Honāvar, India
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Sahana K.,SDM College | Shetti N.M.,SDM College
Progress In Electromagnetics Research C | Year: 2017

A new technique is developed to couple the advantages of both the microstrip patch antenna and rectangular waveguide. An equilateral triangle is used as a radiating patch. This patch is fabricated on one face of a single-layer dielectric substrate with double-sided copper clad coated with tin, and on the other face an iris is fabricated and coupled to the waveguide. Antenna parameters such as return loss and bandwidth are studied for a circular patch. The results obtained are discussed in detail and explained. Matlab PDE toolbox is used to generate two-dimensional meshes. These meshes are converted into a three-dimensional form using subdomain numbers. RWG basis functions are used for MoM to calculate impedances. Reflection coefficient and 2D current are obtained using the complex impedances. © 2017, Electromagnetics Academy. All rights reserved.


Kumsi M.,Mangalore University | Poojary B.,Mangalore University | Lobo P.L.,Mangalore University | Chikkanna C.,SDM College
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences | Year: 2010

A series of substituted [1,3]thiazolo[3,2-b][1,2,4]triazole derivatives 4 were synthesized in good yield by condensing 2-substituted-1,2,4-triazole-5- thiols 3 with various N-aryl-maleimides in acetic acid media. All structures of the newly synthesized compounds were elucidated by elemental analyses and spectral data. © 2010 Verlag der Zeitschrift für Naturforschung, Tübingen.


Kumaraswamy M.N.,Sir Mv Government Science College | Vaidya V.P.,Kuvempu University | Chandrasekhar C.,Sdm College | Prathima Mathias D.A.,IDSG Government College | Mahadevan K.M.,Kuvempu University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

The reaction of naphtho[2,1-b]furan-2-carbohydrazide 2, which in turn was synthesized from ethyl naphtho[2,1-b]furan-2carboxylate 1, with various aromatic aldehydes in refluxing dioxane afforded N-[(aryl)methylene]naphtho[2,1-b] furan-2-carbohydrazides 3a-f. These hydrazones 3a-f on treatment with chloroacetyl chloride in presence of triethylamine produced, title compounds, azetidinone derivatives 4a-f. The structures of the newly synthesized compounds have been established by analytical and spectral studies and investigated for antibacterial, antifungal, anti-inflammatory, diuretic, anthelmintic and antipyretic activities.


Puthiyapurayil P.,Mangalore University | Puthiyapurayil P.,Biocon | Poojary B.,Mangalore University | Chikkanna C.,SDM College
European Journal of Medicinal Chemistry | Year: 2012

On account of the reported anticancer activity of pyrazoles and oxadiazoles, we have designed and synthesized a novel combinatorial library of S-substituted-1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety and tested for in-vitro cytotoxic activity by MTT assay. Amongst the tested compounds, the compound 5e was the most promising anticancer agent with IC50 value of 15.54 μM in MCF-7 cells, compared to Doxorubicin as standard drug. The newly synthesized compounds were characterized by NOE, IR, 1H NMR, 13C NMR and LC-MS analysis. © 2012 Elsevier Masson SAS. All rights reserved.


Vashisht R.,CSIR - Central Electrochemical Research Institute | Vashisht R.,Indian Institute of Science | Mondal A.K.,CSIR - Central Electrochemical Research Institute | Jain A.,CSIR - Central Electrochemical Research Institute | And 50 more authors.
PLoS ONE | Year: 2012

A decade since the availability of Mycobacterium tuberculosis (Mtb) genome sequence, no promising drug has seen the light of the day. This not only indicates the challenges in discovering new drugs but also suggests a gap in our current understanding of Mtb biology. We attempt to bridge this gap by carrying out extensive re-annotation and constructing a systems level protein interaction map of Mtb with an objective of finding novel drug target candidates. Towards this, we synergized crowd sourcing and social networking methods through an initiative 'Connect to Decode' (C2D) to generate the first and largest manually curated interactome of Mtb termed 'interactome pathway' (IPW), encompassing a total of 1434 proteins connected through 2575 functional relationships. Interactions leading to gene regulation, signal transduction, metabolism, structural complex formation have been catalogued. In the process, we have functionally annotated 87% of the Mtb genome in context of gene products. We further combine IPW with STRING based network to report central proteins, which may be assessed as potential drug targets for development of drugs with least possible side effects. The fact that five of the 17 predicted drug targets are already experimentally validated either genetically or biochemically lends credence to our unique approach. © 2012 Vashisht et al.


Ganapayya B.,SDM College | Jayarama A.,Mangalore Institute of Technology and Engineering | Sankolli R.,Indian Institute of Science | Hathwar V.R.,Indian Institute of Science | Dharmaprakash S.M.,Mangalore University
Journal of Molecular Structure | Year: 2012

3-(2,3-Dimethoxyphenyl)-1-(pyridin-2-yl)prop-2-en-1-one (DMPP) a potential second harmonic generating (SHG) has been synthesized and grown as a single crystal by the slow evaporation technique at ambient temperature. The structure determination of the grown crystal was done by single crystal X-ray diffraction study. DMPP crystallizes with orthorhombic system with cell parameters a = 20.3106(8) , b = 4.9574(2) , c = 13.4863(5) , α = 90°, β = 90°, γ = 90° and space group Pca2 1. The crystals were characterized by FT-IR, thermal analysis, UV-vis-NIR spectroscopy and SHG measurements. Various functional groups present in DMPP were ascertained by FTIR analysis. DMPP is thermally stable up to 80 °C and optically transparent in the visible region. The crystal exhibits SHG efficiency comparable to that of KDP. © 2011 Elsevier B.V. All rights reserved.


Shanbhag A.V.,Sdm College | Venkatesha T.V.,Kuvempu University | Prabhu R.A.,Mgc College | Praveen B.M.,Kuvempu University
Bulletin of Materials Science | Year: 2011

The corrosion inhibition characteristics of acetyl coumarine (AC), bromo acetyl coumarine (BAC) and thiazole derivatives (BTMQ and BTCQ) on the corrosion of zinc in 0.1 M HCl solution were investigated by weight loss, potentiodynamic polarization and impedance techniques. The inhibition efficiency increased with increase in inhibitor concentration upto 5×10-4 M, then gave almost same inhibition efficiency. The polarizationmeasurements indicated the mixed nature of inhibitors. The adsorption of compounds obeyed Langmuir's adsorption isotherm. The thermodynamic functions for adsorption processes were evaluated. © Indian Academy of Sciences.


Soumyasri S.M.,Sdm College | Ballal R.,Sdm Institute Of Technology
IET Conference Publications | Year: 2013

This review paper concentrates on preserving privacy in wireless sensor networks. In this system, two location anonymization algorithms has been proposed, namely, resource and quality aware algorithms, that aim to enable the system to providehigh quality location monitoring services for system users, while preserving personal location privacy. Both algorithms rely on the well established k-anonymity privacy concept, that is, a person is indistinguishable among k persons, to enable trusted sensor nodes to provide the aggregate location information of monitored persons for our system. Privacy is typically addressed through privacy policies, which informthe user about a service provider's data handling practices and serve as the basis for the user's decision to releasedata. This paper studies privacy through a distributed anonymity algorithm that is applied in a sensor network, before service providers gain access to the data.


Sharath R.,Kuvempu University | Sharath R.,M.S. Ramaiah Institute of Technology | Sharath R.,University of Agricultural Sciences, Bangalore | Harish B.G.,Kuvempu University | And 4 more authors.
Phytotherapy Research | Year: 2010

Bacopa monnieri (L.) Wettest. (Scrophulariaceae) is a well-known medicinal herb. In the Indian system of medicine it is known as Brahmi (Sanskrit) and Indian water hyssop. Methanolic extract of Bacopa monnieri and its isolated constituent Bacoside-A were screened for wound healing activity. Bacoside-A was screened for wound healing activity by excision, incision and dead space wound on Swiss albino rats. Significant wound healing activity was observed in both extract and the Bacoside-A treated groups. The SDS-PAGE caseinolytic zymogram analysis of inhibition of matrix metalloproteases (MMPs) enzyme from the excision wound by Bacoside-A, an isolated constituent, was done with the concentrations 100 and 200 μmg/ml. In Bacoside-A treated groups, epithelialization of the excision wound was faster with a high rate (18.30 ± 0.01 days) of wound contraction. The tensile strength of the incision wound was increased (538.47 ± 0.14 g) in the Bacoside-A treated group. In the dead space wound model, the weight of the granuloma was also increased (89.15 ± 0.08 g). The histological examination of the granuloma tissue of the Bacoside-A treated group showed increased cross-linking of collagen fibers and absence of monocytes. The wound healing activity of Bacoside-A was more effective in various wound models compared to the standard skin ointment Nitrofurazone. Copyright © 2010 John Wiley & Sons, Ltd.


PubMed | Center for Research in Ayurveda and Allied science and SDM College
Type: Journal Article | Journal: Ayu | Year: 2016

Measuring chemical stability of polyherbal formulations is very challenging due to diversity in phytochemical composition. As there are no comprehensive guidelines for stability testing of herbal products, there is a need for a sensitive tool to detect how the quality of herbal products varies with time under the influence of environmental conditions.To validate the employability of high-performance thin layer chromatography (HPTLC) for real-time stability of Hutabhugadi Churna (HC).The chromatograms were developed using toluene/ethyl acetate/formic acid (10:5:1) and ethyl acetate/formic acid (10:1) as a mobile phase for chloroform and ethanolic extract, respectively. The plates were scanned under 254, 366, 540 (pre-derivatization) and 540 nm (post-derivatization). Samples were analyzed immediately after preparation and after 3(rd) and 6(th) months of storage. Alteration of fingerprint profiles from the initial pattern, in terms of number of peaks, was employed as diagnostic tools. Percentage variation in composition at given period was calculated.HC is found to be stable at room temperature up to 1.3 months using the method of calculation of 10% degradation period employing slope and intercept values for the initial, 3(rd) and 6(th) months deviation in number of bands. The data obtained were subjected to regression analysis in context to number of bands obtained. The curve was found to be linear with R(2) value of 0.89-0.96 supported by their tolerance range of 0.04-0.11.The proposed model is a new logic with prospects to become working method for stability assessment of polyherbal formulations under controlled conditions.

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