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Dygai A.M.,Russian Academy of Medical Sciences | Zyuz'kov G.N.,Russian Academy of Medical Sciences | Zhdanov V.V.,Russian Academy of Medical Sciences | Udut E.V.,Russian Academy of Medical Sciences | And 12 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2011

In vitro experiments demonstrated increased colony-forming capacity of erythroid, granulo-monocytic, and mesenchymal progenitors of the bone marrow and parenchymal progenitor elements of the liver after treatment with immobilized hyaluronidase. Increased sensitivity of these progenitor cells to erythropoietin, granulocyte colony-stimulating factor, fibroblast growth factor, and stem cell factor, respectively, was demonstrated. Immobilized hyaluronidase enhanced the formation of tissue-specific hepatic CFU against the background of reduced yield of stromal precursors in liver tissue culture containing insulin. © 2011 Springer Science+Business Media, Inc. Source


Dygai A.M.,Russian Academy of Medical Sciences | Zyuz'kov G.N.,Russian Academy of Medical Sciences | Zhdanov V.V.,Russian Academy of Medical Sciences | Udut E.V.,Russian Academy of Medical Sciences | And 11 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2012

Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensification of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-inducing environment cells and elevation of serum erythropoietin concentration. The use of the enzyme allows 10-fold reduction of the maximum effective erythropoietin dose. © 2012 Springer Science+Business Media New York. Source


Dygai A.M.,Russian Academy of Medical Sciences | Zhdanov V.V.,Russian Academy of Medical Sciences | Zyuzkov G.N.,Russian Academy of Medical Sciences | Stavrova L.A.,Russian Academy of Medical Sciences | And 15 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2012

High hepatoprotective activity of granulocytic CSF and hyaluronidase immobilized using electron-beam immobilization technology was demonstrated on the model of CCl4-induced hepatitis: the preparations produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects developed against the background of stimulation of bone marrow multipotent precursor cells and their mobilization into circulation accompanied by an increase in the content of parenchymatous progenitor cells in the liver. The most pronounced positive effect was observed in combined treatment with the test preparations. © 2012 Springer Science+Business Media, Inc. Source


Dygai A.M.,Russian Academy of Medical Sciences | Zyuz'Kov G.N.,Russian Academy of Medical Sciences | Zhdanov V.V.,Russian Academy of Medical Sciences | Udut E.V.,Russian Academy of Medical Sciences | And 11 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2013

Pegylated hyaluronate-endo-β-N-acetylhexosaminidase was shown to potentiate significantly the hemostimulatory effect of pegylated erythropoietin. It was found that enhanced production of hemopoietin by adherent and non-adherent cells of the hemopoiesis-inducing microenvironment and elevated serum content of endogenous erythropoietin along with increased susceptibility of erythroid precursors to pegylated erythropoietin underlay this phenomenon. © 2013 Springer Science+Business Media New York. Source


Dygai A.M.,Russian Academy of Medical Sciences | Zyuz'Kov G.N.,Russian Academy of Medical Sciences | Gurto R.V.,Russian Academy of Medical Sciences | Zhdanov V.V.,Russian Academy of Medical Sciences | And 11 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2013

We studied the effect of hyaluronate-endo-β-N-acetylhexosaminidase on the secretory function of the liver and bone marrow microenvironment cells in chronic hepatitis. Enhanced production of substances stimulating parenchymal tissue-specifi c precursors and stem cell homing factors by liver cells was revealed. At the same time, production of SDF-1 and other chemoattractants and adhesion factors of progenitor cells by bone marrow elements was reduced. © 2013 Springer Science+Business Media New York. Source

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