Science Signaling

New York City, DC, United States

Science Signaling

New York City, DC, United States
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VanHook A.M.,Science Signaling
Science signaling | Year: 2017

This week's article highlights the contribution of T cell reactivity to nonviral antigens to the success of adoptive T cell transfer in treating a virus-driven cancer. Copyright © 2017, American Association for the Advancement of Science.


Ferrarelli L.K.,Science Signaling
Science signaling | Year: 2017

This week's articles show that combining antiangiogenic therapy and immune checkpoint inhibition improves antitumor immunity. Copyright © 2017, American Association for the Advancement of Science.


Ferrarelli L.K.,Science Signaling
Science Signaling | Year: 2017

An active lifestyle in mice stimulates adrenergic signaling in the nervous system that enhances the function of antitumor natural killer cells.


Ferrarelli L.K.,Science Signaling
Science Signaling | Year: 2017

This week's articles describe a new hydrogel that promotes chronic wound healing and a way to limit intestinal tissue damage from radiation, chemo, or hematopoietic cell transplant therapies.


Mushegian A.A.,Science Signaling
Science Signaling | Year: 2017

A plant pathogen suppresses the host immune response by preventing histone acetylation.


VanHook A.M.,Science Signaling
Science Signaling | Year: 2017

This week's articles highlight a peptide that controls myoblast fusion; a metabolic adaptation that enables naked mole-rats to resist the detrimental effects of anoxia; a transcription factor that coordinates signaling in the mammary epithelial stem cell niche; and transgenerational epigenetic inheritance of the response to an environmental stimulus.


VanHook A.M.,Science Signaling
Science Signaling | Year: 2017

This week's articles show that vesicle fusion proteins are involved in long-term potentiation and highlight the structural properties that contribute to functional differences between angiotensin II receptors.


Van Hook A.M.,Science Signaling
Science Signaling | Year: 2017

Normal epithelial cells induce metabolic changes in neighboring transformed cells to force them out of the epithelium.


Foley J.F.,Science Signaling
Science Signaling | Year: 2013

This Focus Issue of Science Signaling, which complements the Science Special Issue on Inflammation, includes research that reveals regulators of a receptor implicated in an inflammatory bowel disease, as well as the contribution of a matrix metalloproteinase to skin inflammation. Perspectives discuss the role of proinflammatory cytokines in brain inflammatory disorders and the regulation of multiple types of cell death in tissues in response to proinflammatory factors. Together with content from the Science Signaling Archives, these articles underline the importance of understanding the basis of inflammatory responses that can both protect and harm the host. © 2013 American Association for the Advancement of Science.


Gough N.R.,Science Signaling
Science Signaling | Year: 2015

With contributions from the Board of Reviewing Editors and the Chief Scientific Editor, Science Signaling highlights some common concerns surrounding repro-ducibility and issues related to appropriate methodological considerations for accurately quantifying and then modeling regulatory phenomena. Specific topics include sources of error, understanding biological "n" and the application of appropriate statistical analyses, quantitative Western blotting, quantitative mass spectrometry-based proteomics, and parameterization for establishing quantitative models of cellular networks.

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