Dharwad, India
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Shivakumar J.,Karnataka Institute of Medical Science | Shenoy J.P.,Father Muller Medical College | Karne S.L.,SDMCMSH | Muniyappanavar N.S.,BRIMS
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

The forced vital capacity (FVC) maneuver is central to a multitude of information about the functioning of the lungs. But for it serve this purpose proper performance of this complex maneuver is essential. Standards have been prescribed by various agencies to monitor the FVC maneuver, concentrating mainly on adults. Children in general find it difficult to satisfy these adult based standards, and especially the forced expiratory time (FET) criterion, which is a part of the end of test (EOT) criteria, is found to be most difficult to achieve. Technically acceptable FVC maneuvers obtained from 91 children yielded FET values which were analyzed and Pearson's correlation coefficients were derived with height, weight, age and body surface area (BSA). The children in the present study produced an average FET of 1.53s, and over the age, height and weight ranges FET exhibited a positive correlation. Hence adult based standards may not be achieved by children vis-à-vis FET, even though the curves obtained are technically acceptable as far as complete expiration is concerned.

Kamble P.,SDMCMSH | Trivedi D.J.,SDMCMSH | Bargale A.,SDMCMSH | Pandhare V.,GCSMC | Padalkar P.,BVUMC
International Journal of Pharma and Bio Sciences | Year: 2011

The aim of our study is to determine the effects of alcohol intake and cigarette smoking on the activity of Xanthine oxidase (XO), Lipid peroxidation (LPO) and Uric acid in patients with Acute Myocardial Infarction (AMI). This study includes 60 patients of AMI [smokers (n=15), non-smokers (n=15), alcoholics (n=15) and non-alcoholics (n=15)] and 30 normal controls. Xanthine oxidase, Lipid peroxidation and Uric acid levels in smokers, nonsmokers, alcoholics, non-alcoholics and controls are (34.6±2.9, 33.8±2.4, 34.6±2.8, 33.9±2.5, 30.3±1.2), (5.45±0.75, 5.34±0.86, 5.07±0.82, 5.71±0.61, 2.39±0.82) and (6.24±0.36, 5.78±0.86, 5.78±0.85, 6.24±0.37, 5.2 ±1.82) respectively. Our result shows that the levels of XO, LPO and uric acid in smokers are elevated than controls. Regarding alcoholics there is no significant difference in the study parameters. Therefore, these results mainly focus towards smoking habit which can be an additional factor to enhance the severity of AMI.

Srinivas K.K.,SDMCMSH | Uppin I.V.,JNMC | Nerle R.B.,JNMC
Journal of Clinical and Diagnostic Research | Year: 2011

Background: A study was conducted at the KLES hospital and MRC, Belgaum, for a period of 1 year from April 2004 to March 2005. Objectives: To compare the efficacy of open pyeloplasty and laparoscopic pyeloplasty in the treatment of primary ureteropelvic junction obstruction with regards to the subjective outcome. Materials and Methods: A total of 30 patients of congenital UPJO was evaluated and operated. All the 30 patients were randomized into two groups of 15 each. One group formed the open pyeloplasty group and the other formed the laparoscopic pyeloplasty group. All the patients were assessed for the subjective outcome post-operatively and all the patients were followed up for a minimum of 3 months. The results were analyzed by using the Student's paired and unpaired tests Results: The mean age group, the laterality of involvement of the kidney and the sex ratio were almost similar between the two groups. The pre-operative pain and the activity levels were almost similar and comparable between the 2 groups. But, there was a significant post-operative improvement in the pain and the activity level in each group. In our study, we found that the improvement in the pain and the activity level post-operatively was much better in the laparoscopic pyeloplasty group patients as compared to those in the open pyeloplasty group patients. The time period when oral feeds were started and the drain was removed, was slightly more in the laparoscopic group, owing to the transperitoneal approach. There was no conversion to open procedure done in any of laparoscopic cases. The postoperative cosmesis was better inthe laparoscopic pyeloplasty patients as compared to the open pyeloplasty patients. Conclusion: Our study was done on a small number of patients and the post-operative follow up was only for 3 months. It is difficult to draw conclusions from such a study. Hence, a large randomised controlled trial with a long period of follow up studies are needed to establish the role of laparoscopic pyeloplasty in the treatment of UPJ obstruction. The potential advantages of laparoscopic pyeloplasty over open pyeloplasty are decreased post-operative pain, a shorter period of hospitalisation, a short convalescence and improved cosmesis. Laparoscopic pyeloplasty is a technically challenging procedure and it is still in its infancy. It is being practised at only few medical centres around the world. With the recent technological advances, laparoscopic pyeloplasty has become a valid alternative to endoscopic pyelotomy and open pyeloplasty.

Anuradha S.K.,SDMCMSH | Surekha Y.A.,VIMS | Narayan S.,NHH | Sonth S.,SNMC | And 4 more authors.
Journal of Clinical and Diagnostic Research | Year: 2011

Background: A study was conducted in VIMS hospital at Bellary during the epidemic of August 2004 to July 2005. Objectives: To know the hospital based incidence of J.E and to study the age and sex pattern of the infection in the paediatric age group. Materials and Methods: 82 children admitted to the Paediatric ward, VIMS, Bellary with clinical diagnosis of acute viral encephalitis, during the epidemic of August 2004 to July 2005 were studied. After pooling the samples, they were subjected to J.E. MAC ELISA. Results: Out of 82 patients tested by J.E. MAC ELISA, 19 (24%) were positive for J.E. and 12 (14.63%) were positive for flaviviral infection. CSF was positive in all 19 cases with 100% positivity. Serum was positive in 10 cases with 15.87% positivity. This indicates that there are significant number of J.E. cases in Bellary emphasising the rampant nature and stressing the measures to be taken to overwhelm this devastating disease. Conclusion: The hospital based incidence of J.E. was found to be significant in the area of the study. The paediatric age group, between 4to 6 years was found to be most predisposed to J.E., probably because of low immunity in the age group. Male predominance was seen with male to female ratio of 1.42:1. Illiteracy, low socio economic status and living in unhygienic conditions near rice fields contributed to the high incidence of J.E. in and around Bellary. The serological results clearly establish the etiology. Isolation of JEV from specimens would have strengthened the diagnosis.

Dixit U.R.,SDMCMSH | Bendigeri N.D.,KBNIMS
Indian Journal of Community Health | Year: 2015

Background: AIDS has been killing large number of people. The rate of infection of young children is quite high yet they are the ones who are not proportionately covered under ART. Children are vulnerable to infections more compared to adults and if malnutrition co-exists it makes them more vulnerable. Aims and objectives: To assess the impact of ART treatment on immune status; to study the common opportunistic infections among the study group; to study the relationship between supplementary nutrition and opportunistic infection. Materials and methods: A secondary data was collected about 46 children. Informed consent was taken from the parents/ guardians. Children were suggested to eat one extra meal and ground nuts and one egg thrice weekly. Result: There was significant increase in the CD4 count in these children (p <0.01) and the occurrence of opportunistic infections reduced significantly in those taking supplementary nutrition (p<0.001). In terms of opportunistic infections, skin infections were more common followed by tuberculosis and diarrhea. Conclusion: Supplementary nutrition reduces the opportunistic infections and also improves the immunity. However, the study needs to be done with more sample size. © 2015, Indian Association of Preventive and Social Medicine. All rights reserved.

Trivedi D.J.,SDMCMSH | Trivedi C.D.,DYPESMC | Bargale A.,SDMCMSH
International Journal of Pharma and Bio Sciences | Year: 2011

Measurable morphological changes in plasma and cell membrane glycoprotein are noted in various diseases. Lectin mediated agglutination of red blood cell can reveal such alteration. Present investigation was undertaken to assess the binding characteristics of P. tithymaloidus agglutinin on erythrocytes from thyroid disorders to find any alteration in membrane glycoproteins. In our study, hyperthyroidism has shown significantly increased hemagglutination titer (82.3± 52.9), where as decreased hemagglutination titer has been observed in hypothyroidism (34.1±23.1). Observed finding substantiate that thyroid induced metabolic stress bring change in membrane glycoproteins which is reflected in the form of altered lectin binding activity on erythrocyte.

Bargale A.,SDMCMSH | Ganu J.V.,General Motors | Trivedi D.J.,SDMCMSH | Nagane N.,BVDUMC | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2011

The aim of the present study is to correlate hs-CRP and uric acid levels in preeclamptic women. This study was performed on three groups; mild preeclampsia (n=17), severe preeclampsia (n=13) and healthy pregnant women as controls (n=30). Hs- CRP and uric acid levels were measured in maternal serum by latex turbidimetric method and Uricase-PAP method respectively. In this study we found serum hs-CRP and Uric acid levels were higher in preeclamptic women (3.733±1.096, 8.007±1.077) as compared to normotensive pregnant women (1.216±0.552, 5.50±1.103). Similarly, serum hs-CRP and uric acid levels were significantly elevated in women with severe preeclampsia (4.769±0.807, 9.042±0.650) than mild preeclampsia cases. The positive and significant correlations were found in hs-CRP/Blood Pressure, Uric Acid /Blood Pressure and hs- CRP/Uric Acid. Our results shows that serum hs-CRP and Uric Acid levels have increased as disease progressed from mild to severe condition. Therefore, hs-CRP can be an additional marker to predict severity of disease.

Bargale A.B.,SDMCMSH | Ganu J.V.,General Motors | Trivedi D.J.,SDMCMSH | Kamble P.S.,SDMCMSH | Mudaraddi R.,SDMCMSH
International Journal of Pharma and Bio Sciences | Year: 2011

Preeclampsia (PE) is a multisystem disorder characterized by hypertension, proteinuria and edema. Endothelial cell (EC) injury plays an important role in the pathogenesis of PE. The antioxidant enzyme SOD is a scavenger of superoxide anion and prevents oxidative damage of EC. Dysfunction of EC is associated with dyslipidemia due to oxidation of LDL, which is lowered by the enzyme PON-1. The aim of present study is to determine superoxide dismutase and paraoxonase-1 activity in preeclamptic women. In this study we found that serum SOD and PON-1 activity was decreased in preeclamptic women (3.614±0.539, 45.815±4.725) as compared to normal pregnant women (5.796±1.242, 65.012±6.318). But, SOD and PON-1 activity in between mild and severe PE women's were not-significant. Our observed results show decrease in the antioxidant SOD and PON-1 activity point towards their role in the pathogenesis of PE.

Kamble P.,SDMCMSH | Bhagwat V.,General Motors | Trivedi D.J.,SDMCMSH | Bargale A.,SDMCMSH
International Journal of Pharma and Bio Sciences | Year: 2011

The present study was undertaken to study the free radical activity in malaria patients suffering from plasmodium falciparum (n=14) and plasmodium vivax (n=21) against the healthy control subjects (n=25). Lipid peroxidation was assessed by measuring serum lipid peroxide in both groups of malaria patients by using Malondialdehyde as standard. The serum Ceruloplasmin is also studied along with serum Lipid peroxidation. The level of serum Lipid peroxidation was significantly high (p<0.001) in patients with Plasmodium falciparum malaria as compared to Plasmodium vivax infected patients and healthy controls. Increase in serum Lipid peroxidation may be due to over activity of free radical, which corresponds with severity of tissue damage while increase in serum Ceruloplasmin could be due to acute phase response in malaria.

Type: Journal Article | Journal: Journal of cytology | Year: 2011

Somatostatinomas are rare pancreatic endocrine neoplasms (PEN). We present a case of a PEN in a 63-year-old lady having diabetes mellitus, cholelithiasis, steatorrhea, weight loss, indigestion, nausea and fatigue. Ultrasonography revealed a large calcified mass occupying the liver, pancreas and emboli in the splenic vein. Fine needle aspiration cytology (FNAC) of the metastatic mass in the liver showed features of neuroendocrine tumor. Correlating the clinical picture, computed tomography and cytological findings, a diagnosis of pancreatic somatostatinoma was suggested. Serum somatostatin levels and biopsy findings confirmed the same. The patient was put on chemotherapeutic agents and octreotide and is doing well after two years of follow-up. We discuss the FNAC findings of pancreatic endocrine tumors and its differentiating features from hepatoma and other small round cell tumors.

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