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Greenville, WI, United States

Halsby K.D.,Public Health England | Walsh A.L.,Public Health England | Campbell C.,Hospital Universitari Germans Trias jol | Hewitt K.,Public Health England | And 2 more authors.
PLoS ONE | Year: 2014

Background: Around 67 million pets are owned by households in the United Kingdom, and an increasing number of these are exotic animals. Approximately a third of pets are purchased through retail outlets or direct from breeders. A wide range of infections can be associated with companion animals. Objectives: This study uses a systematic literature review to describe the transmission of zoonotic disease in humans associated with a pet shop or other location selling pets (incidents of rabies tracebacks and zoonoses from pet food were excluded). Data sources: PubMed and EMBASE. Results: Fifty seven separate case reports or incidents were described in the 82 papers that were identified by the systematic review. Summary information on each incident is included in this manuscript. The infections include bacterial, viral and fungal diseases and range in severity from mild to life threatening. Infections associated with birds and rodents were the most commonly reported. Over half of the reports describe incidents in the Americas, and three of these were outbreaks involving more than 50 cases. Many of the incidents identified relate to infections in pet shop employees. Limitations: This review may have been subject to publication bias, where unusual and unexpected zoonotic infections may be over-represented in peer-reviewed publications. It was also restricted to English-language articles so that pathogens that are more common in non-Western countries, or in more exotic animals not common in Europe and the Americas, may have been under-represented. Conclusions/implications: A wide spectrum of zoonotic infections are acquired from pet shops. Salmonellosis and psittacosis were the most commonly documented diseases, however more unusual infections such as tularemia also appeared in the review. Given their potential to spread zoonotic infection, it is important that pet shops act to minimise the risk as far as possible. © 2014 Halsby et al.

Jin Y.-M.,Jilin University | Xu T.-M.,Jilin University | Zhao Y.-H.,School Specialty | Wang Y.-C.,Jilin University | Cui M.-H.,Jilin University
Tumor Biology | Year: 2014

Worldwide, cervical cancer (CC) is the third most common malignancy in women, and it remains a leading cause of cancer-related death of women. Genomic studies indicate that phosphoinositide 3-kinase (PI3K)/AKT signaling is one of the most frequently deregulated pathways in several human cancers, including CC. This signaling pathway has an important role in cancer cell proliferation, survival, motility, and metabolism, and therefore could be an attractive therapeutic target. In a previous study, we used a sensitive and high-speed homogeneous assay for the detection of kinase activity and for screening of PI3K/AKT signaling inhibitors in a high-throughput screening (HTS) format and then obtain formononetin, as an O-methylated isoflavone existed in a number of plants and herbs like Astragalus membranaceus. We showed that formononetin inhibited the phosphorylation of AKT and induced the apoptosis of CC cell line HeLa in a dose-dependent manner. Furthermore, formononetin suppressed xenograft tumor growth in nude mice. Our results indicated that formononetin may be used as an anti-cancer drug for cervical cancer in the future. © 2013 International Society of Oncology and BioMarkers (ISOBM).

Zhou Z.,Zhanjiang Normal University | Fu C.,School Specialty
Chemistry of Natural Compounds | Year: 2013

A new flavanone, for which the structure 7,8-dihydroxy-5,6- methylenedioxyflavone (1) was established, and five known compounds, quercetin (2), kaempferol (3), luteolin (4), ginkgetin (5), and isoginkgetin (6), were isolated from the rhizomes of Cyperus rotundus L. The new compound 1 showed inhibitory activity in superoxide radical scavenging assay with IC50 value of 3.1 μM. Compounds 2-6 exhibited antioxidant activity in scavenging DPPH and superoxide radicals with IC50 values ranging from 3.1 to 23.7 μM. © 2013 Springer Science+Business Media New York.

School Specialty | Date: 2014-10-20

In one embodiment, a light-emitting pompon including a handle, a plurality of flexible streamers, and a plurality of elongate light-emitting objects is provided. The handle may include a first end and a second end and the plurality of streamers may extend from the first end of the handle. The plurality of elongate light-emitting objects may extend from the first end of the handle. In some embodiments, the plurality of elongate light-emitting objects may be flexible. A light source may be disposed in the handle. The light source may be configured to emit light towards the first end of the handle such that the emitted light enters into and is dispersed out of the plurality of light-emitting objects. In some embodiments, the light source may be spaced from the plurality of elongate light-emitting objects.

News Article | February 4, 2014
Site: www.prweb.com

Zilliant, an optimization company that helps businesses make better pricing and sales decisions, today announced that the company achieved record-breaking growth in 2013. Zilliant’s success is accelerating because of its software-as-as-service (SaaS) model and the new Zilliant Optimization Platform, which enables industry-leading implementation times for its MarginMax and SalesMax applications to deliver better financial results to customers faster. “Companies are beginning to recognize that to overcome the massive complexity in their businesses, they need to rely on optimization models to make sales and pricing decisions,” said Greg Peters, president and CEO of Zilliant. “As demand for sales and price optimization solutions increases, we’re staying committed to product innovation to help customers achieve stronger financial results at a faster rate.” With the launch of MarginMax 8.0 on the new Zilliant Optimization Platform, Zilliant can deliver market-aligned prices to customers in less than 90 days. Zilliant is now the only company offering a “true SaaS,” multi-tenant B2B optimization platform in the marketplace. Zilliant increased market share in existing industry verticals and expanded into new markets with wins throughout Europe, South America and Asia. New customers in 2013 include: Brady WPS, School Specialty and Horizon Milling. “Optimization models are the only way to answer key questions such as which products and markets offer the greatest growth potential, where pricing and strategy are misaligned, and how to manage cost volatility and capacity allocation,” Peters said. “But the real gains come from transforming these insights into actionable guidance for front-line sales and marketing decision makers, which is where Zilliant excels.” About Zilliant Zilliant provides B2B companies with data-driven guidance, enabling better pricing and sales decisions to help businesses make their numbers. The Zilliant Optimization Platform uses advanced science in its price optimization, cross-sell and retention applications to enable companies to overcome the massive complexity in their businesses. Our flexible SaaS model allows customers to quickly and confidently improve their financial performance by integrating into existing systems and processes. Learn more about how Zilliant helps companies price more profitably and sell more effectively at http://www.zilliant.com.

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