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Rajesh S.R.,Sd College | Singh N.K.,Inter-University Center for Astronomy and Astrophysics | Singh N.K.,KTH Royal Institute of Technology
New Astronomy | Year: 2014

We propose a mechanism to produce fluctuations in the viscosity parameter (α) in differentially rotating discs. We carried out a nonlinear analysis of a general accretion flow, where any perturbation on the background α was treated as a passive/slave variable in the sense of dynamical system theory. We demonstrate a complete physical picture of growth, saturation and final degradation of the perturbation as a result of the nonlinear nature of coupled system of equations. The strong dependence of this fluctuation on the radial location in the accretion disc and the base angular momentum distribution is demonstrated. The growth of fluctuations is shown to have a time scale comparable to the radial drift time and hence the physical significance is discussed. The fluctuation is found to be a power law in time in the growing phase and we briefly discuss its statistical significance. © 2014 Elsevier B.V. All rights reserved.


Kumar S.N.,Central Tuber Crops Research Institute | Sreekala S.R.,Central Tuber Crops Research Institute | Chandrasekaran D.,SD College | Nambisan B.,Central Tuber Crops Research Institute | Anto R.J.,Integrated Cancer Research Program
PLoS ONE | Year: 2014

The rhabditid entomopathogenic nematode associated Bacillus cereus and the antifungal compounds produced by this bacterium were evaluated for their activity in reducing postharvest decay of peanut kernels caused by Aspergillus species in in vitro and in vivo tests. The results showed that B. cereus had a significant effect on biocontrol effectiveness in in vitro and in vivo conditions. The antifungal compounds produced by the B. cereus were purified using silica gel column chromatography and their structure was elucidated using extensive spectral analyses. The compounds were identified as diketopiperazines (DKPs) [cyclo-(L-Pro-Gly), cyclo(L-Tyr-L-Tyr), cyclo-(L-Phe-Gly) and cyclo(4-hydroxy-L-Pro-L-Trp)]. The antifungal activities of diketopiperazines were studied against five Aspergillus species and best MIC of 2 μg/ml was recorded against A. flavus by cyclo(4-hydroxy-L-Pro-L-Trp). To investigate the potential application of cyclo(4-hydroxy-L-Pro-L-Trp) to eliminate fungal spoilage in food and feed, peanut kernels was used as a food model system. White mycelia and dark/pale green spores of Aspergillus species were observed in the control peanut kernels after 2 days incubation. However the fungal growth was not observed in peanut kernels treated with cyclo(4-hydroxy-L-Pro-L-Trp). The cyclo(4-hydroxy-L-Pro-L-Trp) was nontoxic to two normal cell lines [fore skin (FS) normal fibroblast and African green monkey kidney (VERO)] up to 200 μg/ml in MTT assay. Thus the cyclo(4-hydroxy-L-Pro-L-Trp) identified in this study may be a promising alternative to chemical preservatives as a potential biopreservative agent which prevent fungal growth in food and feed. To the best of our knowledge, this is the first report demonstrating that the entomopathogenic nematode associated B. cereus and cyclo(4-hydroxy-L-Pro-L-Trp) could be used as a biocontrol agents against postharvest fungal disease caused by Aspergillus species. © 2014 Kumar et al.


Kundu V.,Kurukshetra University | Dhiman R.L.,Sd College | Maan A.S.,Maharshi Dayanand University | Goyal D.R.,Maharshi Dayanand University
AIP Conference Proceedings | Year: 2011

The optical properties of glasses with composition x Li2O (30-x) Bi2O3-70B2O3; x=0, 5, 10, 15 & 20 mol %, prepared by normal melt quench technique were investigated by means of UV-VIS measurement. It was observed that the optical band gap of the present glass system decreases with increasing Li2O content up to 15 mol%, and with further increase in lithium oxide content i.e. x>15mol% the optical band gap increases. It was also observed that the present glass system behaves as an indirect band gap semiconductor. © 2011 American Institute of Physics.


Gupta V.,Maharishi Markandeshwar University | Verma M.,Maharishi Markandeshwar University | Gulati N.,Sd College
Journal of Uncertain Systems | Year: 2016

We prove the existence and uniqueness of common fixed point for a sequence of mapping, considering each pair of mapping satisfies the contractive condition on fuzzy metric space. We also prove same for generalized fuzzy metric spaces. We give the lemma to prove the main result in generalized fuzzy metric space. In this paper we extend the theorem of Gajic [5] in fuzzy metric space as well as in generalized fuzzy metric space for sequence of mappings. We give example to explain our main result. © 2016 World Academic Press, UK. All rights reserved.


Nishanth S.K.,Central Tuber Crops Research Institute | Nambisan B.,Central Tuber Crops Research Institute | Dileep C.,SD College
Peptides | Year: 2014

In continuation of our search for new bioactive secondary metabolites from Bacillus cereus associated with entomopathogenic nematode (EPN), three cyclic dipeptides (CDPs), cyclo(l-Leu-d-Arg) (1), cyclo(2-hydroxy-Pro-l-Leu) (2), and cyclo(l-Val-l-Pro) (3) were purified from the ethyl acetate extract of B. cereus. The chemical structure of the compounds was identified by 1D, 2D NMR and HR-ESI-MS. Cyclo(l-Leu-d-Arg) recorded best antifungal activity and the highest activity was recorded against Cryptococcus neoformans (1 μg/mL), which is better than the standard antifungal agent amphotericin B. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used for finding cell proliferation inhibition and cyclo(l-Leu-d-Arg) recorded significant activity against breast cancer cell line (MDAM-B231) (IC50 value: 25 μM) and the three cyclic dipeptides recorded no toxicity against normal human cell (fore skin (FS) normal fibroblast) up to 50 μM except cyclo(l-Val-l-Pro). Cyclo(l-Leu-d-Arg) induced significant morphological changes and DNA fragmentation associated with apoptosis in MDAM-B231 cells by acridine orange/ethidium bromide staining and flow cytometry analysis. Out of three cyclic dipeptides tested only cyclo(2-hydroxy-Pro-l-Leu) recorded significant antioxidant activity. The hydroxyl radical scavenging activity of cyclo(2-hydroxy-Pro-l-Leu) is greater than BHA, the standard antioxidant agent. Cyclo(l-Leu-d-Arg) was isolated for the first time from a natural source with a d-arginine residue. To the best of our knowledge, this is the first time that the bioactivity of the isolated cyclic dipeptides is reported against medically important fungi and cancer cells. This study is a significant contribution to the knowledge of cyclo(l-Leu-d-Arg) from B. cereus as potential sources of new drugs in the pharmacological industry, especially as potent antifungal and anticancer agent. © 2013 Elsevier Inc.


Gupta V.,Maharishi Markandeshwar University | Kanwar A.,Maharishi Markandeshwar University | Gulati N.,Sd College
Smart Innovation, Systems and Technologies | Year: 2016

The present study is devoted to use the notion of joint common limit (shortly, JCLR property) for coupled maps and utilize this concept to prove common coupled fixed point theorem on fuzzy metric space. In this paper, we also prove some fixed point theorems using the concept CLR property, E.A property and integral type contractive condition in fuzzy metric space. Illustrative examples supporting main results have been given. © Springer India 2016.


Arora S.,Kurukshetra University | Kumara S.,Sd College
Optoelectronics and Advanced Materials, Rapid Communications | Year: 2010

Polyimides with high glass transition temperatures were prepared by reaction of various diaminopyrazole derivatives with 4, 4'-(hexafluoroisopropylidene)diphthalic anhydride and characterized by spectral and thermal techniques. Glass transition temperatures of resulting polyimides in the range of 193-216 °C were obtained. Vacuum-deposited thin films of polyimides were corona poled under different poling conditions and analyzed for poling stability of aligned dipolar chromophore. At room temperature, polar order remained stable for all the polymers with only 1-2 % decay even after 30 days of poling under the conditions (5 kV, 185 °C, 30 min.). It was further observed that after 200 h, poled order stabilized in the range 81- 92 % and 69-85 % of initial value when polymeric thin films were heated at 80 °C and 90 °C respectively.


Nishanth Kumar S.,Central Tuber Crops Research Institute | Dileep C.,SD College | Mohandas C.,Central Tuber Crops Research Institute | Nambisan B.,Central Tuber Crops Research Institute | Ca J.,Central Tuber Crops Research Institute
Journal of Peptide Science | Year: 2014

A new microbial cyclic dipeptide (diketopiperazine), cyclo(d-Tyr-d-Phe) was isolated for the first time from the ethyl acetate extract of fermented modified nutrient broth of Bacillus sp. N strain associated with rhabditid Entomopathogenic nematode. Antibacterial activity of the compound was determined by minimum inhibitory concentration and agar disc diffusion method against medically important bacteria and the compound recorded significant antibacterial against test bacteria. Highest activity was recorded against Staphylococcus epidermis (1 μg/ml) followed by Proteus mirabilis (2 μg/ml). The activity of cyclo(d-Tyr-d-Phe) against S. epidermis is better than chloramphenicol, the standard antibiotics. Cyclo(d-Tyr-d-Phe) recorded significant antitumor activity against A549 cells (IC50 value: 10 μM) and this compound recorded no cytotoxicity against factor signaling normal fibroblast cells up to 100 μM. Cyclo(d-Tyr-d-Phe) induced significant morphological changes and DNA fragmentation associated with apoptosis in A549 cells. Acridine orange/ethidium bromide stained cells indicated apoptosis induction by cyclo(d-Tyr-d-Phe). Flow cytometry analysis showed that the cyclo(d-Tyr-d-Phe) did not induce cell cycle arrest. Effector molecule of apoptosis such as caspase-3 was found activated in treated cells, suggesting apoptosis as the main mode of cell death. Antioxidant activity was evaluated by free radical scavenging and reducing power activity, and the compound recorded significant antioxidant activity. The free radical scavenging activity of cyclo(d-Tyr-d-Phe) is almost equal to that of butylated hydroxyanisole, the standard antioxidant agent. We also compared the biological activity of natural cyclo(d-Tyr-d-Phe) with synthetic cyclo(d-Tyr-d-Phe) and cyclo(l-Tyr-l-Phe). Natural and synthetic cyclo(d-Tyr-d-Phe) recorded similar pattern of activity. Although synthetic cyclo(l-Tyr-l-Phe) recorded lower activity. But in the case of reducing power activity, synthetic cyclo(l-Tyr-l-Phe) recorded significant activity than natural and synthetic cyclo(d-Tyr-d-Phe). The results of the present study reveals that cyclo(d-Tyr-d-Phe) is more bioactive than cyclo(l-Tyr-l-Phe). To the best of our knowledge, this is the first time that cyclo(d-Tyr-d-Phe) has been isolated from microbial natural source and also the antibacterial, anticancer, and antioxidant activity of cyclo(d-Tyr-d-Phe) is also reported for the first time. Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd.


Kumar R.,Sd College | Chand F.,Kurukshetra University
Pramana - Journal of Physics | Year: 2014

Approximate solutions to the N-dimensional radial Schrödinger equation for the potential ar2 + br - c/r are obtained by employing the formulation described in Ciftci et al, J. Phys. A 43, 415206 (2010). The problem, for some special cases, is solved numerically. Using this analysis, the energy spectra of a two-dimensional two-electron quantum dot (QD) in a magnetic field are also obtained. The results of this study are in good agreement with the other studies. © Indian Academy of Sciences.


Jain D.,Sd College | Rana S.,Sd College
Indian Journal of Animal Research | Year: 2013

The Indian Peafowl is becoming locally extinct from several parts of its former range due to habitat conversion, changing cropping pattern, poaching and pesticide use. Due to limited detailed study on population indices of Indian Peafowl, there is no exact estimate of population density of surviving population of Indian Peafowl in the country. The aim of the present study was to know the population indices of Indian Peafowl in Ambala, Kurukshetra and Yamuna Nagar districts of Haryana using call count and line transect method. The survey was also conducted to know the various habitat variables which influence the density index of Indian Peafowl. The findings are expected to provide baseline information for developing and adopting management as well as conservation strategies for Indian Peafowl in Haryana state.

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