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Kawamura N.,Osaka Rosai Hospital | Tokoeda Y.,Shonan Kamakura General Hospital | Oshima M.,Sapporo Tokushukai Hospital | Okahata H.,Kure kyosai Hospital | And 6 more authors.
Vaccine | Year: 2011

A phase III, randomized, double-blind study evaluated the efficacy, reactogenicity, safety and immunogenicity of a human rotavirus vaccine, RIX4414 in Japanese infants aged 6-14 weeks when administered as two doses (0, 1-month schedule). Efficacy against any and severe rotavirus gastroenteritis leading to medical intervention caused by circulating wild-type rotavirus from two weeks post-Dose 2 until two years of age was 79.3% (95% CI: 60.5-89.8%) and 91.6% (95% CI: 62.4-99.1%), respectively. Solicited, unsolicited symptoms and serious adverse events were reported at a similar frequency in both groups. Serum anti-rotavirus antibody seroconversion rate one-month post-Dose 2 was 85.3% (95% CI: 68.9-95%) in RIXX4414 group. RIX4414 was efficacious, well-tolerated and immunogenic in Japanese infants and introduction of vaccination could help in reducing the disease burden. © 2011 Elsevier Ltd.


Kawahara A.,Sapporo Tokushukai Hospital | Kurosaka D.,Iwate Medical University | Yoshida A.,Asahikawa University
Clinical Ophthalmology | Year: 2013

Background: The purpose of this study was to compare surgically induced astigmatism (SIA) between one-handed and two-handed cataract surgery techniques. Methods: Eighty-eight eyes of 44 patients with no ocular disease other than cataract, who underwent cataract surgery by a single surgeon, were selected for this study. Cataract surgery was performed by coaxial phacoemulsification and intraocular lens implantation via a 2.4 mm transconjunctival single-plane sclerocorneal incision at the 12 o'clock position. In each patient, one eye was subjected to coaxial phacoemulsification using a one-handed technique while the fellow eye was subjected to coaxial phacoemulsification using a two-handed technique. For the two-handed technique, a corneal side port was created at the 2 o'clock position. The appropriate incision meridian was identified by a preoperative axis mark. SIA was calculated using the Alpins method. Results: Mean SIA was 0.40 ± 0.28 diopters (D) in the one-handed technique group and 0.39 ± 0.25 D in the two-handed technique group. No statistically significant difference was found in the mean SIA score. The mean torque value was -0.05 ± 0.26 D in the one-handed technique group and 0.11 ± 0.37 D in the two-handed technique group. Mean torque was significantly lower (P,0.05) in the one-handed technique group than in the two-handed technique group. Conclusion: The results indicate that the corneal side port in two-handed cataract surgery has a rotating effect on the axis of astigmatism. © 2013 Kawahara et al.


Tanisawa K.,Sapporo Tokushukai Hospital | Takahashi A.,Asahikawa University | Yoshida A.,Asahikawa University
Japanese Journal of Clinical Ophthalmology | Year: 2015

Purpose: To report orbital apex syndrome in a case of ANCA-related mucosal lesion of the sphenoidal sinus. Case: A 73-year-old female presented with headache, diplopia, proptosis and impaired vision in her right eye since one week before. She had had diabetes mellitus, hypertension and elevated lipids. Findings: Corrected visual acuity was 0.01 right and 0.9 left. The right eye showed proptosis and impaired motility in all directions. Magnetic resonance imaging (MRI) showed mucosal lesion in the right sphenoidal sinus adjacent to the optic canal and cavernous sinus. She was positive for MPO-ANCA, suggesting granulomatosis related to polyangiitis. Peroral prednisolone at the daily dosis of 20 mg was followed by normalization of mucosal lesion in the paranasal sinus and by normalization of visual acuity and motility 6 weeks later. She has been doing well for 13 months until present. Conclusion: Orbital lesion secondary to granulomatosis with polyangiitis shows poor prognosis in general. The present case resulted in favorable outcome, as inflammatory neuropathy may have been present secondary to paranasal sinusitis.


Suzuki S.,Asahikawa University | Koga M.,Kinki Central Hospital | Amamiya S.,Sapporo Tokushukai Hospital | Nakao A.,Red Cross | And 8 more authors.
Diabetologia | Year: 2011

Aims/hypothesis It is difficult to use HbA1c as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA1c were compared to evaluate whether they reflect glycaemic control in patients with NDM. Methods This study included five patients with NDM. Age at diagnosis was 38±20 days. Insulin therapy was started in all patients, and levels of GA, HbA1c and HbF were measured monthly for 6 months. One-month average preprandial plasma glucose (aPPG) was calculated using self-monitoring of blood glucose. Results Plasma glucose and GA were elevated (29.7± 13.1 mmol/l [n=5] and 33.3±6.9% [n=3], respectively) but HbA1c was within normal limits (5.4±2.6% [35.5± 4.9 mmol/mol]; n=4) at diagnosis. With diabetes treatment, aPPG (r=-0.565, p=0.002), GA (r=-0.552, p=0.003) and HbF (r=-0.855, p<0.0001) decreased with age, whereas HbA1c increased (r=0.449, p=0.004). GA was strongly positively correlated with aPPG (r=0.784, p<0.0001), while HbA1c showed no correlation with aPPG (r=0.221, p=0.257) and was significantly inversely correlated with HbF (r=-0.539, p=0.004). Conclusions/interpretation GA is a useful indicator of glycaemic control in patients with NDM, whereas HbA1c is influenced by age-related changes in HbF and does not accurately reflect glycaemic control. © Springer-Verlag 2011.


Narita M.,Sapporo Tokushukai Hospital | Tanaka H.,Sapporo Cough Asthma Allergy Center
Cytokine | Year: 2012

To the Editor, we read with great interest the article by Chung et al. which appeared recently in the journal. In that paper the authors reported that the decreased IL-18 response in severe pneumonia group vs. non-severe group was observed regardless of asthma status of the patients, whose findings were somewhat different from ours on non-asthmatic patients which showed higher serum levels of IL-18 in severe cases of pneumonia than in mild cases in terms of both in children and in adults. In this point, the timing of venous sampling must be an important factor in explaining the discrepant results. Our previous results suggest that the level of IL-18 in blood as a marker of disease severity should cautiously be interpreted considering a timing of sampling; a value of IL-18 in a blood sample which is obtained at the first visit to the hospital does not always represent the highest level of IL-18 because of the fact that the time which elapsed from the onset of illness to the blood sampling may vary among patients. Analyses on sequential samples, therefore, must be necessary to fully understand the perplexing nature of cytokine activation during Mycoplasma pneumoniae infection. © 2012 Elsevier Ltd.

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