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Le Touquet – Paris-Plage, France

Screencell | Date: 2013-03-19

Pharmaceutical preparations for the detection, diagnostic and treatment of cancer; veterinary preparations for the detection and diagnostic of cancer; sanitary preparations for medical purposes; Dietetic substances adapted for medical use, namely, dietetic foods, dietetic beverages, dietetic sugar, dietetic sugar substitutes; food for babies; plasters for medical and surgical purposes; materials for dressing, namely, bandages and gauze for dressing, burn dressings and self adhesives dressings; material for dental fillings and dental impressions; disinfectants for medical instruments; pesticides; fungicides; herbicides; bath preparations, medicated; sanitary pads, panties or towels; chemical preparations for medical or pharmaceutical purposes, namely, chemical preparations for the isolation of cells, chemical and pharmaceutical preparations for the detection and treatment of cell mutation; medicinal herbs; herbs teas for medicinal purposes; parasiticides; dietetic sugar for medical purposes; alloys of precious metals for dental purposes. Scientific apparatus and instruments, not for medical use, namely, optical mirrors, glass tubes, Erlenmeyer flasks and beakers for scientific purposes, conductivity meters, chromatography columns for use in purification in the laboratory and parts and fittings therefor, spectrometers and parts and fittings therefor, instruments for measuring relative DNA/RNA and protein and parts and fittings therefor, spectrophotometer for measuring relative DNA/RNA and protein, cellular mixed ester membranes for use in the science and research industry, ultra-high vacuum chambers; surveying apparatus and instruments, namely, surveying machines and instruments, surveying compass needles, magnetic compasses; photographic apparatus and instruments, namely, photographic cameras, photographic exposure meters, photographic filters, photographic flash bulbs and flash units, photographic projectors; cinematographic apparatus and instruments, namely, cinematographic cameras, cinematographic film, cinematographic machines and apparatus, sound recording apparatus and instruments; optical apparatus and instruments, namely, optical filters, optical glasses, optical lens sights, optical scanners, optical readers, optical reflectors; weighing equipment, namely, scales and balances; measuring apparatus and instruments, namely, bevels, lasers for measuring purposes, liquid level sensors, gas level sensors, angle finders, measuring buckets, cups, spoons and glassware, measuring rules; checking apparatus and instruments for measuring, testing and checking the temperature, pressure, quantity and concentration of gas and liquids; life-saving apparatus and instruments, namely, positive pressure breathing systems, defibrillators; teaching apparatus and instruments, namely, medical teaching mannequins, video projectors, medical diagnostic simulators for use as teaching aids for detection of cancer; apparatus for recording, transmission or reproduction of sound or images; blank magnetic recording media; blank recordable acoustic or optical discs; blank floppy discs; automatic vending machines and mechanisms for coin-operated apparatus; cash registers, calculating machines, data processing equipment and computers; computer game programs; computer software, recorded for scientific analysis of genetic sequences; computer peripheral devices; batteries, electric; wires, electric; relays, electric; spectacles; optical goods, namely, optical filters, optical lenses, optical glasses, optical reflectors; spectacles cases; diagnostic apparatus for scientific or research use other than for medical use; integrated circuit cards; safety tarpaulins. Surgical apparatus and instruments for medical, dental and veterinary use; medical apparatus and instrument for diagnostic use, namely, apparatus for medical diagnostic testing in the fields of cancer or other tissue-based diagnostic testing, cytology and cell-based testing; dental instruments, namely, picks, burrs, mirrors, oral irrigators, prophy angles, bridges, drills, inlays, onlays, implants, crowns; artificial limbs, eyes and teeth; orthopedic articles, namely, orthopedic belts, orthopedic braces, orthopedic joint implants; suture materials; feeding bottles; feeding bottle teats; clothing especially for operating rooms, namely, surgical scrub suits; massage apparatus; esthetic massage apparatus; artificial limbs; surgical implants comprising artificial materials; surgical drapes; bed pans or basins for medical use, furniture especially made for medical purposes, surgical cutlery. Evaluations, assessments and research in the fields of science and technology provided by engineers; design and development of computer and software; research and development for others in the field of cytology; technical project studies, namely, research and development of new products for others; architecture; design of interior dcor; development, design, installation, maintenance, updating or rental of software; computer programming; consultancy in the field of computer hardware; data conversion of computer programs and data, not physical conversion; conversion of data or documents from physical to electronic media; automotive safety testing and consultation, namely, conducting crash tests and providing advice, information and reports as to the roadworthiness of vehicles; graphic arts designing, styling, namely, industrial design; authentic works of art.

Screencell and Dana-Farber Cancer Institute | Date: 2012-09-07

Methods and materials for increasing the number of target cells recovered from a fluid sample containing cells are described. The methods include isolating the target cells on a filter and then implanting the filter containing the target cells in an immunodeficient non-human animal, where at least some of the target cells can proliferate.

Awe J.A.,University of Manitoba | Awe J.A.,Gothenburg University | Awe J.A.,University of Skovde | Xu M.C.,University of Manitoba | And 7 more authors.
Translational Oncology | Year: 2013

Circulating tumor cells (CTCs) have been identified with the potential to serve as suitable biomarkers for tumor stage and progression, but the availability of effective isolation technique(s) coupled with detailed molecular characterization have been the challenges encountered in making CTCs clinically relevant. For the first time, we combined isolation of CTCs using the ScreenCell filtration technique with quantitative analysis of CTC telomeres by TeloView. This resulted in the identification and molecular characterization of different subpopulations of CTCs in the same patient. Threedimensional (3D) telomeric analysis was carried out on isolated CTCs of 19 patients that consisted of four different tumor types, namely, prostate, colon, breast, melanoma, and one lung cancer cell line.With telomeric analysis of the filter-isolated CTCs, the level of chromosomal instability (CIN) of the CTCs can be determined. Our study shows that subpopulations of CTCs can be identified on the basis of their 3D telomeric properties. Copyright © 2013 Neoplasia Press, Inc. All rights reserved.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-11-2015 | Award Amount: 7.42M | Year: 2016

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recognized as a hallmark of therapeutic efficacy. Currently, there is no non-invasive modality that can directly image these forces in vivo. Our objective is the non-invasive measurement of both IFP within tumours as well as the forces they exert on their surrounding environment. This will be used to predict a tumours metastatic potential and importantly, changes in these forces will be used to predict the therapeutic efficacy of drug therapy. To attain this goal, the biomechanical properties of the tumour and its neighbouring tissue will be measured via MR-elastography at various measured deformation states. Resultant images will be used to reconstruct images of the internal and external forces acting on the tumour. We call this novel imaging modality Magnetic Resonance Force (MRF) imaging. We will calibrate MRF via cell cultures and pre-clinical models, and then test the method in breast, liver, and brain cancer patients. Thereby, we will investigate whether MRF data can predict metastatic spread and measure IFP in patients. We will also investigate the potential to non-invasively modulate the force environment of cancer cells via externally applied shear forces with the aim of impacting cell motility and proliferation. This can provide novel mechanism for anticancer therapeutic agents via mechanotransduction.

Desitter I.,ScreenCell | Guerrouahen B.S.,ScreenCell | Benali-Furet N.,ScreenCell | Wechsler J.,ScreenCell | And 8 more authors.
Anticancer Research | Year: 2011

Background: Circulating tumor cells (CTCs) likely derive from clones in the primary tumor, suggesting that they can be used for all biological tests applying to the primary cells. Materials and Methods: The ScreenCell® devices are single-use and low-cost innovative devices that use a filter to isolate and sort tumor cells by size. Results: The ScreenCell® Cyto device is able to isolate rare, fixed, tumor cells, with a high recovery rate. Cells are well preserved morphologically. Immunocytochemistry and FISH assays can be performed directly on the filter. The ScreenCell® CC device allows isolation of live cells able to grow in culture. High quality genetic materials can be obtained directly from tumor cells isolated on the ScreenCell® MB device filter. Conclusion: Due to their reduced size, versatility, and capacity to isolate CTCs within minutes, the ScreenCell® devices may be able to simplify and improve non-invasive access to tumor cells.

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