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Pereira M.,National AIDS Research Institute ICMR | Sheta D.,National AIDS Research Institute ICMR | Ghorpade S.V.,Sassoon General Hospitals | Gaikwad S.N.,Sassoon General Hospitals | And 4 more authors.
International Journal of Pharma and Bio Sciences | Year: 2013

Emergence of multidrug-resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing countries. Hence, there is a need for continuous monitoring of drug resistance to anti-tuberculosis drugs in tuberculosis patients. A study was conducted to determine the prevalence anti-TB drug resistance in Mycobacterium tuberculosis isolates obtained from sputum samples of clinically suspected TB patients with no history of previous anti-TB treatment attending a tertiary care hospital from February 2006 to August 2007 in Pune, India. Mycobacterium tuberculosis isolates were subjected to drug susceptibility testing (DST) to four firstline anti-TB drugs namely Isoniazid, Rifampicin, Streptomycin and Ethambutol by Bactec MGIT 960 system being currently used in the Revised National Tuberculosis Control Program (RNTCP). It was found that MDR-TB prevalence in newly diagnosed pulmonary tuberculosis patients in Pune has not increased compared to the earlier data. Adequate data on MDR-TB at national and regional level are not available. Hence, it is essential to conduct nationwide drug resistance surveillance for TB with continuous monitoring of trends to curb the emergence of drug resistance to ensure the success of tuberculosis control programs in the country.

Sahasrabudhe P.,Deenanath Mangeshkar Hospital and Sassoon General Hospitals | Panse N.,Sassoon General Hospitals | Waghmare C.,Sassoon General Hospitals | Waykole P.,Sassoon General Hospitals
Indian Journal of Surgery | Year: 2012

We report our experience of technique of V-Y-plasty in treatment of pilonidal sinus. A retrospective study of 25 patients performed from 2005 to 2010 at Deenanath Mangeshkar Hospital and Sassoon General Hospitals, Pune, was performed. The unilateral or bilateral V-Y advancement flap technique was used in the management of these patients. The outcome was assessed on the basis of efficacy of flap surgery in achieving wound healing and recurrence. The follow-up ranged from 6 months to 5 years. The study included 25 cases of pilonidal sinus. Nineteen patients (76%) underwent unilateral V-Y-plasty and six patients (24%) underwent bilateral V-Y-plasty. Eighty-four percent cases were from the age group of 21-30 years. Sixty-eight percent patients were mobilized on the fourth postoperative day and 32% patients were mobilized on the third postoperative day. No recurrence was found in any of the patients. Itching and hypertrophic scar were found in two cases (8%), and decreased sensation was found in one patient (4%). The V-Y advancement flap technique for the treatment of pilonidal sinus is efficient and can reduce recurrence. Unilateral/bilateral V-Y flap achieves suture line away from midline, obliteration of natal fold and coverage of defect without tension. In follow-up none of the patients showed recurrence. This technique has distinctly less morbidity and avoids of multiple dressings, reducing the total cost of the treatment. V-Y advancement flap is distinctly better choice among the available flaps as it is less time-consuming, requires less technical expertise as compared to Z-plasty and perforator flaps, and is reliable and easy to plan. © 2012 Association of Surgeons of India.

Mane A.,National Dairy Research Institute | Gujar P.,Sassoon General Hospitals | Chandra J.,National Dairy Research Institute | Lokhande R.,Sassoon General Hospitals | And 3 more authors.
Mycopathologia | Year: 2015

The present study was undertaken to detect Pneumocystis jirovecii infection among HIV-positive patients presenting with symptoms of lower respiratory tract infection and analyze the associated dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) mutations. P. jirovecii infection was detected in 12.6 % cases. We did not find DHPS gene mutations at the commonest positions of codon 55 and 57; however, mutation at codon 171 was detected in two cases. No mutations in DHFR gene were detected. The results indicate low prevalence of DHPS and DHFR mutations in Indian P. jirovecii isolates, suggesting that the selective pressure of sulfa drugs on the local strains has probably not reached the levels found in developed nations. © 2014, Springer Science+Business Media Dordrecht.

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