Chennai, India
Chennai, India

Sathyabama University is a private university at Chennai in Tamil Nadu, India, founded in 1988 as Sathyabama Engineering College by Jeppiaar Educational Trust and inaugurated by then Chief Minister of Tamil Nadu, Janaki Ramachandran. It was formerly known as Sathyabama Institute of Science and Technology . The university is headed by Jeppiaar, a former politician under the late M. G. Ramachandran. It is a Christian minority institution.The Ministry of Human Resources Development declared the college a 'Deemed University' on 16 July 2001 and as a 'University' on 13 September 2006, under section 3 of the UGC Act. According to the 2010 University Web Ranking website Sathyabama was ranked 5th among universities in Chennai. In a recent report by Outlook India, Sathyabama University has been ranked as the 86th best university in India.Nationally, the university has gained an unsavory reputation, along with other institutions established by Jeppiaar for repressing social interaction between students of different genders and for a series of draconian rules. Wikipedia.

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Usha Nandhini S.,Sathyabama University | Masilamani Selvam M.,Sathyabama University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: To develop a new antibacterial antibiotic from streptomyces strains were isolated from a sample of marine soil in and around Tamil Nadu coastal areas. Methods: Totally 35 strptomyces species were isolated from marine soil by spread plate method and were screened for their antagonistic activity against five different pathogenic bacterial strains by cross streak method and agar well diffusion method. One of the strain was found to be more active against five different bacterial strains. Results: The strain was identified as Streptomyces coelicolor Strain SU6 (JQ828940) by 16S rRNA partial gene sequencing. The antibacterial compound produced by the active strain was identified by GC-MS report as 3-ethyl,3-methyl heptane and Diisodecyl ether. Conclusion: The observations from this study confirmed that Streptomyces isolated from marine environment may be potentially used for extracting novel antibiotics for treating bacterial infections in human.


Nanda A.,Sathyabama University | Majeed S.,Sathyabama University
International Journal of PharmTech Research | Year: 2014

Efficacy of silver nanoparticles against pathogenic microbes has been known from ancient era. Now a day, bacteria are getting resistant to varied antibiotics based on their wide adaptability nature. In the present study, silver nanoparticles (AgNPs) were bio-synthesized in-vitro by extracellular method from Penicillium glabrum (MTCC1985). The appearance of yellowish brown color in the conical flask suggested the formation of Ag-NPs. The supernatant of the fungus culture changed the solution into brownish color upon the completion of the 5 minute reaction. The nanoparticles were confirmed by Uv-Vis spectrophotometer, Fourier transform infrared (FTIR) analysis, Field emission scanning electron microscopy (FESEM), Atomic force microscopy (AFM). Size of the nanoparticles was measured in between 26nm to 32nm by FESM. Silver nanoparticles showed good antimicrobial activity against the selected pathogens but combined formulation with antibiotics, the biosynthesized Nanoparticles from Penicillium glabrum (MTCC1985) amplified the antimicrobial potency of the antibiotics studied.


Saravanan D.,Sathyabama University | Radhakrishnan M.,Sathyabama University
International Journal of PharmTech Research | Year: 2016

In the present study, aqueous and solvent extracts of leaves collected from nine mangrove plants were screened against Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Staphylococcus aureus (VRSA) and Extended spectrum beta lactamase (ESBL) strains. Out of nine mangrove plants Avicennia sp., Rhizophora sp., Ceriops decandra and Thillai species showed antimicrobial activity against test pathogens. Methanolic extracts of Avicennia sp., and Rhizophora sp., showed 10 mm,9mm and 10mm, 13mm against S. aureus and Pseudomonas aeruginosa, respectively. Methanol extract of Ceriops decandra showed 12 mm inhibition against S. aureus and Pseudomonas aeruginosa. Methanol extracts of Thillai sp., showed 10mm activity against Pseudomonas sp. The crude extract of Avicennia sp., produced two spots in thin layer chromatography (TLC) when chloroform: methanol (60:40) used as a solvent system. In bioautography, the first spot (Rf value 0.65) showed activity. The active compound purified by preparative TLC showed maximum activity (15 mm inhibition) against MRSA. The methanolic crude extract of Rhizophora sp., and Ceriops decandra produced Rf value 0.58 and 0.6 respectively. The active compound of Rhizophora sp., and Ceriops decandra purified by TLC showed maximum activity of 18 and 16 mm activity against MRSA. Further isolation and characterization of active compounds is in progress. © 2016, Sphinx Knowledge House. All rights reserved.


Karthick Raja Namasivayam S.,Sathyabama University | Allen Roy E.,Sathyabama University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: The objective of the present study is to evaluate anti biofilm effect of both the aqueous and chitosan coated extracts of Azadirachta indica, Vitex negundu,Tridax procumbens and Ocimum tenuiflorumi was evaluated against biofilm development of clinical isolate of E.coli Methods: Crude aqueous and chitosan extracts of respective plants with different concentration was evaluated against biofilm adopting microtitre plate crystal violet assay. Biofilm matrix was extracted from the respective treatment and the biochemical composition mainly total carbohydrates and total protein was studied. Results: Biofilm inhibition study revealed both free and chitosan coated plant extracts inhibited biofilm formation, enhanced effect on biofilm inhibition was recorded in polymer coated extracts of the all the tested plants. Biochemical composition of biofilm matrix mainly total carbohydrates and total protein was highly reduced in all the tested concentration of polymer coated plant extracts. Conclusion: Anti biofilm effect of plant extracts coated with biocompatible polymer chitosan would suggests the possible utilization of the extracts as the effective anti bacterial agents against pathogenic bacteria.


Anuradha Jabasingh S.,Sathyabama University
International Biodeterioration and Biodegradation | Year: 2011

The present study is aimed at simultaneous cellulase synthesis and coir pith degradation by Aspergillus nidulans using coir pith as chief substrate. The lignocellulosic biomass, coir pith is known to be an excellent carbon source for microbial cellulase production under solid state fermentation. The alkali pretreatment with sodium hydroxide was seen to enhance enzymatic hydrolysis. The effect of coir pith weight, moisture content, initial pH and growth temperature on cellulase activity and yield were investigated by response surface methodology (RSM) employing a four-factor-five-level central composite design (CCD). The results of Fourier transform infrared spectroscopy (FTIR), X-Ray diffraction (XRD) and Scanning electron microscopy (SEM) of coir pith showed structural changes through pretreatment, in favor of enzymatic hydrolysis. Maximum carboxy methyl cellulase activity (CMCase) of 28.64 U/g and cellulase yield of 66.32% were achieved with 8 g coir pith at 70% moisture content and 40 °C temperature with pH 5 as evident from run numbers 25 and 30. Filter paper (FPase) and cellobiase (CBase) activities of 10.23 U/g and 4.31 U/g respectively were observed on the 11th day after the inoculation. © 2011 Elsevier Ltd.


Sowmya B.,Sathyabama University | Sheela Rani B.,Sathyabama University
Applied Soft Computing Journal | Year: 2011

This paper explains the task of segmenting any given colour image using fuzzy clustering algorithms and competitive neural network. The fuzzy clustering algorithms used are Fuzzy C means algorithm, Possibilistic Fuzzy C means. Image segmentation is the process of dividing the pixels into homogeneous classes or clusters so that items in the same class are as similar as possible and items in different classes are as dissimilar as possible. The most basic attribute for image segmentation is the luminance amplitude for a monochrome image and colour components for a colour image. Since there are more than 16 million colours available in any image and it is difficult to analyse the image on all of its colours, the likely colours are grouped together by means of image segmentation. For that purpose soft computing techniques namely Fuzzy C means algorithm (FCM), Possibilistic Fuzzy C means algorithm (PFCM) and competitive neural network (CNN) have been used. A self-estimation algorithm has been developed for determining the number of clusters. The images segmented by these three soft computing techniques are compared using image quality metrics: peak signal to noise ratio (PSNR) and compression ratio. The time taken for image segmentation is also used as a comparison parameter. The techniques have been tested with images of different size and resolution and the results obtained by CNN are proven to be better than the fuzzy clustering technique. © 2010 Elsevier B.V. All rights reserved.


Mathan N.,Sathyabama University
Biosciences Biotechnology Research Asia | Year: 2014

CNTFET is a novel device that is projected to outperform scaled CMOS technologies.Multiplier is one of the very important hardware blocks such as FIR filters, digital signal processors etc.The performance speed of the multiplier often affects the overall speed performance in VLSI systems. On the whole, multiplication employs most of the execution time in many Digital signal processor (DSP) devices. So, high speed multiplier is greatly desired. In this paper, a high speed existing radix-4 multiplier based Shannon adder is analysed intensively. To achieve an efficient radix-4 multiplier, the proposed hybrid adder was implemented for further power reduction in high speed parallel radix-4 multiplier circuits. The proposed radix-4 multiplier is more desirable for obtaining the low power consumption, less propagation delay and efficient power delay product. Simulations are executed using Synopsys HSpice in 32nm CMOS and 32nm CNTFET Technologies. The simulation results exhibits the transcendences of the proposed structures in terms of Power consumption, propagation delay and Power delay product compared to the advanced technology of CMOS and CNTFET based designs.


Inbakandan D.,Sathyabama University
Biofouling | Year: 2010

Marine bacteria from the hull of a ship in the form of biofilms or microfouling were isolated, cultured, and identified by phylogenetic analysis using 16S rDNA sequences. With an average length of 946 bp, all the 16 sequences were classified using the Ribosomal database project (RDP) and were submitted to the National Center for Biotechnology Information. Phylogenetic analysis using 16S rDNA sequences indicated that the 16 strains belonged to the Firmicutes (IK-MB6 Exiguobacterium aurantiacum, IK-MB7 Exiguobacterium arabatum, IK-MB8 Exiguobacterium arabatum, IK-MB9 Jeotgalibacillus alimentarius, IK-MB10 Bacillus megaterium, IK-MB11 Bacillus pumilus, IK-MB12 Bacillus pumilus, IK-MB13 Bacillus pumilus, IK-MB14 Bacillus megaterium), High GC, Gram-positive bacteria (IK-MB2 Micrococcus luteus, IK-MB5 Micrococcus luteus, IK-MB16 Arthrobacter mysorens), G-Proteobacteria (IK-MB3 Halomonas aquamarina, IK-MB15 Halotalea alkalilenta), CFB group bacteria (IK-MB1 Myroides odoratimimus), and Enterobacteria (IK-MB4 Proteus mirabilis). Among the 16 strains, representatives of the Firmicutes were dominant (56.25%) compared to the high GC, Gram-positive bacteria (18.75%), G-Proteobacteria (12.5%), CFB group bacteria (6.25%), and Enterobacteria (6.25%). Analysis revealed that majority of marine species found in marine biofilm are of anthropogenic origin.


Jeevitha D.,Sathyabama University | Amarnath K.,Sathyabama University
Colloids and Surfaces B: Biointerfaces | Year: 2013

Designing novel materials for biomedical applications generally require the use of biodegradable materials. This study aims to engineer a biodegradable [chitosan (CS) and poly (lactic acid) (PLA)] as AQ carrier with nanometer dimensions and to evaluate the anticancer potency of the prepared CS/PLA-AQ NPs in human carcinoma (HepG2) cells. CS-PLA complex, which are well dispersed and stable in aqueous solution, was prepared by the precipitation of lactic acid in chitosan solution by dropping method and characterized by SEM, TEM, DLS and FTIR. The results thus displayed that the prepared nanoparticles carried a positive charge and showed the size in the range from 100 to 200. nm. The in vitro (AQ) release study showed that these nanoparticles provided a continuous release of the entrapped AQ for 10 days, and the release behavior was influenced by the pH value of the medium thereby making feasible to develop CS-PLA for enhanced and sustained release of AQ. MTT assay revealed higher cytotoxic efficacy of CS/PLA-AQ NPs than Free AQ in HepG2 cells. Further, the mitochondrial membrane damage indicated by loss of mitochondrial membrane potential and necrotic cell death could be attributed to the increased reactive oxygen species production. Our results also suggest that upon CS/PLA-AQ NPs exposure the cell viability decreased due to apoptosis, as demonstrated by the formation of apoptotic bodies, sub-G1 hypodiploid cells, and DNA fragmentation. Henceforth, CS/PLA-AQ NPs demonstrated a strong antitumor activity in vitro by reducing cell viability, inducing cell necrosis, decreasing the negative surface charge and mitochondrial membrane potential, and fragmenting DNA. © 2012 Elsevier B.V.


In current trends Carbon Nano Tube Field Effect Transistor is considered as promising successor of Metal Oxide Semiconductor Field Effect Transistor. MOSFET scaling has faced serious limitations related to fabrication technology and device performances as the critical dimension goes down to sub-22 nm range. The limitations are electron tunneling through the thin insulator films, more power dissipation and short channel effects and also variations in doping concentration. These limitations can be overcome to some extent by modifying the channel material in the MOSFET structure with a single carbon nanotube. The high electron and hole mobility of carbon nano tubes with high k gate dielectrics, enhanced high performance nanoscale transistors. Filter is one of the major building blocks in DSP. The polyphase filters are very important component in the design of various filter structures. To evaluate the performance of high celerity transposed polyphase decimation filter using 10 nanometre CNTFET technologies. The results are obtained by analyzing average power, delay, and energy consumption. The CNTFET technology based filter design is analyzed and compared with CMOS technology based design. © 2016 Elsevier Ltd.

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