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Columbia, MD, United States

Patent
Science and Engineering Services, Inc. | Date: 2010-05-21

A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.


Patent
Science and Engineering Services, Inc. | Date: 2011-09-16

A liquid chromatography interface is provided having an integrated column/ESI tip assembly including a liquid chromatography separation column, an ESI tip for generating ions having at least one emitting channel, and a temperature-controlled enclosure surrounding the liquid chromatography separation column. The enclosure has at least one opening and the ESI tip is exposed outside the enclosure through the opening. The enclosure has a heating or cooling device providing a substantially homogeneous distribution of temperature throughout an internal space of the enclosure where the liquid chromatography separation column is disposed. The enclosure includes at least one gas flow mixing element to permit heat exchange by directing a flow of gas toward the ESI tip. The integrated column/ESI tip assembly resides within a thermo-stabilized volume of substantially the same temperature from an entrance of the liquid chromatography separation column to the outlet of the ESI tip.


Grant
Agency: Department of Defense | Branch: Office for Chemical and Biological Defense | Program: SBIR | Phase: Phase II | Award Amount: 749.99K | Year: 2009

We propose to build in Phase II a compact, rugged laser photoacoustic spectrometric (L-PAS) prototype sensor system (at technology readiness level TRL-6) for continuous, real-time broadband analysis of multiple chemicals. It will incorporate a tunable infrared quantum cascade laser (QCL), photoacoustic cell and air sampler system in a sealed decontamination-capable module and an efficient algorithm for rapid high sensitivity, multi-component CW agent measurements in under a minute. In Phase I we have utilized a laboratory L-PAS instrument to successfully demonstrate feasibility through CWA simulant measurements in clean dry air and with multiple interferents. Several developments crucial for building compact field-usable sensor were completed, including: room temperature continuous-wave QCL in 9.5-10.5µm range with >100mW output; single mode operation; mode-hop-free multi-step laser tuning over ~700nm wavelength range in


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 100.00K | Year: 2009

DESCRIPTION (provided by applicant): The purpose of this proposal is to develop novel hybrid ion mobility - FTICR instrument. Such combination using a novel ion mobility separation method is thought to extend the range of capabilities of the conventional Fourier transform ion cyclotron resonance (FT-ICR) technique as well as establishing novel ways of utilizing the powerful FT-ICR instrumentation in the fields of glycomics and elucidation of the protein conformation and structure. PUBLIC HEALTH RELEVANCE: We propose new hybrid ion mobility - mass spectrometer device with unique high resolution capabilities.


Grant
Agency: Department of Defense | Branch: Defense Advanced Research Projects Agency | Program: SBIR | Phase: Phase I | Award Amount: 98.53K | Year: 2009

An elastic backscatter lidar operating at a covert wavelength in the ultraviolet can be employed to perform high-precision three-dimensional pointing and tracking of small UAV targes in a tactical environment. Imaging of the rapidly pulsing lidar beam will control the airspace by acquiring a hard target return from any solid object in the airspace above a threshold that is well-below the cross-section of even a very small UAV. Detection of targets by wide-field and narrow-field passive optical sensors in the proposed sensor will hand-off to auto-tracking based on the lidar return. Boresighted imagery of the passive sensors will be used during both daytime and nighttime to confirm detection and destruction of the small UAV. The lidar beam and its imaging is solar blind. A coude optical system in the idar telescope mount will serve for laser beam weapon delivery. It is boresighted to the lidar and passive optical sensors.

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