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Maia L.G.M.,Tiradentes University | Alves A.V.F.,Science and Technology Institute ITP | Bastos T.S.,Science and Technology Institute ITP | Moromizato L.S.,Science and Technology Institute ITP | And 5 more authors.
Journal of Photochemistry and Photobiology B: Biology | Year: 2014

Objective The purpose of this research was to evaluate the histological changes of the periodontal ligament and alveolar bone during dental movement in diabetic rats subjected to low level laser therapy (LLLT). Methods The movement of the upper molar was performed in 60 male Wistar rats divided into four groups (n = 15): CTR (control), DBT (diabetic), CTR/LT (irradiated control) and DBT/LT (irradiated diabetic). Diabetes was induced with alloxan (150 mg/kg, i.p.). LLLT was applied with GaAlAs laser at 780 nm (35 J/cm2). After 7, 13 and 19 days, the periodontal ligament and alveolar bone were histologically analyzed. Results The mean of osteoblasts (p < 0.01) and blood vessels (p < 0.05) were significantly decreased in DBT compared with CTR at 7 days, whereas the mean of osteoclasts was lower at 7 (p < 0.001) and 13 days (p < 0.05). In DBT/LT, only the mean of osteoclasts was lower than in CTR (p < 0.05) at 7 days, but no difference was observed at 13 and 19 days (p > 0.05). The collagenization of the periodontal ligament was impaired in DBT, whereas DBT/LLT showed density/disposition of the collagen fibers similar to those observed in CTR. Conclusions LLLT improved the periodontal ligament and alveolar bone remodeling activity in diabetic rats during dental movement. © 2014 Elsevier B.V. All rights reserved. Source

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