Time filter

Source Type

Ulianova O.V.,Saratov State Agrarian University | Ulianov S.S.,Chernyshevsky Saratov State University | Li P.,Wuhan University of Science and Technology | Luo Q.,Wuhan University of Science and Technology
Quantum Electronics | Year: 2011

A new method of photoinactivation of bacteria aimed at producing prototypes of vaccine preparations against extremely dangerous infections is described. The reactogenicity of the new prophylactic preparations was studied using the laser speckle contrast analysis (LASCA). The performed experimental studies show that bacterial suspensions, irradiated using different regimes of photo- inactivation, do not cause detrimental effect on the blood microcirculation in laboratory animals. © 2011 Kvantovaya Elektronika and Turpion Ltd. Source

Kuznetsov V.A.,Saratov State Agrarian University
Russian Physics Journal | Year: 2011

It is demonstrated that the resonant mechanism on inhomogeneities formed for a fixed distribution of dielectric permittivity can underlie the directed self-organization of the electron flow in semiconductors. The behavior of the resonant flow velocity amplitudes depending on the inhomogeneity factors is considered in the ballistic regime. © 2011 Springer Science+Business Media, Inc. Source

Pankratov A.N.,Chernyshevsky Saratov State University | Tsivileva O.M.,Russian Academy of Sciences | Drevko B.I.,Saratov State Agrarian University | Nikitina V.E.,Russian Academy of Sciences
Journal of Biomolecular Structure and Dynamics | Year: 2011

The role of spatial and electron structure, hydrophobic properties and concentration of organoselenium compounds on their interaction with fungal metabolites - extracellular lectins of Lentinula edodes (shiitake mushroom) has been considered. By the hybrid method of density functional theory at the B3LYP/6-31G(d,p) theory level, spatial and electronic structure of the 1,5-diphenyl-3-selenopentanedione-1,5 (preparation DAPS-25), 1,5-di(4-methoxyphenyl)-3-selenopentanedione-1,5 and 1,5-di(4-ethoxyphenyl)-3- selenopentanedione-1,5 molecules has been studied. The above molecules have been stated to be substantially similar to each other by their electronic and spatial characteristics. By means of the QSAR properties evaluation by the atomic-additive schemes, it has been shown that the molecules of the preparation DAPS-25, its dimethoxy- and diethoxy-substituted are close to each other by the hydrophilic-lipophilic balance, whereas di-n-octoxy derivative DAPS-25 is explicitly hydrophobic. The hemagglutinating activity of lectins in the presence of the preparation DAPS-25 and its alkyloxy-substituted increases, therewith the most effective addition is 1,5-di(4-ethoxyphenyl)-3-selenopentanedione-1,5. Apparently, the greater effectiveness of the said substance compared to DAPS -25 is caused by the formation of hydrogen bonds with a participation of unshared electron pairs of oxygen atoms from the ethoxy groups and mobile hydrogen atoms from the OH groups of glycoconjugates on erythrocytes surface. The positive effect of 1,5-di(4-n-octoxyphenyl)-3-selenopentanedione-1,5 is not so prominent, since the enlarged alkyl chain shields the aromatic fragments of organoselenium molecule participating in the binding with lectin. ©Adenine Press (2011). Source

Guliy O.I.,Saratov State Agrarian University | Zaitsev B.D.,RAS Institute of Radio Engineering and Electronics | Kuznetsova I.E.,RAS Institute of Radio Engineering and Electronics | Borodina I.A.,RAS Institute of Radio Engineering and Electronics | Ignatov O.V.,Russian Academy of Sciences
Current Immunology Reviews | Year: 2016

The bacterial surface is a complex combination of various immunogenic components of genus, species, and strain specificity. Polyclonal and monoclonal antibodies, used widely in the manufacture of diagnostic test systems, have traditionally served as biological components for the specific detection of bacterial cells. In molecular biology, bacterial cell detection is performed with the help of genetic engineering technologies for cloning recognizing fragments (hypervariable immunoglobulin domains (miniantibodies). These technologies are cheaper and can be competitive in selectivity with hybridoma technologies. At present, research is actively working to improve cell detection sensitivity with the use of electro-optical and electro-acoustical analysis, the main problem being to select antibodies with greater analytical sensitivity. This review highlights the use of specific antibodies and miniantibodies in electro-optical and electro-acoustical analysis for the detection of bacterial cells. © 2016 Bentham Science Publishers. Source

Kuznetsov V.A.,Saratov State Agrarian University
Semiconductors | Year: 2010

A technique for determining the depth of band gap sagging and the mechanism of this effect (related to the deformation potential, which may arise in the range of existence of mixed alloy systems) has been proposed based on analysis of the energy diagrams of II-VI semiconductor compounds. Choosing a proper composition of a binary or ternary system, one can increase its photosensitivity in a specified spectral range due to the band gap sagging. © 2010 Pleiades Publishing, Ltd. Source

Discover hidden collaborations