Schulke and Mayr GmbH

Norderstedt, Germany

Schulke and Mayr GmbH

Norderstedt, Germany
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Muller G.,University of Greifswald | Langer J.,Robert Koch Institute | Siebert J.,Schulke and Mayr GmbH | Kramer A.,University of Greifswald
Skin Pharmacology and Physiology | Year: 2013

The objective of the present investigation was to examine the residual antimicrobial activity after a topical exposure of reconstructed human epidermis (RHE) to equimolar solutions of either chlorhexidine digluconate (CHG, 0.144% w/v) or octenidine dihydrochloride (OCT, 0.1% w/v) for 15 min. RHE-associated antiseptic agents were more effective on Staphylococcus aureus than on Pseudomonas aeruginosa. S. aureus was not detected after 24 h of contact, which demonstrated a microbicidal efficacy of greater than 5-log10 reduction. In contrast, P. aeruginosa was reduced by approximately 2 log 10 at the same incubation time, which parallels the growth of the initial inoculum. This result could be interpreted either as a microbiostatic effect or as an adherence of P. aeruginosa to a low positively charged surface. Small amounts of CHG and OCT can penetrate the stratum corneum. Using these antiseptic agents, the viability of keratinocytes was reduced to 65-75% of that of the untreated RHE control following 24 h incubation in the presence of test microorganisms. With consideration of antimicrobial activity and cytotoxic effect, OCT corresponds better to a biocompatible antiseptic agent than CHG. © 2013 S. Karger AG, Basel.


Streek M.,Schulke and Mayr GmbH
Oil Gas European Magazine | Year: 2014

This article describes the development and the current status of the legal framework for placing biocides in the European market. Due to increasing requirements on the toxicological and eco-toxicological properties of biocidal actives the number of available biocidal active substances for oil & gas applications has decreased dramatically. © 2014 URBAN-VERLAG Hamburg/Wien GmbH.


Vanscheidt W.,Paula Modersohn Platz 3 | Harding K.,University of Cardiff | Teot L.,Hopital Lapeyronie | Siebert J.,Schulke and Mayr GmbH
International Wound Journal | Year: 2012

The aim of this study was to evaluate the cytotoxic effect of octenidine dihydrochloride/phenoxyethanol (OHP) found in vitro by conducting a randomized, double-blind controlled clinical study focusing on its safe and effective use in chronic venous leg ulcers. In total, 126 male and female patients were treated with either OHP (n = 60) or Ringer solution (n = 66). The treatment lasted over a period of maximum 12 weeks. For the assessment of the wound-healing process, clinical outcome parameters were employed, that is, time span until 100% epithelization, wound status and the wound surface area were analysed. Side effects were recorded during the study period. The median time to complete ulcer healing was comparable between the OHP and Ringer solution groups (92 versus 87 days; P = 0·952), without being influenced by wound size or duration of the target ulcer (P-values: 0·947/0·978). In patients treated with OHP, fewer adverse events (AEs) were observed compared with the Ringer group (17% versus 29% of patients reported 20 versus 38 AEs). OHP is well suitable for the treatment of chronic wounds without cytotoxic effects. Furthermore, OHP does not impair the wound healing in chronic venous ulcers. © 2011 The Authors. © 2011 Blackwell Publishing Ltd and Medicalhelplines.com Inc.


Siegert W.,Schulke and Mayr GmbH
Tribologie und Schmierungstechnik | Year: 2014

Technical and hygienic problems originating from micro-organism invasion and growth when using wa-ter-mixed metal working fluids still affect users today and have to be prevented. There are many ways in which micro-organisms can invade the freshly prepared water-mixed metal working fluid, e. g. through dirty water, waste, tramp oils, air, the work-piece, operating personnel and inadequate industrial and production hygiene. One of the important measures can in general be sum- , marised under the heading of preservation. The aim of preservation is to protect a given product or medium against microbial material degradation for a sufficiently long period of time in the prevailing local con-ditions. The most widely used control method today is chemi-cal preservation using antimicrobial chemicals.


Hubner N.-O.,University of Greifswald | Siebert J.,Schulke and Mayr GmbH | Kramer A.,University of Greifswald
Skin Pharmacology and Physiology | Year: 2010

Octenidine dihydrochloride (octenidine) was introduced for skin, mucous membrane and wound antisepsis more than 20 years ago. Until now, a wealth of knowledge has been gained, including in vitro and animal studies on efficacy, tolerance, safety and clinical experience both from case reports and prospective controlled trials. Nowadays, octenidine is an established antiseptic in a large field of applications and represents an alternative to older substances such as chlorhexidine, polyvidone-iodine or triclosan. The review is based on the current literature and unpublished original data as well. © 2010 S. Karger AG.


Hentz M.,Schulke and Mayr GmbH
European Coatings Journal | Year: 2013

Many waterborne coating and adhesive systems are susceptible to microbiological spoilage. The common isothiozolinone mixture of MIT and BIT provides very effective long-term action, but it can be slow to become effective. Bis(3-aminopropyl) dodecylamine (BDA) is shown to operate synergistically with MIT/BIT and offers an effective way to overcome this weakness.


Koburger T.,Hygiene North GmbH | Hubner N.-O.,University of Greifswald | Braun M.,Schulke and Mayr GmbH | Siebert J.,Schulke and Mayr GmbH | Kramer A.,University of Greifswald
Journal of Antimicrobial Chemotherapy | Year: 2010

Background: This study presents a comparative investigation of the antimicrobial efficacy of the antiseptics PVP-iodine, triclosan, chlorhexidine, octenidine and polyhexanide used for pre-surgical antisepsis and antiseptic treatment of skin, wounds and mucous membranes based on internationally accepted standards. Methods: MICs and MBCs were determined in accordance with DIN 58940-7 and 58940-8 using Staphylococcus aureus (including methicillin-resistant Staphylococcus aureus), Enterococcus faecalis (including vancomycin-resistant Enterococcus), Streptococcus pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Clostridium perfringens, Haemophilus influenzae and Candida albicans. The microbicidal efficacy was determined in accordance with DIN EN 1040 and 1275 using S. aureus, P. aeruginosa and C. albicans. Results: For chlorhexidine, octenidine and polyhexanide, MIC48 and MBC24 ranged from 16 to 32 mg/L. Maximum values for triclosan ranged from 256 to 512 mg/L, with an efficacy gap against P. aeruginosa, while the maximum values of PVP-iodine were 1024 mg/L, with a gap against S. pneumoniae. Comparing the minimal effective concentrations, octenidine was most effective. After 1 min, only octenidine and PVP-iodine fulfil the requirements for antiseptics. Conclusions: Tests under standardized and harmonized conditions help to choose the most efficacious agent. When a prolonged contact time is feasible, ranking of agents would be polyhexanide=octenidine> chlorhexidine>triclosan>PVP-iodine. This is consistent with the recommendations for antisepsis of acute wounds. Polyhexanide seems to be preferable for chronic wounds due to its higher tolerability. If an immediate effect is required, ranking would be octenidine=PVP-iodine≫polyhexanide>chlorhexidine>triclosan. © The Author 2010.


Jorge A.C.G.,Schulke and Mayr GmbH
IASH 2015 - 14th International Symposium on Stability, Handling and Use of Liquid Fuels | Year: 2015

The active 3,3'-Methylenebis[5-methyloxazolidine], also known as MBO has been widely used in Europe since 1976. It is now available in the USA where a microbicide containing CMI/MI is already broadly used since decades. How are both biocidal actives in comparison in regards of their efficacy against microorganism and their properties as fuel additive in ULSD? MBO can now be used for the US fuel market for treating ULSD. It is free of sulfur and chlorine and provides further physical and chemical properties which is beneficial for the use as an fuel additive. These properties will be compared with the active known as CMI/MI which is a mixture of 5-chloro-2-methyl-3-(2H)-isothiazolone (CMI) and 2-methyl-3-(2H)-isothiazolone. It is mainly used in the product as a solution. Furthermore the latest ASTM E1259-10 test result shows the efficacy of MBO and CMI/MI in ULSD (B20) in the lowest and highest recommended dose rate.


Goroncy-Bermes P.,Schulke and Mayr GmbH | Koburger T.,Hygiene Nord GmbH | Meyer B.,Ecolab
Journal of Hospital Infection | Year: 2010

Two different hand rubs were tested in order to investigate the minimum volume required for microbicidal efficacy according to the European Norm EN 1500; we also sought to determine whether there is a correlation with hand size. Eight male volunteers with big hands (mean 184 cm2) and eight female volunteers with significantly smaller hands (mean 148 cm2; P < 0.001) participated in our study. Application of 2 mL of both products (P) provided mean log10 reductions significantly smaller than those of the reference disinfectant (R) (product A: P = 3.34, R = 4.00, P = 0.001; product B: P = 3.37, R = 3.75, P = 0.022). Higher volumes (product A: 3 and 4 mL; product B: 2.5, 3 and 4 mL) ensured that the pass criteria of the European Norm (EN) 1500 were fulfilled. For both products log10 reductions increased with increasing product volume until a plateau was reached. For the smaller female hands, this plateau level was reached after applying 3 mL of product A and 2.5 mL of product B. The plateau level on male hands was observed after treating the hands with ≥4 mL of product A and 3 mL of product B. The increase in product volume also correlated with the decrease in the number of volunteers considering the product volume applied as insufficient. In conclusion, the applied volume for hygienic hand rub should not fall below 3 mL in order to achieve maximum benefit. © 2009 The Hospital Infection Society.


WiseGuyReports.Com Publish a New Market Research Report On – “Chemicals for Cosmetics and Toiletries Market Global Potential Growth,Share,Demand and Analysis Of Key Players Research Report Forecasts to 2021”. This report studies Chemicals for Cosmetics and Toiletries in Global market, especially in North America, Europe, China, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with capacity, production, price, revenue and market share for each manufacturer, covering  BASF?  AkzoNobel  Evonik Industries  Solvay-Rhodia  Stepan  Bayer  Eastman Chemical  Honeywell International  Shell Chemicals  J.M. Huber  Arkema  Merck  Pilot Chemical  Royal DSM  Schulke and Mayr  Viva Corp  Wacker Chemie  Biochemica International  Fenchem Biotek  Gyan Flavours Export  Hubei Xiangxi Chemical Industry For more information or any query mail at [email protected] Market Segment by Regions, this report splits Global into several key Regions, with production, consumption, revenue, market share and growth rate of Chemicals for Cosmetics and Toiletries in these regions, from 2011 to 2021 (forecast), like  North America  Europe  China  Japan  Southeast Asia  India Split by product type, with production, revenue, price, market share and growth rate of each type, can be divided into  Type I  Type II  Type III Split by application, this report focuses on consumption, market share and growth rate of Chemicals for Cosmetics and Toiletries in each application, can be divided into  Application 1  Application 2  Application 3 Global Chemicals for Cosmetics and Toiletries Market Research Report 2016  1 Chemicals for Cosmetics and Toiletries Market Overview  1.1 Product Overview and Scope of Chemicals for Cosmetics and Toiletries  1.2 Chemicals for Cosmetics and Toiletries Segment by Type  1.2.1 Global Production Market Share of Chemicals for Cosmetics and Toiletries by Type in 2015  1.2.2 Type I  1.2.3 Type II  1.2.4 Type III  1.3 Chemicals for Cosmetics and Toiletries Segment by Application  1.3.1 Chemicals for Cosmetics and Toiletries Consumption Market Share by Application in 2015  1.3.2 Application 1  1.3.3 Application 2  1.3.4 Application 3  1.4 Chemicals for Cosmetics and Toiletries Market by Region  1.4.1 North America Status and Prospect (2011-2021)  1.4.2 Europe Status and Prospect (2011-2021)  1.4.3 China Status and Prospect (2011-2021)  1.4.4 Japan Status and Prospect (2011-2021)  1.4.5 Southeast Asia Status and Prospect (2011-2021)  1.4.6 India Status and Prospect (2011-2021)  1.5 Global Market Size (Value) of Chemicals for Cosmetics and Toiletries (2011-2021) 2 Global Chemicals for Cosmetics and Toiletries Market Competition by Manufacturers  2.1 Global Chemicals for Cosmetics and Toiletries Capacity, Production and Share by Manufacturers (2015 and 2016)  2.2 Global Chemicals for Cosmetics and Toiletries Revenue and Share by Manufacturers (2015 and 2016)  2.3 Global Chemicals for Cosmetics and Toiletries Average Price by Manufacturers (2015 and 2016)  2.4 Manufacturers Chemicals for Cosmetics and Toiletries Manufacturing Base Distribution, Sales Area and Product Type  2.5 Chemicals for Cosmetics and Toiletries Market Competitive Situation and Trends  2.5.1 Chemicals for Cosmetics and Toiletries Market Concentration Rate  2.5.2 Chemicals for Cosmetics and Toiletries Market Share of Top 3 and Top 5 Manufacturers  2.5.3 Mergers & Acquisitions, Expansion 7 Global Chemicals for Cosmetics and Toiletries Manufacturers Profiles/Analysis  7.1 BASF?  7.1.1 Company Basic Information, Manufacturing Base and Its Competitors  7.1.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.1.2.1 Type I  7.1.2.2 Type II  7.1.3 BASF? Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.1.4 Main Business/Business Overview  7.2 AkzoNobel  7.2.1 Company Basic Information, Manufacturing Base and Its Competitors  7.2.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.2.2.1 Type I  7.2.2.2 Type II  7.2.3 AkzoNobel Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.2.4 Main Business/Business Overview  7.3 Evonik Industries  7.3.1 Company Basic Information, Manufacturing Base and Its Competitors  7.3.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.3.2.1 Type I  7.3.2.2 Type II  7.3.3 Evonik Industries Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.3.4 Main Business/Business Overview  7.4 Solvay-Rhodia  7.4.1 Company Basic Information, Manufacturing Base and Its Competitors  7.4.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.4.2.1 Type I  7.4.2.2 Type II  7.4.3 Solvay-Rhodia Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.4.4 Main Business/Business Overview  7.5 Stepan  7.5.1 Company Basic Information, Manufacturing Base and Its Competitors  7.5.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.5.2.1 Type I  7.5.2.2 Type II  7.5.3 Stepan Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.5.4 Main Business/Business Overview  7.6 Bayer  7.6.1 Company Basic Information, Manufacturing Base and Its Competitors  7.6.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.6.2.1 Type I  7.6.2.2 Type II  7.6.3 Bayer Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.6.4 Main Business/Business Overview  7.7 Eastman Chemical  7.7.1 Company Basic Information, Manufacturing Base and Its Competitors  7.7.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.7.2.1 Type I  7.7.2.2 Type II  7.7.3 Eastman Chemical Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.7.4 Main Business/Business Overview  7.8 Honeywell International  7.8.1 Company Basic Information, Manufacturing Base and Its Competitors  7.8.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.8.2.1 Type I  7.8.2.2 Type II  7.8.3 Honeywell International Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.8.4 Main Business/Business Overview  7.9 Shell Chemicals  7.9.1 Company Basic Information, Manufacturing Base and Its Competitors  7.9.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.9.2.1 Type I  7.9.2.2 Type II  7.9.3 Shell Chemicals Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.9.4 Main Business/Business Overview  7.10 J.M. Huber  7.10.1 Company Basic Information, Manufacturing Base and Its Competitors  7.10.2 Chemicals for Cosmetics and Toiletries Product Type, Application and Specification  7.10.2.1 Type I  7.10.2.2 Type II  7.10.3 J.M. Huber Chemicals for Cosmetics and Toiletries Capacity, Production, Revenue, Price and Gross Margin (2015 and 2016)  7.10.4 Main Business/Business Overview  7.11 Arkema  7.12 Merck  7.13 Pilot Chemical  7.14 Royal DSM  7.15 Schulke and Mayr  7.16 Viva Corp  7.17 Wacker Chemie  7.18 Biochemica International  7.19 Fenchem Biotek  7.20 Gyan Flavours Export  7.21 Hubei Xiangxi Chemical Industry For more information or any query mail at [email protected] Wise Guy Reports is part of the Wise Guy Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe. Wise Guy Reports features an exhaustive list of market research reports from hundreds of publishers worldwide. 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