Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya

Nampally, India

Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya

Nampally, India
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Haarika B.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Bikshapathi D.V.R.N.,CMR College Pharmacy | Chandramouli M.S.,Gandhi hospital
Der Pharmacia Lettre | Year: 2016

The objective of the proposed research work is to prepare and evaluate the mouth dissolving/disintegrating tablets (MDTs) of losartan Potassium, which avoid the first-pass metabolism, improved the dissolution rate and enhance the bioavailability. Losartan potassium is an angiotention receptor antagonist, used in the management of hypertension. Mouth dissolving tablets (MDTs) were prepared by direct compression method by using different concentrations of superdisintegrant like Crospovidone, Sodium Starch Glycolate , Croscarmellose sodium, Micro Crystalline Cellulose and evaluated for physicochemical evaluation parameter such as hardness, friability, weight variation, drug content uniformity, water absorption ratio, wetting time, in-vitro, in-vitro dissolution studies. The twelve formulations, F1-F9 were formulated and among these formulations, F3 was optimized. The hardness, friability, weight variation and drug content were found to be within pharmacopeias limits. The In vitro drug release from formulation containing super disintegrant CP was found between 87.64±0.36 to 98.75±0.61 in 10 min and the maximum drug release was found with F3 formulation. The disintegration studies shown that the all formulations disintegrated in less than 1 minute. The formulation F3 shown less disintegration time of 17 seconds. The croscarmellose sodium and sodium starch glycolate shown more disintegration time than crospovidone. An accelerated stability study on optimized formulation was performed. The formulation was found to be stable, there was no change in the hardness, friability, disintegration time, and In-vitro drug release pattern. DSC and FTIR data revealed that no interactions takes place between the drug and polymers used in the optimized formulation. In conclusion, it can be stated that the objective of the study has been achieved. From the above study the formula used for F3 formulation was concluded as an optimized formulation due to its less disintegration time and good % drug release when compared with other formulations.


Tulja Rani G.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Gowri Shankar D.,Andhra University | Kadgapathi P.,Hetero Drugs Ltd | Satyanarayana B.,Neosun Biotech India Pvt. Ltd
Indian Journal of Pharmaceutical Education and Research | Year: 2011

A simple, efficient, and reproducible RP-HPLC method for the simultaneous determination of propranolol hydrochloride and diazepam in bulk and in pharmaceutical formulations has been developed and validated. The separation was carried out on Waters C18 (250 ×4.6 mm i.d, 5 μ) column using acetonitrile: 0.4% potassium dihydrogen ortho phosphate (adjusted to pH 3.52 with ortho phosphoric acid) in the ratio of 60:40 v/v as eluent. The flow rate was 1 ml/min and effluent was detected at 229 nm. The retention time of propranolol hydrochloride and diazepam were 2.330 and 6.663 min. respectively. The linear dynamic range was 2-24 μg/ml and 0.25- 3.0 μg/ml for propranolol hydrochloride and diazepam, respectively. Percentage recoveries for propranolol hydrochloride and diazepam were 100.03 and 99.72%, respectively. All the analytical validation parameters were determined and found in the limit as per ICH guidelines, which indicates the validity of the method. The developed method is also found to be precise and robust for the simultaneous determination of propranolol hydrochloride and diazepam in tablet dosage forms.


Tulja Rani R.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Gowri Sankar D.,Andhra University | Kadgapathi P.,Hetero Drugs Ltd. Balanagar | Suthakaran R.,P.A. College | Satyanarayana B.,Neosun Biotech India Pvt
International Journal of PharmTech Research | Year: 2010

Three simple, sensitive and accurate visible spectrophotometric methods (A, B and C) have been developed for the estimation of drotoverine hydrochloride in bulk and in pharmaceutical formulations. Method A, B are based on the Ion pair complex of the drug with two dyes namely erichrome black T and orange G in acidic buffer solution followed by their extraction into organic solvent, chloroform. The absorbance of chloroform layer was measured at the respective wavelength of maximum absorbance against the reagent blank. Method C is based on the oxidation /reduction reaction between drotaverine hydrochloride and folin-ciocalteu phenol's reagent to form a blue colored chromogen. All the variables have been optimized. The concentrations of measurements are reproducible within a relative standard deviation of less than 1%. The linearity was found to be 5 to 40, 5 to 30, and 10 to 70 μg/mL for method A, B and C respectively. The proposed methods were validated statistically. Recovery studies were carried out by standard addition method.


Tulja Rani G.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Gowri Shankar D.,Andhra University | Shireesha M.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Satyanarayana B.,Neosun Biotech Pvt. Ltd
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

Simple, sensitive, rapid and accurate spectrophotometric method has been developed for the determination of losartan and irbesartan in pure and pharmaceutical preparation. The method is based on the formation of ion-association complex of drug with orange-G in acidic buffer followed by its extraction into organic solvent (chloroform). The absorbance of organic layer was measured at their respective wavelength of maximum absorbance against the reagent blank. Beer's law is obeyed in the concentration range of 25-150 μg/mL for losartan and 20-100 μg/mL for irbesartan at the selected wavelengths. The results of analysis validated statistically and by recovery studies. The proposed method is simple, economical and useful in the estimation of these drugs in pharmaceutical formulations.


Tuljarani G.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Gowri Sankar D.,Andhra University | Kadgapathi P.,Hetero Drugs Ltd. | Satyanarayana B.,Neosun Biotech India Pvt. Ltd
Oriental Journal of Chemistry | Year: 2010

Two simple and sensitive methods have been developed for the estimation of rosvastatin in bulk and in pharmaceutical dosage forms. Method A is based on the oxidative coupling of rosvastatin with MBTH in presence of oxidant cerric ammonium sulphate and the Xmax of the colored species was found to be 658 nm. Method B is based on the formation of co-ordination complex between rosvastatin and cobalt thiocyanate and the blue colored complex formed is extracted into nitrobenzene which posses characteristic absorption maxima 626 nm. The colored species obeyed Beer's Law in the concentration range 2-14 μg/mL and 50-250 μg/mL for method A and method B respectively. Marketed pharmaceutical preparations were analyzed and the results obtained by the proposed methods were in agreement with labeled amount. Recovery studies were carried out by standard addition method. The results of analysis have been validated by application of statistical principles to the data obtained and the methods were found to be satisfactory. Both the proposed methods were simple, rapid, and economical and can be used for routine analysis of rosvastatin in bulk and pharmaceutical dosage forms.


Haarika B.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The present work aims to prepare and evaluate twelve different formulations of orally disintegrating tablets (ODT's) containing Rizatriptan benzoate using various superdisintegrants like SSG, Crospovidone and Croscarmellose sodium by direct compression method to enhance patient compliance. The tablets were evaluated for pre and post compression studies and found to be within the limits. Based on the disintegrating time and dissolution studies, formulation F11 prepared by using the super disintegrants SSG and Croscarmellose sodium in combination was found to be best formulation. The disintegration time was very less for optimized formulation F11 (18 sec), drug release was complete and very fast (within 18 minutes 99.9%) when compared with other prepared formulations. DSC and FTIR data revealed that no interactions takes place between the drug and polymers used in the optimized formulation. Stability studies were conducted for optimized formulation F11 and found to be stable which retained their original properties with minor differences. Oral disintegrating tablets are suitable dosage forms in disease conditions like migraine as these dosage forms are patient compliant as well as show rapid onset of action as they are quick dissolving dosage forms.


Rajitha B.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Prashanthi S.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Ramsubha Reddy K.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Tulja Rani G.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya
International Journal of PharmTech Research | Year: 2011

Two simple, precise, and rapid extractive spectrophotometric methods were developed for the estimation of tramadol hydrochloride in both pure and pharmaceutical dosage forms. The methods were based on the formation of colored complex by the drug with reagents like erichorme black-T (method-I) and orange-G (method-II) in an acidic buffer. The linearity ranges of tramadol hydrochloride were found to be 2 to 18 μg/mL for method-I and 2.5 to 15 μg/mL for method-II. The ion-associated complex formed was quantitatively extracted under the experimental conditions with chloroform and the absorbances of the organic layers were measured at 506 nm and 486 nm for method- I and method-II, respectively. The correlation coefficient (r2) for method-I and II were found to be 0.999 and 0.999, respectively. The methods were statistically evaluated and were found to be precise and accurate.


Tulja Rani G.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Gowri Sankar D.,Andhra University | Kadgapathi P.,Hetero Drugs Ltd. | Kadgapathi P.,Neosun Biotech India Pvt | Satyanarayana B.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya
E-Journal of Chemistry | Year: 2011

A simple, fast, precise, selective and accurate RP-HPLC method was developed and validated for the simultaneous determination of atenolol and indapamide from bulk and formulations. Chromatographic separation was achieved isocratically on a Waters C18 column (250×4.6 mm, 5 μ particle size) using a mobile phase, methanol and water (adjusted to pH 2.7 with 1% orthophosphoric acid) in the ratio of 80:20. The flow rate was 1 mL/min and effluent was detected at 230 nm. The retention time of atenolol and indapamide were 1.766 min and 3.407 min. respectively. Linearity was observed in the concentration range of 12.5-150 μg/mL for atenolol and 0.625-7.5 μg/mL for indapamide. Percent recoveries obtained for both the drugs were 99.74-100.06% and 98.65-99.98%, respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness. The method developed can be used for the routine analysis of atenolol and indapamide from their combined dosage form.


Tangeda S.J.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Garlapati A.,Kakatiya University
Indian Journal of Heterocyclic Chemistry | Year: 2011

Title compounds (4a-p) were prepared by reacting corresponding 2-chloromethyl benzimidazole with carbon disulfide and various alkyl, aralkyl and heterocyclic amines in dimethylformamide. The newly synthesized compounds were characterized by IR, 1H NMR, MS and elemental analysis. All the compounds have been screened for antibacterial and antifungal activities.


Madhu C.H.,Dr Reddys Laboratory | Tangeda S.J.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Qarlapati A.,Kakatiya University
Indian Journal of Heterocyclic Chemistry | Year: 2011

Some new benzimidazolyl and benzotriazolyl dithiocarbamates (4a-e & 5a-e) were prepared by reacting corresponding benzimidazoles and benzotriazoles with carbon disulfide and various alkylhalides in dimethylformamide. The newly synthesized compounds were characterized by 1H NMR, MS and elemental analysis. All the compounds have been screened for cytotoxic activity using Trigonella seeds.

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