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Preetam P.,SDM Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Tornwaldt's cyst is a benign cyst located in the upper posterior nasopharynx. It is a relatively rare lesion and most are small and asymptomatic whereas some cause nasal obstruction, postnasal drip, occipital headache or Eustachian tube dysfunction. In our case a 28-year-old man presented with nasal obstruction since 10-years whose diagnostic nasal endoscopy showed a large well-encapsulated lesion arising from the posterior wall of the nasopharynx. A Magnetic resonance imaging (MRI) was performed which was suggestive of a fluid filled cystic lesion. The patient underwent successful marsupialisation using endonasal endoscopic approach using rigid endoscopes and powered instrumentation. Histopathology of the aspirate revealed a respiratory lined epithelial cyst. Based on the clinical, radiological and histopathological findings a diagnosis of Tornwaldt's cyst was made. We report this case to highlight the role of MRI in diagnosis and use of endoscopic assisted powered instrumentation for treatment of Tornwaldt's cyst.

Kulkarni R.D.,SDM Medical College and Hospital | Rao C.B.,Craniofacial Unit
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology | Year: 2010

Introduction: Orofacial space infections are common presentations in maxillofacial clinics even in the post-antibiotic era. One of the main factors determining the spread of infection is the host defense mechanism. Diabetes is one of the most common systemic illness suppressing the immunity of an individual and increasing their susceptibility to infections. This study was carried out to compare the spaces involved, the severity of infection, the virulent organism, the efficacy of empirical antibiotics, the length of hospital stay, and the complications encountered in the management of maxillofacial space infection of odontogenic origin in diabetic patients as compared with nondiabetic patients. Methodology: A 4-year prospective study was carried out on patients with maxillofacial space infection of odontogenic origin. The patients were divided into 2 groups on the basis of presence or absence of diabetes. Results: A total of 111 patients were identified out of which 31 were diabetic. The organisms commonly isolated were Streptococcus species with submandibular space being the most common space involved in both the groups. The empirical antibiotic used was amoxicillin plus clavulanic acid combined with metrogyl in 70.27% cases. Conclusion: Streptococcus species is still the most common causative pathogen irrespective of the diabetic status of the patient. The same empirical antibiotic therapy of amoxicillin plus clavulanic acid combined with metrogyl along with hyperglycemia control and surgical drainage of infection yielded satisfactory resolution of infection in the diabetic patients as well. © 2010 Mosby, Inc.

Amane H.S.,SDM Medical College and Hospital | Burte N.P.,MNR Medical College
Indian Journal of Pharmacology | Year: 2011

Objective: To compare the efficacy and safety profile of dalteparin, a low-molecular-weight heparin with a standard unfractionated heparin in patients with unstable angina pectoris. Materials and Methods: This was a 6-month, prospective, parallel, randomized and open-labeled study. Patients of angina pectoris were randomized to receive either unfractionated heparin or dalteparin for 5 days. They were followed for 21 days during three visits on 1 st, 5 th and 21 st days. A series of resting electrocardiogram were undertaken in all patients on each visit. Results: The frequency of the combined clinical outcome of death, myocardial infarction and recurrence of angina was similar during 21 days of follow-up with either dalteparin or intravenous unfractionated heparin. In patients who received dalteparin 2.43% patients developed minor bleeding in the form of epistaxis and 2.5% patients who received unfractionated heparin developed minor bleeding in the form of macroscopic hematuria. Conclusion: Dalteparin is as effective and safe as unfractionated heparin in the treatment of unstable angina. Dalteparin does not require routine laboratory monitoring as with unfractionated heparin.

Meravanige G.,SDM Medical College and Hospital | Kamdod M.A.,SDM Medical College and Hospital
International Journal of Pharma and Bio Sciences | Year: 2012

Objective: To investigate the effect of tinospora cordifolia (TC) on the healing of burn wounds in wistar rats and compare it with control and silver sulfadiazine treated groups. Materials and Methods: Partial thickness burn wounds were made on three groups of rats (n=6 in each group) at the nape of neck under ether anesthesia. The Burn wounds were treated topically with petroleum base, 1% silver sulfadiazine and 2% TC, respectively once daily till complete healing. The wound contraction rate and epithelialization time were observed. Data was analysed by one way ANOVA and Tukeys multiple post hoc procedures. Results: The mean epithelialization time was significantly (P<0.0004*) decreased in TC treated group compared to control and silver sulfadiazine groups. Percentage of wound contraction was significantly more on 4 th (P<0.0003*), 8th (P<0.0019*), 12th (P<0.0060*) and 16th day (P<0.0016*) in TC treated group in comparison to the control. Conclusion: Topical TC showed healing potential on burn wounds in wistar rats.

Girish M.,SDM Medical College and Hospital | Priyadarshini K.,SDM Medical College and Hospital
International Journal of Pharma and Bio Sciences | Year: 2012

Objective: To investigate the effect of tinospora cordifolia (TC) on resutured incision and dead space wounds in albino rats. Materials and Methods: Resutured incision and dead space wounds were inflicted in albino rats under light ether anesthesia with aseptic precautions. Treatment group received tinospora cordifolia and control animals received vehicle orally for a period of 10 days. On the 11th day, after estimating breaking strength of resutured incision wounds, animals were sacrificed and granulation tissue removed from dead space wounds to estimate breaking strength, hydroxyproline content, quantification of granulation tissue and histopathological assessment in both control and treated groups. Results: TC significantly (P<0.05) promoted the healing process in both the wound models studied. Conclusion: TC promote wound healing, perioperative use of TC could promote the healing of surgical wounds.

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