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Chaudhary S.A.,Saraswati Institute of Pharmaceutical science | Mehta T.A.,Nirma University
Drug Development and Delivery | Year: 2011

Thaumatin is natural sweetener first found as a mixture of protein obtained from a plant called Thaumatococcus deniellii. It is prepared from the seeds of the plant through various processes. It is 10,000 times sweeter than sucrose, thus it can be used in pharmaceutical formulations and other food items as a sweetener and flavoring agent in very less quantities to avoid the bitter after-taste of artificial sweeteners like sucralose and aspartame. It is a mixture of two types of proteins (thaumatin I and thaumatin II), making it useful as a sweetener and flavor enhancer for taste-masking certain bitter drugs. Source

Ankit B.C.,Saraswati Institute of Pharmaceutical science | Tejal A.M.,Nirma University
Journal of Pharmacy and Bioallied Sciences | Year: 2012

Quick dissolving film prepared by various grades of polyox like Polyox N10,N80, N750 and N205. Polyox having excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva. Film is optimized for concentration of polymer and plasticizer using CCD design. The tensile Strength, folding Endurance, % drug released at 10 min (Y10) and disintegration time were selected as dependent variables. The data revealed that 2% of polyox N 750 and 15% of PEG 400 showed excellent film forming property with rapid drug release profile. Source

Nadaraj V.,Kongunadu Arts and Science College | Selvi S.T.,Kongunadu Arts and Science College | Selvi S.T.,Government of Tamilnadu | Bai H.P.,Kongunadu Arts and Science College | And 2 more authors.
Medicinal Chemistry Research | Year: 2012

The microwave-induced three-component onepot synthesis of 2-amino-3-carbethoxy-4-phenylpyrano[3,2-c] quinolin-5(6H)-ones (4a-l) from 4-hydroxyquinolin-2(1H)- ones, aromatic aldehydes and ethyl cyanoacetate was described. The detailed synthesis, structure analysis, and antimicrobial screening for the title compounds were also reported. Pharmacological screen studies like anti-inflammatory and antibacterial activities of newly synthesized quinoline derivatives were evaluated against carrageenaninduced rat paw edema model and Gram-positive and Gramnegative bacteria, respectively. © Springer Science+Business Media, LLC 2011. Source

Nadaraj V.,Kongunadu Arts and Science College | Selvi S.T.,Kongunadu Arts and Science College | Selvi S.T.,Government of Tamilnadu | Mohan S.,Saraswati Institute of Pharmaceutical science | Thangadurai T.D.,Kookmin University
Medicinal Chemistry Research | Year: 2012

A series of pyrimido[4,5-b]quinolin-2,4(1H,3H)- dione derivatives (5-deazaalloxazines) was synthesized by the reaction of various substituted 2-chloroquinolin-3-carboxylic acids with urea/thiourea. The structure of these newly synthesized compounds was characterized by standard spectroscopic and analytical techniques. The antimicrobial activities of the title compounds were evaluated against Gram-positive and Gram-negative bacteria and fungi using a micro dilution procedure and compared with those of standard drugs. The minimum inhibitory concentration of the derivative compounds was also determined by measuring their in vitro activities against both bacteria and fungi strains. © Springer Science+Business Media, LLC 2011. Source

Modi H.,University | Patel K.,Saraswati Institute of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

This study investigated heapatoprotective activity of various extracts of Aegle Marmelos, belonging to the family Rutaceae, in Wistar Female rats with liver damage induced by ethanol. Herbal drugs play crucial role in treatment of various diseases due to its antioxidant property. It was found that AMCL, AMAL & AMAQ, at a dose of 500 mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), alkaline phosphate and total bilirubin to a significant extent. The groups treated with various extract of A.Marmelos & Silyamarine shows significant (P<0.001) restoration of liver weight & liver volume nearer to normal control group. Since results of biochemical studies of blood samples of ethanol treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by ethanol and blood samples from the animals treated with AMCL & AMAQ showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells against ethanol induced hepatocellular injury. The effects of AEAC and AQEAC were comparable with standard drug silymarin. Source

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