Vallabh Vidyanagar, India

Sardar Patel University
Vallabh Vidyanagar, India

Sardar Patel University is a university in the Gujarat state of India. It is named after independence leader Shri Sardar Vallabhbhai Patel . It was founded in 1955 by Shri Bhailalbhai D. Patel, known as Bhaikaka. This university considered as one of the best in India for higher education.The university was established by an Act of the Legislative Assembly of the then-Bombay Province in December 1955 and was UGC recognized under 2 of the UGC Act in October 1968. The university has many affiliated colleges and AICTE approved by All India Council for Technical Education, , New Delhi. 05-05-2010, Originally it had the status of a rural university but now it has diversified with the motto of "Excellence Matters". The university is the first among all the universities in Gujarat to volunteer for the accreditation in 2000. Sardar Patel University is listed among Top 30 Universities in India. Wikipedia.

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Bavarva J.H.,Stanley ott Cancer Center | Narasimhacharya A.V.R.L.,Sardar Patel University
Journal of Ethnopharmacology | Year: 2010

Ethnopharmacological relevance: Leucas cephalotes (Roth.) Spreng. (Laminaceae) is an ayurvedic traditional medicinal plant used in India, Nepal and Pakistan to treat several ailments including diabetes. Aim of the study: The aim of the present study is to investigate the antidiabetic, antihyperlipaemic and antioxidant activities of Leucas cephalotes for its purported use in diabetes. Materials and methods: The ethanol extract of leaves of Leucas cephalotes was administered (150, 300 and 450 mg kg-1 bw) to diabetes induced (IDDM and NIDDM) rats and carbohydrate, lipid, antioxidant, urea and creatinine profiles were assessed. Results: All the three doses of extract decreased plasma glucose and lipid profiles and, improved the antioxidant status of both types of diabetic rats. The extract administration improved hepatic glycogen content and hexokinase activity, decreased glucose-6-phosphatase activity, blood urea, creatinine contents and decreased lipid peroxidation in diabetic rats. Of the three doses used, 450 mg kg-1 bw dose was found to be more potent in its effects comparable to those of glibenclamide and metformin. Conclusion: Leucas cephalotes regulates both carbohydrate and lipid metabolism and, improves body antioxidant defense systems in both types of diabetes. © 2009 Elsevier Ireland Ltd.

Dave K.,Sardar Patel University | Lahiry A.,Gujarat State Biotechnology Mission
Current Topics in Medicinal Chemistry | Year: 2012

It is known that potassium channels are important for cell proliferation. HERG, a potassium channel protein, is a transmembrane protein, which increases in concentration on the cell surface of cancer cells. Apart from cancer cells, this protein is found only in the brain & heart tissue, in very low number. The proliferation of cells in cancer is dependent on activation of this protein, and it has been noted that blocking of this protein with drug molecule, helps inhibit the proliferation of the cells further. The current work aims to study the binding potentials of κ-PVIIA, conotoxin isolated from Conus purpurascens venom with HERG K + channel of tumor cells, where HERG mutation has been noted. The toxin under consideration i.e. κ-conotoxins-PVIIA (κ-PVIIA) is a 27 residue peptide. The docking studies suggest that the conotoxin binds stably to the HERG protein. The study shows that the peptide interacts with the charged extracellular unit of the HERG protein, i.e. the extracellular portion of the S5 domain named S5-P extracellular linker. Study of binding of toxins of similar origin, with normal potassium channels has been studied in silico. Further, wet laboratory work needs to be conducted for development of a drug molecule from this toxin, to treat some number of cancers. © 2012 Bentham Science Publishers.

Soni S.S.,Sardar Patel University | Kotadia D.A.,Sardar Patel University
Catalysis Science and Technology | Year: 2014

Pd(0)-doped mesoporous TiO2 nanoparticles (Pd/TiO2) have been synthesized using an EISA method. The catalytic activity of Pd/TiO2 nanoparticles (NPs) is significantly enhanced under solar light irradiation for the Heck reaction. The Heck coupling product gives a considerable amount of Z-isomer, due to photochemical isomerization of the initially formed E-isomer, providing a facility for the time-dependent selectivity of E/Z-isomers under sunlight at ambient conditions. This journal is © The Royal Society of Chemistry.

Fadadu K.B.,Sardar Patel University | Soni S.S.,Sardar Patel University
Electrochimica Acta | Year: 2013

New hemicyanine dyes having indole nucleus with different alkyl chain length were synthesized and characterized using 1H NMR and mass spectroscopy. These dyes were used to sensitize the TiO2 film in dye sensitized solar cell. Nanocrystalline dye solar cells were fabricated and characterized using various electrochemical techniques. It has been found that the alkyl chain length present in the dye molecules greatly affects the overall performance of dye solar cell. Molecules having longer alkyl chain are having better sensitizers which enhance Voc to significant extent. Chain length dependent performance was further investigated using Tafel polarization and impedance method. Hemicyanine dye having hexyl chain has outperformed by attaining 2.9% solar to electricity conversion efficiency. © 2012 Elsevier Ltd. All rights reserved.

Polyacrylonitrile (PAN)-grafted sodium salt of partially carboxymethylated tamarind kernel powder (Na-PCMTKP-g-PAN, %G = 413.76 and %GE = 96.48) was prepared using the established optimal reaction conditions for ceric-initiated graft copolymerization of acrylonitrile onto Na-PCMTKP (DS̄ = 0.15) in a homogeneous medium. The graft copolymer was hydrolyzed by 0.7N KOH solution at 90-95°C to yield the superabsorbent hydrogel H-Na-PCMTKP-g-PAN. The nitrile groups of Na-PCMTKP-g-PAN were completely converted into a mixture of hydrophilic carboxamide and carboxylate groups during alkaline hydrolysis, followed by in situ crosslinking of the grafted PAN chains. The products were characterized spectroscopically and morphologically. The swelling behavior of the unreported superabsorbent hydrogel, H-Na-PCMTKP-g-PAN, was studied by carrying out its absorbency measurements in low-conductivity water, 0.15M salt (NaCl, CaCl2, and AlCl3) solutions, and simulated urine (SU) at different timings. The swelling behavior of the hydrogel in different swelling media followed the second-order kinetics. The values of the various swelling characteristics were reported. © 2013 Wiley Periodicals, Inc.

Chapla D.,Sardar Patel University | Pandit P.,Sardar Patel University | Shah A.,Sardar Patel University
Bioresource Technology | Year: 2012

The selective production of xylooligosaccharides (XOS) was carried out using partially purified xylanase from . Aspergillus foetidus MTCC 4898. Corncob xylan was extracted using a mild alkali treatment which yielded 178.73. ±. 5.8. g. of. xylan/kg of corncobs. Partially purified . β-xylosidase free xylanase was found efficient in releasing xylooligosaccharides from corncob xylan. Maximum yield of xylooligosaccharides was 6.73. ±. 0.23. mg/ml after 8. h of reaction time using 20. U of xylanase at 45. °C. Purification of XOS was done using activated charcoal column chromatography. The purified XOS preparation contained mainly xylobiose and xylotriose. XOS mixture was found suitable for food industry looking at its high thermal stability at low pH. Prebiotic effect of XOS was evaluated by . in vitro fermentation of XOS using known probiotic strains viz. . Bifidobacterium adolescentis, . Bifidobacterium bifidum, . Lactobacillus fermentum, . Lactobacillus acidophilus. The results of this study revealed better growth of . Bifidobacterium spp. on XOS than . Lactobacillus spp. © 2011 Elsevier Ltd.

Surati K.R.,Sardar Patel University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2011

The mixed ligand mononuclear complex [Mn(bipy)(HPMFP)(OAc)]ClO4 was synthesized by reaction of Mn(OAc)3·2H2O with HPMFP and 2,2′-bipyridyl. The corresponding Schiff base complexes were prepared by condensation of [Mn(bipy)(HPMFP)(OAc)]ClO4 with ethylenediamine, ethanolamine and glycine (where HPMFP = 1-phenyl-3methyl-4- formyl-2-pyrazolin-5one, bipy = 2,2′-bipyridyl). All the compounds have been characterized by elemental analysis, magnetic susceptibility, conductometry measurements and 1H and 13C NMR, FT-IR, mass spectrometry. Electronic spectral and magnetic susceptibility measurements indicate square pyramidal geometry around manganese(III) ion. The thermal stabilities, activation energy E*, entropy change ΔS *, enthalpy change ΔH* and heat capacity of thermal degradation for these complexes were determined by TGA and DSC. The in vitro antibacterial and antifungal activity of four coordination compounds and ligand HPMFP were investigated. In vitro activates of Bacillus subtillis (MTCC-619), Staphylococcus aureus (MTCC-96), Escherichia coli (MTCC-722) and Klebsiella pneumonia (MTCC-109) bacteria and the fungus Candida albicans (ATCC-90028) were determined. All the compounds showed good antimicrobial activity. The antimicrobial activities increased as formation of Schiff base. © 2010 Elsevier B.V. All rights reserved.

Patel R.,Sardar Patel University
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2012

A significant effect of aggregation dynamics for aqueous ferrofluid (AF) and kerosene based ferrofluid (KF) using magnetic field dependent capillary viscosity and magneto-optical relaxation measurements is studied. For better comparison parameters of AF and KF are kept similar. Ferrohydrodynamic equations of chain forming ferrofluids, dilute ferrofluids, and Brownian dynamic simulations are compared. It is observed that the rotational viscosity of AF is larger than that of KF due to field induced aggregates in it and strong dipolar interactions. It is also observed that at Ωτ ∼ 0.04 both AF and KF viscosity becomes almost similar, suggesting similar behavior at that shear rate. The magneto-optical relaxation in AF exhibits nonexponential behavior when relaxed from higher magnetic field and follows irreversible thermodynamics, whereas for KF the relaxation is exponential and follows the effective field method. This discrepancy is explained based on aggregation dynamics of magnetic particles. Results are well described by the corresponding theoretical models. © 2012 American Physical Society.

Kotadia D.A.,Sardar Patel University | Soni S.S.,Sardar Patel University
Catalysis Science and Technology | Year: 2013

Symmetrical and unsymmetrical Brønsted acidic Ionic Liquids (ILs) have been synthesized via a one-pot halogen-free route and characterized by TGA-DTA and DSC to compare their stability and activity. The acidities of the four ILs have also been tested by the Hammett method. These ILs were utilised as catalysts for the dehydration of fructose to 5-hydroxymethylfurfural (HMF) in the presence of dimethylsulphoxide (DMSO) as solvent. The effects of reaction time, temperature and catalyst concentration were studied. The ILs are very efficient for the reaction at relatively lower temperature with very good HMF yield and selectivities. The used ILs could be easily recycled without any significant loss in fructose conversion and HMF yield. This journal is © The Royal Society of Chemistry 2013.

Kotadia D.A.,Sardar Patel University | Soni S.S.,Sardar Patel University
Journal of Molecular Catalysis A: Chemical | Year: 2012

The use of ionic liquid in catalysis is attracting more and more attention in the field of chemistry. In line with the research we have studied Supported Ionic Liquid Catalyst (SILC) which consist of benzimidazolium based ionic liquid immobilized on silica based solid support. The SILC proved to be an efficient heterogeneous catalyst for solvent less synthesis of 1-amidoalkyl naphthols from 2-naphthol, amides and aldehydes. The process represents a simple, ecologically safer, cost effective route to 1-amidoalkyl naphthol with high product quality, as well as easy product recovery and catalyst recycling. © 2011 Elsevier B.V. All rights reserved.

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