Soni S.,Sardar Bhagwan Singh PG Institute of Bio medical science and Research |
Ram V.,Sardar Bhagwan Singh PG Institute of Bio medical science and Research |
Negi V.J.,Sardar Bhagwan Singh PG Institute of Bio medical science and Research |
Chaudhary B.S.,Sardar Bhagwan Singh PG Institute of Bio medical science and Research |
And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013
In our present investigation we developed the multiunit gastro retentive beads bearing Metronidazole (MTZ) (log p=0.0) and sodium alginate (SA). This gastroretentive system can remain in the gastric region for a prolonged period of time and increases the gastric retention time which significantly increases the bioavailability, reduces drug waste and improves the solubility for the drugs that are less soluble in high pH environment. In this we developed beads system which comprises of MTZ, SA, buoyancy imparting agents and cross linking agents. These beads are prepared by ionotropic gelation technique and evaluated for the particle size, drug content, % buoyancy and in-vitro release. Percentage buoyancy of the beads was found excellent and they remain afloat for 12 hours and also show release characteristics for 12 hours. As the concentration of polymer increases (M4) the drug release extends upto 12 hours. This result however reveals that this system can be employed for the treatment of upper GI tract infection as well as system drug delivery.