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Dravid M.N.,SBH Government Medical College | Phute S.U.,SBH Government Medical College | Khadse R.K.,SBH Government Medical College | Adchitre H.R.,SBH Government Medical College | Kulkarni S.D.,SBH Government Medical College
Journal of Hospital Infection | Year: 2012

Climate change and the depletion of fossil fuels have forced the developed world to look for clean energy alternatives. Solar cooking is developing in Asian and African countries blessed with ample sun, but is still at an early stage. A portable autoclave was developed in India using this technology. The Prince-40 Concentrator provided adequate capacity to autoclave culture media and treat biomedical waste in a small laboratory set-up, and could save electricity worth Rs. 15,000 (188.10 GBP)/year or LPG worth Rs. 37,500 (470.25 GBP)/year. This technology would be of immense use in health centres in rural areas with frequent power cuts or no power supply. © 2012 The Healthcare Infection Society.


Shrigiriwar M.B.,Svn Government Medical College | Gadhari R.K.,Sbh Government Medical College | Jadhao V.T.,B J Medical College | Tingne C.T.,Indira Gandhi Government Medical College | Kumar N.B.,Indira Gandhi Government Medical College
Journal of Indian Academy of Forensic Medicine | Year: 2014

In Nagpur region of Maharashtra (India), many deaths were reported due to lightning strikes. In most cases of deaths due to lightning, bodies of deceased persons were found in remote areas with torn clothes and burn injuries. The injuries present over body may apprehend the relatives and raise suspicion of foul play. In this study total 31 cases were studied which were brought for medico legal post-mortem with history of lightning of which 87% were farmers and farm labourers. Twenty nine percent of cases belonged to the age group of 41-50 years. Most of the cases were found in the months of June, July and October. Filigree burns were found only in 4 cases. Careful examination of victims along with history of thunderstorm in the vicinity will help the autopsy surgeon to confirm the diagnosis of lightning.


Mane A.Y.,Saraswati Institute of Medical science | Bhagwat V.R.,SBH Government Medical College
Biomedicine | Year: 2011

Baackground and objectives: Thyroid disorders often accompany abnormal serumenzyme levels and disturbances in liver functions. This study was done to assessrelationship between serum enzymes and liver functions in thyroid disorders. Methods: Serum levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and creatine Phosphokinase (CPK) were determined by uv-kinetic methods in 94 thyroid patients and 71 euthyroid controls. Serum total bilirubin, total protein and albumin were also assayed by colorimetric methods. Results: Serum AST and ALT levels were significantly higher while ALP was significantly low in hypothyroidism. Transaminases levels in hypothyroid patients were more than the upper limits of normal range. The serum ALP activity was found to be highest in hyperthyroid patients compared to hypothyroids and the controls. There is an inverse relation of serum triiodothyronine and CPK levels in hypothyroid disease. In hypothyroid patients mean CPK level was significantly higher by 4.2 times that of the controls. Conclusion: The results indicate that liver functions in both hypo and hyperthyroid patients are normal. Marginally elevated AST and ALT levels point to muscle dysfunction while high ALP level in hyperthyroids suggests disturbance in bone homeostasis. Serum CPK assay together with thyroid profile increases diagnostic sensitivity in subclinical hypothyroidism.


Mane A.Y.,Saraswathi Institute of Medical science | Bhagwat V.R.,SBH Government Medical College
International Journal of Pharma and Bio Sciences | Year: 2012

Thyroid hormones affect bone metabolism by altering normal bone remodeling processes. This study involved assessment of biochemical markers of bone turnover in 94 patients with thyroid dysfunction. Clear hypocalcaemia was observed in hypothyroidism while in hyperthyroid patients there was frank hypercalcaemia. In hyperthyroidism there is increased activity of osteoclast which leads to increased bone turnover (increased resorption/demineralization). Serum magnesium levels were lower in hypothyroid patients, which is the result of impaired magnesium homeostasis. Serum alkaline phosphatase levels were highest in hyperthyroid patients. The biochemical profile of elevated bone specific alkaline phosphatase, total calcium and ionised calcium together with normal liver function tests strongly indicate that bone resorption occurs at higher rate and speeded up by the thyroid hormones in hyperthyroid patients. Bone turnover is increased in favor of resorption and the rate is associated with the levels of thyroid hormones in hyperthyroidism. Opposite changes occur in hypothyroid patient. If other reasons for increased bone turnover are ruled out then elevated bone resorption markers point to subclinical hyperthyroidism.


Bawa M.S.,SBH Government Medical College | Srivastav M.,Lokmanya Tilak Municipal Medical College
Indian Journal of Occupational and Environmental Medicine | Year: 2013

Background: Work hazards have been a major cause of concern in driving industry especially in taxi drivers. This study integrates the various factors that influence physical and emotional well-being of taxi drivers into the theoretical model that shows that the work environment, stress and personality characteristics directly influence taxi drivers′ health. Objective: The aim of the following study is to study the relative and combined influence of work environment, personality characteristics and stress on the health of taxi drivers. Meterials and Methods: The present study is cross-sectional (descriptive) study taxi drivers in Mumbai. They are selected using multistage random sampling method. Calculated sample size is 508. Data produced after the survey is analyzed using IBM SPSS 16.0 software. Results: Nearly 65% of taxi drivers belonged to middle-age group of 21-40 years of age. Majority (59%) of taxi drivers belonged to the lower upper socio-economic class. 70% of taxi drivers worked for more than 8 h daily. 63% gave the history of one or more addictions. 52% taxi drivers had type B1 personality, only 6% had stress prone and aggressive type A1 personality. Traffic congestion (67.1%) was reported as the leading stressor followed by narrow bottle neck roads (43%), too many speed breakers (41%), rude gestures and behavior by other drivers (42%) and bad weather (36%). Nearly 86% taxi drivers had one or more symptoms of morbidities. Gastrointestinal symptoms predominated followed by musculoskeletal symptoms and depression. Conclusion: Socio-demographic attributes, work environment, stress and personality significantly influence physical and psychological morbidities in taxi drivers.


Phalkey R.K.,University of Heidelberg | Bhosale R.V.,Health Integrated | Joshi A.P.,Joshi Hospital | Wakchoure S.S.,Health Integrated | And 3 more authors.
BMC Public Health | Year: 2013

Background: Epidemic diphtheria is still poorly understood and continues to challenge both developing and developed countries. In the backdrop of poor immunization coverage, non-existent adult boosters, weak case based surveillance and persistence of multiple foci, there is a heightened risk of re-emergence of the disease in epidemic forms in India. Investigating each outbreak to understand the epidemiology of the disease and its current status in the country is therefore necessary. Dhule a predominantly tribal and rural district in Northern Maharashtra has consistently recorded low vaccination coverages alongside sporaidic cases of diphtheria over the last years. Methods. This study reports the findings of an onsite survey conducted to assess a recent outbreak of diphtheria in Dhule district and the response mounted to it. Secondary data regarding outbreak detection and response were obtained from the district surveillance office. Clinical data were extracted from hospital records of eleven lab confirmed cases including one death case. Frequency distributions were calculated for each identified clinical and non- clinical variable using Microsoft™ Excel® 2010. Results: Our findings suggest a shift in the median age of disease to adolescents (10-15 years) without gender differences. Two cases (18%) reported disease despite immunization. Clinical symptoms included cough (82%), fever (73%), and throat congestion (64%). About 64% and 36% of the 11 confirmed cases presented with a well defined pseudomembrane and a tonsillar patch respectively. Drug resistance was observed in all three culture positive cases. One death occurred despite the administration of Anti-Diphtheric Serum in a partially immunized case (CFR 9%). Genotyping and toxigenicity of strain was not possible due to specimen contamination during transport as testing facilities were unavailable in the district. Conclusions: The outbreak raises several concerns regarding the epidemiology of diphtheria in Dhule. The reason for shift in the median age despite consistently poor immunization coverage (below 50%) remains unclear. Concomitant efforts should now focus on improving and monitoring primary immunization and booster coverages across all age groups. Gradually introducing adult immunization at ten year intervals may become necessary to prevent future vulnerabilities. Laboratory networks for genotyping and toxigenicity testing are urgently mandated at district level given the endemicity of the disease in the surrounding region and its recent introduction in remote Dhule. Contingency funds with pre- agreements to obtain ADS and DT/Td vaccines at short notice and developing standard case management protocols at district level are necessary. Monitoring the disease, emerging strains and mutations, alongside drug resistance through robust and effective surveillance is a pragmatic way forward. © 2013 Phalkey et al.; licensee BioMed Central Ltd.


PubMed | P.A. College, Columbia Asia Hospital, Tn Medical College and Sbh Government Medical College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015

The main aim of the study is to study the clinical profile of disorders of the liver and hepatobiliary system in paediatric patients and to correlate the histopathology findings of liver biopsy in chronic liver disease. Another aim being to assess the prognosis and to know the outcome and the effects of treatment in chronic liver diseases in paediatric age group.It was a prospective study, included the clinical profile of Chronic Liver Diseases (CLD) in children and the histopathological correlation. A total of 55 children were thoroughly investigated by doing relevant investigations and liver biopsy.A male predominance (60%) was noted with maximum incidence in the age group of 6-12 years. The incidence of CLD was 1.1% of total admissions. The most common presenting complaint was jaundice and abdominal distension. Hepatic encephalopathy was noted in 29% patients. Hepatomegaly was seen in 63% patients and spleenomegaly was seen in 60% patients. The incidence of cirrhosis on liver biopsy was 42% (23cases) in CLD patients. The most common diagnosis on histopathology was Wilsons disease (22%), followed by hepatitis and autoimmune hepatitis. The predominant spectrum of CLD was metabolic liver disease and also the predominant cause of death.As the incidence of CLD is quite low, a very high index of suspicion is required for its diagnosis. Some uncommon causes of CLD in children were seen in our study like neutral lipid storage disease, 1-Antitrypsin deficiency disease, lupus hepatitis, Alagille syndrome and Budd-Chiari syndrome. A patient of CLD with jaundice and hepatomegaly should be treated aggressively as those are the poor prognostic indicators of the disease. Hepatic encephalopathy and cirrhosis are also associated with poor outcome in patients with CLD. Liver biopsy histopathology by an expert and its correlation with laboratory investigations plays an important role in the diagnosis of CLD. The major cause of deaths in patients with CLD is due to end stage liver disease and fulminant hepatic failure and the only way to prevent and treat these patients is by liver transplantation.


PubMed | SBH Government Medical College, Government Cancer Hospital and Asian Institute of Oncology
Type: | Journal: Case reports in surgery | Year: 2016

Esophageal leiomyoma is a relatively rare tumor of esophagus but it is the most common benign neoplasm of the esophagus. Small esophageal leiomyoma can be observed but larger ones and those producing symptoms should be excised. As observed for other esophageal tumors, dysphagia is its main symptom. Traditionally, open thoracotomy and enucleation are its main treatment but in the last few years video assisted thoracoscopic surgical (VATS) enucleation is gaining recognition with proven advantages of minimally invasive surgery. Herein we present our experience with patient presenting with cough rather than dysphagia as a main symptom, who was diagnosed to be having giant esophageal leiomyoma. VATS guided enucleation was accomplished successfully. Size of lesion was 16 4 3cm. Postoperative recovery was uneventful and patient is not having any signs of recurrence, after three years during follow-up period.


Bhagwat V.R.,SBH Government Medical College | Venugopal N.T.,DY Patil Medical College
Biomedicine (India) | Year: 2013

Background and objectives: Dyslipidemia is a most common finding in patients with cardiovascular abnormalities in India. The sensitivity and specificity in prediction of coronary artery disease is variable among biochemical markers. Assessment of risk for coronary artery disease involving apolipoproteins is very much essential for Indian patients. Material and Methods: This is a case control study done in 31 patients with angiographically confirmed multiple coronary occlusions. Conventional as well as novel lipid profile involving apolipoproteins A1, B and Lipoprotein-(a) serum levels were measured by immuno-turbidimetric assay in the patients along with 13 normal control subjects. Results: Total cholesterol and total triglyceride levels are found to be higher. However, they do not correlate with the degree of coronary occlusion in the patients. Indirect markers such as LDL:HDL ratio do not truly reflect the severity of coronary atherosclerosis. ApoB values are parallel with the degree of coronary occlusions and therefore indicate increased risk of coronary artery disease. Elevated Lp(a) levels in the patients positively correlate with severity of coronary occlusion. Conclusion: The A1:LDL ratio is better than A1:B ratio in terms of sensitivity for coronary artery disease risk stratification. Lp(a) seems to be more sensitive indicator than apoB. Lp(a) appears to be a primary risk factor when the total cholesterol or LDL is marginally elevated.


Kulkarni G.V.,Sbh Government Medical College | Surdi A.D.,Srtrgovt Medical College
International Journal of Pharma and Bio Sciences | Year: 2015

Diabetes is one of the leading causes of death worldwide. As lung is a target organ for diabetes type 1 and 2, in this cross-sectional study, we studied the pulmonary functions of 60 type 2 diabetic patients and 60 matched controls by spirometry. Blood sugar, fasting and post-prandial was measured in all subjects by oxidase-peroxidase method. We found a significant reduction in FVC, FEV1, MVV in diabetics compared to controls. A significant increase in FVC/FEV1% was seen in diabetics compared to controls. Blood sugar, correlated significantly and negatively with FVC, FEV1 and MVV, significantly and positively with FVC/FEV1% in diabetic subjects. Our results showed mainly the restrictive type of lung impairment in type 2 diabetes and significant impairment of lung function with increasing blood sugar levels. It is advisable that diabetic patients should undergo periodic spirometric check up to assess severity of lung function impairment and their glycemic control should be improved.

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