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BOLOGNA, Italy

Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-10-2014 | Award Amount: 6.03M | Year: 2015

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers. The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to todays available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.


Trademark
Scriba Nanotecnologie S.R.L. | Date: 2008-05-30

Automatic industrial machines for the manufacturing of labels; automatic industrial labeling machines for applying labels to containers and bottles; automatic stamping machines; packing and packaging machines; wrapping machines; machine tools, namely, rotary dies for cutting boxes for the packaging industry; machines and machine tools for the cutting and forming of materials; printing presses. Electronic tags for goods; bar code readers; electronic apparatus for reading electronic tags; bar code scanners; radio frequency identification (RFID) tags; radio frequency identification tag readers; encoded micro tags of plastic, metal or silicate for use in the field of passive labeling, tracing or tracking of persons, animals, vehicles or goods of any kind; optical data carriers and recording discs containing computer software for the identification, marking and tracking of products; optical data carriers and recording discs containing computer software for creating searchable databases of information and data; optical data carriers and recording discs containing computer software for handling the data necessary for tracking the identification and source-related information of products provided by farmers, manufacturers, distributors, pack houses, exporters, importers, logistic suppliers, warehouses, and retailers through all stages of the supply chain; optical data carriers and recording discs containing computer software for controlling self-service terminals; data processors; computer chips; computers; computer terminals; printers; cash registers; optical data carriers and recording discs containing computer programs used for electronic cash register systems; optical data carriers and recording discs containing computer software for electronic cash register systems, for monitoring, recording and verifying cash counting and sorting; access control and alarm monitoring systems. Shipping labels, not of textile; franking machines, being stamping machines; adhesive labels; bar code labels; blank or partially printed paper labels; label paper; label printing machine ribbons; label printing machines; paper labels; paper identification tags; paper tags; price tags; bar code ribbons; packing cardboard and paper; plastic bags for packing; absorbent pads of paper and cellulose for use in food packaging. Quality control for others; computer programming; conversion of data or documents from physical to electronic media; data conversion of computer programs and data, excluding physical conversion; installation of computer software; recovery of computer data; technical and technological consultancy in the technology field of security systems and anti-counterfeiting solutions; technical and technological consultancy in the technology field of electronic identification, marking and tracking of products; consultancy in software development for the marking, identifying and tracking of products and for the encoding of goods information; technology supervision and inspection in the field of product quality control; technical project research in the field of product tracking technology for the food, feed, pharmaceutical and chemical industries; technical consultancy services in the field of databases and computer equipment; developing computer programs for electronic cash register systems; computer software design, maintenance of computer software; design of computer hardware, integrated circuits, communications hardware and software and computer networks for others; consumer product safety testing and consultation.


Trademark
Scriba Nanotecnologie S.R.L. | Date: 2008-05-30

Automatic industrial machines for the manufacturing of labels; automatic industrial labeling machines for applying labels to containers and bottles; automatic stamping machines; packing and packaging machines; wrapping machines; machine tools, namely, rotary dies for cutting boxes for the packaging industry; machines and machine tools for the cutting and forming of materials; printing presses. Electronic tags for goods; bar code readers; electronic apparatus for reading electronic tags; bar code scanners; radio frequency identification (RFID) tags; radio frequency identification tag readers; encoded micro tags of plastic, metal or silicate for use in the field of passive labeling, tracing or tracking of persons, animals, vehicles or goods of any kind; optical data carriers and recording discs containing computer software for the identification, marking and tracking of products; optical data carriers and recording discs containing computer software for creating searchable databases of information and data; optical data carriers and recording discs containing computer software for handling the data necessary for tracking the identification and source-related information of products provided by farmers, manufacturers, distributors, pack houses, exporters, importers, logistic suppliers, warehouses, and retailers through all stages of the supply chain; optical data carriers and recording discs containing computer software for controlling self-service terminals; data processors; computer chips; computers; computer terminals; printers; cash registers; optical data carriers and recording discs containing computer programs used for electronic cash register systems; optical data carriers and recording discs containing computer software for electronic cash register systems, for monitoring, recording and verifying cash counting and sorting; access control and alarm monitoring systems. Shipping labels, not of textile; franking machines, being stamping machines; adhesive labels; bar code labels; blank or partially printed paper labels; label paper; label printing machine ribbons; label printing machines; paper labels; paper identification tags; paper tags; price tags; bar code ribbons; packing cardboard and paper; plastic bags for packing; absorbent pads of paper and cellulose for use in food packaging. Quality control for others; computer programming; conversion of data or documents from physical to electronic media; data conversion of computer programs and data, excluding physical conversion; installation of computer software; recovery of computer data; technical and technological consultancy in the technology field of security systems and anti-counterfeiting solutions; technical and technological consultancy in the technology field of electronic identification, marking and tracking of products; consultancy in software development for the marking, identifying and tracking of products and for the encoding of goods information; technology supervision and inspection in the field of product quality control; technical project research in the field of product tracking technology for the food, feed, pharmaceutical and chemical industries; technical consultancy services in the field of databases and computer equipment; developing computer programs for electronic cash register systems; computer software design, maintenance of computer software; design of computer hardware, integrated circuits, communications hardware and software and computer networks for others; consumer product safety testing and consultation.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP.2011.1.4-4 | Award Amount: 5.09M | Year: 2012

The vision of iONE-FP7 is to exploit for the first time flexible organic electronics for the development and testing of Active Multifunctional Implantable Devices (AMIDs) to treat Spinal Cord Injury (SCI). The devices will (a) have long-term stability associated to high biocompatibility and safety, (b) have reduced risk of a host versus graft immune response, (c) mimic the local microenvironment for stem/precursor cell recruitment and differentiation, (d) monitor locally the functionality of the regenerated nerve cells to intervene with loco-regional therapies (e) perform local stimulation with tunable electric fields, (f) deliver locally growth factors, neurotransmitters, and drugs. The use of flexible organic electronics devices (ultra-thin film organic field effect transistor (FET), organic electro-chemical transistor, nanoparticle organic memory FET) will advance the state-of-the-art of implantable devices for SCI from passive to active layouts that will promote nerve regeneration by a combination of local stimuli delivered on demand, will sense inflammation, and will control the immune-inflammatory response. The biomedical impact of the project will be demonstrated in vitro and in vivo. In vitro, the neural therapeutic plasticity induced by the iONE-FP7 device will be evaluated on stem cells, which will be differentiated to neural progenitor cells, and then to neural cells. In vivo, the study of neural plasticity will be transferred to endogeneous stem cells by implanting the iONE-FP7 device into a contusion SCI animal model. iONE-FP7 will acquire the knowledge and the technology required to regenerate the nerve in the niche of the injury.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP.2010.2.2-1 | Award Amount: 3.98M | Year: 2011

Functional organic molecules and metal and semiconductor nanocrystals represent attractive building blocks due to their composition-, size- and structure-dependent electronic properties, and the ability to design and manipulate these properties via low-cost and established chemical synthesis. Building from the pressing need of the European market to develop novel, scalable and cheaper technologies for sensing applications, the main objective of the HYSENS project is to exploit inexpensive organic functional molecules and inorganic nanocrystals as building blocks to synthesize novel high-knowledge materials for the development of sensors for Group I, II transition metal cations and anions (Cl-, NO3-). The hybrid material intelligence resulting from the engineered combination of individual units will allow the execution of logic functions able to reduce false sensing outputs towards the development of sensors with enhanced selectivity and sensitivity. Our goal is to elucidate the mechanisms governing the optical and electrical response of such engineered hybrid materials arising from the interaction between the organic functional molecule component and the inorganic nanocrystal core component. Establishment of component-function relationships will lead to disruptive new knowledge that will impact on optical and electrical sensors technologies.

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