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Jain S.,Saraswathi Institute of Medical science
Journal of Krishna Institute of Medical Sciences University | Year: 2016

Background: Shavasana is one of the most popular yogic exercises used for relaxation of body. Aim and Objectives: The present study was done to find out direct effect of Shavasana on cardiac output and peripheral resistance by using Impedance Cardiovasograph (Nivomon, Larsen & Toubro Medical's). Material and Methods: One hundred asymptomatic healthy male subjects, aged 17-23 years, participated voluntarily in the present study. Cardiac output, systemic peripheral resistance and other cardiovascular parameters were measured before and after Shavasana of 30 minutes. Results: Statistically significant decrement was observed in all cardiovascular parameters after shavasana but decrement was more pronounced in Diastolic Blood Pressure (DBP), Heart Rate (HR), Systemic Peripheral Resistance (SPR) and Systemic Vascular Resistance Index (SVRI) in comparison to decrement in Systolic Blood Pressure (SBP), Cardiac Output (CO), Stroke Volume (SV), Cardiac Index (CI), Stroke Volume Index (SI). Conclusion: The practice of Shavasana for short duration immediately improves cardiovascular parameters including cardiac output and systemic peripheral resistance which directly influence blood pressure and might be beneficial in normal subjects and hypertensive patients as well. © Journal of Krishna Institute of Medical Sciences University. Source

Omhare A.,Gsvm Medical College | Singh S.K.,Mlb Medical College | Nigam J.S.,Saraswathi Institute of Medical science | Sharma A.,D.D.U. Hospital
Pathology Research International | Year: 2014

Background. FNAC is a useful method for evaluating suspicious salivary glands lesions due to its low cost, minimum morbidity, rapid turnaround time, high specificity, and sensitivity. Aim. To knowthe frequency of the salivary gland lesions and cytohistological correlation in the Jhansi region, Uttar Pradesh, India. Material and Methods. In present study 124 cases were included and cytohistological correlation was made in 86 cases only. FNA was performed by using a 23/24-gauge needle without local anaesthesia. Air dried and 95% ethyl alcohol fixed wet smears were stained with Giemsa stain and Papanicolaou stain, respectively. Paraffin embedded tissue sections were stained with Haematoxylin and Eosin. Results. Parotid gland was the most commonly involved salivary gland. The commonest age group was 20 to 29 years, 30 to 39 years, and 60 to 69 years for nonneoplastic lesions, benign tumours, and malignant tumours, respectively.The overall male to female ratio was 1.17 : 1.The diagnostic accuracy of FNAC was 100%, 93.3%, and 88.2% for nonneoplastic lesions, benign tumours, and malignant tumours, respectively. Conclusion. The high accuracy, sensitivity, and specificity of FNAC confirmthat preoperative cytology is a useful, quick, reliable diagnostic technique for rapid diagnosis and suitable for developing countries. Copyright © 2014 Anita Omhare et al. Source

Sood N.,Deen Dayal Upadhyay Hospital | Nigam J.S.,Saraswathi Institute of Medical science
Pathology Research International | Year: 2014

Purpose. Triple-negative breast cancer (TNBC) is defined by the loss of expression of ER, PR, and Her2neu expressions. The aim of this study was to examine the expression of the EGFR, CK5, and Ki-67 among triple-negative breast cancer cases and to correlate the expression of the basal markers with the clinicopathological prognostic parameters. Materials and Methods. Thirty-six female patients with TNBC based on ER, PR, and the HER2neu negativities were studied by immunohistochemistry for EGFR, CK5, and Ki-67 expression. Statistical analysis was done using the SPSS software version 20. Results. The mean and median ages were 45.18 years and 46.70 years, respectively. Infiltrating ductal carcinoma NOS was the predominant histopathological type (29/36 [80.6%]). The commonest histological grade was grade 2 (17/36 [47.2%]). Tumour necrosis was seen in 16/36 (44.4%) patients. Infiltrative margins were shown in 69.44% (25/36) cases. Ki-67 was positive in 80.56% (29/36) cases, 61.11% (22/36) were CK5-positive, and 86.11% (31/36) were EGFR-positive. The only significant positive association observed was between the CK5 and histological grade (P<0.05). Conclusion. CK5 shows a statistically significantly correlation with TNBC histological grade. The majority of the specimens show EGFR expression. Therefore TNBCs could potentially benefit from EGFR-targeted therapeutic strategies. © 2014 Neelam Sood and Jitendra Singh Nigam. Source

Singh H.K.,Saraswathi Institute of Medical science
Medico-Legal Update | Year: 2012

Profiling of Medico legal cases will help authorities for planning, prevention and treatment of casualties. This Study was carried out on Medico legal cases reporting to casualty of SIMS Panchsheel Nagar in one year duration from 1st Jan. to 31st Dec.2009. The main objectives of the study were to analyze pattern and study demographic variables of Medico legal cases and suggest preventive measures which would possibly reduce incidence of these case. Out of total 583 cases 4 were brought dead so excluded from study. Males (76.51%) outnumbered the females and maximum cases were of age group 21-30 yrs. (32.10%) more cases from rural area(62.5%) were reported, April month saw maximum no of cases (11.6%), Maximum admission were done during office hours (50.3%), maximum no. of incidence was seen on NH-24(63.4%), RTA was the commonest mode of injury (71.50%). Lacerated wound was the commonest injury (23.49%) and more than one region of body was involved in maximum cases (36.6%). Lower limb bones were involved in 7.43% of cases. 79.10% cases were treated effectively and discharged. Source

Jain S.,Saraswathi Institute of Medical science
Indian Journal of Public Health Research and Development | Year: 2016

Obesity is major problem in present population especially in children and young adults. Obesity is a state of excess adipose tissue mass. Stress is inevitable in the present scenario. Obesity adversely affects almost all the systems of the body including cardiovascular and respiratory system and reduces exercise tolerance & stress tolerance. Exposure to sudden extreme stress is commonly seen in medical students. Therefore the present study was conducted to assess the effect of acute stress on cardiac output and systemic peripheral resistance in obese young adults. Sixty asymptomatic healthy male medical students, aged 17-25 years, participated voluntarily in the present study. Subjects were divided in to two groups of 30 each. Group A comprised of non- obese (BMI<25, control group) and group B comprised of obese subjects (BMI> 30). Cold pressor test (CPT) was used to induce acute stress which involves immersion of hand in cold water of 8oc for 2 minutes. Cardiac output and peripheral resistance were measured by using Impedance Cardiovasograph (Nivomon). All the parameters were recorded before and immediately after cold pressor test in both the groups. Results showed significant increase in cardiac output and systemic peripheral resistance (p<0.05) immediately after exposure to cold stress for two minutes in comparison to baseline parameters in both the groups, however this increase was more significant in group B (p<0.01) than control group (p<0.05). On comparison of parameters before CPT and 5 minutes after CPT, no significant difference was observed in parameters including cardiac output and systemic peripheral resistance (P>0.05) in control group but these were significantly higher in obese subjects of group B. Results show greater increase in cardiac output and systemic peripheral resistance in obese on exposure to acute stress and delayed recovery to baseline values in comparison to non obese. © 2016, Indian Journal of Public Health Research and Development. All rights reserved. Source

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