artificial feeding, group A (Almiron 1, adapted formula) and group B with minor digestive disorders (Almiron Digest, modified formula) were included. Epidemiological and anthropometric variables (weight, length, head circumference, weight/length ratio), digestive disorders, tolerance, adherence and satisfaction survey for parents/professionals in the controls (baseline, at one month, 3 and 6 months) were recorded. Results. From November 2007 to May 2008, 172 pediatricians included 777 infants, 537 in group A (69%) and 240 in group B (31%). Inclusion age of 3.35 weeks ± 3.4 days (42% younger than 1 month); 54% were males. No statistically significant differences were found between groups for epidemiological variables, personal backgrounds or anthropometric parameters in any visit. The growth pattern was adequate according to the reference curves. In the baseline visit, statistically significant differences were observed between groups A and B for regurgitations (236 infants, 22% versus 49.5%), dyschezia (111 infants, 5% versus 35%), cholics in infants (301 infants, 20% versus 81%), constipation (162 infants, 11% versus 43%). Decrease of digestive disorders was significantly greater in group B (p< 0.001) in months 1 and 3. No statistically significant differences were observed for tolerance, adherence or in satisfaction surveys, these being adequate in both groups Conclusions. The growth patterns were adequate in both groups, reaching reference curves at the end of the study. The minor digestive disorders improved in the modified formula group at month 1 and 3 of initiation of its administration. Acceptability and adherence in the modified formula group were very satisfactory.