Iwamoto S.,Kansai Medical University |
Hazama S.,Yamaguchi University |
Kato T.,Kansai Rosai Hospital |
Miyake Y.,Nishinomiya Municipal Central Hospital |
And 6 more authors.
Anticancer Research | Year: 2014
Background: This study was the first multicenter phase II study of cetuximab plus folinic acid/5-fluorouracil/irinotecan (FOLFIRI) in KRAS wild-type mCRC as a second-line treatment in Japan including BRAF and PIK3CA genotyping. Patients and Methods: Tumors of 112 pre-registered patients were genotyped for KRAS, BRAF, and PIK3CA. The primary study end-point was response rate, and secondary end-points were progression-free survival (PFS), overall survival (OS), and safety. Results: Sixty-seven patients (59.8%) were EGFR-positive and KRAS wild-type. The mean age of the enrolled patients (n=60) was 62.6 years (range=37-82 years). The response rate was 31.7% and stable disease was observed in 53.3%. No objective response was observed in patients with BRAF or PIK3CA mutations. The median PFS and OS were 7.4 and 18.2 months, respectively. Grade-3/4 adverse events were leucopenia (26.7%), neutropenia (43.3%), paronychia (10.0%), fissure (10.0%) and acne-like rash (5.0%). Conclusion: Second-line cetuximab plus FOLFIRI was effective and well-tolerated.
Suda T.,Japan National Astronomical Observatory |
Komiya Y.,Japan National Astronomical Observatory |
Yamada S.,Hokkaido University |
Katsuta Y.,Hokkaido University |
And 7 more authors.
Monthly Notices of the Royal Astronomical Society: Letters | Year: 2013
The stellar initial mass function (IMF) plays a crucial role in the determination of the number of surviving stars in galaxies, of the chemical composition of the interstellar medium and of the distribution of light in galaxies. A key unsolved question is whether the IMF is universal in time and space. Here, we use the state-of-the-art results of stellar evolution to show that the IMF of our Galaxy made a transition from an IMF dominated by massive stars to the present-day IMF at an early phase of the Galaxy formation. Updated results from stellar evolution in a wide range of metallicities have been implemented in a binary population synthesis code, and compared with the observations of carbon-enhanced metal-poor (CEMP) stars in our Galaxy. We find that the application of the present-day IMF to Galactic halo stars causes serious contradictions with four observable quantities connected with the evolution of asymptotic giant branch (AGB) stars. Furthermore, a comparison between our calculations and the observations of CEMP stars might help us to constrain the transitionmetallicity for the IMF, which we tentatively set at [Fe/H]≈-2. A novelty of the current study is the inclusion ofmassloss suppression in intermediate-mass AGB stars at low metallicity. This significantly reduces the overproduction of nitrogen-enhanced stars, which was a major problem in previous studies when using the IMF dominated by high-mass stars. Our results also demonstrate that the use of the present-day IMF for all time in chemical evolution models results in the overproduction of Type I.5 supernovae. More data on stellar abundances will help us to understand how the IMF has changed, and what caused such a transition. © 2013 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.
Higashi T.,Tokyo University of Agriculture and Technology |
Yunghui M.,South China Agricultural University |
Komatsuzaki M.,Ibaraki University |
Miura S.,Japan National Agriculture and Food Research Organization |
And 4 more authors.
Soil and Tillage Research | Year: 2014
No-tillage, cover crops, and N fertilization play important roles in conserving or increasing soil organic carbon (SOC). However, the effects of their interaction are less well known, particularly in Asian countries. We examined the effects of three tillage management systems, moldboard plow/rotary harrow (MP), rotary cultivator (RC), and no-tillage (NT); three winter cover crop types (FL: fallow, RY: rye, and HV hairy vetch); and two nitrogen fertilization rates (0 and 100kgNha-1 for upland rice and 0 and 20kgNha-1 for soybean production) on changes in SOC. Vertical distributions at 0-2.5, 2.5-7.5, 7.5-15, and 15-30cm depths of soil carbon content and bulk density were measured each year. From 2003 to 2011, NT and RC management increased SOC by 10.2 and 9.0Mgha-1, whereas SOC under the MP system increased only by 6.4Mgha-1. Cover crop species also significantly increased SOC in the same period by 13.4 and 8.6Mgha-1 for rye and hairy vetch, respectively, although SOC with fallow increased only by 5.4Mgha-1. Continuous soil management for 9 years enhanced SOC accumulation. Summer crop species between upland rice and soybean strongly affected SOC; the SOC increases were 0.29Mgha-1year-1 for the upland rice rotation and 1.84Mgha-1year-1 for the soybean rotation. However, N fertilization levels did not significantly affect SOC. These results suggest that the NT system and rye cover crop enhance carbon sequestration in Kanto, Japan, but that their contributions differ depending on the combination of main and cover crops. © 2014 .
Kashiwazaki D.,Kashiwaba Neurosurgical Hospital |
Yoshimoto T.,Kashiwaba Neurosurgical Hospital |
Mikami T.,Hokkaido University |
Muraki M.,Sapporo University |
And 3 more authors.
Journal of Neurosurgery | Year: 2012
Object. Identification of the risk of rupture and vulnerability of arterial plaque is not yet clearly understood. The aim of this study was to assess the clinical features of the motion of intraplaque contents (MIC) detected by B-mode ultrasonography. The MIC is characterized by the peculiar movement of the intraplaque contents that is not synchronized with the heartbeat; however, the movement of the carotid artery (CA) wall depends on the heartbeat. Methods. From January 2008 to November 2010, 1798 consecutive patients with transient ischemic attacks (TIAs) or acute ischemic stroke underwent CA ultrasonography for the examination of the MIC. Patients with CA stenosis greater than 50% were followed up until they underwent carotid endarterectomy or CA angioplasty and stent placement. If neither of these procedures were used, the patients were followed up at 90 days. Chi-square and Mann-Whitney tests were performed to compare the categorical and continuous demographic data and risk factors. The effect of the MIC on the rate of recurrent cerebral ischemia was examined using Kaplan-Meier and univariate Cox regression analyses. Results. One hundred and fifteen patients had CA stenosis greater than 50%. Among these 115 patients, 58 with a total of 59 CA stenoses had MIC. Twenty-four recurrent ischemic events were associated with MIC, whereas only 6 such events occurred in the absence of MIC. The MIC decreased event-free survival (log-rank test = 15.8, p < 0.001); univariate Cox analysis confirmed that MIC increased the risk of a recurrent ischemic event (HR 5.12, 95% CI 2.08-12.58; p < 0.001). Conclusions. The MIC is one of the findings of vulnerable plaques. The MIC is more useful in predicting the recurrence of TIAs or ischemic events in patients with symptomatic CA stenosis.
PubMed | Sapporo University and Sapporo Medical University
Type: | Journal: Scientific reports | Year: 2017
Lipolysis-stimulated lipoprotein receptor (LSR) is a unique molecule of tricellular contacts of normal and cancer cells. We investigated how the loss of LSR induced cell migration, invasion and proliferation in endometrial cancer cell line Sawano. mRNAs of amphiregulin (AREG) and TEA domain family member 1 (TEAD1) were markedly upregulated by siRNA-LSR. In endometrial cancer tissues, downregulation of LSR and upregulation of AREG were observed together with malignancy, and Yes-associated protein (YAP) was present in the nuclei. siRNA-AREG prevented the cell migration and invasion induced by siRNA-LSR, whereas treatment with AREG induced cell migration and invasion. LSR was colocalized with TRIC, angiomotin (AMOT), Merlin and phosphorylated YAP (pYAP). siRNA-LSR increased expression of pYAP and decreased that of AMOT and Merlin. siRNA-YAP prevented expression of the mRNAs of AREG and TEAD1, and the cell migration and invasion induced by siRNA-LSR. Treatment with dobutamine and 2-deoxy-D-glucose and glucose starvation induced the pYAP expression and prevented the cell migration and invasion induced by siRNA-LSR. siRNA-AMOT decreased the Merlin expression and prevented the cell migration and invasion induced by siRNA-LSR. The loss of LSR promoted cell invasion and migration via upregulation of TEAD1/AREG dependent on YAP/pYAP and AMOT/Merlin in human endometrial cancer cells.
Yoshida F.,Hokkaido University |
Yoshida H.,Sapporo University
Environmental Engineering Science | Year: 2010
This article considers how Japan and the EU manage the recycling of consumer appliances and PCs/cellular phones through a review of their current collection and treatment systems for WEEE (waste electronic and electrical equipment), and on the basis of its findings offers recommendations for the improvement of these systems. We hope thereby to provide information that will be helpful for the better management of WEEE in developed countries as well as in our own. On the basis of our findings, we make the following recommendations: (1) that if Japan hopes to increase its collection rate of WEEE, it has to change its system from one where payment is made at the time of disposal to one where payment is made in advance, whereas the EU has to offer both users and recyclers greater incentives to collect more WEEE; (2) that, within the Japanese system, we have to reduce the cost without reducing the quality of recycling, which, because consumers pay at the time of disposal, is too expensive, whereas the EU must restore the former quality of its recycling, which has been allowed to deteriorate because of the pressure to reduce costs; and (3) that Japan and the EU need to set up a common fund that will enable them to cooperate in the collection and treatment of WEEE to oversee the problems occasioned by the practice of cross-border recycling. © 2009, Mary Ann Liebert, Inc.
Hirano D.,Tokyo University of Marine Science and Technology |
Kitade Y.,Tokyo University of Marine Science and Technology |
Ohshima K.I.,Sapporo University |
Fukamachi Y.,Sapporo University
Journal of Geophysical Research C: Oceans | Year: 2015
The mixing process associated with modified Shelf Water (mSW) overflows that eventually mix to form Cape Darnley Bottom Water (CDBW) was investigated by hydrographic and microstructure observations off the Cape Darnley Polynya (CDP), East Antarctica, in January 2009. Closely spaced microstructure observations revealed that mSW properties varied considerably within a distance of ∼4 km across the shelf edge. Near the bottom, the rate of turbulent kinetic energy dissipation was enhanced to values greater than 10-7 W kg-1, and the vertical scale of the bottom boundary layer (BBL) was on the order of 10 m. The observed BBL around the shelf edge was characterized by strong vertical mixing with turbulent eddy diffusivities of ∼O(10-3-10-2) m2 s-1. A geostrophically balanced density current, which resulted from the presence of mSW over the continental shelf, is considered the primary energy source for the turbulent mixing in the BBL. This turbulent mixing transforms the overflowing mSW through mixing with ambient water masses, specifically with the overlying modified Circumpolar Deep Water. The BBL is also thought to partly contribute to the gradual descent of mSW down the continental slope through bottom Ekman transport. We conclude that turbulent mixing, primarily caused by a density current, plays an important role in CDBW formation, by modifying the mSW overflowing from the CDP. © 2014. American Geophysical Union. All Rights Reserved.
Yoshida F.,Hokkaido University |
Yoshida H.,Sapporo University
Advanced Materials Research | Year: 2014
As 10 years have passed since the Japanese home electrical appliance recycling system came into operation, the results of the system have become clearer, and it is therefore time for us to analyze and evaluate its performance in terms of both the environment and the economy. The system covers 4 specified house appliances, and although roughly 2/3 of these discarded appliances are collected and recycled formally by the manufactures, the greater part of the remaining 1/3 is exported as used items or scrap. Consequently, the government has issued guidelines for the reuse and recycling as countermeasures against illegal dumping and to regulate the export of e-scrap. © (2014) Trans Tech Publications, Switzerland.
Maeda K.,Sapporo University
Nihon Geka Gakkai zasshi | Year: 2013
Taikencyuto (TJ-100) is a Japanese herbal (Kampo) medicine that contains Zanthouxylum and piperitum, Zingiber officinale, Panax ginseng, and Saccharum granorum. TJ-100 enhances intestinal motility, is thought to promote acetylcholine and motilin release, and is a vanilloid receptor. Furthermore, TJ-100 increases intestinal blood flow and works as an antiinflammatory and anticytokine agent by producing calcitonin gene-related peptide and adrenomedullin. TJ-100 is considered to be useful for promoting intestinal motility and preventing ileus during the perioperative period. Further studies must be performed to confirm its usefulness in perioperative care.
Ohno S.,Sapporo University
Nippon Ganka Gakkai zasshi | Year: 2012
Olopatadine hydrochloride ophthalmic solution, 0.2% (olopatadine 0.2%) is approved for allergic conjunctivitis when instilled twice-daily. The objective of this study was to evaluate the efficacy and safety of olopatadine 0.2% (instilled twice-daily) versus vehicle and olopatadine 0.1% (instilled 4-times daily) in Japanese patients with allergic conjunctivitis. A multicenter, parallel-group, double-masked, randomized, conjunctival allergen challenge (CAC) study. Patients > or = 18 years of age with histories of allergic conjunctivitis were treated with either olopatadine 0.2% or olopatadine 0.1% in a single eye and the vehicle in the contralateral eye at 1 visit. Overall, 267 patients were enrolled. Olopatadine 0.2% was superior to its vehicle for ocular itching (p < 0.0001 at the time of observation) and marginally superior for total redness (p = 0.0543 at the time of observation). Olopatadine 0.2% was similar to olopatadine 0.1% for ocular itching at the time of observation. No trends were identified through a review of safety parameters. Olopatadine 0.2% (instilled twice-daily) is safe, well tolerated, superior to the vehicle, and similar to olopatadine 0.1% in preventing ocular itching. Olopatadine 0.2%, which can be instilled less often than olopatadine 0.1%, is a useful new option for allergic conjunctivitis in Japanese patients that could potentially result in better treatment compliance.