Scientific Futures Management Company

Novosibirsk, Russia

Scientific Futures Management Company

Novosibirsk, Russia

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Andreeva T.V.,Russian Academy of Medical Sciences | Vereshagin E.I.,Scientific Futures Management Company | Ermakova N.N.,Russian Academy of Medical Sciences | Madonov P.G.,Scientific Futures Management Company | And 6 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2010

Neuroprotective activity of immobilized granulocyte CSF (nanotechnology with electronbeam synthesis) and hyaluronidase was studied on the model of posthypoxic encephalopathy. Oral administration of immobilized granulocyte CSF had no effect on manifestations of posthypoxic psychoneurological disorders in animals. Combined treatment with immobilized granulocyte CSF and hyaluronidase prevented impairment of orientation and exploratory behavior and development of amnesia in mice with hypoxic injury. © 2010 Springer Science+Business Media, Inc.


Dygai A.M.,Russian Academy of Medical Sciences | Skurikhin E.G.,Russian Academy of Medical Sciences | Andreeva T.V.,Russian Academy of Medical Sciences | Madonov P.G.,Scientific Futures Management Company | And 4 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2010

Experiments were performed on the model of cytostatic myelosuppression induced by cyclophosphamide. We compared the effect of immobilized granulocyte CSF (the preparation was created in Russia) and reference standard preparation of granulocyte CSF on the development of neutrophilic leukopenia and hemopoietic precursors of various classes. It was found that preparations of granulocyte CSF decreased the duration and degree of peripheral blood neutropenia. The granulocytopoiesis-stimulating effect was related to stimulation of multipotent hemopoietic precursors, granulocyte-erythroid-macrophage-megakaryocyte precursors, and granulocyte precursors. Induction of division and maturation of multipotent hemopoietic precursors, granulocyte-erythroid-macrophage- megakaryocyte precursors, and granulocyte precursors and recovery of cellularity of the granulocytic hemopoietic stem after administration of immobilized granulocyte CSF were observed at later terms compared to treatment with the reference preparation of granulocyte CSF. © 2010 Springer Science+Business Media, Inc.


Andreeva T.V.,Russian Academy of Medical Sciences | Artamonov A.V.,Scientific Futures Management Company | Bekarev A.A.,Scientific Futures Management Company | Vereschagin E.I.,Scientific Futures Management Company | And 5 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2011

The effects of immobilized granulocyte colony-stimulating factor (mediated by cells of the hemopoiesis-inducing microenvironment) on hemopoietic precursors of various classes were studied on the model of cytostatic-induced myelosuppression (administration of cyclophosphamide). The action of this preparation was compared with that of the standard preparation of granulocyte colony-stimulating factor. Thy 1,2+ cells potentiated the effects of immobilized and standard granulocyte colony-stimulating factors on granulocyte-erythroid-macrophagemegakaryocyte precursors. Stromal cells were shown to potentiate the infl uence of these agents on granulocyte precursors. Induction of proliferation of precursor cells by the immobilized factor mediated by cells of the hemopoiesis-inducing microenvironment persisted for a longer period compared to that induced by the standard product. © 2011 Springer Science+Business Media, Inc.

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