Saroj Institute of Technology and Management Lucknow

Lucknow, India

Saroj Institute of Technology and Management Lucknow

Lucknow, India
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Tripathi G.K.,Saroj Institute of Technology and Management Lucknow | Singh S.,Saroj Institute of Technology and Management Lucknow | Nath G.,Banaras Hindu University
International Journal of PharmTech Research | Year: 2011

Gastroretentive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. The objective of present investigation is to develop pH sensitive extended and controlled release formulation of acetohydroxamic acid loaded oil entrapped calcium pectinate micro gel beads. Pectin based oil entrapped micro gel beads were prepared by ionic gelation technique. The drug was formulated into micro gel bead with entrapping the castor oil or mineral oil. Gel beads were prepared instantly after dropping of the formulation mixture into calcium chloride solutions. The beads were optimized by coating with ethylcellulose solution. The prepared beads were evaluated with diameter, floating lag time and % encapsulation efficiency, % drug content and drug release. The prepared beads were spherical and were found high drug content and encapsulation efficiency. The formulation exhibited sustained release behaviour and was best fitted in the Peppas model with n < 0.45. Subsequent coating of the selected batch of microbeads exhibited zero-order sustained pattern of the drug release up to 8 hr. The goodness of fitting the release data to the model was indicated by high correlation coefficient value and small errors. The optimized batch was found to be higher gastric retention efficiency in the albino rats and eradication efficiency for isolated Helicobacter pylori (H. pylori) strain. The results indicate that the prepared optimize bead was promising for the maintenance of effective concentration of the drug in the vicinity of H. pylori infection and was effective in term of complete termination of the infection from the stomach.


Tripathi G.K.,Saroj Institute of Technology and Management Lucknow | Singh S.,Saroj Institute of Technology and Management Lucknow
Tropical Journal of Pharmaceutical Research | Year: 2010

Purpose: To develop pH-sensitive controlled release formulation of clarithromycin in oil-entrapped calcium pectinate microgel bead. Methods: Pectin-based oil-entrapped microgel beads were prepared by ionic gelation technique. The gel beads were formed instantly after adding the liquid formulation mixture dropwise into calcium chloride solution. The beads were optimized by coating with ethylcellulose solution and then evaluated for their diameter, floating lag time, encapsulation efficiency and drug release. Results: Particle size, encapsulation efficiency and buoyancy were significantly affected by the concentration of the polymer and calcium chloride.The formulation exhibited sustained release profile and was best fitted to the Peppas model with n < 0.45. Ethylcellulose-coated formulation batch, C16, was the most suitable controlled formulation with drug release of 65 ± 2.61% in 8 h. Conclusion: An ethylcellulose-coated formulation with potential for sustained delivery of clarithromycin in the acidic region of the gastrointestinal tract was successfully developed. © Pharmacotherapy Group.

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