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Hatchette T.F.,Dalhousie University | Drews S.J.,Provincial Laboratory for Public Health ProvLab | Drews S.J.,University of Calgary | Bastien N.,National Microbiology Laboratory NML | And 15 more authors.
Journal of Clinical Microbiology | Year: 2013

The recent emergence of influenza A virus (H7N9) emphasizes the need for its rapid detection.While commercial nucleic acid amplification tests (NAATs) are commonly used to detect seasonal influenza virus, this study demonstrated that the analytical sensitivity of commercial assays is highly variable compared to that of CDC-based in-house NAATs for the detection of H7N9.© 2013, American Society for Microbiology.All Rights Reserved. Source

Lehotay D.C.,Saskatchewan Disease Control Laboratory SDCL | Lehotay D.C.,University of Saskatchewan | Hall P.,Saskatchewan Disease Control Laboratory SDCL | Hall P.,University of Saskatchewan | And 5 more authors.
Clinical Biochemistry | Year: 2011

Newborn screening programs detect treatable disorders in infants before they become symptomatic. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has greatly increased the screening possibilities by monitoring levels of amino acids and acylcarnitines. After the initial screening step, LC-MS/MS can also be used in screening positive samples as a second tier test to differentiate between true and false positive samples. As the list of disorders screened for by LC-tandem MS increases, questions arise about screening for untreatable disorders, such as some lysosomal storage diseases (LSDs). For LSDs screening methods are being developed and tested more quickly than treatments are becoming available. This goes against one of the main tenets of newborn screening which requires that a treatment be available. LC-MS/MS can detect several disorders with a single injection, which is important in high throughput laboratories. Measuring different amino acids and acylcarnitines can be used to detect up to 45 different inherited disorders depending on how diseases are counted. The LSD assays are designed in a similar way to detect multiple disorders with common sample preparation and a single injection. The clinical implications of applying this technology to NBS on a large scale in many jurisdictions across the world are discussed. © 2010 The Canadian Society of Clinical Chemists. Source

Hatchette T.F.,Dalhousie University | Drews S.J.,University of Alberta | Grudeski E.,Enterovirus and Enteric Virus Laboratory | Booth T.,Enterovirus and Enteric Virus Laboratory | And 20 more authors.
Journal of Clinical Microbiology | Year: 2015

The recent emergence of a severe respiratory disease caused by enterovirus D68 prompted investigation into whether Canadian hospital and provincial laboratories can detect this virus using commercial and laboratory-developed assays. This study demonstrated analytical sensitivity differences between commercial and laboratory-developed assays for the detection of enterovirus D68. Copyright © 2015, American Society for Microbiology. All Rights Reserved. Source

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