Cambridge, MA, United States
Cambridge, MA, United States

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Patent
Sdg Inc. | Date: 2014-10-10

The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.


Methods and apparatuses for directly charging capacitors in a down-hole pulsed power system used for electrocrushing drilling. An above ground power supply is directly connected to the capacitors. The power supply can be a switching power supply, a DC supply, or an AC supply. Capacitor voltage is monitored and controlled. The system reduces noise caused by coupling control signal cables and the power cable, and does not have the ground swing control problems of other charging schemes. The power may alternatively be provided by microwave transmission.


Patent
SDG Inc. | Date: 2013-03-05

The present invention is embodied by a composition capable of chaperoning a typically non-orally available therapeutic or diagnostic agent through the environment of the digestive tract such that the therapetuic or diagnostic agent is bioavailable. The composition may or may not be targeted to specific cellular receptors, such as hepatocytes. Therapeutic agents include, but are not limited to, insulin, calcitonin, serotonin, and other proteins. Targeting is accomplished with biotin or metal based targeting agents.


Method and apparatus for isolating and switching lower voltage pulses from high voltage pulses in electrocrushing and electrohydraulic drills. A transformer with a high permeability core acts as a magnetic switch or saturating inductor to switch high voltage pulses to initiate an electrocrushing arc and lower voltage pulses to sustain the arc. The transformer isolates the lower voltage components from the high voltage pulses, and switches to deliver the low voltage current when the core saturates. The transformer enables impedance matching to the arc during all stages of drilling. The saturation time of the transformer core is the time delay between initiation of delivering the high voltage pulse and initiation of delivering the lower voltage current.


Patent
Sdg Inc. | Date: 2015-01-08

The present invention is embodied by a composition capable of chaperoning a typically non-orally available therapeutic or diagnostic agent through the environment of the digestive tract such that the therapeutic or diagnostic agent is bioavailable. The composition may or may not be targeted to specific cellular receptors, such as hepatocytes. Therapeutic agents include, but are not limited to, insulin, calcitonin, serotonin, and other proteins. Targeting is accomplished with biotin or metal based targeting agents.


Patent
Sdg Inc. | Date: 2013-06-12

The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.


Patent
Sdg Llc | Date: 2014-07-29

A method and apparatus for breaking mineral particles comprising suspending the particles in a liquid flowing in a conduction path, the liquid comprising a dielectric constant higher than the particles and wherein an electric voltage pulse is sent to electrodes to pass an electric field in the mineral particles with sufficient stress to fracture the mineral particles.


Patent
Sdg Inc. | Date: 2014-05-02

The present invention is embodied by a composition capable inducing weight loss in a patient in need thereof.


Electrocrushing drills and methods for operating electrocrushing drills. Electrocrushing drill bits comprise one or more high voltage electrodes surrounded by a ground or current return structure, which can be a ring or a comprise rod shaped electrodes. Openings in the rim of the current return structure facilitate removal of drilling debris and bubbles created by the electrocrushing process out from the bottom face of the bit and up the wellbore. The high voltage electrodes can be arranged in a circle. The current return structure may partially cover the bottom face of the drill bit, thereby enclosing the high voltage electrodes in openings that may be sector shaped. Also a method and apparatus for interrupting communications between downhole data acquisition systems and a surface controller system during each drill pulse, thereby reducing noise. A direct connection between the two systems enables high speed communications, thereby improving safety by providing the operator with more advance warning of a possible blowout. Also a method and apparatus for dividing a flow of drilling fluid both to sweep drilling debris and bubbles out of the drill bit and hole and to cool high power electrical components.


An apparatus and method for controlling power delivered to a pulsed power system which includes a command charge switch for controlling when power produced by a primary power system is fed into a cable. The command charge switch also controls the power delivered to the pulsed power system in a bottom hole assembly.

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