Saraswati Institute of Medical science

Hāpur, India

Saraswati Institute of Medical science

Hāpur, India
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Kumar A.,International Medical School | Biswas U.K.,Nilratan Sarkar Medical College | Nagtilak S.,Saraswati Institute of Medical science | Ramiah S.,University of Peradeniya
Asian Pacific Journal of Tropical Disease | Year: 2011

Objective: To evaluate the usefulness of lipid ratios in predicting coronary heart disease risk in normolipidaemic myocardial infarct (MI) patients and compare the findings with healthy controls. Methods: Lipid profile was determined in 1 021 normolipidaemic myocardial infarct patients and was compared with 1 021 age/sex-matched controls. Total cholesterol (TC), triglycerides (TG) and HDL-cholesterol (HDL-C) were analyzed enzymatically using kits obtained from Randox Laboratories Limited, Crumlin, UK. Plasma LDL-cholesterol (LDL-C) was determined from the values of TC and HDL-C using the friedwald's formula. The values were expressed as mean±SD and data from patients and controls were compared using students' t-test. Results: TC, TC/HDL-C ratio, TG, LDL-C, LDL-C/HDL-C ratio were higher in MI patients (P<0.001). HDL-C concentration was significantly lower in MI patients than controls (P<0.001). Higher ratio of TC/HDL-C, TG/HDL-C and LDL-C/HDL-C was observed in acute myocardial infarct patients as compared with controls. Conclusions: Establishment of lipid ratio from routine lipid profile assay could be very useful in predicting the future risk of acute mocardial infarction. © 2011 Asian Pacific Tropical Medicine Press.

Muthukrishnan S.,Saraswati Institute of Medical science
Indian Journal of Forensic Medicine and Toxicology | Year: 2010

Saliva can be of forensic significance because traces of drugs that are circulating in the body can be present in saliva. The composition of the saliva accurately mirrors the proteins that are present in both the blood and the urine. Thus, testing of saliva, which is easier and less obtrusive than obtaining a blood or urine sample, can be used for forensic analysis. Promising preliminary research results have shown that aberrant genetic material (deoxyribonucleic acid; DNA) and the messenger ribonucleic acid (mRNA) that helps process the genetic information into a protein from cells can also be detected in saliva. This review evaluates the use of saliva for forensic analysis.

Singh R.,Saraswati Institute of Medical science | Agarwal R.,Spm Sn Medical College | Singh S.,PMHS | Gupta S.C.,Spm Sn Medical College
Indian Journal of Community Health | Year: 2014

Background: Non-communicable diseases (NCDs) are major contributors of morbidity and mortality in the middle aged and elderly population. Aim: The purpose of this study was to estimate the prevalence/distribution of hypertension in persons aged 45 years or above and to find the association with certain selected demographic factors. Materials and Methods: The study used a cross-sectional community based survey of the civilian, non-institutionalized population of Agra district through an in-home interview and a clinical examination (measurement of blood pressure). A total of 544 persons from an urban and rural community were selected by multistage simple random sampling technique. Results: Out of total 544 participants, 47% and 53% were from urban and rural area respectively. Maximum participants were in the age group of 45-54 year (47.43%).The prevalence of hypertension significantly increased with increasing age, being 28.29% in 45-54 year age group to 62.07% in 75+ age group with statistically significant (p<0.001) difference.The overall prevalence of hypertension was found to be 36.42%, which was more common (41.96%) in urban area as compared to rural area (31.46%). Males and females had almost equal (36.49% Vs 35.92%) prevalence of hypertension. The prevalence of hypertension was found to be highest in urban males (40.90%). It was also significantly higher among graduate & above educated group (45.32%). In regard to occupation the hypertension prevalence was lowest among the unskilled laborers (27.27%) and highest among shopkeeper/clerk/teacher/professionals (51.81%) with a significant difference. Majority of the urban participants (50%) were from socioeconomic class I & II, whereas majority from rural background (59.77%) were in socioeconomic class IV & V. The prevalence of hypertension decreased significantly (p<0.01) from' 51.11% in S.E. class-I to 30.25% in class-V. About 17.14% of the retired and unemployed persons were having stage II hypertension. Conclusion: Strategies to detect and treat hypertension in the early stage have to be implemented early.

Mane A.Y.,Saraswati Institute of Medical science | Bhagwat V.R.,SBH Government Medical College
Biomedicine | Year: 2011

Baackground and objectives: Thyroid disorders often accompany abnormal serumenzyme levels and disturbances in liver functions. This study was done to assessrelationship between serum enzymes and liver functions in thyroid disorders. Methods: Serum levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and creatine Phosphokinase (CPK) were determined by uv-kinetic methods in 94 thyroid patients and 71 euthyroid controls. Serum total bilirubin, total protein and albumin were also assayed by colorimetric methods. Results: Serum AST and ALT levels were significantly higher while ALP was significantly low in hypothyroidism. Transaminases levels in hypothyroid patients were more than the upper limits of normal range. The serum ALP activity was found to be highest in hyperthyroid patients compared to hypothyroids and the controls. There is an inverse relation of serum triiodothyronine and CPK levels in hypothyroid disease. In hypothyroid patients mean CPK level was significantly higher by 4.2 times that of the controls. Conclusion: The results indicate that liver functions in both hypo and hyperthyroid patients are normal. Marginally elevated AST and ALT levels point to muscle dysfunction while high ALP level in hyperthyroids suggests disturbance in bone homeostasis. Serum CPK assay together with thyroid profile increases diagnostic sensitivity in subclinical hypothyroidism.

Shobitha M.,HIMSR | Agarwal J.L.,Saraswati Institute of Medical science | Sadh K.,Saraswati Institute of Medical science
Indian Journal of Public Health Research and Development | Year: 2015

Introduction: Meditation is described as a family of self-regulation practices that focus on training attention and awareness in order to foster general mental well-being.1 Dynamic meditation is an awareness based meditation2, 3 Objective: 1. To evaluate the effect of dynamic meditation for 15 days on electroencephalographic wave patterns of healthy subjects. 2. To evaluate the effect of dynamic meditation for 15 days on blood pressure, heart rate and respiratory rate. Methodology: Electroencephalogram, electrocardiogram, blood pressure (BP) and respiratory rate were recorded before and after the practice of dynamic meditation for 15 days in 45 healthy subjects Results: After 15 days of sessions in dynamic meditation the subjects showed slow wave electroencephalographic patterns of high voltage theta and high voltage alpha waves. Resting heart rate, blood pressure and respiratory rate were reduced significantly (table1). Conclusion: Dynamic meditation is beneficial in improving the cardiorespiratory functions and produces high voltage slow wave electroencephalographic patterns indicating mind relaxation irrespective of gender. © 2015 Indian Journal of Public Health Research & Development. All Rights Reserved.

Goel A.K.,Saraswati Institute of Medical science | Sylonia S.,Saraswati Institute of Medical science | Goel R.,Dental Care Center
Clinical Rhinology | Year: 2011

Nasoalveolar cyst is a nonodontogenic, soft tissue cyst characterized by its extraosseous location in the nasal alar region. It is synonymous with nasolabial cyst, nasal vestibule cyst, nasal wing cyst and mucoid cyst of the nose. It also called Klestadt's cyst. In this study, we would like to highlight the clinical presentation and the radiological features of nasolabial cyst in order to assist other healthcare providers in the diagnosis and treatment of this uncommon entity.

Varma M.,Sri Aurobindo Institute of Medical science | Kachhawa K.,Sri Aurobindo Institute of Medical science | Sahu A.,Sri Aurobindo Institute of Medical science | Kachhawa P.,Saraswati Institute of Medical science
Journal of Pure and Applied Microbiology | Year: 2014

Diabetic Nephropathy is a microvascular complication of diabetes, representing the leading cause of end stage renal disease in the world, and a major cause of morbidity and mortality in type 2 diabetic subjects. The aim of the study was to evaluate the effect of antioxidant enzymes on Diabetic Nephropathy patients. Superoxide dismutase (SOD), Catalase, Malondialdehyde (MDA), fasting blood sugar, serum urea, serum creatinine and serum uric acid were assayed in 160 subjects In which 71 Diabetic Nephropathy patients, 36 Nephropathy patients without diabetes and 53 healthy control. In our study, we found statistical significantly decrease SOD, Catalase level and increase production of MDA in DM-CKD and also found deranged renal function. Reduced activity of serum antioxidant enzymes and increased level of MDA were observed in Diabetic Nephropathy patients compare to healthy control.

Goel A.,Saraswati Institute of Medical science
Otorhinolaryngology Clinics | Year: 2011

Arteriovenous malformations are rare in the head and neck region and generally arise from intracranial vessels. We present a rare case of arteriovenous malformation related to pinna. The role of color Doppler sonography in the diagnosis and management of such case is discussed along with review of literature.

Goel A.K.,Saraswati Institute of Medical science | Yadav S.P.S.,Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical science | Goel R.,Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical science
Ear, Nose and Throat Journal | Year: 2010

Very few cases of hemangioma of the ethmoid sinuses have been reported in the literature. These lesions can be difficult to diagnose in the paranasal sinuses because obtaining an adequate biopsy specimen can be dangerous in view of the potential for profuse bleeding. We report a case of a cavernous hemangioma in the right posterior ethmoid sinus of a 45-year-old man. The mass was excised in its entirety. © 2010, Vendome Group, LLC. All rights reserved.

PubMed | Saraswati Institute of Medical science
Type: Journal Article | Journal: International journal of critical illness and injury science | Year: 2012

A prospective randomized control study was conducted to compare and evaluate quality of anesthesia with ketamine or fentanyl as co-induction with propofol.Sixty ASA I or II, 18-50 year old patients who were scheduled for minor surgeries of short duration (<30 min anticipated duration) were selected. The patients were randomly allocated to group I and group II comprising 30 patients each. The patients of group I were given ketamine injection 0.5 mg/kg and group II patients fentanyl injection (1.5 g/kg) as co-induction agent. Two minutes later, induction of anesthesia was given with inj propofol (2.5 mg/kg) and appropriate-sized laryngeal mask airway was inserted. The anesthesia was maintained with 60% N(2)O in O(2) and intermittent bolus of inj propofol (0.5 mg/kg) after observing significant changes in the heart rate, blood pressure, lacrimation, sweating, and abnormal movements.There was significant decrease (P<0.05) in the pulse rate, systolic and diastolic blood pressure at 1, 3, and 5 min in group II (fentanyl group) whereas the change was insignificant (P>0.05) at 10 min.It was observed that ketamine as premedicant was better than fentanyl with respect to hemodynamic stability and caused less adverse effects intraoperatively and postoperatively.

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