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Kumar A.,International Medical School | Biswas U.K.,Nilratan Sarkar Medical College | Nagtilak S.,Saraswati Institute of Medical science | Ramiah S.,University of Peradeniya
Asian Pacific Journal of Tropical Disease

Objective: To evaluate the usefulness of lipid ratios in predicting coronary heart disease risk in normolipidaemic myocardial infarct (MI) patients and compare the findings with healthy controls. Methods: Lipid profile was determined in 1 021 normolipidaemic myocardial infarct patients and was compared with 1 021 age/sex-matched controls. Total cholesterol (TC), triglycerides (TG) and HDL-cholesterol (HDL-C) were analyzed enzymatically using kits obtained from Randox Laboratories Limited, Crumlin, UK. Plasma LDL-cholesterol (LDL-C) was determined from the values of TC and HDL-C using the friedwald's formula. The values were expressed as mean±SD and data from patients and controls were compared using students' t-test. Results: TC, TC/HDL-C ratio, TG, LDL-C, LDL-C/HDL-C ratio were higher in MI patients (P<0.001). HDL-C concentration was significantly lower in MI patients than controls (P<0.001). Higher ratio of TC/HDL-C, TG/HDL-C and LDL-C/HDL-C was observed in acute myocardial infarct patients as compared with controls. Conclusions: Establishment of lipid ratio from routine lipid profile assay could be very useful in predicting the future risk of acute mocardial infarction. © 2011 Asian Pacific Tropical Medicine Press. Source

Muthukrishnan S.,Saraswati Institute of Medical science
Indian Journal of Forensic Medicine and Toxicology

Saliva can be of forensic significance because traces of drugs that are circulating in the body can be present in saliva. The composition of the saliva accurately mirrors the proteins that are present in both the blood and the urine. Thus, testing of saliva, which is easier and less obtrusive than obtaining a blood or urine sample, can be used for forensic analysis. Promising preliminary research results have shown that aberrant genetic material (deoxyribonucleic acid; DNA) and the messenger ribonucleic acid (mRNA) that helps process the genetic information into a protein from cells can also be detected in saliva. This review evaluates the use of saliva for forensic analysis. Source

Mane A.Y.,Saraswati Institute of Medical science | Bhagwat V.R.,SBH Government Medical College

Baackground and objectives: Thyroid disorders often accompany abnormal serumenzyme levels and disturbances in liver functions. This study was done to assessrelationship between serum enzymes and liver functions in thyroid disorders. Methods: Serum levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and creatine Phosphokinase (CPK) were determined by uv-kinetic methods in 94 thyroid patients and 71 euthyroid controls. Serum total bilirubin, total protein and albumin were also assayed by colorimetric methods. Results: Serum AST and ALT levels were significantly higher while ALP was significantly low in hypothyroidism. Transaminases levels in hypothyroid patients were more than the upper limits of normal range. The serum ALP activity was found to be highest in hyperthyroid patients compared to hypothyroids and the controls. There is an inverse relation of serum triiodothyronine and CPK levels in hypothyroid disease. In hypothyroid patients mean CPK level was significantly higher by 4.2 times that of the controls. Conclusion: The results indicate that liver functions in both hypo and hyperthyroid patients are normal. Marginally elevated AST and ALT levels point to muscle dysfunction while high ALP level in hyperthyroids suggests disturbance in bone homeostasis. Serum CPK assay together with thyroid profile increases diagnostic sensitivity in subclinical hypothyroidism. Source

Sharma M.,TMMC and RC Moradabad | Srivastava A.,TMMC and RC Moradabad | Singh B.,TMMC and RC Moradabad | Gupta S.C.,Saraswati Institute of Medical science
Indian Journal of Community Health

Background: Injuries are becoming major public health problem worldwide and since India is also passing through a major socio-demographic, epidemiological and technological transition; injuries are coming up as an emerging health problem. Objectives: To find out prevalence of "Injuries", causative mechanism, place of injury & distribution in rural & urban area of Agra district. Material & Methods: It is type of observational study in rural & urban area of Agra district. The area to be surveyed was selected by multistage stratified random sampling technique. A recall period of three months for minor injuries & one year for major injuries or deaths due to injury was used. A total of 4 villages covering 2439 population and in urban area 2 mohallas & 2 slums covering 2410 population were surveyed. Data collected was entered on Fox. Pro (vs 2.6) and analyzed by SPSS (vs. 10). Results: A total of 93 persons in rural and 142 persons in urban had major while 147 peoples in rural and 200 peoples in urban had minor injuries during the recall period. Among the injured most common mechanism for major & minor injury was due to fall (45.16% & 36.73%). Regarding place maximum major injury occur at home (32.26%) in rural while in urban it was road/highway (46.48%) but for minor it the home being commonest place in both rural & urban (40.82% & 55%). Conclusions: Considering the high morbidities due to injuries focusing health education efforts based on local epidemiology and behavioral practices is needed. Source

Sylonia S.,Saraswati Institute of Medical science
Clinical Rhinology

Nasoalveolar cyst is a nonodontogenic, soft tissue cyst characterized by its extraosseous location in the nasal alar region. It is synonymous with nasolabial cyst, nasal vestibule cyst, nasal wing cyst and mucoid cyst of the nose. It also called Klestadt's cyst. In this study, we would like to highlight the clinical presentation and the radiological features of nasolabial cyst in order to assist other healthcare providers in the diagnosis and treatment of this uncommon entity. Source

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