Schepens Eye Research Institute

Boston, United States

Schepens Eye Research Institute

Boston, United States

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Patent
Schepens Eye Research Institute | Date: 2015-03-19

The disclosure features systems for providing information to a user about the users environment, the system featuring a detection apparatus configured to obtain image information about the environment, where the image information corresponds to information at multiple distances relative to a position of the user within the environment, and an electronic processor configured to obtain focal plane distance information defining a set of one or more distance values relative to the position of the user within the environment, construct one or more confocal images of the environment, from the image information and the set of one or more distance values, wherein each of the one or more confocal images corresponds to a different distance value and comprises a set of pixels, and transform the one or more confocal images to form one or more representative images comprising fewer pixels and a lower dynamic range.


Patent
Schepens Eye Research Institute | Date: 2015-07-17

Systems, apparatus, and methods are provided for quantifying inter-ocular suppression in binocular vision impairment. The systems, apparatus, and methods may include a stimulus presentation device and a controller which present different stimuli to each eye of a patient. The stimuli can include letters, numbers, or shapes which are arranged in rows, and columns with a stimulus presented to each eye in a location corresponding a stimulus presented to the other eye. The combined contrast of corresponding stimuli equals a predetermined value, and this contrast can be adjusted with each iteration of stimuli presented. This adjustment can be based upon the patients reports of what is seen and adjustments made by an algorithm executed by the controller. Suppression can thus be determined in terms of visual field location and quantified.


Patent
Schepens Eye Research Institute | Date: 2016-11-18

Systems, apparatus, and methods are provided for quantifying inter-ocular suppression in binocular vision impairment. The systems, apparatus, and methods may include a stimulus presentation device and a controller which present different stimuli to each eye of a patient. The stimuli can include letters, numbers, or shapes which are arranged in rows, and columns with a stimulus presented to each eye in a location corresponding a stimulus presented to the other eye. The combined contrast of corresponding stimuli equals a predetermined value, and this contrast can be adjusted with each iteration of stimuli presented. This adjustment can be based upon the patients reports of what is seen and adjustments made by an algorithm executed by the controller. Suppression can thus be determined in terms of visual field location and quantified.


Patent
Massachusetts Eye, Ear Infirmary and Schepens Eye Research Institute | Date: 2016-10-12

Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.


Patent
Schepens Eye Research Institute | Date: 2016-06-10

The invention provides compositions and methods for utilizing endomucin as an anti-inflammatory agent.


Patent
Schepens Eye Research Institute | Date: 2015-06-05

This present invention provides compositions and methods for treating cancer and immune inflammatory disorders by modulating EMR2 signaling pathway.


Patent
Schepens Eye Research Institute | Date: 2016-03-29

Described herein are materials and methods of treating dry eye disease in a subject.


Patent
The Regents Of The University Of California and Schepens Eye Research Institute | Date: 2016-04-06

The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or an undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface. The pharmaceutical composition of the present invention comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The pharmaceutical composition of the present invention may also comprise one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent, excipient, astringent, vasoconstrictor, emollient, sodium hyaluronate, hyaluronic acid, and surface active phospholipids, in a pharmaceutically acceptable carrier for topical administration.


Patent
Schepens Eye Research Institute | Date: 2016-03-07

The invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-17 and methods for using this composition to treat IL-17-mediated ocular inflammatory disorders. The invention also discloses devices for delivering this composition to the eye.


Patent
Massachusetts Eye, Ear Infirmary and Schepens Eye Research Institute | Date: 2016-04-11

Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.

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