Kulakov I.V.,Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan |
Nurkenov O.A.,Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan |
Turdybekov D.M.,Science and Production Center Phytochemistry |
Mahmutova A.S.,Science and Production Center Phytochemistry |
And 3 more authors.
Chemistry of Heterocyclic Compounds | Year: 2010
Optimal conditions were found for the synthesis of a number of new N-aminoglycosides of the alkaloid cytisine, using commercially available monosaccharides, namely, D-glucose, D-galactose, D-xylose, and L-arabinose. X-ray structural analysis indicated an absolute β-anomeric configuration of N-(β-D-galactopyranosyl)cytisine in the crystalline state. The comparative cytotoxicity of cytisine and some of its N-aminoglycosides was determined. © 2010 Springer Science+Business Media, Inc.