Saratov State Medical University
Saratov, Russia
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Muzurova L.V.,Saratov State Medical University | Kochelaevskaya I.E.,Saratov State Medical University
Russian Open Medical Journal | Year: 2017

The individual variability of morphometric parameters of feet in 18-19 year-old girls (Saratov region, Russia) with different somatic types is examined. Materials and Methods - 240 18-19 year-old girls (the students of Saratov State Medical University n.a. V.I. Razumovsky, the locals of Saratov region) were examined during the annual special medical examination. The somatic type's identification of the examined girls was conducted in accordance with B.A. Nikitiuk and A.I. Kozlov (1990). The examination of the foot type was performed with planthogram. During the research the shape of feet (Egyptian, Greek, Roman), the frequency of its occurrence in somatic types was determined. Shriter index, which characterizes the height of the arch of the foot and Veysflog index, which characterizes the spring function of the foot, was calculated. Also, the frequency of occurrence in the arches of the foot somatotype and its various forms were determined. Results and Conclusion - The most common form of Egyptian foot is typical of women with mezomorphic hypotrophic and brachymorphic normotrophic somatotype; Roman foot - for brahimorphic hypertrophic and brahimorphic hypotrophic somatotypes; Greek foot - for dolihomorphic gipotorophic and brachymorphic hypertrophic somatotypes. High arch is common for Greek foot in the brahimorphic hypotrophic somatotype; elevated arch - for Roman foot in dolihomorphic normotrophic somatotype; flattened arch - for Egyptian foot in dolihomorphic normotrophic somatotype; platypodia - for Greek foot with brahimorphic hypotrophic somatotype. The foot of all forms and heights of the arch possesses a good spring function. © 2017, LLC Science and Innovations, Saratov, Russia.

Mikhailova E.V.,Saratov State Medical University | Chudakova T.K.,Saratov State Medical University
Eksperimental'naya i Klinicheskaya Farmakologiya | Year: 2015

The article is devoted to defining the diagnostic significance of hematological toxicity indices, systemic inflammatory response in children with influenza, and effectiveness of the inclusion of drug reamberin 1.5% solution for infusion in the program of infusion therapy of children with severe influenza symptoms. Results of clinical and laboratory observations over 130 flu children aged from 5 months to 12 years are presented. The Laboratory indicators of systemic inflammation, including C-reactive protein (CRP), leukocyte index of intoxication, and hematological index of intoxication, proved to be informative enough for the early diagnostics of severe and complicated influenza. A decrease in the CRP level and hematological parameters of intoxication observed upon the inclusion of reamberin infusion therapy in the treatment program of patients with severe course of influenza showed pronounced detoxifying effect of the drug. Thus, the inclusion of reamberin infusion into the treatment of influenza accelerates stopping of the clinical symptoms of disease and reduces the duration of inpatient treatment. © 2015, Izdatel'stvo Meditsina. All rights reserved.

Medvedeva M.F.,Saratov State Medical University | Doubrovski V.A.,Saratov State Medical University
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2017

The resolution of the acousto-optical method for blood typing was estimated experimentally by means of two types of reagents: monoclonal antibodies and standard hemagglutinating sera. The peculiarity of this work is the application of digital photo images processing by pixel analysis previously proposed by the authors. The influence of the concentrations of reagents, of blood sample, which is to be tested, as well as of the duration of the ultrasonic action on the biological object upon the resolution of acousto-optical method were investigated. The optimal experimental conditions to obtain maximum of the resolution of the acousto-optical method were found, it creates the prerequisites for a reliable blood typing. The present paper is a further step in the development of acousto-optical method for determining human blood groups. © COPYRIGHT SPIE.

Herrschaft H.,University of Cologne | Nacu A.,Moldova State University | Sholomov I.,Saratov State Medical University | Hoerr R.,Dr. Willmar Schwabe GmbH and Co. KG Pharmaceuticals | Schlaefke S.,Dr. Willmar Schwabe GmbH and Co. KG Pharmaceuticals
Journal of Psychiatric Research | Year: 2012

A multi-centre, double-blind, randomised, placebo-controlled, 24-week trial with 410 outpatients was conducted to demonstrate efficacy and safety of a 240 mg once-daily formulation of Ginkgo biloba extract EGb 761 ® in patients with mild to moderate dementia (Alzheimer's disease or vascular dementia) associated with neuropsychiatric symptoms. Patients scored 9 to 23 on the SKT cognitive battery, at least 6 on the Neuropsychiatric Inventory (NPI), with at least one of four key items rated at least 4. Primary outcomes were the changes from baseline to week 24 in the SKT and NPI total scores. The ADCS Clinical Global Impression of Change (ADCS-CGIC), Verbal Fluency Test, Activities of Daily Living International Scale (ADL-IS), DEMQOL-Proxy quality-of-life scale and 11-point box scales for tinnitus and dizziness were secondary outcome measures. Patients treated with EGb 761 ® (n = 200) improved by 2.2 ± 3.5 points (mean ± sd) on the SKT total score, whereas those receiving placebo (n = 202) changed only slightly by 0.3 ± 3.7 points. The NPI composite score improved by 4.6 ± 7.1 in the EGb 761 ®-treated group and by 2.1 ± 6.5 in the placebo group. Both drug-placebo comparisons were significant at p < 0.001. Patients treated with EGb 761 ® also showed a more favourable course in most of the secondary efficacy variables. In conclusion, treatment with EGb 761 ® at a once-daily dose of 240 mg was safe and resulted in a significant and clinically relevant improvement in cognition, psychopathology, functional measures and quality of life of patients and caregivers. © 2012 Elsevier Ltd.

Belyanina S.I.,Saratov State Medical University
Russian Journal of Genetics | Year: 2012

The data on karyopool analysis of Chironomus plumosus from Novozybkov raion of Bryansk oblast, radioactively contaminated as a result of the Chernobyl accident, are presented. In the karyopool of this population, four types of heterozygous inversions (A1. 2, B1. 2, C1. 2, D1. 2) and a structurally small rearrangement in arm D, which is thought to be also associated with inversion, were identified. For inversions A1. 2, C1. 2, and structurally small rearrangement in arm D the cases of somatic mosaicism were described. The mean number of inversions per individual constituted 0. 78. The number of genotypic combinations was 13. In 5% of the individuals chromosome B was identified, while 15. 6% were polyploid (3n). In 1. 8% of triploids somatic mosaicism for the level of polytene chromosomes was observed. Most of the larvae were characterized by partial asynapsis of the homologs in different regions of chromosome III. Specific features of the Chironomus plumosus karyopool from Novozybkov are thought to be associated with the habitation of a number of generations of this population on radioactively polluted territory. © 2012 Pleiades Publishing, Ltd.

The karyopools of the phytophilous chiromomid species of Glyptotendipes glaucus (Mg.) were studied. Chironomids originated from a number of reservoirs located in the Novozybkovsky raion of the Bryansk region, which was affected by the Chernobyl radioactive release, and two reservoirs located in the Saratov region. Differences in the inversion spectrum and frequencies, both among Bryansk and between Bryansk and Saratov populations, were found. There were no new inversions in the Novozybkovsky populations; however, structurally small rearrangements in long chromosomes were noted. Typical abnormalities included mosaicism of the chromosome morphotypes in cells of the same saline gland, which was especially distinctive in the larvae from the forbidden zone; decondensation of the telomere regions of chromosomes; and mosaic asynapsis of the chromosome IV homologs (up to complete disjunction). Also, several larvae were polyploids. Other species of Glyptotendipes inhabiting the Novozybkovsky reservoirs were represented by the single species of G. paripes (near the Korchy settlement). The karyotypes of its several larvae were represented by an unorganized chromosomal substance. The other Glyptotendipes species seem to have lower adaptive abilities under the conditions in question and were eliminated from precatastrophe biotopes, while G. glaucus succeeded in adaptating to the new environment. © 2014, Pleiades Publishing, Inc.

Terentyuk G.,Chernyshevsky Saratov State University | Panfilova E.,Chernyshevsky Saratov State University | Khanadeev V.,Chernyshevsky Saratov State University | Chumakov D.,Chernyshevsky Saratov State University | And 7 more authors.
Nano Research | Year: 2014

Nanocomposites (NCs) consisting of a gold nanorod core and a mesoporous silica shell doped with hematoporphyrin (HP) have been fabricated in order to improve the efficiency of cancer treatment by combining photothermal and photodynamic therapies (PDT + PTT) in vivo. In addition to the long-wavelength plasmon resonance near 810-830 nm, the fabricated NCs exhibited a 400-nm absorbance peak corresponding to bound HP, generated singlet oxygen under 633-nm excitation near the 632.5-nm Q-band, and produced heat under a 808-nm near-infrared (NIR) laser irradiation. These modalities were used for a combined PDT + PTT treatment of large (about 3 cm3) solid tumors in vivo with a xenorafted tumor rat model. NCs were directly injected into tumors and irradiated simultaneously with 633-nm and 808-nm lasers to stimulate the combined photodynamic and photothermal activities of NCs. The efficiency of the combined therapy was evaluated by optical coherence tomography, histological analysis, and by measurements of the tumor volume growth during a 21-day period. The NC-mediated PDT led to weak changes in tissue histology and to a moderate 20% decrease in the tumor volume. In contrast, the combined PDT + PTT treatment resulted in the large-area tumor necrosis and led to dramatic decrease in the tumor volume. [Figure not available: see fulltext.] © 2013 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

Cytogenetic analysis was performed on samples of Chironomus plumosus L. (Diptera, Chironomidae) taken from waterbodies of various types in Bryansk region (Russia) and Gomel region (Belarus). Karyotypes of specimens taken from stream pools of the Volga were used as reference samples. The populations of Bryansk and Gomel regions (except for a population of Lake Strativa in Starodubskii district, Bryansk region) exhibit broad structural variation, including somatic mosaicism for morphotypes of the salivary gland chromosome set, decondensation of telomeric sites, and the presence of small structural changes, as opposed to populations of Saratov region. As compared with Saratov and Bryansk regions, the Balbiani ring in the B-arm of chromosome I is repressed in populations of Gomel region. It is concluded that the chromosome set of Ch. plumosus in a range of waterbodies of Bryansk and Gomel regions is unstable. © 2015, Pleiades Publishing, Inc.

We studied the effects of irradiation with teraherz electromagnetic waves at frequencies corresponding to nitric oxide emission and absorption molecular spectrum (150,176-150,664 GHz) on activity of the sympathoadrenal and pituitary - adrenal axes of the stress response in albino male rats under conditions of acute immobilization stress. It was shown that terahertz waves exert stress-limiting effect and are capable of reducing the levels of catecholamines, corticotropin, and corticosterone in male rats exposed to acute stress. © 2013 Springer Science+Business Media New York.

The article highlights the main problems and perspectives of launching open access medical journals in Russia, using The Saratov Journal of Medical Scientific Research as an example. Launching the journal's open access website is viewed as a major achievement, enabling smooth communication and coordination of the editorial work. Insufficient English language skills among authors and editors are the main problem hampering international recognition of Russian scholarly journals.

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