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Upper Dir, Pakistan
Upper Dir, Pakistan
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Khoso B.K.,Jinnah Postgraduate Medical Center | Shaikh I.,SBBU
Medical Forum Monthly | Year: 2015

Objective: The aim of our study was to determine the levels of ESR and CRP in psoriasis with/without psoriatic arthritis and to find whether there is any correlation of their values with its severity and presence or absence of psoriatic arthropathy. Study Design: Prospective study. Place and Duration of Study: This study was conducted at Jinnah Postgraduate Medical Centre, Karachi from January 2014 to August 2014. Materials and Methods: 60 patients, 35 males and 25 females were enrolled. After detailed history and severity assessment by PASI, blood was sent for ESR and CRP levels. All data was documented and analyzed. Result: There were 60 patients (35 males and 25 females) with age ranging from 20-65 years and had a history of psoriasis from 1-38 years. 89% had chronic plaque psoriasis and 30% had psoriatic arthropathy. PASI score ranged from 4-26 (Mean 7.92±6.38). The means of ESR and CRP were 16.44 ± 12.66 mm/hr and 3.84±3.63 mg/L respectively. Neither ESR nor CRP levels directly correlated with PASI or with psoriatic arthropathy. Conclusion: ESR and CRP doesn't seem to have prognostic significance in mild to moderate psoriasis and psoriatic arthropathy. However there might be any role of ESR or CRP. in patients with severe psoriatic arthropathy.


Khan M.,University of Agriculture, Peshawar | Jan A.,University of Agriculture, Peshawar | Hashim S.,University of Agriculture, Peshawar | Marwat K.B.,SBBU
Pakistan Journal of Botany | Year: 2015

A number of zinc finger proteins are known to function in biotic and abiotic stress responses. The putative OsC3H52 gene promoter region, a member of CCCH zinc finger proteins family was isolated and characterized in this study. The in silico analysis of 1742bp promoter region of OsC3H52 gene using Plant care and Plant pan promoter analysis tools revealed the presence of ARE, TCA, G-BOX, TC rich repeats and MYBGAHV, GATABOX, WRKY71OS and Circadian cis-acting elements, respectively, which are involved in plant growth and development and stress responses. To clone the putative OsC3H52 gene promoter region, a promoter fragment of 1742 bp was amplified using indica rice (cv.Swat-1) genomic DNA. The putative OsC3H52 gene promoter region was cloned adjacent to GUS gene using pBIG binary vector and transformed into Agrobacterium tumefaciens (EHA105). For transformation of indica rice, cv. Swat-1, calli was induced from rice seed scutella using N6 medium supplemented with 2 mg/L 2,4-D and 0.5 mg/L kinetin. Six weeks old scutellar callli was used for Agrobacterium mediated transformation. The regenerated putative pBI POsC3H52: GUS transgenic plantlets were confirmed for transgene integration using PCR. Histochemical activity of the GUS gene in POsC3H52: GUS transgenic rice revealed its expression in calli and different parts of the plant including crown, leaf sheath, young leaves and emerging roots. The above results revealed that the putative OsC3H52 gene promoter is a functional promoter and it should be analyzed further in response to biotic and abiotic stress stimuli. © 2015, Pakistan Botanical Society. All rights Reserved.


Hashim S.,University of Agriculture, Peshawar | Jan A.,University of Agriculture, Peshawar | Marwat K.B.,SBBU | Khan M.A.,University of Agriculture, Peshawar
Pakistan Journal of Botany | Year: 2014

Ammi visnaga (bisnaga, toothpick weed or khella) belongs to the family Apiaceae and it is a herbaceous medicinal plant. It is found mainly in the Mediterranean regions and also distributed abundantly throughout the world as introduced species. Many times, A. visnaga is weed as well as used in many countries as herbal medicine for different purposes. Ancient records reveal various medicinal properties of A. visnaga as a popular source to cure variety of different ailments. The plant is used directly as a herb or as a component for production of a number of herbal medicines used in the cure of renal colic, ureteric stones, angina pectoris, the coronary vessels, cardiovascular disorders and asthma. Also it is used as a folk medicine for vitiligo and psoriasis. This review highlights the commonly recognized medicinal uses of A. visnaga, its chemistry and ethnobotanical uses and will also serve as ready reference for future research.


Hashim S.,University of Agriculture, Peshawar | Bakht T.,University of Agriculture, Peshawar | Bahadar Marwat K.,SBBU | Jan A.,University of Agriculture, Peshawar
Pakistan Journal of Botany | Year: 2014

Tribulus terrestris (puncture vine) belongs to family Zygophyllaceae and it is a herbaceous, mat forming plant in nature. It extensively grows in warm dry tropics all over the world and ecologically adaptated as a typical C4 xeromorphic plant. T. terrestris is a noxious weed along with its use in many countries as a folk medicine for different purposes from time immemorial. Ancient records describe various medicinal properties of T. terrestris as a popular source to cure variety of different disease conditions in China, India, and Greece. The plant is used directly as a herb or as a main component for production of a number of medicines and food supplements such as for physical rejuvenation, therapy for the conditions affecting liver, kidney, cardiovascular system and immune systems. Also it is used as a folk medicine for increased muscle strength, sexual potency and in treatments of urinary infections, heart diseases and cough. It is considered invigorating stimulant, aphrodisiac, and nutritive. This review discusses the most commonly recognized medicinal properties of this herb. The chemistry of T. terrestris extracts to establish the relationship between medicinal properties of this important plant will also be reviewed.


Medrar Hussain M.,Abasyn University | Ahmad B.,Abasyn University | Rashid E.,Abasyn University | Hashim S.,University of Agriculture, Peshawar | And 2 more authors.
Pakistan Journal of Botany | Year: 2014

The aim of present study was to screen the antimicrobial activities of extracts of leaves and stems of Adiantum capillus veneris and Tagetes patula against multidrug-resistant (MDR) bacterial strains. Extracts from the leaves and stems of these plants were extracted with methanol and water and tested for their antibacterial activity by disc diffusion method against ten MDR bacterial strains i.e., Citrobacter freundii, Escherichia coli, Providencia, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris, Salmonella typhi, Shigella and Vibrio cholerae. Leaves methanol extract (LME) of Adiantum showed maximum Zone of Inhibition (ZI) against Providencia, Klebsiella pneumoniae, Shigella, Vibrio cholerae, Staphylococcus aureus, Proteus vulgaris and Salmonella typhi, whereas its stem methanol extract (SME) was very active against Escherichia coli, Klebsiella pneumoniae and Salmonella typhi. Similarly LME of Tagetes showed highest ZI against Escherichia coli and Vibrio cholerae while SME showed highest ZI to Escherichia coli, Vibrio cholerae, Providencia, Shigella and Klebsiella pneumoniae. Leaves water extract (LWE) of Adiantum was very active against all ten bacterial strains while its stem water extract (SWE) showed maximum ZI against Escherichia coli, Klebsiella pneumoniae and Salmonella typhi, Shigella, Proteus vulgaris and Providencia. LWE of Tagetes was only active against Vibrio cholerae whereas SWE was very active against Salmonella typhi and active against P. vulgaris, Citrobacter freundii and Vibrio cholerae. It was concluded from this study that extracts of both Adiantum and Tagetes have prominent activities against most of the MDR bacterial strains and needs further studies for utmost benefits.


Bakht T.,University of Agriculture, Peshawar | Khan I.A.,University of Agriculture, Peshawar | Marwat K.B.,SBBU | Hussain Z.,University of Agriculture, Peshawar
Pakistan Journal of Botany | Year: 2014

A field experiment was conducted at the Research Farm of The University of Agriculture, Peshawar during the year 2012 to determine the impact of row spacing and weed management strategies on tomato (Lycopersicon esculentum Mill.). The local variety 'Roma' was sown in a randomized complete block (RCB) design with split plot arrangements, having four replications. The main plots were row spacings while subplots of the experiment comprised of ten treatments including five mulches viz., white and black polyethylene, wheat straw, newspaper and saw dust, three herbicide treatments (fenoxaprop-pethyl, pendimethalin and s-metolachlor), hand weeding and a weedy check. The data were recorded on weed density m-2, fresh and dry weed biomass, number of branches plant-1, and fruit yield (kg ha-1). All these parameters were significantly affected by row spacing and weed management treatments. Increase in weed population was observed with increasing in row spacing. The competitiveness of tomato with weeds can be enhanced by using black plastic as mulch. In light of the results, the row spacing of 60 cm is the optimum one for tomato plants, as the fruit yields decreased at 40 cm and 80 cm row spacing.


Objective: Psoriasis is a chronic inflammatory skin disease of unknown origin. Different factors might be influencing its course. The aim of our study was to observe and analyze different clinoepidemiological variables of psoriasis in patients reporting to a tertiary care hospital in Karachi. Study Design: Prospective study Place and Duration of Study: This study was conducted at Jinnah Postgraduate Medical Centre, Karachi, Pakistan from January 2014 to December 2014. Materials and Methods: 200 patients (116 Males and 84 females) ages 18 and above with mild to severe psoriasis were selected and assessed on one occasion which included detailed history and examination. All data was documented on completion of study. Results: A total 200 cases were studied. 90% had chronic plaque psoriasis. There was male preponderance with a male to female ratio of 1.38:1. Mean peak age of onset was 11-20 years of age and was earlier in females than males. More than two-third of patients had onset of psoriasis before or at 40 years of age. Familial occurrence was present in 38% of patients and 35% had first degree relative involvement. Psoriatic arthropathy was present in 35% of patients. 86.36% of the patients with arthropathy had onset of psoriasis before 40 years of age. 21% of patients reported worsening of their psoriasis with sun. 32% of the patients in this study were smokers and most of them were males. Conclusion: The findings of this study done in Karachi, Pakistan correlates with previous hospital-based studies done in different parts of the world.

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