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Patent
Scripps Health | Date: 2017-01-18

Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.


Davidson J.E.,Scripps Health
Annals of the American Thoracic Society | Year: 2013

Family presence on bedside teaching rounds is advocated by professional organizations and endorsed in family-centered models of care delivery. Nevertheless, many physicians and staff members fear that family presence may prolong rounds and increase family anxiety or stress. Although understudied, these concerns have not been validated by the research conducted to date. Currently available evidence suggests that family members are less concerned with the stress imposed by rounds than with their need for information. When given the choice, between 85 and 100% of family members would prefer to be present on rounds. Research data suggest that either there is no significant change in teaching time or teaching time may decrease. The quality of teaching may actually improve when family members are present on teaching rounds. The available evidence informs us that families should be given the choice to participate in rounds, anticipating that the majority will accept the invitation. More research is necessary to raise the level of evidence in this line of inquiry. Copyright © 2013 by the American Thoracic Society.


Patent
Scripps Health | Date: 2014-01-14

Methods of printing a bio-ink on a substrate are provided comprising at least one bio ink layer, said method comprising: i) positioning a printhead comprising a two-dimensional array of print nozzles within proximity of or in contact with a substrate; and ii) ejecting a bio-ink through the print nozzles onto the substrate, forming a bio ink layer, wherein the bio-ink construct comprises at least one bio-ink layer. The methods further encompass methods of printing a live tissue and methods of treating tissue defects.


Patent
Scripps Health | Date: 2013-09-27

Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.


Patent
Scripps Health | Date: 2013-10-29

Disclosed herein are methods of producing induced pluripotent stem cells from chondrocytes, and further, methods of producing chondrocytes from said induced pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.


Patent
Scripps Health | Date: 2013-10-29

Provided are tri-component matrices having collagen, hyaluronan, and chondroitin sulfate. Also provided are processes for producing a tri-component matrix. Additionally, provided are processes for providing cells capable of producing cartilage to a bone or cartilage defects.


Patent
Scripps Health | Date: 2015-03-13

Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.


Patent
Scripps Health | Date: 2016-02-29

A joint replacement balancing system which provides real-time feedback to a surgeon during a joint replacement surgery to assist the surgeon to balance a joint replacement. The joint replacement balancing system includes a non-transitory processor-readable medium storing code representing instructions to cause a processor to receive a signal from a joint balancing apparatus, determine if the joint replacement is out of balance, determine a corrective course of action to bring the joint into balance and generate and display to the surgeon during the joint replacement surgery a recommended corrective course of action to complete the joint replacement surgery.


Patent
Scripps Health | Date: 2016-02-29

There is disclosed a method of balancing a joint during a surgical procedure, to both maximize the range of motion of the joint and to reduce the likelihood of follow-up procedures. The method includes outputting a signal including a first data set associated with at least one of a force, a position, a displacement or a rotation associated with an apparatus disposed between a first bony structure and a second bony structure, the apparatus including a first portion configured to be coupled to the first bony structure, a second portion configured to be disposed between the first portion and the second bony structure, and a transducer and an actuator disposed between the first portion and the second portion. The method additionally includes outputting a signal including a second data set, the second data set associated with at least one of a force, a position, a displacement or a rotation associated with the apparatus after the performance of at least a part of a surgical procedure, the surgical procedure based at least in part on a recommendation based on the first data set.


Patent
Scripps Health, Janssen Diagnostics Inc. and Ortho Clinical Diagnostics Inc. | Date: 2015-05-15

Compositions, systems and methods for the diagnosing the risk of acute myocardial infarction are provided. The methods described herein relate to the use of biomarkers, such as gene expression profiles, and analytical tools for providing information to a health care provider or the patient, that is relevant to the cardiovascular health of the patient.

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