Sarsuna College

West Bengal, India

Sarsuna College

West Bengal, India
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Kumar Gupta S.,Sarsuna College | De S.,Technical Center | Chatterjee A.,University of Calcutta
Reliability Engineering and System Safety | Year: 2017

Bivariate reliability and vector bivariate hazard rate or hazard gradient functions are expected to have a role for meaningful assessment of the field performance for items under two-dimensional warranty coverage. In this paper a usage rate based simple class of bivariate reliability function is proposed and various bivariate reliability characteristics are studied for warranty claims data. The utilities of such study are explored with the help of a real life synthetic data. © 2016 Elsevier Ltd

Mandal A.,Rajendra Memorial Research Institute of Medical Sciences | Das S.,All India Institute of Medical Sciences | Kumar A.,Rajendra Memorial Research Institute of Medical Sciences | Roy S.,CSIR - Central Electrochemical Research Institute | And 11 more authors.
Frontiers in Immunology | Year: 2017

The survival of intracellular protozoan parasite, Leishmania donovani, the causative agent of Indian visceral leishmaniasis (VL), depends on the activation status of macrophages. l-Arginine, a semi-essential amino acid plays a crucial regulatory role for activation of macrophages. However, the role of L-arginine transport in VL still remains elusive. In this study, we demonstrated that intra-macrophage survival of L. donovani depends on the availability of extracellular L-arginine. Infection of THP-1-derived macrophage/human monocyte-derived macrophage (hMDM) with Leishmania, resulted in upregulation of L-arginine transport. While investigating the involvement of the transporters, we observed that Leishmania survival was greatly impaired when the transporters were blocked either using inhibitor or siRNA-mediated downregulation. CAT-2 was found to be the main isoform associated with L-arginine transport in L. donovani-infected macrophages. L-arginine availability and its transport regulated the host arginase in Leishmania infection. Arginase and inducible nitric oxide synthase (iNOS) expression were reciprocally regulated when assayed using specific inhibitors and siRNA-mediated downregulation. Interestingly, induction of iNOS expression and nitric oxide production were observed in case of inhibition of arginase in infected macrophages. Furthermore, inhibition of L-arginine transport as well as arginase resulted in decreased polyamine production, limiting parasite survival inside macrophages. L-arginine availability and transport regulated Th1/Th2 cytokine levels in case of Leishmania infection. Upregulation of L-arginine transport, induction of host arginase, and enhanced polyamine production were correlated with increased level of IL-10 and decreased level of IL-12 and TNF-α in L. donovani-infected macrophages. Our findings provide clear evidence for targeting the metabolism of L-arginine and L-arginine-metabolizing enzymes as an important therapeutic and prophylactic strategy to treat VL. © 2017 Mandal, Das, Kumar, Roy, Verma, Ghosh, Singh, Abhishek, Saini, Sardar, Purkait, Kumar, Mandal and Das.

Banerjee S.,West Bengal State University | Sensarma D.,West Bengal State University | Basuli K.,West Bengal State University | Naskar S.,Sarsuna College | Sarma S.S.,University of Calcutta
Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering | Year: 2012

The Reconstruction Conjecture is one of the most engaging problems under the domain of Graph Theory. The conjecture proposes that every graph with at least three vertices can be uniquely reconstructed given the multiset of subgraphs produced by deleting each vertex of the original graph one by one. This conjecture has been proven true for several infinite classes of graphs, but the general case remains unsolved. In this paper we will outline the problem and give a practical method for reconstructing a graph from its node-deleted. © 2012 ICST Institute for Computer Science, Social Informatics and Telecommunications Engineering.

Sensarma D.,West Bengal State University | Banerjee S.,West Bengal State University | Basuli K.,West Bengal State University | Naskar S.,Sarsuna College | Sarma S.S.,University of Calcutta
Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering | Year: 2012

Two-level logic minimization is a central problem in logic synthesis, and has applications in reliability analysis and automated reasoning. This paper represents a method of minimizing Boolean sum of products function with binary decision diagram and with disjoint sum of product minimization. Due to the symbolic representation of cubes for large problem instances, the method is orders of magnitude faster than previous enumerative techniques. But the quality of the approach largely depends on the variable ordering of the underlying BDD. The application of Binary Decision Diagrams (BDDs) as an efficient approach for the minimization of Disjoint Sums-of-Products (DSOPs). DSOPs are a starting point for several applications. The use of BDDs has the advantage of an implicit representation of terms. Due to this scheme the algorithm is faster than techniques working on explicit representations and the application to large circuits that could not be handled so far becomes possible. Theoretical studies on the influence of the BDDs to the search space are carried out. In experiments the proposed technique is compared to others. The results with respect to the size of the resulting DSOP are as good or better as those of the other techniques. © 2012 ICST Institute for Computer Science, Social Informatics and Telecommunications Engineering.

Naskar S.,Sarsuna College | Basuli K.,WBSU | Sarma S.S.,University of Calcutta
Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering | Year: 2012

Many problems in science and engineering [1, 3, 8, 10] can be formulated in terms of graphs. There are problems where spanning trees are necessary to be computed from the given graphs. Connected subgraph with all the n vertices of the graph G(V,E), where |V|=n, having exactly of n(1 edges called the spanning tree of the given graph. The major bottleneck of any tree generation algorithm is the prohibitively large cost of testing whether a newly born tree is twin of a previously generated one and also there is a problem that without checking for circuit generated subgraph is tree or non-tree. This problem increases the time complexity of the existing algorithms. The present approach avoids this problem with a simple but efficient procedure and at the same time ensures that a large number of non-tree subgraphs are not generated at all. © 2012 ICST Institute for Computer Science, Social Informatics and Telecommunications Engineering.

Pradhan D.,Dhruba Chand Halder College | Saha I.,Sarsuna College | Chatterjee A.,University of Calcutta | Mondal A.,West Bengal State University | And 2 more authors.
Biological Rhythm Research | Year: 2012

Lithium, widely used for the treatment of mania, has adverse side effects on circadian rhythms of pineal and testicular hormones. Objective was to examine the role of lithium on circadian rhythms of other hormones and glucose profiles in light-dark (12L:12D), constant light (12L:12L) and constant dark (12D:12D) regimens in rats. Intraperitoneal injection of lithium (2 mEq/kg body wt daily for 15 days) sustained circadian rhythms of T3, T4, thyroid-stimulating hormone (TSH), corticosterone, norepinephrine and epinephrine in light-dark and constant dark but not in constant light. But it abolished circadian rhythms of insulin and blood glucose in all the photoperiodic regimens, except insulin, without changing their pattern in constant dark. Patterns of circadian rhythms of thyroid and TSH, and adrenal hormones remained unchanged after lithium treatment in L-D or D-D, except TSH in L-D. The probable role of photoperiodic cue and lithium on circadian and/or nycthemeral (daily) rhythms of hormones and blood glucose profiles is discussed. © 2012 Taylor & Francis.

Dey A.,Indian Association for The Cultivation of Science | Karan S.,Indian Association for The Cultivation of Science | Dey A.,Sarsuna College | De S.K.,Indian Association for The Cultivation of Science
Materials Research Bulletin | Year: 2011

Polyethylene oxide (PEO) complexed with potassium iodide (KI) is synthesized to investigate the ionic conductivity of alkaline based polymer electrolytes. The structural and morphological characterizations of the nanocomposite polymer electrolytes are performed by X-ray diffractometry (XRD), atomic force microscopy (AFM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) measurements. The ionic conductivity increases with the increase of KI concentration up to about 20 wt.%. The effect of nanosized ceria (CeO 2 ∼ 10 nm) fillers on ionic conductivity in PEO-KI polymer electrolyte is also carried out, keeping PEO to KI wt.% ratio 80:20 and 85:15. The result reveals that the addition of ceria nanoparticles enhances the conductivity by two orders of magnitude. The presence of ceria at the highest concentration induces the same molecular environment within PEO chain as that of undoped PEO. Temperature dependence of ionic conductivity follows Arrhenius mechanism. © 2011 Elsevier Ltd. All rights reserved.

Gupta S.K.,Sarsuna College | De S.,General Motors | Chatterjee A.,University of Calcutta
Reliability Engineering and System Safety | Year: 2014

Warranty modelling with incomplete data is a major issue in reliability analysis. The incomplete failure region characterized by warranty field data may be classified into several domains representing failures from manufacturing/assembly defects, usage or fatigue. In the present paper a data driven approach has been suggested to demark the regions optimally through estimation of the change point in a hazard function. In the perspective of bivariate warranty analysis, as relevant in automobiles, we have assumed the lifetime distribution to be a mixture of distributions corresponding to the burn-in period and the useful life period. The proportions of observations in different regions demarketed by the warranty policy in the bivariate plane have been estimated by considering mileage along with age. The estimation scheme has been verified and validated through extensive simulation studies. The utilities of the results have been demonstrated by addressing several issues through a real life synthetic warranty data set from a large automobile company. © 2014 Elsevier Ltd. All rights reserved.

Dey A.,Sarsuna College
Nanotechnology Reviews | Year: 2015

Conducting polymer-wide band gap semiconductor nanocomposites are prepared by polymerizing pyrrole in the presence of colloidal titanium dioxide (TiO2) sol. Characterizations of nanocomposites are carried out by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and X-ray diffraction (XRD). Direct current (dc) and alternating current (ac) conductivities of nanocomposites have been investigated as a function of temperature and frequency for different concentrations of polypyrrole (PPY). The temperature dependence of ac conductivity suggests that small polaron tunneling occurs in the charge transfer process. A very large dielectric constant of about 13,000 at room temperature has been observed. The interface between PPY and TiO2 plays an important role in yielding a large dielectric constant in the composite. © 2015 by De Gruyter 2015.

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