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Ankit B.C.,Saraswati Institute of Pharmaceutical science | Tejal A.M.,Nirma University
Journal of Pharmacy and Bioallied Sciences | Year: 2012

Quick dissolving film prepared by various grades of polyox like Polyox N10,N80, N750 and N205. Polyox having excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva. Film is optimized for concentration of polymer and plasticizer using CCD design. The tensile Strength, folding Endurance, % drug released at 10 min (Y10) and disintegration time were selected as dependent variables. The data revealed that 2% of polyox N 750 and 15% of PEG 400 showed excellent film forming property with rapid drug release profile.


Modi H.,JJT University | Patel K.,Saraswati Institute of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

This study investigated heapatoprotective activity of various extracts of Aegle Marmelos, belonging to the family Rutaceae, in Wistar Female rats with liver damage induced by ethanol. Herbal drugs play crucial role in treatment of various diseases due to its antioxidant property. It was found that AMCL, AMAL & AMAQ, at a dose of 500 mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), alkaline phosphate and total bilirubin to a significant extent. The groups treated with various extract of A.Marmelos & Silyamarine shows significant (P<0.001) restoration of liver weight & liver volume nearer to normal control group. Since results of biochemical studies of blood samples of ethanol treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by ethanol and blood samples from the animals treated with AMCL & AMAQ showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells against ethanol induced hepatocellular injury. The effects of AEAC and AQEAC were comparable with standard drug silymarin.


Nadaraj V.,Kongunadu Arts and Science College | Selvi S.T.,Kongunadu Arts and Science College | Selvi S.T.,Government of Tamilnadu | Mohan S.,Saraswati Institute of Pharmaceutical science | Thangadurai T.D.,Kookmin University
Medicinal Chemistry Research | Year: 2012

A series of pyrimido[4,5-b]quinolin-2,4(1H,3H)- dione derivatives (5-deazaalloxazines) was synthesized by the reaction of various substituted 2-chloroquinolin-3-carboxylic acids with urea/thiourea. The structure of these newly synthesized compounds was characterized by standard spectroscopic and analytical techniques. The antimicrobial activities of the title compounds were evaluated against Gram-positive and Gram-negative bacteria and fungi using a micro dilution procedure and compared with those of standard drugs. The minimum inhibitory concentration of the derivative compounds was also determined by measuring their in vitro activities against both bacteria and fungi strains. © Springer Science+Business Media, LLC 2011.


Nadaraj V.,Kongunadu Arts and Science College | Selvi S.T.,Kongunadu Arts and Science College | Selvi S.T.,Government of Tamilnadu | Bai H.P.,Kongunadu Arts and Science College | And 2 more authors.
Medicinal Chemistry Research | Year: 2012

The microwave-induced three-component onepot synthesis of 2-amino-3-carbethoxy-4-phenylpyrano[3,2-c] quinolin-5(6H)-ones (4a-l) from 4-hydroxyquinolin-2(1H)- ones, aromatic aldehydes and ethyl cyanoacetate was described. The detailed synthesis, structure analysis, and antimicrobial screening for the title compounds were also reported. Pharmacological screen studies like anti-inflammatory and antibacterial activities of newly synthesized quinoline derivatives were evaluated against carrageenaninduced rat paw edema model and Gram-positive and Gramnegative bacteria, respectively. © Springer Science+Business Media, LLC 2011.


Chaudhary A.B.,Saraswati Institute of Pharmaceutical science | patel R.K.,Gujarat University | Chaudhary S.A.,Saraswati Institute of Pharmaceutical science
International Journal of ChemTech Research | Year: 2010

The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of losartan potassium and Perindopril Erbumine in tablet formulation. Chromatography was performed on a ODS Hypersil C18 (250 mm × 4.6 mm i.d., 5 μm particle size) column with mobile phase containing Acetonitrile: Acidic Water pH 3.4 (50+50). The flow rate was 1.5 mL/min and the eluent was monitored at 218 nm. The selected chromatographic conditions were found to effectively separate Losartan Potassium (RT- 4.57 min) and Perindopril Erbumine (RT- 2.31 min). Linearity for losartan potassium and Perindopril Erbumine were found in the range of 1-30 μg/mL. The values obtained of LODs were 0.182 and 0.272 μg/mL, LOQs were 0.551 and 0.826 μg/mL for losartan potassium and Perindopril Erbumine, respectively. The proposed method was found to be fast, accurate, precise, and reproducible and can be used for simultaneous analysis of these drugs in tablet formulations.


Chaudhary S.A.,Saraswati Institute of Pharmaceutical science | Mehta T.A.,Nirma University
Drug Development and Delivery | Year: 2011

Thaumatin is natural sweetener first found as a mixture of protein obtained from a plant called Thaumatococcus deniellii. It is prepared from the seeds of the plant through various processes. It is 10,000 times sweeter than sucrose, thus it can be used in pharmaceutical formulations and other food items as a sweetener and flavoring agent in very less quantities to avoid the bitter after-taste of artificial sweeteners like sucralose and aspartame. It is a mixture of two types of proteins (thaumatin I and thaumatin II), making it useful as a sweetener and flavor enhancer for taste-masking certain bitter drugs.


Chaudhary S.A.,Saraswati Institute of Pharmaceutical science | Mehta T.A.,Nirma University | Chaudhary A.B.,Saraswati Institute of Pharmaceutical science
International Journal of ChemTech Research | Year: 2010

RZT is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain. Marketed freeze dried tablet of RZT is available. Freeze drying is cumbersome and it yields a fragile and hygroscopic product. Thus, the aim of the present investigation is to formulate orally disintegrating tablets (ODTs) of Rizatriptan using simple and cost effective dosage forms. Approach used was use of superdisintegrants to prepare tablets. Tablets were prepared by direct compression using superdisintegrants such crospovidone, croscarmellose sodium, and sodium starch glycolate with incorporation of diluents like lactose, MCC and mannitol. Tablets of RZT prepared using crospovidone with MCC exhibited the least friability and disintegration time (s). To decrease the disintegration time further, modified diluents like spray dried lactose, Avicel PH 102 and Orocell 200.used along with the superdisintegrants for the preparation of ODTs. Tablet prepared using orocell showed good disintegration but shows less dispersion. Further trial was done in combinations of Orocell with Avicel PH 102. Among them Avicel PH 102 and orocell in 35:65 ratio showed less time of disintegration and rapid dissolution.


Dobariya T.D.,Saraswati Institute of Pharmaceutical science | Multani P.J.,Saraswati Institute of Pharmaceutical science
International Journal of ChemTech Research | Year: 2013

The present research work aims to develop a simple, sensitive, accurate and reproducible method for the estimation of Pimobendan by Spectrophotometric and chromatographic methods. In Spectrophotometric method an absorbance maximum for Pimobendan was found to be at 328 nm using methanol as a solvent and linearity was observed in concentration range of 1-7μg/ml. In RP-HPLC, chromatographic separation was carried out on Shimadzu LC-2010 CHT using Inertsil®ODS-3(4.6 X 100mm,3μm) column as stationary phase and mobile phase containing Buffer(KH2PO4,PH=2.5): Acetonitrile (80:20 v/v) at flow rate of 1 ml/min using UV detection at 328 nm. The retention time for Pimobendan was found to be 4.2 min. The methods were successfully validated in accordance to ICH guidelines. The drug was found to undergo degradation when exposed to acidic, basic, oxidation, thermal and photo degradation conditions. The developed method can be applied successfully to estimate Pimobendan in tablet dosage form without the interference of common excipients.

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