Saveetha Medical College and Hospital

Thandalam, India

Saveetha Medical College and Hospital

Thandalam, India
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Senthil Kumar B.,Salem College | Vijaya Kumar J.,Saveetha Medical College and Hospital
International Journal of Pharmaceutical Sciences Review and Research | Year: 2014

The aim of the study was to investigate phytochemicals and GCMS analysis of ethanolic extract of Cycas circinalis and Ionidium suffruticosum. The bioactive constituents were traced out in C.circinalis and I.suffruticosum by phytochemical screening (qualitative methods) and the GCMS method. C.circinalis showed the presence of terpenoids, flavonoids, cardiac glycosides, Phytosterols, amino acids, and alkaloids. In GCMS analysis C.circinalis showed 16 bioactive components with high concentration of α-D-Glucopyranoside, α -D-glucopyranosyl (77.73%), Decanoic acid, ethyl ester (11.92%) whereas I.suffruticosum showed the presence of tanins, flavonoids, terpenoids, saponin, cardiac glycosides, amino acids and alkaloids. In GCMS analysis I.suffruticosum showed 18 bioactive components with high concentration of 3-Trifluoroacetoxydodecane (16.76%), 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (15.32%), Decanoic acid, ethyl ester (14.98%), E-2-Tetradecen-1-ol (10.46%), Spiro[2.2]pentane-1-carboxylic acid, 2-cyclopropyl-2-methyl (5.01%), 2H-Pyran, 2-(7-heptadecynyloxy)tetrahydro (8.31%), Squalene (6.24%). The phytochemical constituent’s common in both C.circinalis and I.suffruticosum was Decanoic acid, ethyl ester and 3-Trifluoroacetoxydodecane. The presence of some of these bioactive constituents in the plant extract may provide the scientific evidences for many medicinal effects of these plants. © 2014, Global Research Online. All rights reserved.


Senthil Kumar B.,Salem College | Vijaya Kumar J.,Saveetha Medical College and Hospital
International Journal of Pharmaceutical Sciences Review and Research | Year: 2015

Pharmacological and toxicological evaluations of medicinal plants are essential for drug development. Cycas circinalis and Ionidium suffruticosum are the two herbs which had been used since ancient times for treating various ailments traditionally in Indian system of Medicine (Siddha Medicine), but the medicinal effects of both the herbs were yet to be proved scientifically. The present study was done to evaluate the sub-acute toxicity of both the medicinal herbs as a preliminary part in proving its medicinal effect on maintaining the fertility of male. OECD guidelines 407 were followed for the sub-acute toxicity study. A total of 42 male Wistar rats were randomly divided into seven groups of 6 animals in each group for 3 dosages up to 28 days and each group was administered 250 mg/kg, 500 mg/kg, 1000 mg/kg body weight of C.circinalis and I.suffruticosu methanolic extracts. The hematological and biochemical parameters were analyzed and compared between the control and experimental group, there was only slight variations were noted and was found to be within the standard laboratory values and statistical analysis of the parameters showed i nsignificance. The histopathological examination of various vital organs of both control and experimental groups were compared and no abnormal architecture, morphological disturbances, desquamation, disorganization, infiltration and no destruction of the tissues were noted. The sub-acute toxicity study proves that the ethanolic extract of C.circinalis and I.suffruticosum, when given orally at concentration up to 1000mg/kg body weight did not exhibit any toxicological effect and proved to be safe until 1000mg/kg. © 2015, Global Research Online. All rights reserved.


Babu S.K.,Vinayaka Missions University | Jagadesan V.K.,Saveetha Medical College and Hospital | Ramasamy S.,Saveetha University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2012

Cycus circinalis L. (Cc) and Ionidium suffruticosum Ging., (Is) were used in Siddha system of medicine (Indian Medicine) for years together to improve the fertility of male. Both the herbs have aphrodisiac activity. The study was carried out to evaluate the acute toxic effect of the ethanolic extract of both the herbs Cc and Is and to determine the LD50. The acute toxicity study (Main test) was done as per the guide lines of Organization for Economic Cooperation and Development (OECD) guideline 425. As the herbs were used for treating male infertility by traditional practitioners for years together, the toxicity study was also proposed to study in male albino rats. About 18 male albino rats of three groups having six rats in each group of Control, Experimental I and Experimental II. The ethanolic extracts of Cc and Is were administered by oral gavage. The distilled water was administered to control rats, Cycus circinalis extract for Experimental I and Ionidium suffruticosum extracts for Experimental II in single dosages of 175, 550, and 2000mg/kg bodyweight with 48hrs of interval between the dosages as recommended in OECD guidelines 425. The weight of rats, Wellness parameters, mortality, hematological parameters, biochemical markers, and histopathological analysis of all vital organs were observed to know the acute toxic effect of the drugs Cc and Is. All the parameters of the study do not show any significant changes between the control and experimental groups. There was no mortality among the experimental groups. The high no- observed adverse effects level (NOAEL) value of 2000 mg/kg bodyweight implies that the drug could be safe and the LD50 value of both Cc and Is was found to be more than 2000 mg/kg bodyweight by this acute toxicity study.


Aiyappan S.K.,Saveetha Medical College and Hospital | Ranga U.,Saveetha Medical College and Hospital | Veeraiyan S.,Saveetha Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Uterine Arteriovenous Malformations (AVMs) are rare but life threatening causes of abnormal vaginal bleeding. Accurate clinical and radiological diagnosis is essential because uterine instrumentation that is often used for management of other sources of abnormal bleeding, can lead to massive hemorrhage. Timely diagnosis and early proper treatment can markedly reduce the associated disease mortality. Ultrasound with colour and spectral doppler is the initial imaging modality of choice. Three-dimensional computed tomography (CT) angiography can determine the actual extent of the vascular malformation and helps in pre-interventional planning noninvasively. Uterine AVM can be either congenital or acquired in nature with latter being more common. We hereby report two cases of acquired uterine arteriovenous malformations diagnosed by color doppler sonography and confirmed by three-dimensional CT angiography. Both the cases reported here had previous history of dilation and curettage for abortion. Clinically one patient presented with profuse uterine bleeding and another with meno-metrorrhagia and both cases underwent surgical removal of uterus.


Aiyappan S.K.,Saveetha Medical College and Hospital | Ranga U.,Saveetha Medical College and Hospital | Veeraiyan S.,Saveetha Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Portal venous system aneurysm is a rare condition with very few reported cases in English literature. With the increasing availability of advanced imaging modalities like Doppler ultrasound, computed tomography and magnetic resonance imaging, portal venous system aneurysms are being increasingly reported. Here, we report a rare case of multiple intrahepatic portal venous system aneurysms complicated by thrombosis in a young patient with chronic liver disease and portal hypertension. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved.


Ranga U.,Saveetha Medical College and Hospital | Aiyappan S.K.,Saveetha Medical College and Hospital | Veeraiyan S.,Saveetha Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Orodentocutaneous fistula is a rare entity where periapical dental abscess communicates with both oral cavity and external skin. In few cases, patients presents initially with only cutaneous manifestation with no recollectable history of dental problem. Delay in diagnosis of odontogenic cause of skin lesion makes the disease more chronic and extensive. We hereby present a case of orodentocutaneous fistula that presented with intermittently discharging skin lesion and was evaluated by using CT fistulography.


Janani A.V.,Saveetha University | Surapaneni K.M.,Saveetha Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2010

OBJECTIVES: The exact pro-oxidant and antioxidant status in alcoholic liver disease among the chronic alcoholics is still not clear. Consumption of excess amounts of ethanol causes liver damage by several mechanisms. Chronic alcohol consumption is associated with increased incidence of variety of illnesses including cirrhosis. Studies have shown that ethanol consumption may result in increased oxidative stress with increased formation of lipid peroxides and free radicals. METHODS: To add a new insight to the question, changes in the levels of antioxidant vitamins ascorbic acid and plasma vitamin E (non enzymatic antioxidant parameters) and activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase in erythrocytes were measured in 30 patients with alcoholic liver disease (study subjects) and compared to 30 age and sex matched healthy subjects (controls). Statistical analysis between controls and patients was performed by the unpaired t-test using the SPSS package. RESULTS: It was observed that there was a significant increase in the activities of SOD and GPx and a significant decrease in erythrocyte ascorbic acid, plasma vitamin E levels and catalase activity in patients with alcoholic liver disease, among chronic alcoholics when compared to controls. CONCLUSIONS: The results of our study have shown higher oxygen free radical production, evidenced by the decreased levels of ascorbic acid, vitamin E and catalase activity, supporting the hypothesis that there is increased oxidative stress in patients with alcoholic liver disease. The increased activities of antioxidant enzymes may be a compensatory regulation in response to increased oxidative stress. The decreased concentrations of the antioxidant vitamin status support the hypothesis that lipid peroxidation is an important causative factor in the pathogenesis of alcoholic liver disease among chronic alcoholics. These data reveal that antioxidant defense mechanisms might be impaired in these patients. These findings also provide a theoretical basis for the development of novel therapeutic strategies, such as antioxidant supplementation.


Ranga U.,Saveetha Medical College and Hospital | Aiyappan S.K.,Saveetha Medical College and Hospital | Veeraiyan S.,Saveetha Medical College and Hospital
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | Year: 2012

We report a case of thyroglossal fistula in a young male that was clearly demonstrated using computed tomography fistulography. © 2012 Elsevier Inc.


Baby M.K.,Sri Ramachandra University | Muthu P.K.,Saveetha Medical College and Hospital | Johnson P.,Sri Ramachandra University | Kannan S.,Saveetha Medical College and Hospital
Lung India | Year: 2014

Background: Nasal mucociliary clearance (NMC) system transports the mucus layer covering the nasal epithelium towards nasopharynx by ciliary beating at a frequency of 7-16 Hz. NMC is altered by septal deviations, upper respiratory infections, and drugs. Few studies have revealed significant depression of ciliary activity in smokers. We conducted this study to compare NMC and influence duration of smoking on NMC in adult smokers and nonsmokers using saccharin test. Materials and Methods: Our study included 30 nonsmokers and 30 smokers (21-40 years) who were not on any medications and had no history of any systemic illness. Time elapsing until the first experience of sweet taste at posterior nasopharynx, following placement of saccharin particle approximately 1 cm behind the anterior end of inferior turbinate was recorded as NMC time in minutes using standard method described by Anderson. Mean NMC of both groups were compared using Student's t -test and influence of duration was analyzed by one-way Analysis of variance (ANOVA). Results: NMC was significantly prolonged in smokers (481.2 ± 29.83; P < 0.01) in comparison to nonsmokers (300.32 ± 17.42 s). A statistically significant increase in NMC was observed with an increase in duration of smoking habit (NMC in smoking <1 year = 492.25 ± 79.93 s, 1-5 years = 516.7 ± 34.01 s, >5 years = 637.5 ± 28.49 s; F statistic = 20.8968, P = 0.0000). Conclusions: NMC measurement is a simple and useful index for the assessment of effect of smoking on the ciliary activity of respiratory mucosa. Prolonged clearance observed in smokers of our study may be due to slowed ciliary beat frequency or reduction in number of cilia and changes in viscoelastic properties of mucus.


Prathibha K.M.,Saveetha Medical College and Hospital | Johnson P.,Sri Ramachandra University | Ganesh M.,Chettinad Hospital and Research Institute | Subhashini A.S.,Sri Ramachandra University
Journal of Clinical and Diagnostic Research | Year: 2013

Background: A lack of consensus on the possible association between diabetes and salivary dysfunction motivated us to conduct this investigation on the salivary parameters in diabetic and non diabetic subjects. This could also make the use of saliva as an alternative to that of blood in the diagnosis/monitoring of diabetes mellitus. Objectives: To compare the salivary flow rates and the salivary physical and biochemical parameters of diabetic (D) and non diabetic (ND) subjects. Material and Methods: The participants in this study included 30 non diabetic subjects and 30 diabetic volunteers who had Type 2 Diabetes mellitus for a minimum of 2 years. Unstimulated whole saliva was collected in the fasting state. Salivary pH, flow rate and organic and inorganic constituents were evaluated. Data which was collected was statistically analysed and interpreted. Results: Salivary pH (ND=7.09±0.29, D=6.69±0.35), flow rate (ND=0.67±0.07, D=0.46±0.02) and salivary amylase (ND=92.51±13.74, D=19.20±1.8) were significantly lower in diabetics. They had significantly higher levels of salivary glucose (ND=4.33 ± 0.29, D=17.31±2.05), total proteins (ND=424.46±237.34, D=877.29±603.84), sodium (ND=4.31±0.65, D=14.42±1.83) and potassium (ND=20.84±0.71, D=25.95±1.56) and lower levels of calcium (ND=6.39±0.5, D=4.22±0.12) in comparison to those in the non-diabetic group. Conclusion: Significant variations were observed in salivary physical and biochemical parameters between diabetics and non diabetics. Evaluation of salivary parameters can be a cost effective and a non invasive alternative for screening, diagnosis and monitoring of diabetes, to blood.

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