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Norderstedt, Germany

Muller G.,University of Greifswald | Langer J.,Robert Koch Institute | Siebert J.,Schulke and Mayr GmbH | Kramer A.,University of Greifswald
Skin Pharmacology and Physiology | Year: 2013

The objective of the present investigation was to examine the residual antimicrobial activity after a topical exposure of reconstructed human epidermis (RHE) to equimolar solutions of either chlorhexidine digluconate (CHG, 0.144% w/v) or octenidine dihydrochloride (OCT, 0.1% w/v) for 15 min. RHE-associated antiseptic agents were more effective on Staphylococcus aureus than on Pseudomonas aeruginosa. S. aureus was not detected after 24 h of contact, which demonstrated a microbicidal efficacy of greater than 5-log10 reduction. In contrast, P. aeruginosa was reduced by approximately 2 log 10 at the same incubation time, which parallels the growth of the initial inoculum. This result could be interpreted either as a microbiostatic effect or as an adherence of P. aeruginosa to a low positively charged surface. Small amounts of CHG and OCT can penetrate the stratum corneum. Using these antiseptic agents, the viability of keratinocytes was reduced to 65-75% of that of the untreated RHE control following 24 h incubation in the presence of test microorganisms. With consideration of antimicrobial activity and cytotoxic effect, OCT corresponds better to a biocompatible antiseptic agent than CHG. © 2013 S. Karger AG, Basel.

In summary it can be stated that a systematic and structured approach is absolutely vital if defects occur in the surgical instruments' reprocessing circuit. This is the only way to quickly and reliably identify the cause. The nature and scope of changes should be taken account of here. Based on this, different parameters of the entire instrument circuit must be checked, queried and optimized, if necessary. The experiences gleaned over several years in this field reveal that problems and causes can be of a manifold nature and the countermeasures taken must be carefully pondered. An action guide, adapted to the respective reprocessing establishment, is a valuable tool for assuring a systematic and structured procedure.

Vanscheidt W.,Paula Modersohn Platz 3 | Harding K.,University of Cardiff | Teot L.,Hopital Lapeyronie | Siebert J.,Schulke and Mayr GmbH
International Wound Journal | Year: 2012

The aim of this study was to evaluate the cytotoxic effect of octenidine dihydrochloride/phenoxyethanol (OHP) found in vitro by conducting a randomized, double-blind controlled clinical study focusing on its safe and effective use in chronic venous leg ulcers. In total, 126 male and female patients were treated with either OHP (n = 60) or Ringer solution (n = 66). The treatment lasted over a period of maximum 12 weeks. For the assessment of the wound-healing process, clinical outcome parameters were employed, that is, time span until 100% epithelization, wound status and the wound surface area were analysed. Side effects were recorded during the study period. The median time to complete ulcer healing was comparable between the OHP and Ringer solution groups (92 versus 87 days; P = 0·952), without being influenced by wound size or duration of the target ulcer (P-values: 0·947/0·978). In patients treated with OHP, fewer adverse events (AEs) were observed compared with the Ringer group (17% versus 29% of patients reported 20 versus 38 AEs). OHP is well suitable for the treatment of chronic wounds without cytotoxic effects. Furthermore, OHP does not impair the wound healing in chronic venous ulcers. © 2011 The Authors. © 2011 Blackwell Publishing Ltd and Medicalhelplines.com Inc.

Siegert W.,Schulke and Mayr GmbH
Tribologie und Schmierungstechnik | Year: 2014

Technical and hygienic problems originating from micro-organism invasion and growth when using wa-ter-mixed metal working fluids still affect users today and have to be prevented. There are many ways in which micro-organisms can invade the freshly prepared water-mixed metal working fluid, e. g. through dirty water, waste, tramp oils, air, the work-piece, operating personnel and inadequate industrial and production hygiene. One of the important measures can in general be sum- , marised under the heading of preservation. The aim of preservation is to protect a given product or medium against microbial material degradation for a sufficiently long period of time in the prevailing local con-ditions. The most widely used control method today is chemi-cal preservation using antimicrobial chemicals.

Hentz M.,Schulke and Mayr GmbH
European Coatings Journal | Year: 2013

Many waterborne coating and adhesive systems are susceptible to microbiological spoilage. The common isothiozolinone mixture of MIT and BIT provides very effective long-term action, but it can be slow to become effective. Bis(3-aminopropyl) dodecylamine (BDA) is shown to operate synergistically with MIT/BIT and offers an effective way to overcome this weakness.

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