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La Jolla, California, United States

Colwell Jr. C.W.,Scripps Health
Instructional course lectures | Year: 2011

Venous thromboembolic events, including deep venous thromboses and pulmonary embolisms, have a high risk of occurrence in patients treated with lower extremity arthroplasty and hip fracture surgery. Although the prevalence of these complications has been lowered with the use of venous thromboembolic prophylaxis, the current rate is still troublesome because of the possibility of death or the need for lifetime treatment of postthrombotic syndrome and/or pulmonary hypertension. Prophylactic methods currently include mechanical devices and pharmacologic agents. Mechanical devices are difficult to compare because they are not standardized, the devices are often used in multimodal prophylactic regimens, and the devices cannot be used when the patient is ambulating or at home. A new portable compression device allows use during ambulation and can be used by the patient at home. A recent study of this portable device in patients treated with total hip arthroplasty showed an efficacy similar to that of low-molecular-weight heparin, with fewer major bleeding complications. Pharmacologic prophylaxis includes low-molecular-weight heparin, synthetic pentasaccharide, warfarin, and aspirin. All of these agents have different degrees of efficacy and safety. New oral agents for thromboprophylaxis are on the horizon but are not yet approved by the Food and Drug Administration.

Davidson J.E.,Scripps Health
Annals of the American Thoracic Society | Year: 2013

Family presence on bedside teaching rounds is advocated by professional organizations and endorsed in family-centered models of care delivery. Nevertheless, many physicians and staff members fear that family presence may prolong rounds and increase family anxiety or stress. Although understudied, these concerns have not been validated by the research conducted to date. Currently available evidence suggests that family members are less concerned with the stress imposed by rounds than with their need for information. When given the choice, between 85 and 100% of family members would prefer to be present on rounds. Research data suggest that either there is no significant change in teaching time or teaching time may decrease. The quality of teaching may actually improve when family members are present on teaching rounds. The available evidence informs us that families should be given the choice to participate in rounds, anticipating that the majority will accept the invitation. More research is necessary to raise the level of evidence in this line of inquiry. Copyright © 2013 by the American Thoracic Society.

Sundaram H.,11119 Rockville Pike | Kiripolsky M.,Scripps Health
Clinics in Plastic Surgery | Year: 2013

The physician and surgeon will find here a detailed and comprehensive discussion of nonsurgical rejuvenation tools and techniques, along with thoughtful insights into evaluating and treating the aging upper face, such as the concept of visualizing a "periorbital frame" that is bordered by the eyebrows, glabella, temporal fossa, and superior mid face. Further, the authors emphasize combined treatments and how they work together for optimal rejuvenative outcomes. Presented are clinical approaches to pretreatment evaluation, use of neuromodulators, fillers, radiofrequency, and ultrasound. Complication avoidance and correction are discussed for these treatments. © 2013 Elsevier Inc.

Scripps Health, Janssen Diagnostics Inc. and Ortho Clinical Diagnostics Inc. | Date: 2015-05-15

Compositions, systems and methods for the diagnosing the risk of acute myocardial infarction are provided. The methods described herein relate to the use of biomarkers, such as gene expression profiles, and analytical tools for providing information to a health care provider or the patient, that is relevant to the cardiovascular health of the patient.

Scripps Health | Date: 2013-09-27

Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.

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