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News Article | May 24, 2017
Site: www.businesswire.com

FRAMINGHAM, Mass.--(BUSINESS WIRE)--SCIEX Diagnostics, the in vitro diagnostics division of SCIEX, a global leader in mass spectrometry in the life sciences industry, announced today the first and only FDA-cleared (via the de novo pathway) LC-MS based Vitamin D assay kit, the Vitamin D 200M Assay, exclusively for the SCIEX Topaz™ System. The Topaz System is a fully integrated LC-MS platform driven by ClearCore™ MD, the new and intuitive software designed specifically for use in clinical labs. The Office of Inspector General (OIG) recently reported Vitamin D as one of the top five laboratory assays reimbursed by Medicare, accounting for 8.7 million laboratory tests and $337 million in reimbursement dollars. Vitamin D is an important building block for human health, and Vitamin D has been linked in literature to several clinically important diseases. Thus it is necessary to provide physicians with accurate results to allow for confident diagnosis of Vitamin D stores and management of Vitamin D deficiency-related diseases. According to the CDC, LC-MS technology is the gold standard method for testing Vitamin D, offering greater specificity and less cross-reactivity over immunoassay methods. The CDC has established a Vitamin D Standardization-Certification Program (VDSCP) and the SCIEX Topaz Vitamin D 200M Assay Kit has successfully met the rigorous performance criteria. While individually quantitating D2 and D3 isomers, the Topaz System running the Vitamin D 200M Assay Kit, also automatically differentiates between D3 epimers, providing the specificity to deliver highly accurate diagnostic results in a single analysis. The Vitamin D 200M Assay for the Topaz System is intended for in vitro diagnostic use in the quantitative determination of total 25-hydroxyvitamin D (25-OH-D) through the measurement of 25-hydroxyvitamin D3 (25-OH-D3) and 25-hydroxyvitamin D2 (25-OH-D2) in human serum using LC-MS/MS technology by a trained laboratory professional in a clinical laboratory. The Assay is intended for use with the Topaz System. The Vitamin D 200M Assay for the Topaz System is intended to be used in conjunction with other clinical or laboratory data to assist the clinician in making individual patient management decisions in an adult population in the assessment of Vitamin D sufficiency. “Clinical diagnostic labs are challenged every day to deliver highly accurate and reliable test results in order to make critical treatment decisions,” said Dr. Aaron Hudson, Sr. Director and GM of SCIEX Diagnostics. “Through the Topaz System, SCIEX offers a LC-MS-based IVD system that is easy to learn and validate in the clinical lab. It will enable clinical labs to expand their in-house testing services through the SCIEX Vitamin D Assay Kit, as well as add to their own laboratory developed tests (LDTs), thus empowering the lab to do more, save more and deliver more confident results to support clinicians and physicians. The Topaz System from SCIEX Diagnostics is “Mass Spectrometry Made Simple”, and primed to set the new standard for delivering superior patient care.” To learn more about the SCIEX Vitamin D Assay Kit SCIEX Topaz System and the SCIEX Vitamin D 200M Assay Kit, available in the United States only from SCIEX: sciex.com/massspecmadesimple SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please visit sciexdiagnostics.com. ©2017 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB Sciex™ is being used under license. For in vitro diagnostic use. Rx Only. IVD-MKT-12- 5686-A


News Article | May 25, 2017
Site: www.businesswire.com

FRAMINGHAM, Mass.--(BUSINESS WIRE)--SCIEX, a global leader in life science analytical technologies, has announced that the MSB Strategic Planning Committee has selected Dr. Shigeru Terabe, Professor Emeritus of the University of Hyogo in Kamigori, Hyogo, Japan, as the recipient of the Arnold O. Beckman Medal and Award for Outstanding Scientific Achievements in the Field of Electro-driven Separation Techniques. The Medal Ceremony was presented on Tuesday, March 28th as part of a Special Award Plenary Session at the 33rd International Symposium on Microscale Bioseparations (MSB 2017). The Arnold O. Beckman award is given to an individual for remarkable career achievements, with particular consideration being given to the development of new methods, techniques and high-impact applications in the field of electro-driven separations. The award comprises a Medal, a Diploma and a Monetary Prize. Professor Terabe earned his undergraduate, masters and doctoral degrees from Kyoto University, Japan in 1963, 1965 and 1973, respectively. Professor Terabe began is career at the Shionogi & Company Ltd, where he was a research chemist. Later, he joined Arizona State University, where he was a research associate before returning to Kyoto University, Japan to become an assistant professor. In 1990, he was appointed to the Faculty at Himeji Institute of Technology, Kamigori, Hyogo, Japan and has since been engaged in the practice of analytical chemistry. After retiring, Professor Terabe served as a Research Supervisor of the program “Precursory Research for Embryonic Science and Technology” funded by the Japanese government from 2004–2010. In his role, Professor Terabe assisted 40 top young analytical scientists by funding ca. 5 million USD per year for the project, “Structure Function and Measurement Analysis.” Professor Terabe has been a driving force in understanding the fundamentals of capillary electrophoresis including the introduction of Micellar Electrokinetic Chromatography and a myriad of its applications, as well as the development of sweeping, a “stacking” approach for neutral analytes. His 250 original research publications have been cited more than 15,000 times altogether ranking him in the top 200 among all chemists. Professor Terabe has been awarded the ACS Award in Chromatography in 2004, CASSS Award in 2007, and the Chemical Society of Japan Award in 2008 in recognition of his contributions to analytical chemistry. He served as an Editor of Journal of Chromatography for 15 years and in 2011 he was Chairman of the IUPAC International Congress on Analytical Sciences. “This annual Medal and Award sponsored by SCIEX recognizes the achievements of those that have made a momentous impact on capillary electrophoresis,” said Jeff Chapman, Sr. Director, SCIEX. “Professor Terabe’s invention of micellar electrokinetic chromatography has inspired many scientists, both utilizing and building upon this fundamental methodology.” “I am humbled to be the recipient of the prestigious Arnold O. Beckman award, a notable honor that has recognized distinguished colleagues that have impacted diverse scientific and technical disciplines,” said Dr. Shigeru Terabe, Professor Emeritus of the University of Hyogo in Kamigori, Hyogo, Japan. “Dr. Beckman’s achievements have inspired me and I would like to express my gratitude to MSB for this esteemed award.” Learn more about SCIEX and SCIEX Capillary Electrophoresis Solutions SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please visit sciex.com. For Research Use Only. Not for use in diagnostic procedures. RUO-MKT-12-5561-A © 2017 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB Sciex™ is being used under license.


SHANGHAI--(BUSINESS WIRE)--SCIEX Diagnostics, the in vitro diagnostics division of SCIEX, a global leader in mass spectrometry in the life sciences industry, announced today that the AB SCIEX TRIPLE QUAD™ 4500MD LC-MS/MS system has been approved by the China Food and Drug Administration (CFDA) and meets the market access requirements for medical device products. With this accreditation, SCIEX aims to help propel China’s clinical laboratory programs to a new level by meeting the challenges of clinical diagnostic labs to deliver highly accurate and reliable test results. The AB SCIEX TRIPLE QUAD™ 4500MD LC-MS/MS system consists of a triple quadrupole mass spectrometer (TRIPLE QUADTM 4500MD), a high-performance liquid chromatography system (JasperTM), and software including Analyst®MD, Cliquid®MD and MultiQuantTMMD and it is intended to use with various reagents to analyze compounds in human specimens. The compounds include diagnostic indicators (endogenous substances: amino acids, vitamins, hormones) and therapeutic monitoring compounds (exogenous substances: therapeutic / toxic drugs). The AB SCIEX TRIPLE QUAD™ 4500MD LC-MS/MS system delivers excellent detection levels for the analytes commonly requested in clinical in vitro diagnostic applications. Designed to maximize uptime in clinical laboratories and support continuous high-throughput operations, the AB SCIEX TRIPLE QUAD™ 4500MD LC-MS/MS system features the industry leading SCIEX Turbo V™ ion source and Curtain Gas™ interface for outstanding reliability, sensitivity and reproducibility in routine clinical testing and ensures day-to-day, month-to-month, or week-to-week measurement consistency. The AB SCIEX TRIPLE QUAD™ 4500MD LC-MS/MS system provides scientists with the ability to perform multiple assays, and quantitate multiple compounds in a single run with a suitable reagent, resulting to fewer tests, significant time and cost savings in clinical laboratories. “We are very pleased to share this news to with our customers and with the industry. We know that the routine diagnostic testing lab requires accurate trace level quantitation of multiple compounds in human specimens,” said Shao Hong, SCIEX China GM. “The AB SCIEX TRIPLE QUAD™ 4500MD LC-MS/MS system is a truly reliable platform, which can help meet clinical lab objectives, by saving time, cutting costs, and supporting physicians with greater confidence and reliable results. We believe that AB SCIEX TRIPLE QUAD™ 4500MD LC-MS/MS system will lead us to a new era in clinical in vitro diagnostic field.“ Learn more about the SCIEX Triple Quad 4500MD system. SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please visit sciex.com. For in vitro diagnostic use. Rx Only. IVD-MKT-12-6126 ©2017 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB Sciex™ is being used under license.


FRAMINGHAM, Mass.--(BUSINESS WIRE)--SCIEX, a global leader in life science analytical technologies, today announced that it has launched its game-changing SWATH® data independent acquisition (DIA) technology for analytical scientists working across all application areas. SWATH Acquisition is ground-breaking in allowing the simultaneous and comprehensive identification and quantification of virtually every detectable compound in a sample, from a single analysis (MS/MSALL). SWATH Acquisition has unique capabilities for quantitative accuracy, offering exceptionally high reproducibility across multiple samples with wide dynamic range. Importantly, the technology enables the creation of a permanent digital record of quantitative MS/MS data for the entire sample. Following the successful implementation of SWATH for proteomics research, this technology is widely used today in the industrialization of proteomics research and can now bring significant advantages for analytical scientists in other fields, including forensics, food testing, environmental analysis, and biologics. The transition from traditional proteomics workflows to the SCIEX patented SWATH® Acquisition has transformed proteomics experiments, allowing all data to be robustly captured across very large sample cohorts to enable industrialized proteomics and precision medicine approaches. The ability of the SCIEX TripleTOF® system technology to acquire high resolution MS/MS spectra at high acquisition rates has made it the only mass spectrometer on which SWATH Acquisition can be routinely performed. Now with the new X500 series mass spectrometers, with the similar acquisition rates, on a routine use system SWATH Acquisition is now poised to revolutionize other fields. For example, food-testing laboratories survey ingredients and food products for quality and safety. Pesticide residues in certain foods such as baby food are required to be as low as under 10 µg/kg, and foods such as fruits or vegetables often exhibit a high number of active components and can be difficult to analyze. When using traditional LC-MS/MS approaches to analyze complex matrices such as foods, there is a risk of missing the identification of an important low level residue. SWATH Acquisition eradicates this issue, allowing scientists to completely survey samples for every detectable chemical contaminant present while also ensuring rapid, reliable detection of low abundance compounds that are usually masked by dominant compounds in a sample. Laboratories investigating water quality carry out rigorous treatment and testing procedures to identify a variety of chemical hazards. The difficulty with water analysis is that substances can be present at exceptionally low concentrations, in the range of low nanograms per liter, and a single sample may contain hundreds of contaminants. SWATH technology collects ultra-high quality MS and MS/MS on all detectable peaks to provide rapid and reliable identification and quantification of compounds in samples. Characterization and quantification of host cell proteins is an important stage in the development of biotherapeutics. Even with rigorous purification processes, small amounts of host cell proteins may be present in the final product. Traditional analysis methods including ELISA are not comprehensive enough to detect previously unknown HCP contaminants, and standard information dependent LC-MS strategies are not sensitive enough to detect low-level peptides in a reproducible manner. The unbiased SWATH Acquisition approach in contrast enables the detection of peptides down to very low levels in the sample, allowing researchers to generate reproducible data which is crucial for drug development studies. Forensic testing involves routine screening and quantification of drugs and medications in numerous biological matrices, such as blood. This testing requires robust hardware, reproducible results and highly sensitive analysis. SWATH technology collects comprehensive MS data and MS/MS data from a single sample injection, which results in a digital archive of the forensic sample. This allows re-interrogation of the sample without physical re-analysis, removing the need for expensive and inconvenient sample storage, and saving time. This unbiased solution also provides high quality results that will stand up in court. “The most important aspect of the X500R QTOF System is the ability to work with SWATH Acquisition, especially when analyzing food samples with complex matrices,” said Dr. Amadeo R Fernaìndez-Alba, Head of the European Union Reference Laboratory (EURL) for Fruits and Vegetables, and Professor of Analytical Chemistry at the University of Almeria. “It also enables fast quantification, making it ideally suited to high-throughput applications, without compromising on sensitivity.” “As environmental chemists, we are always trying to find new compounds of concern, whether in drinking water, stormwater, or biota,” said Christopher Higgins, Ph.D., Associate Professor, Department of Civil and Environmental Engineering, Colorado School of Mines. “SWATH looks to provide us an opportunity to collect and archive data, thereby allowing us to re-examine old data without reacquisition. This is an important advantage in environmental monitoring where samples are often limited.” “The beauty of SWATH is that it collects data for everything,” said Dr. Thomas Kofoed, Chief Executive Officer, Alphalyse. “It allows us to identify and quantify each host cell protein reliably in drug batches, and provide a service that customers can trust.” “SWATH is our preferred method for broad-based drug screening when using SCIEX QTOF systems, because SWATH enables the generation of accurate library MS/MS spectral matching results reducing the possibility of false negative identifications,” said Dr. Barry Logan, Executive Director, The Center for Forensic Science Research Education. “Essentially, SWATH provides reliable results for analytes that are toxicologically relevant to forensic investigations because of the complete MS/MS coverage that it provides.” SCIEX will highlight the latest additions to its growing line of mass spectrometry-based solutions at ASMS 2017, June 4-8 in Indianapolis. SCIEX will present customer driven innovations and advancements for all markets, at booth #500 and in their hospitality suite at the JW Marriott – White River Ballroom ABE. Learn more about why only SCIEX can do SWATH SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please visit sciex.com. For Research Use Only. Not for use in diagnostic procedures. RUO-MKT-12-5418-A © 2017 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB Sciex™ is being used under license.


News Article | June 1, 2017
Site: www.businesswire.com

FRAMINGHAM, Mass.--(BUSINESS WIRE)--SCIEX, a global leader in life science analytical technologies, today announced that at ASMS 2017, it will highlight the cutting-edge innovations developed to power their most advanced LC-MS instrumentation and workflows, and is now enabling streamlined workflows making mass spec more accessible to routine users and non-mass spec experts. SCIEX is committed to developing optimized solutions in support of the whole Precision Medicine continuum, from biomarker research to clinical implementation. As such, SCIEX will share how several customer partnerships are key to advancing biomarker discoveries via their industrialized omics pipelines. In addition, they will highlight the first and only FDA-cleared (via the de novo pathway) LC-MS based Vitamin D assay kit, the Vitamin D 200M Assay, exclusively for the SCIEX Topaz™ System. The Topaz System is a fully integrated LC-MS platform driven by ClearCore™ MD, the new and intuitive software designed specifically for use in clinical labs. An array of scientific presentations and posters will be featured at the ASMS 2017 Annual Users Meeting and Breakfast Seminars, at the Indianapolis Marriott Downtown, 350 West Maryland St, Indianapolis, IN. Among the solutions being featured from the SCIEX comprehensive portfolio are: SWATH® Acquisition: The Evolution of Data Independent Acquisition – Since its commercialization 5 years ago, SWATH Acquisition has continued to advance and evolve. Workflow improvements, including the ability to optimize acquisition with variable sized Q1 windows and microflow for sample throughput have delivered significant increases in the number of proteins and peptides quantified, as many as 150 proteomes per week. Building off the successful implementation of SWATH Acquisition across academic research applications, the technology is now bringing significant advantages in other applications, including metabolomics, forensics, food testing, environmental analysis, and biologics characterization. Biotransformation solutions, two streamlined solutions targeted to customer needs New Biotransformation Solutions for Routine and Comprehensive Metabolism and Biologic Catabolism Studies – The latest additions to its growing line of solutions for pharmaceutical drug discovery and development. The Routine Biotransform Solution and the Advanced Biotransformation Solution are powered by the newest SCIEX MetabolitePilot™ Software 2.0, delivers an easy to use interface that places processing, interpretation and reporting all in one place. Among the presentations and discussions involving SCIEX innovations are: “SCIEX is developing application software for our instruments that doesn’t require analysts to be mass spectrometry experts, while still providing laboratories with the high performance they need for advanced workflows,” said Jean-Paul Mangeolle, President of SCIEX. “The solutions we are presenting at ASMS this year support the workflow improvements that enable our customers to see the future differently by implementing the quality of advanced workflows with the ease of routine.” Throughout the ASMS conference, SCIEX will continue showcasing customer driven innovations and advancements across LC-MS market areas, at booth #500 and in their hospitality suite at the JW Marriott – White River Ballroom ABE. In addition, scientists from SCIEX will present innovative solutions across a range of applications with oral presentations, user meetings, workshops, and posters. Find more information and full agenda for SCIEX at ASMS. To learn more about the SCIEX Vitamin D 200M Assay, available in the United States only from SCIEX: sciex.com/massspecmadesimple Follow SCIEX at ASMS on Twitter and tweet and can utilize hashtag #ASMS2017. SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please visit sciex.com. The SCIEX Vitamin D 200M Assay Kit, SCIEX Topaz™ System and ClearCore™ MD software are for in vitro Diagnostic Use. Not available in all countries. All other products discussed in this press release are For Research Use Only. Not for use in diagnostic procedures. © 2017 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB Sciex™ is being used under license.


FRAMINGHAM, Mass.--(BUSINESS WIRE)--SCIEX, a global leader in life science analytical technologies, announced today that EPL Bio Analytical Services, (EPL BAS), an industry leading agriculture-focused analytical contract laboratory, has selected the SCIEX QTRAP® 6500+ with SelexION®+, enabling their researchers to provide analytical solutions to customers with projects involving difficult matrices that the lab could not previously consider accepting. EPL’s analytical laboratory provides customized analytical laboratory testing services to the agricultural crop protection, agricultural chemical, agricultural biotechnology, organic, biocontrol, nutritional, food ingredient, and feed industries and they partner with customers from around the world to provide safe and reliable agricultural products to local and global consumers. EPL’s installation of the SCIEX QTRAP 6500+ LC-MS/MS system with multi-component IonDrive™ Technology and a newly designed IonDrive High Energy Detector+, offers them the high sensitivity, reliability and confidence they require to produce data as objective evidence for the efficacy and safety of a wide range agricultural product, including organic products, synthetic chemistry and plant incorporated protectants. The QTRAP 6500+ system delivers enhanced selectivity, without compromising MRM sensitivity, for more flexibility in dealing with complex interferences. The exclusive QTRAP scan function of MS3 (MS/MS/MS), adds an additional level of mass filtering, while the SelexION+ ion mobility provides an orthogonal separation prior to mass separation and offers the lab yet another tool for eliminating isobaric background interferences in complex assays, making quantitation in complex samples easier and less time consuming. The unique scan functions offered by the SCIEX QTRAP system, including enhanced mass scans (EMS), enhanced resolution scans (ER), and enhanced product ion scans (EPI), deliver maximum flexibility and workflow options enabling researchers to embrace new discoveries and more accurate identification that extend beyond quantitation. “The 6500+ with SelexION allows EPL Bio Analytical Services to have unique product offering and provides a significant competitive advantage that enables their researchers to solve problems other labs cannot,” said Paul Winkler, Food and Beverage Marking Development Manager, Americas at SCIEX. “The acquisition of the QTRAP 6500+ provides EPL Bio Analytical Services with an instrument that has better low mass negative ion performance than their competitors’ laboratories, and with the addition of SelexION, EPL Bio Analytical Services further extends their ability to perform analyses in complex matrices such as environmental and agricultural samples.” “At EPL, the management and staff place a high value on being the industry leader,” said Fred Claussen, VP of Method Development EPL Bio Analytical Services. “When we find a technology that will provide better data to our customers, we go get it. In the competitive world of contract laboratories, having the best technology, along with the best technical staff allows us to more effectively compete for new business and uphold our strong brand on a global level. We believe that the acquisition of these SCIEX solutions gives our laboratory this important competitive edge.” Learn more about SCIEX QTRAP and SelexION Technology SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please visit sciex.com. For Research Use Only. Not for use in diagnostic procedures. RUO-MKT-12-6044-A ©2017 AB Sciex. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB Sciex™ is being used under license. EPL Bio Analytical Services (EPL BAS) is an award-winning, Good Laboratory Practice compliant (GLP), ISO 17025-accredited analytical contract lab. Our vision is to be the “most trusted analytical laboratory in the Ag Industry.” EPL BAS serves the global agricultural industry by analyzing feed and food ingredients, organic products, genetically enhanced crops, bio-pesticides, plants, algae, plant protection agents and crop chemicals. With the goal of providing safe, healthy, and abundant food while protecting and improving the environment, EPL BAS uses advanced innovative technology in the areas of nutritional chemistry, agricultural chemistry, including residue and product chemistry, and molecular biology to provide excellent, timely support for the feed, food, fiber and fuel industries. We don’t have an Ag Division…because we are Ag! Visit us at www.eplbas.com, Facebook, LinkedIn and Twitter.


Guna M.,SCIEX
Journal of the American Society for Mass Spectrometry | Year: 2015

Mass selective axial ejection (MSAE) from a low pressure linear ion trap (LIT) is investigated in the presence of added auxiliary nonlinear radio frequency (rf) fields. Nonlinear rf fields allow ions to be ejected with high sensitivity at large excitation amplitudes and reduced deleterious effects of space charge. These permit the operation of the LIT at ion populations considerably larger than the space charge limit usually observed in the absence of the nonlinear fields while maintaining good spectral resolution and mass accuracy. Experimental data show that the greater the strength of the nonlinear field, the less the effects of space charge on mass assignment and peak width. The only deleterious effect is a slight broadening of the mass spectral peaks at the highest values of added nonlinear fields used. © 2015 American Society for Mass Spectrometry.


Diao X.,U.S. National Institute on Drug Abuse | Wohlfarth A.,U.S. National Institute on Drug Abuse | Pang S.,SCIEX | Scheidweiler K.B.,U.S. National Institute on Drug Abuse | Huestis M.A.,U.S. National Institute on Drug Abuse
Clinical Chemistry | Year: 2016

BACKGROUND: Despite increasing prevalence of novel psychoactive substances, no human metabolism data are currently available, complicating laboratory documentation of intake in urine samples and assessment of the drugs' pharmacodynamic, pharmacokinetic, and toxicological properties. In 2014, THJ-018 and THJ-2201, synthetic cannabinoid indazole analogs of JWH-018 and AM-2201, were identified, with the National Forensic Laboratory Information System containing 220 THJ-2201 reports. Because of numerous adverse events, the Drug Enforcement Administration listed THJ-2201 as Schedule I in January 2015. METHODS: We used high-resolution mass spectrometry (HR-MS) (TripleTOF 5600+) to identify optimal metabolite markers after incubating 10 μmol/L THJ-018 and THJ-2201 in human hepatocytes for 3 h. Data were acquired via full scan and information-dependent acquisition triggered product ion scans with mass defect filter. In silico metabolite predictions were performed with MetaSite and compared with metabolites identified in human hepatocytes. RESULTS: Thirteen THJ-018 metabolites were detected, with the major metabolic pathways being hydroxylation on the N-pentyl chain and further oxidation or glucuronidation. For THJ-2201, 27 metabolites were observed, predominantly oxidative defluorination plus subsequent carboxylation or glucuronidation, and glucuronidation of hydroxylated metabolites. Dihydrodiol formation on the naphthalene moiety was observed for both compounds. MetaSite prediction matched well with THJ-018 hepatocyte metabolites but underestimated THJ-2201 oxidative defluorination. CONCLUSIONS: With HR-MS for data acquisition and processing, we characterized THJ-018 and THJ-2201 metabolism in human hepatocytes and suggest appropriate markers for laboratories to identify THJ-018 and THJ-2201 intake and link observed adverse events to these new synthetic cannabinoids. © 2015 American Association for Clinical Chemistry.


Noestheden M.R.,SCIEX
Journal of the Institute of Brewing | Year: 2015

Following recent studies that showed that the agrochemical mepiquat (1,1-dimethylpiperidinium) forms during the roasting of coffee beans and barley, this work investigates the presence of mepiquat in malted barley and commercially available beers. Liquid chromatography-tandem mass spectrometry was used to develop a sensitive and precise analytical method, with detection limits of 0.031 ng/g in malted barley and 0.014 ng/g in beer. Mepiquat was detected in nine out of 10 malted barley samples, with all results under the Canadian maximum residue limit (100 ng/g). The data suggest a relationship between perceived malted barley colour and mepiquat concentration. The concentration of mepiquat in the beers analysed was also below the maximum residue limits in Canada (100 ng/g) and in the EU (600 ng/g), suggesting that mepiquat is not a regulatory concern in finished beers. © 2015 The Institute of Brewing & Distilling.


News Article | October 28, 2016
Site: www.prweb.com

The structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store epigenetic information. The nucleosomes together with the non-histone proteins define a stable chromatin structure. Regardless of its stability, this structure is disassembled and reassembled during DNA replication, repair, recombination or transcription. During all those processes, defined chromatin regions become accessible to be bound by the required factors, resulting in extensive nucleosome turnover at given genomic loci. The dual nature of chromatin requires a continuous interplay between stable and dynamic structures, which has to be coordinated at the molecular level to maintain the epigenetic information stored in the chromatin structure. Despite the biological relevance of these processes, little is known about the order of chromatin assembly steps, the molecular mechanisms that coordinate the required cellular machinery in time and the quality control of this assembly. To address these questions, the team at the biomedical center of the LMU uses an in-vitro system that resembles the formation of chromatin on double-stranded DNA. This in-vitro system not only enables researchers to dissect critical steps of assembly, but also to verify predictions based on previously published data on proteomic analysis of captured nascent chromatin (NCC) in living cells. SCIEX will sponsor this free webinar on the implementation of label free quantitative SWATH-MS at different assembly times, enabling the identification of distinct aspects of chromatin assembly such as the appearance and disappearance of histone modifications. Two researches from Ludwig Maximilian University (LMU) in Munich present during this webinar, PhD candidate, Moritz Völker-Albert and Dr. Andreas Schmidt. As PhD student in the chromatin proteomics group at the LMU, Moritz Völker-Albert investigates the kinetics of chromatin assembly. Prior to starting his doctorate in Munich in 2013, Völker-Albert completed his master’s degree in biomedical sciences at the Universities of Leiden and Utrecht in the Netherlands. During his studies, he focused on several aspects of chromatin research like chromatin remodeling assays, DNA repair and proteomic analysis of chromatin complexes. Andreas Schmidt earned his doctorate degree from University of Vienna, where he studied phosphorylation of arginine as stress-induced protein tag in bacteria. In collaboration with the group of T. Clausen, the team described the protein arginine kinase and improved enrichment and identification of peptides with this modification. Since 2013, he has worked as PostDoc for development of protocols for proteomics analysis and proteomics data analysis at the Department of Molecular Biology of the Medical Faculty of the LMU. The focus of his work is development of data independent acquisition methods for quantitation of proteins and protein modifications as well as improving the data analysis of data-independent mass spectrometry data. LabRoots will host the webinar on November 23, 2016, beginning at 8:00 a.m. PT, 11:00 a.m. ET. To read full event details or register for free, click here. About SCIEX: SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please visit sciex.com. About LabRoots: LabRoots is the leading scientific social networking website and producer of educational virtual events and webinars. Contributing to the advancement of science through content sharing capabilities, LabRoots is a powerful advocate in amplifying global networks and communities. Founded in 2008, LabRoots emphasizes digital innovation in scientific collaboration and learning, and is a primary source for current scientific news, webinars, virtual conferences, and more. LabRoots has grown into the world’s largest series of virtual events within the Life Sciences and Clinical Diagnostics community.

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