Science and Production Center Phytochemistry

Karagandy, Kazakhstan

Science and Production Center Phytochemistry

Karagandy, Kazakhstan
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Kulakov I.V.,Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan | Nurkenov O.A.,Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan | Turdybekov D.M.,Science and Production Center Phytochemistry | Mahmutova A.S.,Science and Production Center Phytochemistry | And 3 more authors.
Chemistry of Heterocyclic Compounds | Year: 2010

Optimal conditions were found for the synthesis of a number of new N-aminoglycosides of the alkaloid cytisine, using commercially available monosaccharides, namely, D-glucose, D-galactose, D-xylose, and L-arabinose. X-ray structural analysis indicated an absolute β-anomeric configuration of N-(β-D-galactopyranosyl)cytisine in the crystalline state. The comparative cytotoxicity of cytisine and some of its N-aminoglycosides was determined. © 2010 Springer Science+Business Media, Inc.

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