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Kalykova A.S.,Kazakh National Medical University | Kalykova A.S.,Scientific Center for Anti Infectious Drugs | Vetchy D.,University of Veterinary And Pharmaceutical Sciences Brno | Sakipova Z.B.,Kazakh National Medical University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The original substance of the FS-1 is a nano-ion complex with bactericidal and virucidal activity which was developed in Scientific Center for Anti-infectious Drugs (Almaty, RK) and is intended for the treatment of tuberculosis. The purpose of presented work was to develop a rational and optimum technology for preparing of tablets based on the substance of FS-1, and to evaluate the effect of the time of hydrolysis on quality of the developed medical form. For this, 2 batches of FS-1 substance with time of hydrolysis 17 min and 20 min were synthesized. The aim was to obtain tablets with suitable mechanical properties (friability below 1%) and a suitable disintegration time (up to 15 min), as is required by the Ph. Eur. Optimal formulation and process parameters for the preparation of tablets containing FS-1, under which tablets met the requirements for tablet disintegration time, tablet friability, and tablet mass and content uniformity, were identified within presented work. Longer time of hydrolysis of FS-1 substance probably led to unsuitable conversion of iodine into iodide form. Source

Myrzakhmetov M.M.,Kazakh National Technical University | Zhuginisov M.T.,Kazakh National Technical University | Sartaev D.T.,Kazakh National Technical University | Orynbekov E.S.,Kazakh National Technical University | And 2 more authors.
Advanced Materials Research | Year: 2014

Heat-resistant concrete with liquid and water glassis widely used for the lining of thermal units and equipment. In this paper we present the results of studies on the preparation and study of the properties of the sodium silicate composite binder (SNCR) for heat-resistant concrete. Refractoriness quartzite 1450-1500 ° C. According to RFA quartzite consists of α - quartz, in addition, the sample contains kaolinite Al2O3 · 2SiO2 · H2O. SNCR is prepared jointly grinding quartzite and solid sodium silicate, a ball mill, taken from ootnoshenii: 90:10, 85:15, 80:20 to surface area 2800-3000 cm2/g. To determine the optimal composition of the binder were determined flexural and compressive strength of samples, cross members 16khx4khx4 see Hardening SNCR carried drying in 2-stage operation in the temperature range 100-200 °C. Found that the bending strength of SNCR is 1.6-2.6 MPa, compressive 17,0-32,3 MPa.Refractoriness of 1320-1390 °C. The process of phase formation during heat treatment optimum binder composition.Was found that at temperatures of 1200-1300 ° C in SNCR by quartzite than β - quartz formed vykotemperaturnaya modification quartz β - cristobalite, which increases the fire resistance of binder. Presence of cristobalite phase was also found with the mineralogical Onpetrographic method as well. resulting binder can be used for acid-and heat-resistant refractory Producth with 1300 °C and more. © (2014) Trans Tech Publications, Switzerland. Source

Yuldasheva G.A.,Scientific Center for Anti Infectious Drugs | Zhidomirov G.M.,RAS Boreskov Institute of Catalysis | Leszczynski J.,Jackson State University | Ilin A.I.,Scientific Center for Anti Infectious Drugs
Journal of Molecular Structure | Year: 2013

The donor-acceptor interactions in three model systems: water-glycine (a), water-glycine-KI3 (b), water-glycine-KI3-LiCl-ethanol (c) were investigated by UV-, IR-spectroscopy, and the quantum-chemical DFT-B3PW91/midi method. UV- and IR spectrum data for the considered systems agree well with the results of calculations of the spectral characteristics of glycine cluster that consists of six molecules, and models that simulate the influence of the zwitterionic form of glycine on the structure of complex iodine compounds in the systems (b-c). Localization of a negative and a positive charge at the ends of a zwitterion makes it possible for a cluster of glycine zwitterions to be formed in water. In such cluster glycine molecules are located under each other so that the protonated group is always under (or above) the carboxy group. Glycine fragments are bound by strong hydrogen bonds and also by hydrogen bonding interactions with water molecules. In the water-glycine-KI 3-LiCl-ethanol system the cluster of glycine zwitterions splits the iodide ion into I- and I2 (I- reacts with the protonated amino group, and I2 with the carboxy group). This creates conditions for the formation of an iodine complex compound, in which molecular iodine reveals the acceptor properties towards glycine, and the donor properties towards the LiCl-ethanol complex. © 2012 Elsevier B.V. All rights reserved. Source

Ilin A.I.,Scientific Center for Anti Infectious Drugs | Parsadanyan G.G.,Yerevan State Medical University | Nersesyan A.K.,Medical University of Vienna
New Armenian Medical Journal | Year: 2013

The analysis of literature shows that all halogens can react with important biological macromolecules, such as DNA and RNA. The consequences of mentioned reactions can be different, i.e., both protection from further toxic stimuli and toxic (mutagenic and possibly carcinogenic) effects. All halogens are geno-toxic, but induce this effect only at high doses not relevant for humans. The biological consequences of such reactions of halogens with deoxyribonucleic and ribonucleic acids and chromosomes warrant further investigations. Source

Ilin A.,Scientific Center for Anti Infectious Drugs | Kulmanov M.,Scientific Center for Anti Infectious Drugs | Muradyan R.,Institute of Fine Organic Chemistry | Parsadanyan G.,Yerevan State Medical University | And 2 more authors.
Archive of Oncology | Year: 2011

Background: FS-1 is a complex of iodine and synthesized polysaccharides and it is very effective against a number of microbe and virus strains. The aim of the study was to evaluate possible genotoxic properties of FS-1. Methods: The compound was studied in rat and mouse bone marrow micronucleus (MN) assay and the comet assay in murine peripheral blood leukocytes, hepatocytes, and kidney cells. Two treatment protocols were applied, namely acute and subacute ones. In the first protocol, the compound was administered orally once and in subacute treatment two times, 24 h apart. The animals were sacrificed 24 h after the last treatment, and appropriate cells were used to assess DNA damage and MN induction. Results: In none of the tests (MN and comet assays) significant increase compared with respective negative controls was observed. Conclusion: The fact that the compound neither induces DNA damage in various organs of mice nor is effective in the induction of MN in bone marrow cells of rats and mice is important for future genotoxicity studies of FS-1, which can be used in clinical medicine after additional testing of safety for humans. © 2011, Oncology Institute of Vojvodina, Sremska Kamenica. Source

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