Karimnagar, India
Karimnagar, India

Satavahana University is a public university situated in Karimnagar in Telangana. Wikipedia.

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Ashok D.,Osmania University | Vanaja B.R.,Osmania University | Sarasija M.,Satavahana University | Lakshmi B.V.,Osmania University
Journal of the Serbian Chemical Society | Year: 2017

Due to the potential antimicrobial activity of pyranochromenones and pyrazolines moieties, hybrid compounds containing both substituted 4-chloro- -8-methyl-2-(1,3-diphenyl-1H-pyrazol-4-yl)-1,5-dioxa-2H-phenanthren-6-ones (4a-g), were synthesized from substituted (E)-1-(7-hydroxy-4-methyl-8- -coumarinyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-propen-1-ones (3a-g) in good yield using the Vilsmeier reaction, by the microwave-assisted method. The structures of all the compounds were established based on their analytical and spectral data. All the synthesized compounds were tested in vitro for their antibacterial and antifungal activities. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi.

Kankala S.,Kakatiya University | Gundepaka P.,Satavahana University | Gundepaka P.,Jawaharlal Nehru Technological University | Thota N.,KTH Royal Institute of Technology | And 6 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

Regioselective synthesis of isoxazole-mercaptobenzimidazole hybrids and their efficiency in in vivo analgesic and anti-inflammatory activity was described. A comparison of structure-activity relationship for there compounds was also emphasized. © 2012 Elsevier Ltd. All rights reserved.

Kankala S.,Kakatiya University | Nerella S.,Kakatiya University | Vadde R.,Kakatiya University | Vasam C.S.,Satavahana University
RSC Advances | Year: 2013

An efficient and green procedure for the synthesis of Markovnikov i.e. branched vinyl sulfides in aqueous media was developed by employing the dinuclear Rh(i) complexes of hydrophilic phosphines as catalysts in the alkyne hydrothiolation with aliphatic thiols. Deuterium-labeling studies provide evidence for the aptness of these dinuclear catalysts to form selectively the Markovnikov syn-addition products. Catalyst order experiments disclose that the order with respect to the concentration of the catalyst is one, i.e. in solution the active catalyst is dinuclear with one active metal center and the second metal center contribute the cooperative effects to influence the Markovnikov selectivity in hydrothiolation. Further, the possibility of catalyst recovery and recycling experiments were also demonstrated. © 2013 The Royal Society of Chemistry.

Venkatesh M.,University of Hyderabad | Ramakanth S.,University of Hyderabad | Ramakanth S.,Satavahana University | Chaudhary A.K.,University of Hyderabad | James Raju K.C.,University of Hyderabad
Optical Materials Express | Year: 2016

The nickel (Ni) films of three different thicknesses, 65 nm, 135 nm and 1018 nm, were deposited by RF magnetron sputtering technique. These films were subjected to femtosecond laser pulses of ~140 fs duration at 80 MHz repetition rate for generation of terahertz (THz) radiation. The obtained electromagnetic radiation was detected using photoconductive antennas by sampling technique. The THz generation mechanism of Ni films is attributed to the ultrafast demagnetization process and its time depends on the Gilbert damping factor. The ascertained values of the Gilbert damping parameter of Ni films using ferromagnetic resonance (FMR) measurements lies between 0.011 and 0.0069. We have observed that the amplitude of emitted THz radiation from Ni films is proportional Gilbert damping factor of films. The amplitude of emitted THz radiation from 65 nm Ni film is 1.19 and 1.66 times high as compared to 135 and 1018 nm films. © 2016 Optical Society of America.

Dayakar G.,Kakatiya University | Jeyanthi A.,Satavahana University
Der Pharma Chemica | Year: 2013

3H-imidazo[4,5-b]pyridine-2-amine(2) was treated with acetyl acetone to form 1-(3H-imidazo[4,5-b]pyridine-2-yl)-2-(pentan-2,4-dione-2-ylidene)hydrazine(3). This was treated with hydrazine hydrate and phenyl hydrazine hydrate to give pyrrole derivatives 1-(3H-imidazo[4,5-b]pyridine-2-yl)-2-(3,5-dimethyl-1H-pyrrol-2-yl)diazenes(4,5).

Kakkerla R.,Satavahana University | Vaddiraju N.,Satavahana University | Merugu R.,Mahatma Gandhi University
International Journal of Pharma and Bio Sciences | Year: 2016

A series of isoxazolyl schiff's bases (3a-h) were synthesized from N-(5-methyl-3-isoxazolyl)-3- oxobutanamide (1) .The compound (1) upon heating with different primary amines in methanol furnished (E)-3-(methylimino)-N-(5-methylisoxazol-3-yl)butanamides (3a-h) in excellent yield. The structure of all the synthesized compounds has been established by IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds (3a-h) were screened for antibacterial activity against two Gram-positive (Bacillus subtilis MTCC 121 and Staphylococcus aureus MTCC 96) and two Gram-negative (Escherichia coli MTCC 43 and Klebsiella pneumoniae MTCC 530) bacterial strains. The Schiff's bases (E)-N-(5- methylisoxazol-3-yl)-3-(phenylimino)butanamide 3c ( MIC values 11±0.28, 14±0.10, 12±0.31,14±0.31, at 40μg/μL,) and (E)-3-(benzylimino)-N-(5-methylisoxazol-3-yl)butanamide 3f ( MIC values 12±0.38, 14±0.10, 13±0.21,14±0.32, at 40μg/μL,) showed significant activity against all the bacteria tested compared to other compounds in this series. All other compounds except compounds 3a and 3b have shown considerable antibacterial activity against different bacterial stains. Compound 3a and 3b could show activity only at the high concentration. Furthermore, substitutions at phenyl nucleus have not much affected the antibacterial activity.

Kankala S.,Kakatiya University | Edulla R.,Kakatiya University | Modem S.,Kakatiya University | Vadde R.,Kakatiya University | Vasam C.S.,Satavahana University
Tetrahedron Letters | Year: 2011

The intramolecular crossed aldehyde-ketone benzoin condensation in the chalcone of o-phthalaldehyde (OPA) catalyzed by N-heterocyclic carbene (NHCs) generated in situ from readily available imidazolium and thiazolium salts is described. In this reaction, bicyclic α-hydroxyl ketones (naphthalenone type tertiary alcohol) were selectively produced in good yields (75-94%) in shorter reaction times (20 min) through nucleophilic addition of acyl anion generated by umpolung in OPA-chalcone (regio controlled). © 2011 Elsevier Ltd. All rights reserved.

Kankala S.,Kakatiya University | Vadde R.,Kakatiya University | Vasam C.S.,Satavahana University
Organic and Biomolecular Chemistry | Year: 2011

A first example of organo-N-heterocyclic carbene (NHC) catalyzed click-type fast 1,3-dipolar cycloaddition of nitrile oxides with alkynes was developed for the regioselective synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles. Triethylamine (Et 3N) was employed as an effective base to generate both nitrile oxide and the organo-NHC catalyst in situ. This catalytic approach was used to attach a variety of substituents, including other biologically active fragments, onto the isoxazole ring to selectively design multinucleus structures. Further, we have also optimized the conditions for Cu(i)-free Sonogashira cross-coupling to obtain internal alkynes in high yields, which were subsequently used in cycloaddition. A catalytic cycle is proposed and the remarkable regiocontrol in the formation of isoxazoles was ascribed to a beneficial zwitterion intermediate developed by the interaction of the strongly nucleophilic organo-NHC catalyst with alkyne followed by nitrile oxide. © 2011 The Royal Society of Chemistry.

Nayak A.S.,Satavahana University
International Journal of Pharma and Bio Sciences | Year: 2014

A new series of 2,5-disubstituted 1,3,4-thiadiazoles were synthesized by using different aromatic or aliphatic carboxylic acids (1) and thiosemicarbazide (2). The structures of the synthesized compounds were established by their spectral (IR, 1H NMR and Mass) data. All the compounds were screened for their antimicrobial activity against Staphylococcus aureus. Escherichia coli, Compounds showed mild to moderate activity, but not comparable with the standard (Norflaxacin).

Kankala S.,Kakatiya University | Kankala R.K.,National Dong Hwa University | Balaboina R.,Satavahana University | Thirukovela N.S.,Kakatiya University | And 2 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2014

A facile synthesis of piperidine alkene-alkaloids including natural (+)-Caulophyllumine B in high yields has been developed by Heck cross-coupling reaction catalyzed by simple in situ formed palladium-N-heterocyclic carbenes (Pd-NHCs). Formation of Pd(0) nanoparticles has been noticed during the reaction course. The synthesized piperidine alkene-alkaloids were evaluated for in vitro anti-cancer activity against a panel of human tumor cell lines of lung, breast and ovarian. Several of these piperidine alkene-alkaloids were found to possess highest growth inhibition activity than the standard drug cisplatin and support the concept to modulate drug receptor interaction. © 2013 Elsevier Ltd. All rights reserved.

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