Karimnagar, India
Karimnagar, India

Satavahana University is a public university situated in Karimnagar in Telangana. Wikipedia.

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Garige B.,Anurag Group of Institutions | Keshetti S.,Satavahana University | Vattikuti U.,Cmr Group Of Institutions
Pharmacognosy Research | Year: 2016

Background: Galphimia glauca is an evergreen shrub found across peninsular India, belonging to family Malpighiaceae. Objective: The objective of this study was to assess the in vivo depressant effects and muscle coordination activity of G. glauca stem methanol extract (GGSME). Materials and Methods: The stem methanol extract was administered in Swiss albino mice in 1 day to study the central nervous system (CNS) depressant and muscle coordination activity employing animal models such as sodium pentobarbital-induced sleep test, hole-board test, open field test, pentylenetetrazole (PTZ)-induced convulsions, picrotoxin-induced convulsions, grip strengthening test in mice, and Rota-rod test. Results: The LD50of GGSME was found to be >2000 mg/kg body weight (b.w.). Mice treated with stem methanol extract at 100, 200, and 400 mg/kg, b.w. doses extended the sleeping time induced by sodium pentobarbital (40 mg/kg. b.w., i.p.). The stem methanol extract at 400 mg/kg dose showed a significant (P ≤ 0.001) dose-dependent decrease in the number of rears and head dipping number in the hole-board test. The extract exhibited a significant (P ≤ 0.001) effect on the ambulatory behavior of mice in the open field test and also extended the onset of seizures induced by PTZ (90 mg/kg b.w., i.p.) and picrotoxin (10 mg/kg, b.w., i.p.). The extract also exhibited significant (P ≤ 0.001) effects on muscle coordination in rota-rod and grip strengthening test in mice. Conclusion: The study results conclude that the GGSME has a potential CNS depressant and muscle relaxant effects compared to the standard drugs. © 2016 Pharmacognosy Research | Published by Wolters Kluwer - Medknow.

Namratha V.,Satavahana University | Merugu R.,Mahatma Gandhi University | Devanuri N.,Vignans University
International Journal of PharmTech Research | Year: 2015

Natural products once served as the only source of medicines for mankind. The structure determination and biological activity screening of natural products, especially those with a history of medicinal use taking clues form folklore medicine, Ayurveda, siddha, tribal medicine etc., has been an important activity in medicinal chemistry. Flavonoids are a group of polyphenolic compounds found in plant kingdom.To date about 3000 varieties of flavonoids are known. Many have low toxicity in mammals and some of them are widely used in medicine for maintenance of capillary integrity. © 2015, Sphinx Knowledge House. All right reserved.

Ganesh Kumar Y.,Jawaharlal Nehru Technological University | Satyavati D.,Satavahana University | Anil kumar C.,Sree Dattha Institute of Pharmacy | Soujanya N.,Kingston University
Der Pharmacia Lettre | Year: 2014

Olanzapine is an atypical antipsychotic, FDA for the treatment of schizophrenia and bipolar disorder. Olanzapine is structurally similar to clozapine and quetiapine. The present research workis aimed at developing a Formulate and Evaluated of a Rapid disintegrating tablet dosage form of Olanzapine. Who have little or no access to water are also good candidates for Rapid disintegratingtablets of Direct Compression method was employed for blending of drug with polymers in the given ratio as a nine formulations. The prepared powder blends were then compressed into tablets using the necessary Superdisintegrants like CCS, CP, and SSG and Excipients. The tablets were evaluated for Weight variation, thickness, hardness, friability, Drug Content and Disintegrating Time (Sec) were subjected to a 40 minutes in vitro drug release studies (USP dissolution rate test apparatus II, 50 rpm, 370C ±0.50C) using phosphate buffer, pH 6.8 as a dissolution medium (900ml). The amountof Olanzapine released from the tablet formulations at different time intervals was estimated using a UV spectroscopy method. The formulations that showed a considerable retardation of the drug release are considered promising. Among the nine formulations, F5 formulation containing Drug to Crospovidone (CP) in ratio 1:0.25 is optimized based on its ability to till 40 mins of invitro dissolution time, and its % Cumulative Drug Release Of The 96.09% of dissolution study.

Nagabandi V.,P.A. College | Chandragiri A.K.,Satavahana University | Thota S.,P.A. College | Katakam P.,P.A. College
Journal of Pharmaceutical Sciences and Research | Year: 2014

Oral dosage forms have always been considered the preferred route of delivery due to their lower unit dose cost and ease of compliance. Approximately 40-70% of new chemical entities (NCE'S) display poor oral absorption characteristics, generally as a result of poor solubility, poor dissolution rate and therefore result in unsuccessful formulation of conventional oral dosage forms. There has been an increasing trend towards utilizing lipid based drug delivery system (LBDDS). In the current research work an attempt was made to improve the solubility, dissolution rate permeability of poorly water soluble drug naproxen by utilizing lipid based solid dispersions (LBSD) technology. Naproxen is a poorly water soluble drug (BCS class II). LBSD'S were prepared by using different ratios (1:1,1:3 and 1:5) of lipid based hydrophilic carrier such as gelucire 44/14 and hydrophilic inert carrier Pearlitol SD 200 by solvent evaporation technique. Phase solubility and saturation solubility studies were performed in distilled water containing increasing concentrations of these carriers showed linear increase in solubility of naproxen. In vitro dissolution studies revealed that dissolution rate of LBSD was higher than the pure drug and marketed formulation. Ex vivo studies were performed using goat intestine membrane showed permeability was increased with LBSD'S. It was found that there were no drug and excipients interactions as there was no extra peak was observed in FT-IR spectra of final formulation. Hence it can be concluded that the oral bioavailability of naproxen can be successfully improved by preparing Lipid based solid dispersions.

Begum N.,Satavahana University | Keshetty S.,Satavahana University
International Journal of Green Pharmacy | Year: 2017

Introduction: Matricaria recutita has been traditionally used as a long-Term anti-inflammatory herb, thus giving scope for anti-inflammatory studies. The study was conducted to investigate in vitro anti-inflammatory and cyclooxygenase-2 (COX-2) inhibitory activities of dried flower extracts of Matricaria recutita. Materials and Methods: For the present investigation, various extracts were obtained by successive Soxhlet extraction using solvents with increasing polarity, namely, petroleum ether, chloroform, ethyl acetate, methanol, and aqueous (AE). 300 and 500 μg/ml concentrations of the extracts were used for the study. In vitro anti-inflammatory activity was studied by membrane stabilization of human red blood cells (HRBCs). The percentage of membrane stabilization was compared with standard drug diclofenac sodium at a concentration of 300 and 500 μg/ml. In vitro COX-2 inhibitory activity was evaluated by enzyme immunoassay (EIA). Results: AE at a concentration of 500 μg/ml showed maximum membrane stabilization of 82.43% and 68.62% of promising COX-2 inhibition in comparative with remaining extracts. Discussion: The inhibition of membrane stabilization is the measure of anti-inflammatory activity due to analogous nature of lysosomal membrane which releases lysosomal enzymes responsible for inflammation with HRBC membrane. Thus, significant inhibition of HRBC membrane directly correlates the significant anti-inflammatory capacity of the extract. Remarkable inhibition of COX-2 inhibition by EIA states that Matricaria recutita possesses specific COX-2 inhibitory activity. Conclusion: The results observed thus suggest that the AE of dried flowers of Matricaria recutita possesses promising in vitro anti-inflammatory and significant COX-2 inhibitory potential.

Sudhakar C.,Satavahana University | Raghava Raju K.,Satavahana University | Komal Reddy M.,Satavahana University
Journal of Chemical and Pharmaceutical Research | Year: 2014

series of some new 2,2'(2,5-dimethoxy-3,6-dioxocycloxa-1,4-diene-1-4-diyl)bis(azanediyl) diacetic acid analogues were synthesized with the objective for evaluation as antimicrobials. Reaction of 2,5-dibromo-3,6-dimethoxy-1,4- benzoquinone with amino acids in the presence of triethylamine in ethanol gave the corresponding title compounds. The structures of all the newly synthesized compounds have been supported by elemental analysis, IR, 1H NMR and mass spectral data. All the synthesized compounds were tested for their antibacterial activity in comparison with the standard drug Streptomycin.

Kankala S.,Kakatiya University | Nerella S.,Kakatiya University | Vadde R.,Kakatiya University | Vasam C.S.,Satavahana University
RSC Advances | Year: 2013

An efficient and green procedure for the synthesis of Markovnikov i.e. branched vinyl sulfides in aqueous media was developed by employing the dinuclear Rh(i) complexes of hydrophilic phosphines as catalysts in the alkyne hydrothiolation with aliphatic thiols. Deuterium-labeling studies provide evidence for the aptness of these dinuclear catalysts to form selectively the Markovnikov syn-addition products. Catalyst order experiments disclose that the order with respect to the concentration of the catalyst is one, i.e. in solution the active catalyst is dinuclear with one active metal center and the second metal center contribute the cooperative effects to influence the Markovnikov selectivity in hydrothiolation. Further, the possibility of catalyst recovery and recycling experiments were also demonstrated. © 2013 The Royal Society of Chemistry.

Kankala S.,Kakatiya University | Edulla R.,Kakatiya University | Modem S.,Kakatiya University | Vadde R.,Kakatiya University | Vasam C.S.,Satavahana University
Tetrahedron Letters | Year: 2011

The intramolecular crossed aldehyde-ketone benzoin condensation in the chalcone of o-phthalaldehyde (OPA) catalyzed by N-heterocyclic carbene (NHCs) generated in situ from readily available imidazolium and thiazolium salts is described. In this reaction, bicyclic α-hydroxyl ketones (naphthalenone type tertiary alcohol) were selectively produced in good yields (75-94%) in shorter reaction times (20 min) through nucleophilic addition of acyl anion generated by umpolung in OPA-chalcone (regio controlled). © 2011 Elsevier Ltd. All rights reserved.

Kankala S.,Kakatiya University | Vadde R.,Kakatiya University | Vasam C.S.,Satavahana University
Organic and Biomolecular Chemistry | Year: 2011

A first example of organo-N-heterocyclic carbene (NHC) catalyzed click-type fast 1,3-dipolar cycloaddition of nitrile oxides with alkynes was developed for the regioselective synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles. Triethylamine (Et 3N) was employed as an effective base to generate both nitrile oxide and the organo-NHC catalyst in situ. This catalytic approach was used to attach a variety of substituents, including other biologically active fragments, onto the isoxazole ring to selectively design multinucleus structures. Further, we have also optimized the conditions for Cu(i)-free Sonogashira cross-coupling to obtain internal alkynes in high yields, which were subsequently used in cycloaddition. A catalytic cycle is proposed and the remarkable regiocontrol in the formation of isoxazoles was ascribed to a beneficial zwitterion intermediate developed by the interaction of the strongly nucleophilic organo-NHC catalyst with alkyne followed by nitrile oxide. © 2011 The Royal Society of Chemistry.

Nayak A.S.,Satavahana University
International Journal of Pharma and Bio Sciences | Year: 2014

A new series of 2,5-disubstituted 1,3,4-thiadiazoles were synthesized by using different aromatic or aliphatic carboxylic acids (1) and thiosemicarbazide (2). The structures of the synthesized compounds were established by their spectral (IR, 1H NMR and Mass) data. All the compounds were screened for their antimicrobial activity against Staphylococcus aureus. Escherichia coli, Compounds showed mild to moderate activity, but not comparable with the standard (Norflaxacin).

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