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Tuljarani G.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Gowri Sankar D.,Andhra University | Kadgapathi P.,Hetero Drugs Ltd. | Satyanarayana B.,Neosun Biotech India Pvt. Ltd.
International Journal of Chemical Sciences | Year: 2011

A new, simple, accurate and economical spectrophotometric method for the determination of benzapril hydrochloride, quinapril hydrochloride, ranitidine hydrochloride, and drotaverine hydrochloride by using cobalt thiocyanate has been developed. The colored complexes are formed by coordination of secondary/tertiary amine group of drug with metal of cobalt thiocyanate that is extractable into nitrobenzene from aqueous solution. All the chromogens exhibit maximum absorption at 626 nm and obey Beer's law in the concentration range of 100-500, 10-50, 25-175 and 50-300 μg/mL for benzapril hydrochloride, quinapril hydrochloride, ranitidine hydrochloride and drotaverine hydrochloride, respectively. The method was validated in terms of accuracy, precision, and specificity and can be used for routine analysis of these drugs in bulk and pharmaceutical dosage forms.


Tuljarani G.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Gowri Sankar D.,Andhra University | Kadgapathi P.,Hetero Drugs Ltd. | Satyanarayana B.,Neosun Biotech India Pvt. Ltd
Oriental Journal of Chemistry | Year: 2010

Two simple and sensitive methods have been developed for the estimation of rosvastatin in bulk and in pharmaceutical dosage forms. Method A is based on the oxidative coupling of rosvastatin with MBTH in presence of oxidant cerric ammonium sulphate and the Xmax of the colored species was found to be 658 nm. Method B is based on the formation of co-ordination complex between rosvastatin and cobalt thiocyanate and the blue colored complex formed is extracted into nitrobenzene which posses characteristic absorption maxima 626 nm. The colored species obeyed Beer's Law in the concentration range 2-14 μg/mL and 50-250 μg/mL for method A and method B respectively. Marketed pharmaceutical preparations were analyzed and the results obtained by the proposed methods were in agreement with labeled amount. Recovery studies were carried out by standard addition method. The results of analysis have been validated by application of statistical principles to the data obtained and the methods were found to be satisfactory. Both the proposed methods were simple, rapid, and economical and can be used for routine analysis of rosvastatin in bulk and pharmaceutical dosage forms.


Haarika B.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The present work aims to prepare and evaluate twelve different formulations of orally disintegrating tablets (ODT's) containing Rizatriptan benzoate using various superdisintegrants like SSG, Crospovidone and Croscarmellose sodium by direct compression method to enhance patient compliance. The tablets were evaluated for pre and post compression studies and found to be within the limits. Based on the disintegrating time and dissolution studies, formulation F11 prepared by using the super disintegrants SSG and Croscarmellose sodium in combination was found to be best formulation. The disintegration time was very less for optimized formulation F11 (18 sec), drug release was complete and very fast (within 18 minutes 99.9%) when compared with other prepared formulations. DSC and FTIR data revealed that no interactions takes place between the drug and polymers used in the optimized formulation. Stability studies were conducted for optimized formulation F11 and found to be stable which retained their original properties with minor differences. Oral disintegrating tablets are suitable dosage forms in disease conditions like migraine as these dosage forms are patient compliant as well as show rapid onset of action as they are quick dissolving dosage forms.


Tulja Rani G.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Gowri Sankar D.,Andhra University | Kadgapathi P.,Hetero Drugs Ltd. | Kadgapathi P.,Neosun Biotech India Pvt | Satyanarayana B.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya
E-Journal of Chemistry | Year: 2011

A simple, fast, precise, selective and accurate RP-HPLC method was developed and validated for the simultaneous determination of atenolol and indapamide from bulk and formulations. Chromatographic separation was achieved isocratically on a Waters C18 column (250×4.6 mm, 5 μ particle size) using a mobile phase, methanol and water (adjusted to pH 2.7 with 1% orthophosphoric acid) in the ratio of 80:20. The flow rate was 1 mL/min and effluent was detected at 230 nm. The retention time of atenolol and indapamide were 1.766 min and 3.407 min. respectively. Linearity was observed in the concentration range of 12.5-150 μg/mL for atenolol and 0.625-7.5 μg/mL for indapamide. Percent recoveries obtained for both the drugs were 99.74-100.06% and 98.65-99.98%, respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness. The method developed can be used for the routine analysis of atenolol and indapamide from their combined dosage form.


Tangeda S.J.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Garlapati A.,Kakatiya University
Indian Journal of Heterocyclic Chemistry | Year: 2011

Title compounds (4a-p) were prepared by reacting corresponding 2-chloromethyl benzimidazole with carbon disulfide and various alkyl, aralkyl and heterocyclic amines in dimethylformamide. The newly synthesized compounds were characterized by IR, 1H NMR, MS and elemental analysis. All the compounds have been screened for antibacterial and antifungal activities.


Madhu C.H.,Dr Reddys Laboratory | Tangeda S.J.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Qarlapati A.,Kakatiya University
Indian Journal of Heterocyclic Chemistry | Year: 2011

Some new benzimidazolyl and benzotriazolyl dithiocarbamates (4a-e & 5a-e) were prepared by reacting corresponding benzimidazoles and benzotriazoles with carbon disulfide and various alkylhalides in dimethylformamide. The newly synthesized compounds were characterized by 1H NMR, MS and elemental analysis. All the compounds have been screened for cytotoxic activity using Trigonella seeds.

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